Details for: MED4

Gene ID: 38799

Symbol: MED4

Ensembl ID: FBgn0035754

Description: Mediator complex subunit 4

Associated with

  • Epigenetic regulation by wdr5-containing histone modifying complexes
    (R-DME-9917777)
  • Epigenetic regulation of adipogenesis genes by mll3 and mll4 complexes
    (R-DME-9851695)
  • Epigenetic regulation of gene expression
    (R-DME-212165)
  • Epigenetic regulation of gene expression by mll3 and mll4 complexes
    (R-DME-9818564)
  • Gene expression (transcription)
    (R-DME-74160)
  • Mll4 and mll3 complexes regulate expression of pparg target genes in adipogenesis and hepatic steatosis
    (R-DME-9841922)
  • Core mediator complex
    (GO:0070847)
  • Mediator complex
    (GO:0016592)
  • Nucleus
    (GO:0005634)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Transcription coactivator activity
    (GO:0003713)
  • Transcription coregulator activity
    (GO:0003712)

Other Information

Genular Protein ID: 3558414887

Symbol: MED4_DROME

Name: Mediator of RNA polymerase II transcription subunit 4

UniProtKB Accession Codes:

Q9VS38

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CTD 1 ComplexPortal 1 DIP 1 DNASU 1 EMBL 2 EnsemblMetazoa 1 FlyBase 1 GO 6 GeneTree 1 GenomeRNAi 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRO 1 PaxDb 1 Pfam 1 PhylomeDB 1 Proteomes 1 RefSeq 1 SMR 1 STRING 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537569

Title: A Drosophila full-length cDNA resource.

PubMed ID: 12537569

DOI: 10.1186/gb-2002-3-12-research0080

PubMed ID: 11259581

Title: Drosophila Mediator complex is broadly utilized by diverse gene-specific transcription factors at different types of core promoters.

PubMed ID: 11259581

DOI: 10.1128/mcb.21.7.2312-2323.2001

PubMed ID: 12021283

Title: Novel Mediator proteins of the small Mediator complex in Drosophila SL2 cells.

PubMed ID: 12021283

DOI: 10.1074/jbc.m204144200

PubMed ID: 15477388

Title: A high resolution protein interaction map of the yeast Mediator complex.

PubMed ID: 15477388

DOI: 10.1093/nar/gkh878

PubMed ID: 16751183

Title: Coactivator cross-talk specifies transcriptional output.

PubMed ID: 16751183

DOI: 10.1101/gad.1418806

Sequence Information:

  • Length: 258
  • Mass: 28313
  • Checksum: B638BF3DC2294E8B
  • Sequence:
    • MSFHLSTKER LLLLIDDIEM IAKELIEQAH QKISSTELVD LLDLLVAKDE EFRKMLELAE 
EQAKVEEAMD QLRAKVEVHD REIQKLQKSL KDAELILSTA IFQARQKLAS INQANKRPVS 
SEELIKYAHR ISSANAVSAP LTWCIGDLRR PYPTDIEMRN GLLGKSEQNI NGGTVTHQNS 
GMPSEQQRTL SGSAGSGSGS GAGGEVPNAF QNQFNWNLGE LHMTMGASGN TVALETRAQD 
DVEVMSTDSS SSSSSDSQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.