Details for: ASIC2

Gene ID: 40

Symbol: ASIC2

Ensembl ID: ENSG00000108684

Description: acid sensing ion channel subunit 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 6.8285
    Cell Significance Index: 149.5200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 5.8986
    Cell Significance Index: 260.9100
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 4.9883
    Cell Significance Index: 38.2600
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: 4.7467
    Cell Significance Index: 52.3700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 4.7106
    Cell Significance Index: 178.3800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 4.4517
    Cell Significance Index: 1596.7400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.4367
    Cell Significance Index: -9.7100
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 4.3074
    Cell Significance Index: 57.4600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 4.2552
    Cell Significance Index: 121.4300
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 4.0182
    Cell Significance Index: 52.1100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 3.3722
    Cell Significance Index: 2332.3500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 2.4896
    Cell Significance Index: 167.4000
  • Cell Name: L5/6 near-projecting glutamatergic neuron of the primary motor cortex (CL4023043)
    Fold Change: 1.4657
    Cell Significance Index: 14.8100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.9028
    Cell Significance Index: 22.5100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.8419
    Cell Significance Index: 51.7500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5204
    Cell Significance Index: 15.0000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.3790
    Cell Significance Index: 9.0900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3019
    Cell Significance Index: 272.5700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2972
    Cell Significance Index: 29.4000
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.2312
    Cell Significance Index: 2.2000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1273
    Cell Significance Index: 20.7000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1051
    Cell Significance Index: 57.4000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0864
    Cell Significance Index: 1.4800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0809
    Cell Significance Index: 152.2800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0638
    Cell Significance Index: 12.8000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0638
    Cell Significance Index: 6.9400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0139
    Cell Significance Index: 0.4900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0020
    Cell Significance Index: 3.1500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0006
    Cell Significance Index: 0.7600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0017
    Cell Significance Index: -3.1000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0125
    Cell Significance Index: -0.7000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0190
    Cell Significance Index: -3.6200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0297
    Cell Significance Index: -21.9700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0316
    Cell Significance Index: -20.1000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0433
    Cell Significance Index: -1.3800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0509
    Cell Significance Index: -37.3500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0510
    Cell Significance Index: -1.2800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0513
    Cell Significance Index: -1.0300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0557
    Cell Significance Index: -31.4000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0647
    Cell Significance Index: -29.3600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0677
    Cell Significance Index: -0.9700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0774
    Cell Significance Index: -48.3500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1020
    Cell Significance Index: -20.2500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1088
    Cell Significance Index: -3.0400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1138
    Cell Significance Index: -2.4200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1187
    Cell Significance Index: -34.1500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1411
    Cell Significance Index: -20.5100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1494
    Cell Significance Index: -3.1000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1667
    Cell Significance Index: -10.0100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1701
    Cell Significance Index: -29.0500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1780
    Cell Significance Index: -32.0800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1787
    Cell Significance Index: -37.6300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1905
    Cell Significance Index: -11.6800
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.1996
    Cell Significance Index: -2.4200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2242
    Cell Significance Index: -30.7900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2386
    Cell Significance Index: -2.6000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2561
    Cell Significance Index: -5.4700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2782
    Cell Significance Index: -34.2100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2929
    Cell Significance Index: -9.5900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2960
    Cell Significance Index: -13.4200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3014
    Cell Significance Index: -35.1200
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.3214
    Cell Significance Index: -3.7500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.3237
    Cell Significance Index: -22.3900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3323
    Cell Significance Index: -42.9300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3459
    Cell Significance Index: -6.8400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3603
    Cell Significance Index: -41.2800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3868
    Cell Significance Index: -39.5100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3869
    Cell Significance Index: -5.8300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3946
    Cell Significance Index: -41.0900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.4096
    Cell Significance Index: -5.0800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.4114
    Cell Significance Index: -5.1300
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.4298
    Cell Significance Index: -5.1400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4474
    Cell Significance Index: -11.1600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4537
    Cell Significance Index: -9.8300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4626
    Cell Significance Index: -35.5000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4640
    Cell Significance Index: -14.8600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.4716
    Cell Significance Index: -4.4700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4726
    Cell Significance Index: -37.4300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4777
    Cell Significance Index: -25.0800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.4796
    Cell Significance Index: -20.8600
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.4896
    Cell Significance Index: -5.1000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5753
    Cell Significance Index: -42.8800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.5887
    Cell Significance Index: -14.2600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.5951
    Cell Significance Index: -7.5100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.6302
    Cell Significance Index: -4.2700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6348
    Cell Significance Index: -22.2400
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.6444
    Cell Significance Index: -8.5900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6805
    Cell Significance Index: -42.8900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.6882
    Cell Significance Index: -44.4000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.8598
    Cell Significance Index: -40.4100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.8853
    Cell Significance Index: -17.4300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.8856
    Cell Significance Index: -41.2900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.9490
    Cell Significance Index: -20.2100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.9581
    Cell Significance Index: -20.7000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.1085
    Cell Significance Index: -38.5200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -1.1148
    Cell Significance Index: -22.2300
  • Cell Name: interneuron (CL0000099)
    Fold Change: -1.1639
    Cell Significance Index: -13.6000
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -1.1645
    Cell Significance Index: -11.7300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -1.1741
    Cell Significance Index: -27.1300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.2993
    Cell Significance Index: -38.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ASIC2 exhibits unique characteristics that set it apart from other ion channels. Its ability to sense acidic pH and respond to xenobiotic stimuli makes it an essential component of the cellular defense mechanism. Additionally, its role in regulating synaptic transmission, neuronal cell body, and peripheral nervous system development underscores its importance in neural function and development. The gene's expression in various cell types, including inhibitory interneurons, pyramidal neurons, and macroglial cells, further highlights its broad functional repertoire. **Pathways and Functions:** ASIC2 is involved in several critical pathways, including: 1. **Cellular response to acidic pH**: ASIC2 plays a crucial role in sensing acidic pH and responding to it, which is essential for maintaining cellular homeostasis. 2. **Central nervous system development**: ASIC2 is essential for the development and maturation of neurons and glial cells, highlighting its role in neural development and function. 3. **Mechanical stimulus sensing**: ASIC2 is involved in detecting mechanical stimuli involved in sensory perception, such as sound and touch. 4. **Neurotransmitter release**: ASIC2 regulates the release of neurotransmitters, including GABA, which is essential for inhibitory neurotransmission. 5. **Vasoregulation**: ASIC2 is involved in regulating systemic arterial blood pressure by modulating the activity of aortic arch baroreceptors. **Clinical Significance:** Dysregulation of ASIC2 has been implicated in various neurological and cardiovascular disorders, including: 1. **Neurodegenerative diseases**: ASIC2 has been linked to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where its dysregulation contributes to neuronal dysfunction and death. 2. **Cardiovascular disorders**: ASIC2 plays a critical role in regulating blood pressure and vasoregulation, making it a potential target for the treatment of cardiovascular disorders, such as hypertension and heart failure. 3. **Neuropathic pain**: ASIC2 is involved in the development and maintenance of neuropathic pain, highlighting its potential as a therapeutic target for pain management. In conclusion, ASIC2 is a critical ion channel that plays a pivotal role in regulating various cellular processes, including cellular responses to acidic pH, xenobiotic stimuli, and mechanical stimuli involved in sensory perception. Its dysregulation has been implicated in various neurological and cardiovascular disorders, highlighting its potential as a therapeutic target for the treatment of these conditions. Further research is necessary to fully elucidate the function and significance of ASIC2 in maintaining cellular homeostasis and regulating various physiological processes.

