Details for: RHOA

Gene ID: 387

Symbol: RHOA

Ensembl ID: ENSG00000067560

Description: ras homolog family member A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 735.7024
    Cell Significance Index: -114.4400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 410.7736
    Cell Significance Index: -104.1900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 337.4215
    Cell Significance Index: -139.0000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 309.0900
    Cell Significance Index: -125.5700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 282.9985
    Cell Significance Index: -133.6100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 269.8561
    Cell Significance Index: -138.8100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 200.1573
    Cell Significance Index: -134.3100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 133.9471
    Cell Significance Index: -127.8900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 103.8156
    Cell Significance Index: -128.0000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 35.4816
    Cell Significance Index: -108.9800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 33.7033
    Cell Significance Index: -133.0000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 33.6692
    Cell Significance Index: -90.2000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 23.4306
    Cell Significance Index: -51.2800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 8.4279
    Cell Significance Index: 155.7700
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 6.0246
    Cell Significance Index: 64.0100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 4.5545
    Cell Significance Index: 537.1100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 4.4656
    Cell Significance Index: 131.1500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 4.1209
    Cell Significance Index: 265.8600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.7552
    Cell Significance Index: 176.4900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.4798
    Cell Significance Index: 44.5700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.3041
    Cell Significance Index: 453.7400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.8164
    Cell Significance Index: 146.7000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.7770
    Cell Significance Index: 341.4600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.6458
    Cell Significance Index: 55.3800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.5451
    Cell Significance Index: 458.8100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.3347
    Cell Significance Index: 1275.0500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.2958
    Cell Significance Index: 40.5700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.2466
    Cell Significance Index: 64.4000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.1879
    Cell Significance Index: 58.4200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.0451
    Cell Significance Index: 262.1700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.9505
    Cell Significance Index: 67.7800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.8224
    Cell Significance Index: 135.8200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.7303
    Cell Significance Index: 765.0200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.4665
    Cell Significance Index: 189.4700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.4205
    Cell Significance Index: 66.2300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.2473
    Cell Significance Index: 14.1700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.2168
    Cell Significance Index: 120.3700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1846
    Cell Significance Index: 235.0800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.1600
    Cell Significance Index: 82.0400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.1225
    Cell Significance Index: 29.5200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0623
    Cell Significance Index: 213.1100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.9684
    Cell Significance Index: 20.9800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6778
    Cell Significance Index: 18.4500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4971
    Cell Significance Index: 178.3100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4895
    Cell Significance Index: 83.5900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.4287
    Cell Significance Index: 11.4700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.2635
    Cell Significance Index: 199.4600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2123
    Cell Significance Index: 1.9600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0598
    Cell Significance Index: 1.0000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0562
    Cell Significance Index: 76.4500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0283
    Cell Significance Index: 53.3500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0007
    Cell Significance Index: 0.0700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0152
    Cell Significance Index: -11.1200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0165
    Cell Significance Index: -0.4600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0232
    Cell Significance Index: -17.2000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0376
    Cell Significance Index: -7.1600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0546
    Cell Significance Index: -0.3300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0685
    Cell Significance Index: -1.9800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0692
    Cell Significance Index: -127.6600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0699
    Cell Significance Index: -107.6600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0775
    Cell Significance Index: -4.0300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0777
    Cell Significance Index: -48.5500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1045
    Cell Significance Index: -47.4500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1055
    Cell Significance Index: -67.0300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1207
    Cell Significance Index: -5.4700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1669
