Details for: Smn

Gene ID: 39844

Symbol: Smn

Ensembl ID: FBgn0036641

Description: survival motor neuron

Associated with

Other Information

Genular Protein ID: 2604012810

Symbol: SMN_DROME

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11113446

Title: Disruption of SMN function by ectopic expression of the human SMN gene in Drosophila.

PubMed ID: 11113446

DOI: 10.1016/s0014-5793(00)02243-2

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537569

Title: A Drosophila full-length cDNA resource.

PubMed ID: 12537569

DOI: 10.1186/gb-2002-3-12-research0080

PubMed ID: 12783845

Title: Neuromuscular defects in a Drosophila survival motor neuron gene mutant.

PubMed ID: 12783845

DOI: 10.1093/hmg/ddg157

PubMed ID: 14715275

Title: Rpp20 interacts with SMN and is re-distributed into SMN granules in response to stress.

PubMed ID: 14715275

DOI: 10.1016/j.bbrc.2003.12.084

PubMed ID: 16753561

Title: The Sm-protein methyltransferase, dart5, is essential for germ-cell specification and maintenance.

PubMed ID: 16753561

DOI: 10.1016/j.cub.2006.04.037

PubMed ID: 16533947

Title: The Drosophila melanogaster Cajal body.

PubMed ID: 16533947

DOI: 10.1083/jcb.200511038

PubMed ID: 17353360

Title: A Drosophila melanogaster model of spinal muscular atrophy reveals a function for SMN in striated muscle.

PubMed ID: 17353360

DOI: 10.1083/jcb.200610053

PubMed ID: 17595295

Title: U bodies are cytoplasmic structures that contain uridine-rich small nuclear ribonucleoproteins and associate with P bodies.

PubMed ID: 17595295

DOI: 10.1073/pnas.0704977104

PubMed ID: 18791638

Title: Modeling spinal muscular atrophy in Drosophila.

PubMed ID: 18791638

DOI: 10.1371/journal.pone.0003209

PubMed ID: 18621711

Title: Evolution of an RNP assembly system: a minimal SMN complex facilitates formation of UsnRNPs in Drosophila melanogaster.

PubMed ID: 18621711

DOI: 10.1073/pnas.0802287105

PubMed ID: 18369183

Title: Sm protein methylation is dispensable for snRNP assembly in Drosophila melanogaster.

PubMed ID: 18369183

DOI: 10.1261/rna.940708

PubMed ID: 19464282

Title: The spinal muscular atrophy protein SMN affects Drosophila germline nuclear organization through the U body-P body pathway.

PubMed ID: 19464282

DOI: 10.1016/j.ydbio.2009.05.553

PubMed ID: 20452345

Title: Drosophila SMN complex proteins Gemin2, Gemin3, and Gemin5 are components of U bodies.

PubMed ID: 20452345

DOI: 10.1016/j.yexcr.2010.05.001

PubMed ID: 21490958

Title: Survival motor neuron protein regulates stem cell division, proliferation, and differentiation in Drosophila.

PubMed ID: 21490958

DOI: 10.1371/journal.pgen.1002030

PubMed ID: 23103409

Title: Behavioral and electrophysiological outcomes of tissue-specific Smn knockdown in Drosophila melanogaster.

PubMed ID: 23103409

DOI: 10.1016/j.brainres.2012.10.035

PubMed ID: 23063130

Title: SMN is required for sensory-motor circuit function in Drosophila.

PubMed ID: 23063130

DOI: 10.1016/j.cell.2012.09.011

PubMed ID: 23063131

Title: An SMN-dependent U12 splicing event essential for motor circuit function.

PubMed ID: 23063131

DOI: 10.1016/j.cell.2012.09.012

PubMed ID: 22813737

Title: A Drosophila model of spinal muscular atrophy uncouples snRNP biogenesis functions of survival motor neuron from locomotion and viability defects.

PubMed ID: 22813737

DOI: 10.1016/j.celrep.2012.05.014

PubMed ID: 23029159

Title: Drosophila Zpr1 (Zinc finger protein 1) is required downstream of both EGFR and FGFR signaling in tracheal subcellular lumen formation.

PubMed ID: 23029159

DOI: 10.1371/journal.pone.0045649

PubMed ID: 23885126

Title: Identification and characterization of Drosophila Snurportin reveals a role for the import receptor Moleskin/Importin7 in snRNP biogenesis.

PubMed ID: 23885126

DOI: 10.1091/mbc.e13-03-0118

PubMed ID: 23333303

Title: Structural basis of assembly chaperone-mediated snRNP formation.

PubMed ID: 23333303

DOI: 10.1016/j.molcel.2012.12.009

Sequence Information:

  • Length: 226
  • Mass: 24622
  • Checksum: 9F00D85A3E9614C7
  • Sequence:
  • MSDETNAAVW DDSLLVKTYD ESVGLAREAL ARRLADSTNK REEENAAAAE EEAGEISATG 
    GATSPEPVSF KVGDYARATY VDGVDYEGAV VSINEEKGTC VLRYLGYENE QEVLLVDLLP 
    SWGKRVRREQ FLIAKKDEDE QLSRPKASAG SHSKTPKSSR RSRISGGLVM PPMPPVPPMI 
    VGQGDGAEQD FVAMLTAWYM SGYYTGLYQG KKEASTTSGK KKTPKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.