Notum | FBgn0044028 | NCBI 39751

Details for: Notum

Gene ID: 39751

Symbol: Notum

Ensembl ID: FBgn0044028

Description: notum

Associated with

Hedgehog ligand biogenesis
(R-DME-5358346)
Metabolism of proteins
(R-DME-392499)
Post-translational protein modification
(R-DME-597592)
Post-translational protein phosphorylation
(R-DME-8957275)
Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
(R-DME-381426)
Release of hh-np from the secreting cell
(R-DME-5362798)
Signaling by hedgehog
(R-DME-5358351)
Signal transduction
(R-DME-162582)
Deacetylase activity
(GO:0019213)
Digestive tract morphogenesis
(GO:0048546)
Extracellular space
(GO:0005615)
Gpi anchor release
(GO:0006507)
Hydrolase activity
(GO:0016787)
Negative regulation of canonical wnt signaling pathway
(GO:0090090)
Palmitoleyl hydrolase activity
(GO:1990699)
Phospholipase activity
(GO:0004620)
Positive regulation of smoothened signaling pathway
(GO:0045880)
Protein depalmitoleylation
(GO:1990697)
Regulation of compound eye pigmentation
(GO:0048076)
Ventral cord development
(GO:0007419)
Wing disc development
(GO:0035220)
Wing disc dorsal/ventral pattern formation
(GO:0048190)
Wing disc pattern formation
(GO:0035222)

Other Information

Proteins

NOTUM_DROME

Genular Protein ID: 4141521572

Symbol: NOTUM_DROME

Name: N/A

UniProtKB Accession Codes:

Q9VUX3 Q8T385

Database IDs:

Citations:

PubMed ID: 12015973

Title: HSPG modification by the secreted enzyme Notum shapes the Wingless morphogen gradient.

PubMed ID: 12015973

DOI: 10.1016/s1534-5807(02)00180-6

PubMed ID: 12000788

Title: Wingful, an extracellular feedback inhibitor of Wingless.

PubMed ID: 12000788

DOI: 10.1101/gad.991802

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 15469839

Title: Opposing activities of Dally-like glypican at high and low levels of Wingless morphogen activity.

PubMed ID: 15469839

DOI: 10.1016/j.devcel.2004.08.005

PubMed ID: 20412775

Title: The long-range activity of Hedgehog is regulated in the apical extracellular space by the glypican Dally and the hydrolase Notum.

PubMed ID: 20412775

DOI: 10.1016/j.devcel.2010.02.015

PubMed ID: 22872085

Title: Dally and Notum regulate the switch between low and high level Hedgehog pathway signalling.

PubMed ID: 22872085

DOI: 10.1242/dev.078402

PubMed ID: 25731175

Title: Notum deacylates Wnt proteins to suppress signalling activity.

PubMed ID: 25731175

DOI: 10.1038/nature14259

Sequence Information:

Length: 671
Mass: 76937
Checksum: 0230294B1E754D94
Sequence:

MAVEQIDKMA AKAGEATNKW IKPQQPLLTL LLLLATFSQL PAVCSSSILD AASLQEKDPL 
RDTSMNMIQR NYMVMHSASG SGDHSRSLKR ANLANTSITC NDGSHAGFYL RKHPSSKKWI 
VLLEGGWHCF DVRSCRSRWM RLRHLMTSSQ WPETRDVGGI LSPHPEENPY WHNANHVLIP 
YCSSDSWSGT RTEPDTSDRE NSWRFMGALI LRQVIAELIP VGLGRVPGGE LMLVGSSAGG 
MGVMLNLDRI RDFLVNEKKL QITVRGVSDS GWFLDREPYT PAAVASNEAV RQGWKLWQGL 
LPEECTKSYP TEPWRCYYGY RLYPTLKTPL FVFQWLFDEA QMRVDNVGAP VTPQQWNYIH 
EMGGALRSSL DNVSAVFAPS CIGHGVLFKR DWVNIKIDDI SLPSALRCWE HSTRSRRHDK 
LKRSTEPSTA VSHPEHANNQ RHQRHRQRLQ RQKHNNVAQS GGQQRKHNHL SKEEREERKR 
LRQEQRQRRK QRRRQQQQKK ANGGQEHRNK KDNSPKSSNG NDQRKQRRRQ QLTAEERQEQ 
RKRRRKAQQQ QMKMQREQPA AGVFLEASAP QKTRSSNNAS AGTKSKKRHR VPRVPEKCGL 
RLLERCSWPQ CNHSCPTLTN PMTGEEMRFL ELLTAFGLDI EAVAAALGVD MHTLNNMERT 
ELVNMLTQQA N

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Notum

Associated with

Other Information

HSPG modification by the secreted enzyme Notum shapes the Wingless morphogen gradient. PubMed ID: 12015973

Wingful, an extracellular feedback inhibitor of Wingless. PubMed ID: 12000788

The genome sequence of Drosophila melanogaster. PubMed ID: 10731132

Annotation of the Drosophila melanogaster euchromatic genome: a systematic review. PubMed ID: 12537572

Opposing activities of Dally-like glypican at high and low levels of Wingless morphogen activity. PubMed ID: 15469839

The long-range activity of Hedgehog is regulated in the apical extracellular space by the glypican Dally and the hydrolase Notum. PubMed ID: 20412775

Dally and Notum regulate the switch between low and high level Hedgehog pathway signalling. PubMed ID: 22872085

Notum deacylates Wnt proteins to suppress signalling activity. PubMed ID: 25731175