Diap1 | FBgn0260635 | NCBI 39753

Details for: Diap1

Gene ID: 39753

Symbol: Diap1

Ensembl ID: FBgn0260635

Description: Death-associated inhibitor of apoptosis 1

Associated with

Antennal morphogenesis
(GO:0048800)
Apoptotic process
(GO:0006915)
Border follicle cell migration
(GO:0007298)
Caspase binding
(GO:0089720)
Chaeta development
(GO:0022416)
Cysteine-type endopeptidase inhibitor activity
(GO:0004869)
Cysteine-type endopeptidase inhibitor activity involved in apoptotic process
(GO:0043027)
Cytoplasm
(GO:0005737)
Nedd8 ligase activity
(GO:0061663)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of compound eye retinal cell programmed cell death
(GO:0046673)
Negative regulation of jnk cascade
(GO:0046329)
Nucleus
(GO:0005634)
Perinuclear region of cytoplasm
(GO:0048471)
Positive regulation of border follicle cell migration
(GO:1903688)
Positive regulation of canonical wnt signaling pathway
(GO:0090263)
Positive regulation of protein ubiquitination
(GO:0031398)
Positive regulation of toll signaling pathway
(GO:0045752)
Protein autoubiquitination
(GO:0051865)
Protein binding
(GO:0005515)
Protein k48-linked ubiquitination
(GO:0070936)
Protein neddylation
(GO:0045116)
Protein polyubiquitination
(GO:0000209)
Regulation of cell cycle
(GO:0051726)
Sensory organ precursor cell division
(GO:0045035)
Spermatid nucleus differentiation
(GO:0007289)
Spermatogenesis
(GO:0007283)
Ubiquitin-like protein conjugating enzyme binding
(GO:0044390)
Ubiquitin-protein transferase activity
(GO:0004842)
Ubiquitin-specific protease binding
(GO:1990381)
Ubiquitin conjugating enzyme binding
(GO:0031624)
Ubiquitin protein ligase activity
(GO:0061630)
Ubiquitin protein ligase binding
(GO:0031625)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Death-associated inhibitor of apoptosis 1

Genular Protein ID: 1019863088

Symbol: DIAP1_DROME

Name: Death-associated inhibitor of apoptosis 1

UniProtKB Accession Codes:

Q24306 A4V1Z9 A9UN33 Q0E8E4 Q8MRM5 Q9VUX5

Database IDs:

Citations:

PubMed ID: 8548811

Title: Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell death.

PubMed ID: 8548811

DOI: 10.1016/0092-8674(95)90150-7

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537569

Title: A Drosophila full-length cDNA resource.

PubMed ID: 12537569

DOI: 10.1186/gb-2002-3-12-research0080

PubMed ID: 10675329

Title: The Drosophila caspase DRONC is regulated by DIAP1.

PubMed ID: 10675329

DOI: 10.1093/emboj/19.4.598

PubMed ID: 11550090

Title: STRICA, a novel Drosophila melanogaster caspase with an unusual serine/threonine-rich prodomain, interacts with DIAP1 and DIAP2.

PubMed ID: 11550090

DOI: 10.1038/sj.cdd.4400864

PubMed ID: 17397804

Title: Evolution of mitochondrial cell death pathway: Proapoptotic role of HtrA2/Omi in Drosophila.

PubMed ID: 17397804

DOI: 10.1016/j.bbrc.2007.03.079

PubMed ID: 18259196

Title: The interaction of DIAP1 with dOmi/HtrA2 regulates cell death in Drosophila.

PubMed ID: 18259196

DOI: 10.1038/cdd.2008.19

PubMed ID: 19217783

Title: Ubiquitin-mediated regulation of apoptosis.

PubMed ID: 19217783

DOI: 10.1016/j.tcb.2009.01.004

PubMed ID: 21145488

Title: Systematic in vivo RNAi analysis identifies IAPs as NEDD8-E3 ligases.

PubMed ID: 21145488

DOI: 10.1016/j.molcel.2010.11.011

PubMed ID: 22095281

Title: IAPs: guardians of RIPK1.

PubMed ID: 22095281

DOI: 10.1038/cdd.2011.163

PubMed ID: 22304967

Title: XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling.

