Details for: ASIC2

Gene ID: 40

Symbol: ASIC2

Ensembl ID: ENSG00000108684

Description: acid sensing ion channel subunit 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 4.8
    Marker Score: 162239
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 4.03
    Marker Score: 9255
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 3.47
    Marker Score: 18639
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 3.46
    Marker Score: 1554
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 3.11
    Marker Score: 14381
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.95
    Marker Score: 4954
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 2.93
    Marker Score: 5556
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.84
    Marker Score: 21789
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.57
    Marker Score: 97441
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.44
    Marker Score: 90111
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.36
    Marker Score: 6739
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.3
    Marker Score: 8882.5
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.22
    Marker Score: 44224
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 2.22
    Marker Score: 1150
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.2
    Marker Score: 20667
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.19
    Marker Score: 1507
  • Cell Name: granule cell (CL0000120)
    Fold Change: 2.15
    Marker Score: 16232
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.05
    Marker Score: 125895
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 2.02
    Marker Score: 633
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.93
    Marker Score: 18325
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.86
    Marker Score: 15947
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.79
    Marker Score: 3632
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.7
    Marker Score: 5698
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.67
    Marker Score: 2061
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.66
    Marker Score: 2556.5
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.59
    Marker Score: 1979
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.51
    Marker Score: 15556
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.45
    Marker Score: 557
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.39
    Marker Score: 20834
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.38
    Marker Score: 829.5
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 868
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.31
    Marker Score: 951
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.31
    Marker Score: 20477
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.3
    Marker Score: 730
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.23
    Marker Score: 2236.5
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.22
    Marker Score: 588
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.21
    Marker Score: 1464
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.17
    Marker Score: 2761
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.17
    Marker Score: 4862
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.16
    Marker Score: 485
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 1.12
    Marker Score: 290
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.03
    Marker Score: 679
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1
    Marker Score: 5998
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71782.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48008
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 507
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405.5
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.97
    Marker Score: 465
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.96
    Marker Score: 440
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.95
    Marker Score: 3860
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.92
    Marker Score: 278
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5207
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.91
    Marker Score: 1007.5
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.89
    Marker Score: 467
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.89
    Marker Score: 3678
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.87
    Marker Score: 668
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.87
    Marker Score: 1006
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5282
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.86
    Marker Score: 344.5
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.84
    Marker Score: 487
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.83
    Marker Score: 3490.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.83
    Marker Score: 1347
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.83
    Marker Score: 262
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.81
    Marker Score: 3394.5
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.8
    Marker Score: 290.5
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.77
    Marker Score: 1850
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.77
    Marker Score: 16445
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 703
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.77
    Marker Score: 379
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.77
    Marker Score: 7763
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.76
    Marker Score: 455
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.74
    Marker Score: 506
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 461
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.69
    Marker Score: 401
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.68
    Marker Score: 325
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.67
    Marker Score: 298
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.64
    Marker Score: 1310
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.62
    Marker Score: 536
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.61
    Marker Score: 404
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.61
    Marker Score: 937
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.6
    Marker Score: 276
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6
    Marker Score: 407.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 466
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.58
    Marker Score: 758
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 150
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.55
    Marker Score: 307
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.54
    Marker Score: 605
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.54
    Marker Score: 223
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.53
    Marker Score: 222
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.52
    Marker Score: 142
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.51
    Marker Score: 2677
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.51
    Marker Score: 161
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5
    Marker Score: 502
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.49
    Marker Score: 172

