Details for: orb2

Gene ID: 39018

Symbol: orb2

Ensembl ID: FBgn0264307

Description: orb2

Associated with

Other Information

Genular Protein ID: 2429362870

Symbol: ORB2_DROME

Name: Translational regulator orb2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537569

Title: A Drosophila full-length cDNA resource.

PubMed ID: 12537569

DOI: 10.1186/gb-2002-3-12-research0080

PubMed ID: 17965711

Title: Function of the Drosophila CPEB protein Orb2 in long-term courtship memory.

PubMed ID: 17965711

DOI: 10.1038/nn1996

PubMed ID: 18327897

Title: Phosphoproteome analysis of Drosophila melanogaster embryos.

PubMed ID: 18327897

DOI: 10.1021/pr700696a

PubMed ID: 20547833

Title: Drosophila Orb2 targets genes involved in neuronal growth, synapse formation, and protein turnover.

PubMed ID: 20547833

DOI: 10.1073/pnas.1004433107

PubMed ID: 21900268

Title: The Drosophila CPEB protein Orb2 has a novel expression pattern and is important for asymmetric cell division and nervous system function.

PubMed ID: 21900268

DOI: 10.1534/genetics.110.123646

PubMed ID: 22284910

Title: Critical role of amyloid-like oligomers of Drosophila Orb2 in the persistence of memory.

PubMed ID: 22284910

DOI: 10.1016/j.cell.2012.01.004

PubMed ID: 23083740

Title: Drosophila CPEB Orb2A mediates memory independent of its RNA-binding domain.

PubMed ID: 23083740

DOI: 10.1016/j.neuron.2012.08.028

PubMed ID: 23209437

Title: The CPEB protein Orb2 has multiple functions during spermatogenesis in Drosophila melanogaster.

PubMed ID: 23209437

DOI: 10.1371/journal.pgen.1003079

PubMed ID: 24523662

Title: Contribution of Orb2A stability in regulated amyloid-like oligomerization of Drosophila Orb2.

PubMed ID: 24523662

DOI: 10.1371/journal.pbio.1001786

PubMed ID: 24830287

Title: Spermatid cyst polarization in Drosophila depends upon apkc and the CPEB family translational regulator orb2.

PubMed ID: 24830287

DOI: 10.1371/journal.pgen.1004380

PubMed ID: 26638074

Title: Amyloidogenic oligomerization transforms Drosophila Orb2 from a translation repressor to an activator.

PubMed ID: 26638074

DOI: 10.1016/j.cell.2015.11.020

PubMed ID: 26095367

Title: Synaptic Orb2A bridges memory acquisition and late memory consolidation in Drosophila.

PubMed ID: 26095367

DOI: 10.1016/j.celrep.2015.05.037

PubMed ID: 26812143

Title: Molecular basis of Orb2 amyloidogenesis and blockade of memory consolidation.

PubMed ID: 26812143

DOI: 10.1371/journal.pbio.1002361

PubMed ID: 28763009

Title: Metal Binding Properties of the N-Terminus of the Functional Amyloid Orb2.

PubMed ID: 28763009

DOI: 10.3390/biom7030057

PubMed ID: 28700922

Title: The Functional Amyloid Orb2A Binds to Lipid Membranes.

PubMed ID: 28700922

DOI: 10.1016/j.bpj.2017.05.039

PubMed ID: 28525754

Title: Regulated Intron Removal Integrates Motivational State and Experience.

PubMed ID: 28525754

DOI: 10.1016/j.cell.2017.05.006

PubMed ID: 29105522

Title: Orb2 as modulator of Brat and their role at the neuromuscular junction.

PubMed ID: 29105522

DOI: 10.1080/01677063.2017.1393539

PubMed ID: 29317541

Title: Dicer-2 promotes mRNA activation through cytoplasmic polyadenylation.

PubMed ID: 29317541

DOI: 10.1261/rna.065417.117

PubMed ID: 32165583

Title: Cryo-EM structure of a neuronal functional amyloid implicated in memory persistence in Drosophila.

PubMed ID: 32165583

DOI: 10.1126/science.aba3526

Sequence Information:

  • Length: 704
  • Mass: 74504
  • Checksum: A4C8BD564C5F6432
  • Sequence:
  • MDSLKLPKAN SATSSASGSN SNLSGSTSAS ASAATSPTSS GTAVGGILSG APKSPPGLGS 
    STPISVRFNA NEESLDDILQ SFHHSKHSPS GGASGGGDAS PTSNLLGMKN NGLGLVVGNC 
    DSLSSSPSQP QMHAGSASLF GNDEVSLRNN FMQAGGFFNR KSCGGLPNLN LNKPPQLHQQ 
    QHQQQHQQHQ QHQQQQQLHQ HQQQLSPNLS ALHHHHQQQQ QLRESGGSHS PSSPGGGGGG 
    SPYNGSQAGC SSGGISPIPP QMGVSPKYRR SISFPIKGNS PTAIYGNMHM DGMGSGHMNI 
    PTLSIGNGGG GGSTGMVSAG ATGGGDAPYL GNSYGNMMTS NGQMHHGGGL DNSLCDYMRN 
    MSLGGNGGGD GSNSMSLMQD RMRVMGGPKH LSEADAMAIA ASGNDPSVYL NALKMGSPSR 
    LSPHSPHSPI QGGNGGNVGD GTARFSRKVF VGGLPPDIDE DEITTSFRRF GPLVVDWPHK 
    AESKSYFPPK GYAFLLFQDE SSVQQLIDSC ITDEDKLYLC VSSPTIKDKA VQIRPWRLAD 
    ADYVLDATMS LDPRKTVFVG GVPRPLKAFE LAMIMDRLYG GVCYAGIDTD PELKYPKGAG 
    RVAFSNQQSY IAAISARFVQ LQHGDIDKRV EVKPYVLDDQ MCDECEGQRC GGKFAPFFCA 
    NVTCLQYYCE HCWAVIHSRP GREYHKPLVK EGADRPRAVP FRWC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.