    Cell Significance Index: -94.1200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2723
    Cell Significance Index: -2.9600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3184
    Cell Significance Index: -67.0600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3292
    Cell Significance Index: -37.5800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3996
    Cell Significance Index: -114.9800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4850
    Cell Significance Index: -55.5700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5264
    Cell Significance Index: -40.4000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5513
    Cell Significance Index: -28.9500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.6351
    Cell Significance Index: -92.3200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.6388
    Cell Significance Index: -74.4400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.6460
    Cell Significance Index: -22.7000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.8471
    Cell Significance Index: -58.5800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.9080
    Cell Significance Index: -13.7900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.9649
    Cell Significance Index: -24.6500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.9782
    Cell Significance Index: -26.2100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.0636
    Cell Significance Index: -110.7500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.2698
    Cell Significance Index: -100.5700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.3365
    Cell Significance Index: -75.0000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.3716
    Cell Significance Index: -86.4500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.3904
    Cell Significance Index: -85.4600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.3922
    Cell Significance Index: -93.6100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.5633
    Cell Significance Index: -79.0100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.6431
    Cell Significance Index: -24.6200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.6831
    Cell Significance Index: -32.8500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.8234
    Cell Significance Index: -58.4000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -1.9300
    Cell Significance Index: -44.5900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.9723
    Cell Significance Index: -26.9100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -2.0489
    Cell Significance Index: -17.2100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -2.1996
    Cell Significance Index: -134.8600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -2.2591
    Cell Significance Index: -58.0700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.7460
    Cell Significance Index: -80.8800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -2.7791
    Cell Significance Index: -122.9300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -2.8648
    Cell Significance Index: -117.3900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -2.9346
    Cell Significance Index: -18.0600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -2.9636
    Cell Significance Index: -108.7900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Small GTPase**: RHOA is a small GTPase that belongs to the Rho family, which consists of GTP-binding proteins that regulate various cellular processes. 2. **Cytoskeleton organization**: RHOA regulates the organization of the actin cytoskeleton, which is essential for cell migration, shape, and structure. 3. **Cell migration**: RHOA is involved in regulating cell migration, including axon growth, neuronal migration, and immune cell migration. 4. **Signaling pathways**: RHOA interacts with multiple signaling pathways, including the MAPK/ERK, PI3K/AKT, and JAK/STAT pathways. 5. **Cell-cell interactions**: RHOA regulates cell-cell interactions, including adhesion and migration, through its effects on the actin cytoskeleton and cell surface receptors. **Pathways and Functions** 1. **Actin cytoskeleton organization**: RHOA regulates the organization of the actin cytoskeleton, which is essential for cell migration, shape, and structure. 2. **Cell migration**: RHOA is involved in regulating cell migration, including axon growth, neuronal migration, and immune cell migration. 3. **Immune system development**: RHOA plays a crucial role in the development and function of the immune system, including the differentiation of T cells and the regulation of immune cell migration. 4. **Neuronal migration**: RHOA regulates neuronal migration and axon growth, which is essential for the development and function of the nervous system. 5. **Cardiovascular regulation**: RHOA is involved in regulating systemic arterial blood pressure and aortic valve formation, which is essential for maintaining cardiovascular homeostasis. **Clinical Significance** 1. **Cancer**: RHOA is overexpressed in various types of cancer, including breast, lung, and colon cancer, where it promotes tumor progression and metastasis. 2. **Neurological disorders**: RHOA mutations have been implicated in neurological disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. 3. **Cardiovascular disease**: RHOA mutations have been linked to cardiovascular disease, including hypertension and aortic aneurysms. 4. **Immune system disorders**: RHOA is involved in regulating the immune system, and mutations in this gene have been implicated in autoimmune disorders, including rheumatoid arthritis and lupus. 5. **Regenerative medicine**: RHOA has been identified as a key regulator of stem cell migration and differentiation, making it a potential target for regenerative medicine applications. In conclusion, RHOA is a critical regulator of various cellular processes, including cell migration, cytoskeleton organization, and signal transduction. Its dysregulation has been implicated in various diseases, including cancer, neurological disorders, cardiovascular disease, immune system disorders, and regenerative medicine applications. Further research is needed to fully understand the functions and clinical significance of RHOA and its role in maintaining tissue homeostasis and overall health.