PubMed ID: 22304967

DOI: 10.1016/j.molcel.2011.12.032

PubMed ID: 25146930

Title: Ubr3 E3 ligase regulates apoptosis by controlling the activity of DIAP1 in Drosophila.

PubMed ID: 25146930

DOI: 10.1038/cdd.2014.115

PubMed ID: 26383956

Title: Pri sORF peptides induce selective proteasome-mediated protein processing.

PubMed ID: 26383956

DOI: 10.1126/science.aac5677

PubMed ID: 27462444

Title: Ack promotes tissue growth via phosphorylation and suppression of the Hippo pathway component Expanded.

PubMed ID: 27462444

DOI: 10.1038/celldisc.2015.47

PubMed ID: 11511363

Title: Structural analysis of a functional DIAP1 fragment bound to grim and hid peptides.

PubMed ID: 11511363

DOI: 10.1016/s1097-2765(01)00282-9

PubMed ID: 14517550

Title: Molecular mechanism of Reaper-Grim-Hid-mediated suppression of DIAP1-dependent Dronc ubiquitination.

PubMed ID: 14517550

DOI: 10.1038/nsb989

Sequence Information:

Length: 438
Mass: 48038
Checksum: 24CA8BC13F5DEF31
Sequence:

MASVVADLPS YGPIAFDQVD NNTNATQLFK NNINKTRMND LNREETRLKT FTDWPLDWLD 
KRQLAQTGMY FTHAGDKVKC FFCGVEIGCW EQEDQPVPEH QRWSPNCPLL RRRTTNNVPI 
NAEALDRILP PISYDICGAN DSTLEMREHA YAEGVIPMSQ LIQSIGMNAV NAAGSVTGTA 
APQPRVTVAT HASTATQATG DVQPETCRPS AASGNYFPQY PEYAIETARL RTFEAWPRNL 
KQKPHQLAEA GFFYTGVGDR VRCFSCGGGL MDWNDNDEPW EQHALWLSQC RFVKLMKGQL 
YIDTVAAKPV LAEEKEESSS IGGVAVASTQ ASEEEQQTSL SSEEAVSGDV APSVAPTAAT 
RIFNKIVEAT AVATPSTNSS GSTSIPEEKL CKICYGAEYN TAFLPCGHVV ACAKCASSVT 
KCPLCRKPFT DVMRVYFS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Diap1

Associated with

Other Information

Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell death. PubMed ID: 8548811

The genome sequence of Drosophila melanogaster. PubMed ID: 10731132

Annotation of the Drosophila melanogaster euchromatic genome: a systematic review. PubMed ID: 12537572

A Drosophila full-length cDNA resource. PubMed ID: 12537569

The Drosophila caspase DRONC is regulated by DIAP1. PubMed ID: 10675329

STRICA, a novel Drosophila melanogaster caspase with an unusual serine/threonine-rich prodomain, interacts with DIAP1 and DIAP2. PubMed ID: 11550090

Evolution of mitochondrial cell death pathway: Proapoptotic role of HtrA2/Omi in Drosophila. PubMed ID: 17397804

The interaction of DIAP1 with dOmi/HtrA2 regulates cell death in Drosophila. PubMed ID: 18259196

Ubiquitin-mediated regulation of apoptosis. PubMed ID: 19217783

Systematic in vivo RNAi analysis identifies IAPs as NEDD8-E3 ligases. PubMed ID: 21145488

IAPs: guardians of RIPK1. PubMed ID: 22095281

XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling. PubMed ID: 22304967

Ubr3 E3 ligase regulates apoptosis by controlling the activity of DIAP1 in Drosophila. PubMed ID: 25146930

Pri sORF peptides induce selective proteasome-mediated protein processing. PubMed ID: 26383956

Ack promotes tissue growth via phosphorylation and suppression of the Hippo pathway component Expanded. PubMed ID: 27462444

Structural analysis of a functional DIAP1 fragment bound to grim and hid peptides. PubMed ID: 11511363

Molecular mechanism of Reaper-Grim-Hid-mediated suppression of DIAP1-dependent Dronc ubiquitination. PubMed ID: 14517550