Genular Protein ID: 4182305328

Symbol: ASIC2_HUMAN

Name: Amiloride-sensitive brain sodium channel

UniProtKB Accession Codes:

Q16515 E9PBX2 Q13553 Q6DJU1 Q8N3E2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 18 Ensembl 2 GO 26 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 2 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8626462

Title: Cloning and expression of a novel human brain Na+ channel.

PubMed ID: 8626462

DOI: 10.1074/jbc.271.14.7879

PubMed ID: 8631835

Title: The mammalian degenerin MDEG, an amiloride-sensitive cation channel activated by mutations causing neurodegeneration in Caenorhabditis elegans.

PubMed ID: 8631835

DOI: 10.1074/jbc.271.18.10433

PubMed ID: 9037075

Title: BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels.

PubMed ID: 9037075

DOI: 10.1073/pnas.94.4.1459

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10842183

Title: Mammalian ASIC2a and ASIC3 subunits co-assemble into heteromeric proton-gated channels sensitive to Gd3+.

PubMed ID: 10842183

DOI: 10.1074/jbc.m004114200

PubMed ID: 11802773

Title: Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel).

PubMed ID: 11802773

DOI: 10.1042/0264-6021:3610443

PubMed ID: 23034652

Title: Black mamba venom peptides target acid-sensing ion channels to abolish pain.

PubMed ID: 23034652

DOI: 10.1038/nature11494

Sequence Information:

  • Length: 512
  • Mass: 57709
  • Checksum: 7C95B0B32EFF2814
  • Sequence:
    • MDLKESPSEG SLQPSSIQIF ANTSTLHGIR HIFVYGPLTI RRVLWAVAFV GSLGLLLVES 
SERVSYYFSY QHVTKVDEVV AQSLVFPAVT LCNLNGFRFS RLTTNDLYHA GELLALLDVN 
LQIPDPHLAD PSVLEALRQK ANFKHYKPKQ FSMLEFLHRV GHDLKDMMLY CKFKGQECGH 
QDFTTVFTKY GKCYMFNSGE DGKPLLTTVK GGTGNGLEIM LDIQQDEYLP IWGETEETTF 
EAGVKVQIHS QSEPPFIQEL GFGVAPGFQT FVATQEQRLT YLPPPWGECR SSEMGLDFFP 
VYSITACRID CETRYIVENC NCRMVHMPGD APFCTPEQHK ECAEPALGLL AEKDSNYCLC 
RTPCNLTRYN KELSMVKIPS KTSAKYLEKK FNKSEKYISE NILVLDIFFE ALNYETIEQK 
KAYEVAALLG DIGGQMGLFI GASILTILEL FDYIYELIKE KLLDLLGKEE DEGSHDENVS 
TCDTMPNHSE TISHTVNVPL QTTLGTLEEI AC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.