Genular Protein ID: 1018258098

Symbol: RHOA_HUMAN

Name: Rho cDNA clone 12

UniProtKB Accession Codes:

P61586 P06749 Q53HM4 Q5U024 Q9UDJ0 Q9UEJ4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 11 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 13 EMDB 4 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 99 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 100 PDBsum 100 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 26 RefSeq 2 Rhea 2 SABIO-RK 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3822842

Title: Nucleotide sequence of human rho cDNA clone 12.

PubMed ID: 3822842

DOI: 10.1093/nar/15.4.1869

PubMed ID: 7835413

Title: Sequence of rho small GTP-binding protein cDNAs from human retina and identification of novel 5' end cloning artifacts.

PubMed ID: 7835413

DOI: 10.1006/exer.1994.1102

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8039707

Title: Utilization of multiple polyadenylation signals in the human RHOA protooncogene.

PubMed ID: 8039707

DOI: 10.1016/0378-1119(94)90382-4

PubMed ID: 1328215

Title: A rho gene product in human blood platelets. I. Identification of the platelet substrate for botulinum C3 ADP-ribosyltransferase as rhoA protein.

PubMed ID: 1328215

DOI: 10.1016/s0021-9258(19)36775-4

PubMed ID: 7777059

Title: Glucosylation of Rho proteins by Clostridium difficile toxin B.

PubMed ID: 7777059

DOI: 10.1038/375500a0

PubMed ID: 1556108

Title: Structure and function of the 5'-flanking sequence of the human cytosolic selenium-dependent glutathione peroxidase gene (hgpx1).

PubMed ID: 1556108

DOI: 10.1016/s0021-9258(18)42647-6

PubMed ID: 7775453

Title: The enterotoxin from Clostridium difficile (ToxA) monoglucosylates the Rho proteins.

PubMed ID: 7775453

DOI: 10.1074/jbc.270.23.13932

PubMed ID: 8617235

Title: The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase.

PubMed ID: 8617235

DOI: 10.1002/j.1460-2075.1996.tb00539.x

PubMed ID: 8641286

Title: Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho.

PubMed ID: 8641286

DOI: 10.1002/j.1460-2075.1996.tb00574.x

PubMed ID: 8910519

Title: Isolation of a NCK-associated kinase, PRK2, an SH3-binding protein and potential effector of Rho protein signaling.

PubMed ID: 8910519

DOI: 10.1074/jbc.271.46.28772

PubMed ID: 8810274

Title: Clostridium novyi alpha-toxin-catalyzed incorporation of GlcNAc into Rho subfamily proteins.

PubMed ID: 8810274

DOI: 10.1074/jbc.271.41.25173

PubMed ID: 9121475

Title: The PRK2 kinase is a potential effector target of both Rho and Rac GTPases and regulates actin cytoskeletal organization.

PubMed ID: 9121475

DOI: 10.1128/mcb.17.4.2247

PubMed ID: 9635436

Title: The small GTP-binding protein RhoA regulates a delayed rectifier potassium channel.

PubMed ID: 9635436

DOI: 10.1016/s0092-8674(00)81212-x

PubMed ID: 9857026

Title: Cloning and characterization of GEF-H1, a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPases.

PubMed ID: 9857026

DOI: 10.1074/jbc.273.52.34954

PubMed ID: 10066731

Title: Diacylglycerol kinase theta binds to and is negatively regulated by active RhoA.

PubMed ID: 10066731

DOI: 10.1074/jbc.274.11.6820

PubMed ID: 10438814

Title: RhoA interacts with the fusion glycoprotein of respiratory syncytial virus and facilitates virus-induced syncytium formation.

PubMed ID: 10438814

DOI: 10.1128/jvi.73.9.7262-7270.1999

PubMed ID: 10940294

Title: The PDZ protein TIP-1 interacts with the Rho effector rhotekin and is involved in Rho signaling to the serum response element.

PubMed ID: 10940294

DOI: 10.1074/jbc.m000465200

PubMed ID: 11162591

Title: cGMP-dependent protein kinase phosphorylates and inactivates RhoA.

PubMed ID: 11162591

DOI: 10.1006/bbrc.2000.4194

PubMed ID: 11696353

Title: Ht31: the first protein kinase A anchoring protein to integrate protein kinase A and Rho signaling.

PubMed ID: 11696353

DOI: 10.1016/s0014-5793(01)02995-7

PubMed ID: 12221096

Title: XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC.

