ASIC2 | ENSG00000108684 | NCBI 40

Details for: ASIC2

Gene ID: 40

Symbol: ASIC2

Ensembl ID: ENSG00000108684

Description: acid sensing ion channel subunit 2

Associated with

Ion channel transport
(R-HSA-983712)
Stimuli-sensing channels
(R-HSA-2672351)
Transport of small molecules
(R-HSA-382551)
Cellular response to acidic ph
(GO:0071468)
Cellular response to xenobiotic stimulus
(GO:0071466)
Central nervous system development
(GO:0007417)
Chemical synaptic transmission
(GO:0007268)
Dendritic spine
(GO:0043197)
Detection of mechanical stimulus involved in sensory perception
(GO:0050974)
Establishment of localization in cell
(GO:0051649)
Inorganic cation transmembrane transport
(GO:0098662)
Ligand-gated sodium channel activity
(GO:0015280)
Monoatomic ion-gated channel activity
(GO:0022839)
Negative regulation of apoptotic process
(GO:0043066)
Neuronal cell body
(GO:0043025)
Peripheral nervous system development
(GO:0007422)
Phototransduction
(GO:0007602)
Plasma membrane
(GO:0005886)
Positive regulation of synapse assembly
(GO:0051965)
Protein binding
(GO:0005515)
Protein localization to synapse
(GO:0035418)
Regulation of membrane potential
(GO:0042391)
Regulation of monoatomic ion transmembrane transport
(GO:0034765)
Regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback
(GO:0003026)
Regulation of vasoconstriction
(GO:0019229)
Sensory perception of sound
(GO:0007605)
Sensory perception of sour taste
(GO:0050915)
Sodium ion transmembrane transport
(GO:0035725)
Synapse assembly
(GO:0007416)
Voltage-gated sodium channel activity
(GO:0005248)

Other Information

Proteins

Amiloride-sensitive brain sodium channel

Genular Protein ID: 4182305328

Symbol: ASIC2_HUMAN

Name: Amiloride-sensitive brain sodium channel

UniProtKB Accession Codes:

Q16515 E9PBX2 Q13553 Q6DJU1 Q8N3E2

Database IDs:

Citations:

PubMed ID: 8626462

Title: Cloning and expression of a novel human brain Na+ channel.

PubMed ID: 8626462

DOI: 10.1074/jbc.271.14.7879

PubMed ID: 8631835

Title: The mammalian degenerin MDEG, an amiloride-sensitive cation channel activated by mutations causing neurodegeneration in Caenorhabditis elegans.

PubMed ID: 8631835

DOI: 10.1074/jbc.271.18.10433

PubMed ID: 9037075

Title: BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels.

PubMed ID: 9037075

DOI: 10.1073/pnas.94.4.1459

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10842183

Title: Mammalian ASIC2a and ASIC3 subunits co-assemble into heteromeric proton-gated channels sensitive to Gd3+.

PubMed ID: 10842183

DOI: 10.1074/jbc.m004114200

PubMed ID: 11802773

Title: Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel).

PubMed ID: 11802773

DOI: 10.1042/0264-6021:3610443

PubMed ID: 23034652

Title: Black mamba venom peptides target acid-sensing ion channels to abolish pain.

PubMed ID: 23034652

DOI: 10.1038/nature11494

Sequence Information:

Length: 512
Mass: 57709
Checksum: 7C95B0B32EFF2814
Sequence:

MDLKESPSEG SLQPSSIQIF ANTSTLHGIR HIFVYGPLTI RRVLWAVAFV GSLGLLLVES 
SERVSYYFSY QHVTKVDEVV AQSLVFPAVT LCNLNGFRFS RLTTNDLYHA GELLALLDVN 
LQIPDPHLAD PSVLEALRQK ANFKHYKPKQ FSMLEFLHRV GHDLKDMMLY CKFKGQECGH 
QDFTTVFTKY GKCYMFNSGE DGKPLLTTVK GGTGNGLEIM LDIQQDEYLP IWGETEETTF 
EAGVKVQIHS QSEPPFIQEL GFGVAPGFQT FVATQEQRLT YLPPPWGECR SSEMGLDFFP 
VYSITACRID CETRYIVENC NCRMVHMPGD APFCTPEQHK ECAEPALGLL AEKDSNYCLC 
RTPCNLTRYN KELSMVKIPS KTSAKYLEKK FNKSEKYISE NILVLDIFFE ALNYETIEQK 
KAYEVAALLG DIGGQMGLFI GASILTILEL FDYIYELIKE KLLDLLGKEE DEGSHDENVS 
TCDTMPNHSE TISHTVNVPL QTTLGTLEEI AC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ASIC2

Associated with

Other Information

Cloning and expression of a novel human brain Na+ channel. PubMed ID: 8626462

The mammalian degenerin MDEG, an amiloride-sensitive cation channel activated by mutations causing neurodegeneration in Caenorhabditis elegans. PubMed ID: 8631835

BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels. PubMed ID: 9037075

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. PubMed ID: 16625196

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Mammalian ASIC2a and ASIC3 subunits co-assemble into heteromeric proton-gated channels sensitive to Gd3+. PubMed ID: 10842183

Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel). PubMed ID: 11802773

Black mamba venom peptides target acid-sensing ion channels to abolish pain. PubMed ID: 23034652