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Other Information

**Key characteristics:** - The ASIC2 gene is located on chromosome 17q21.1. - It is a large gene encoding for a protein of approximately 1000 amino acids. - The protein is a member of the superfamily of acid-sensing ion channels, which are a group of ion channels that are sensitive to acidic conditions. - ASIC2 is a ligand-gated sodium channel, which means that it opens when a ligand binds to it. - It is expressed in a variety of cell types, including neurons, astrocytes, and endothelial cells. **Pathways and functions:** - ASIC2 is involved in a variety of cellular processes, including: - Central nervous system development - Chemical synaptic transmission - Ion channel transport - Ligand-gated sodium channel activity - Negative regulation of apoptotic process - Peripheral nervous system development - Phototransduction - Protein binding - Protein localization to synapse - Regulation of membrane potential - Regulation of monoatomic ion transmembrane transport - Regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback - Regulation of vasoconstriction - Sensory perception of sound - Sodium ion transmembrane transport - Stimuli-sensing channels - Synapse assembly - Transport of small molecules - The exact roles of ASIC2 in these pathways are not fully understood, but it is clear that it is an important regulator of neuronal function. **Clinical significance:** - Mutations in the ASIC2 gene have been linked to a number of neurological disorders, including autism, schizophrenia, and epilepsy. - These mutations can lead to changes in the function of ASIC2, which can result in neuronal hyperexcitability, synaptic dysfunction, and other neurodegenerative symptoms. - Therefore, ASIC2 is a promising target for the treatment of neurological disorders that are characterized by abnormal neuronal excitability.

Genular Protein ID: 4182305328

Symbol: ASIC2_HUMAN

Name: Amiloride-sensitive brain sodium channel

UniProtKB Accession Codes:

Q16515 E9PBX2 Q13553 Q6DJU1 Q8N3E2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 18 Ensembl 2 GO 25 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 2 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8626462

Title: Cloning and expression of a novel human brain Na+ channel.

PubMed ID: 8626462

DOI: 10.1074/jbc.271.14.7879

PubMed ID: 8631835

Title: The mammalian degenerin MDEG, an amiloride-sensitive cation channel activated by mutations causing neurodegeneration in Caenorhabditis elegans.

PubMed ID: 8631835

DOI: 10.1074/jbc.271.18.10433

PubMed ID: 9037075

Title: BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels.

PubMed ID: 9037075

DOI: 10.1073/pnas.94.4.1459

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10842183

Title: Mammalian ASIC2a and ASIC3 subunits co-assemble into heteromeric proton-gated channels sensitive to Gd3+.

PubMed ID: 10842183

DOI: 10.1074/jbc.m004114200

PubMed ID: 11802773

Title: Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel).

PubMed ID: 11802773

DOI: 10.1042/0264-6021:3610443

PubMed ID: 23034652

Title: Black mamba venom peptides target acid-sensing ion channels to abolish pain.

PubMed ID: 23034652

DOI: 10.1038/nature11494

Sequence Information:

  • Length: 512
  • Mass: 57709
  • Checksum: 7C95B0B32EFF2814
  • Sequence:
    • MDLKESPSEG SLQPSSIQIF ANTSTLHGIR HIFVYGPLTI RRVLWAVAFV GSLGLLLVES 
SERVSYYFSY QHVTKVDEVV AQSLVFPAVT LCNLNGFRFS RLTTNDLYHA GELLALLDVN 
LQIPDPHLAD PSVLEALRQK ANFKHYKPKQ FSMLEFLHRV GHDLKDMMLY CKFKGQECGH 
QDFTTVFTKY GKCYMFNSGE DGKPLLTTVK GGTGNGLEIM LDIQQDEYLP IWGETEETTF 
EAGVKVQIHS QSEPPFIQEL GFGVAPGFQT FVATQEQRLT YLPPPWGECR SSEMGLDFFP 
VYSITACRID CETRYIVENC NCRMVHMPGD APFCTPEQHK ECAEPALGLL AEKDSNYCLC 
RTPCNLTRYN KELSMVKIPS KTSAKYLEKK FNKSEKYISE NILVLDIFFE ALNYETIEQK 
KAYEVAALLG DIGGQMGLFI GASILTILEL FDYIYELIKE KLLDLLGKEE DEGSHDENVS 
TCDTMPNHSE TISHTVNVPL QTTLGTLEEI AC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.