PubMed ID: 12221096

DOI: 10.1074/jbc.m207401200

PubMed ID: 12062101

Title: A Yersinia effector and a Pseudomonas avirulence protein define a family of cysteine proteases functioning in bacterial pathogenesis.

PubMed ID: 12062101

DOI: 10.1016/s0092-8674(02)00766-3

PubMed ID: 12551911

Title: Novel mechanism of the co-regulation of nuclear transport of SmgGDS and Rac1.

PubMed ID: 12551911

DOI: 10.1074/jbc.m211286200

PubMed ID: 12900402

Title: Direct activation of phospholipase C-epsilon by Rho.

PubMed ID: 12900402

DOI: 10.1074/jbc.m306904200

PubMed ID: 12538863

Title: Biochemical characterization of the Yersinia YopT protease: cleavage site and recognition elements in Rho GTPases.

PubMed ID: 12538863

DOI: 10.1073/pnas.252770599

PubMed ID: 16103226

Title: An ECT2-centralspindlin complex regulates the localization and function of RhoA.

PubMed ID: 16103226

DOI: 10.1083/jcb.200501097

PubMed ID: 16236794

Title: Dissecting the role of Rho-mediated signaling in contractile ring formation.

PubMed ID: 16236794

DOI: 10.1091/mbc.e05-06-0569

PubMed ID: 17115030

Title: The armadillo protein p0071 regulates Rho signalling during cytokinesis.

PubMed ID: 17115030

DOI: 10.1038/ncb1504

PubMed ID: 19934221

Title: The Rho-family GEF Asef2 activates Rac to modulate adhesion and actin dynamics and thereby regulate cell migration.

PubMed ID: 19934221

DOI: 10.1242/jcs.053728

PubMed ID: 19403695

Title: Dual roles for RHOA/RHO-kinase in the regulated trafficking of a voltage-sensitive potassium channel.

PubMed ID: 19403695

DOI: 10.1091/mbc.e08-10-1074

PubMed ID: 19362538

Title: The fic domain: regulation of cell signaling by adenylylation.

PubMed ID: 19362538

DOI: 10.1016/j.molcel.2009.03.008

PubMed ID: 19782033

Title: Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement.

PubMed ID: 19782033

DOI: 10.1016/j.molcel.2009.09.004

PubMed ID: 19039103

Title: AMPylation of Rho GTPases by Vibrio VopS disrupts effector binding and downstream signaling.

PubMed ID: 19039103

DOI: 10.1126/science.1166382

PubMed ID: 19948726

Title: Activated Rac1 GTPase translocates protein phosphatase 5 to the cell membrane and stimulates phosphatase activity in vitro.

PubMed ID: 19948726

DOI: 10.1074/jbc.m109.088427

PubMed ID: 20709748

Title: Splice variants of SmgGDS control small GTPase prenylation and membrane localization.

PubMed ID: 20709748

DOI: 10.1074/jbc.m110.129916

PubMed ID: 20400958

Title: Regulation of Rho GTPase crosstalk, degradation and activity by RhoGDI1.

PubMed ID: 20400958

DOI: 10.1038/ncb2049

PubMed ID: 20937854

Title: ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells.

PubMed ID: 20937854

DOI: 10.1073/pnas.1000975107

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21565175

Title: ARHGAP30 is a Wrch-1-interacting protein involved in actin dynamics and cell adhesion.

PubMed ID: 21565175

DOI: 10.1016/j.bbrc.2011.04.116

PubMed ID: 20499158

Title: RACK1 promotes breast carcinoma migration/metastasis via activation of the RhoA/Rho kinase pathway.

PubMed ID: 20499158

DOI: 10.1007/s10549-010-0955-3

PubMed ID: 20974804

Title: The Rho target PRK2 regulates apical junction formation in human bronchial epithelial cells.

PubMed ID: 20974804

DOI: 10.1128/mcb.01001-10

PubMed ID: 23940119

Title: The GEF Bcr activates RhoA/MAL signaling to promote keratinocyte differentiation via desmoglein-1.

PubMed ID: 23940119

DOI: 10.1083/jcb.201304133

PubMed ID: 23325789

Title: cAMP-stimulated phosphorylation of diaphanous 1 regulates protein stability and interaction with binding partners in adrenocortical cells.

PubMed ID: 23325789

DOI: 10.1091/mbc.e12-08-0597

PubMed ID: 24141704

Title: A bacterial toxin catalyzing tyrosine glycosylation of Rho and deamidation of Gq and Gi proteins.

PubMed ID: 24141704

DOI: 10.1038/nsmb.2688

PubMed ID: 23871831

Title: A new mechanism of RhoA ubiquitination and degradation: roles of SCF(FBXL19) E3 ligase and Erk2.

PubMed ID: 23871831

DOI: 10.1016/j.bbamcr.2013.07.005

PubMed ID: 24905543

Title: Haemorrhagic toxin and lethal toxin from Clostridium sordellii strain vpi9048: molecular characterization and comparative analysis of substrate specificity of the large clostridial glucosylating toxins.

PubMed ID: 24905543

DOI: 10.1111/cmi.12321

PubMed ID: 25588844

Title: Front-signal-dependent accumulation of the RHOA inhibitor FAM65B at leading edges polarizes neutrophils.

PubMed ID: 25588844

DOI: 10.1242/jcs.161497

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27807006

Title: RHO binding to FAM65A regulates Golgi reorientation during cell migration.

PubMed ID: 27807006

DOI: 10.1242/jcs.198614

PubMed ID: 28630045

Title: Structure-based analysis of the guanine nucleotide exchange factor SmgGDS reveals armadillo-repeat motifs and key regions for activity and GTPase binding.

PubMed ID: 28630045

DOI: 10.1074/jbc.m117.792556

PubMed ID: 31888991

Title: Structure and regulation of human epithelial cell transforming 2 protein.

PubMed ID: 31888991

DOI: 10.1073/pnas.1913054117

PubMed ID: 31570889

Title: Postzygotic inactivating mutations of RHOA cause a mosaic neuroectodermal syndrome.

PubMed ID: 31570889

DOI: 10.1038/s41588-019-0498-4

PubMed ID: 30061757

Title: Nepsilon-fatty acylation of multiple membrane-associated proteins by Shigella IcsB effector to modulate host function.

PubMed ID: 30061757

DOI: 10.1038/s41564-018-0215-6

PubMed ID: 9302995

Title: Crystal structure of RhoA-GDP and its functional implications.

PubMed ID: 9302995

DOI: 10.1038/nsb0997-699

PubMed ID: 9545299

Title: Crystal structure of human RhoA in a dominantly active form complexed with a GTP analogue.

PubMed ID: 9545299

DOI: 10.1074/jbc.273.16.9656

PubMed ID: 10388627

Title: Biochemical and crystallographic characterization of a Rho effector domain of the protein serine/threonine kinase N in a complex with RhoA.

PubMed ID: 10388627

DOI: 10.1006/jsbi.1999.4114

PubMed ID: 10748207

Title: An open conformation of switch I revealed by the crystal structure of a Mg2+-free form of RHOA complexed with GDP. Implications for the GDP/GTP exchange mechanism.

PubMed ID: 10748207

DOI: 10.1074/jbc.m910274199

PubMed ID: 11927263

Title: MgF(3)(-) as a transition state analog of phosphoryl transfer.

PubMed ID: 11927263

DOI: 10.1016/s1074-5521(02)00112-6

PubMed ID: 12006984

Title: Structural basis for the selective activation of Rho GTPases by Dbl exchange factors.

PubMed ID: 12006984

DOI: 10.1038/nsb796

PubMed ID: 12777804

Title: Structure of a constitutively activated RhoA mutant (Q63L) at 1.55 A resolution.

PubMed ID: 12777804

DOI: 10.1107/s0907444903005390

PubMed ID: 30190425

Title: GEF mechanism revealed by the structure of SmgGDS-558 and farnesylated RhoA complex and its implication for a chaperone mechanism.

PubMed ID: 30190425

DOI: 10.1073/pnas.1804740115

Sequence Information:

  • Length: 193
  • Mass: 21768
  • Checksum: C4DA2DC31FF858BC
  • Sequence:
    • MAAIRKKLVI VGDGACGKTC LLIVFSKDQF PEVYVPTVFE NYVADIEVDG KQVELALWDT 
AGQEDYDRLR PLSYPDTDVI LMCFSIDSPD SLENIPEKWT PEVKHFCPNV PIILVGNKKD 
LRNDEHTRRE LAKMKQEPVK PEEGRDMANR IGAFGYMECS AKTKDGVREV FEMATRAALQ 
ARRGKKKSGC LVL

Genular Protein ID: 3535377301

Symbol: A0A7I2YQV1_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A7I2YQV1

Database IDs:

AlphaFoldDB 1 Bgee 1 CTD 1 DisGeNET 1 EMBL 3 Ensembl 2 GO 3 Gene3D 1 GeneTree 1 HGNC 1 InterPro 4 NCBI Taxonomy 1 NCBIfam 1 PANTHER 2 PRINTS 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SMART 3 SMR 1 SUPFAM 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

Sequence Information:

  • Length: 109
  • Mass: 11990
  • Checksum: 855CA53882BC352B
  • Sequence:
    • MAAIRKKLVI VGDGACGKTC LLIVFSKDQF PEVYVPTVFE NYVADIEVDG KQEPVKPEEG 
RDMANRIGAF GYMECSAKTK DGVREVFEMA TRAALQARRG KKKSGCLVL

Genular Protein ID: 1686133518

Symbol: B4DKN9_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DKN9

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 9 Gene3D 1 InterPro 4 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 1 RefSeq 1 SMART 3 SUPFAM 1

Sequence Information:

  • Length: 173
  • Mass: 19570
  • Checksum: 32B8F0A4C2DB820D
  • Sequence:
    • MAAIRKKLVI VGDGACGKTC LLIVFSKDQF PEVYVPTVFE NYVADYDRLR PLSYPDTDVI 
LMCFSIDSPD SLENIPEKWT PEVKHFCPNV PIILVGNKKD LRNDEHTRRE LAKMKQEPVK 
PEEGRDMANR IGAFGYMECS AKTKDGVREV FEMATRAALQ ARRGKKKSGC LVL

Genular Protein ID: 5413297

Symbol: C9JX21_HUMAN

Name: N/A

UniProtKB Accession Codes:

C9JX21

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 HGNC 1 InterPro 4 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SMART 3 SMR 1 SUPFAM 1 SwissPalm 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 187
  • Mass: 21164
  • Checksum: FC5FBC55C61CFE2A
  • Sequence:
    • MAAIRKKLVI VGDGACGKTC LLIVFSKDQF PEVYVPTVFE NYVADIEVDG KQVELALWDT 
AGQEDYDRLR PLSYPDTDVI LMCFSIDSPD SLENIPEKWT PEVKHFCPNV PIILVGNKKD 
LRNDEHTRRE LAKMKQEPHC VARLECCGTI LAQLQPPPPR FKRFPCLSLL SSWGYRRPLP 
HPGAGET

Genular Protein ID: 2889228444

Symbol: C9JRM1_HUMAN

Name: N/A

UniProtKB Accession Codes:

C9JRM1

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 4 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SMART 1 SMR 1 SUPFAM 1 SwissPalm 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 90
  • Mass: 9715
  • Checksum: D149B6073D36E321
  • Sequence:
    • MAAIRKKLVI VGDGACGKTC LLIVFSKDQF PEVYVPTVFE NYVADIEVDG KQKTSQKSGP 
QKSSISVPTC PSSWLGIRRI FGMMSTQGGS

Genular Protein ID: 1465812677

Symbol: Q9BVT0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9BVT0

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 9 Gene3D 1 InterPro 4 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 101
  • Mass: 11523
  • Checksum: 5067AD783510BA63
  • Sequence:
    • ENIPEKWTPE VKHFCPNVPI ILVGNKKDLR NDEHTRRELA KMKQEPVKPE EGRDMANRIG 
AFGYMECSAK TKDGVREVFE MATRAALQAR RGKKKSGCLV L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.