Details for: park

Gene ID: 40336

Symbol: park

Ensembl ID: FBgn0041100

Description: parkin

Associated with

Other Information

Genular Protein ID: 294271229

Symbol: PRKN_DROME

Name: N/A

UniProtKB Accession Codes:

Q7KTX7 Q86CZ3 Q86LE7 Q95TI4

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID-ORCS 1 CDD 5 CTD 1 ChEBI 31 DIP 1 DNASU 1 EC 1 EMBL 13 EnsemblMetazoa 2 ExpressionAtlas 1 FlyBase 2 GO 39 Gene3D 3 GeneTree 1 GenomeRNAi 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 2 PIRSF 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 2 PaxDb 1 Pfam 3 PhylomeDB 1 Proteomes 2 Reactome 4 RefSeq 2 SMART 2 SMR 1 STRING 1 SUPFAM 2 UCSC 1 UniPathway 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537569

Title: A Drosophila full-length cDNA resource.

PubMed ID: 12537569

DOI: 10.1186/gb-2002-3-12-research0080

PubMed ID: 14646593

Title: Genomic organization and expression of parkin in Drosophila melanogaster.

PubMed ID: 14646593

DOI: 10.1038/emm.2003.52

PubMed ID: 12642658

Title: Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants.

PubMed ID: 12642658

DOI: 10.1073/pnas.0737556100

PubMed ID: 15073152

Title: Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress.

PubMed ID: 15073152

DOI: 10.1242/dev.01095

PubMed ID: 16002472

Title: Parkin negatively regulates JNK pathway in the dopaminergic neurons of Drosophila.

PubMed ID: 16002472

DOI: 10.1073/pnas.0500346102

PubMed ID: 16672980

Title: Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin.

PubMed ID: 16672980

DOI: 10.1038/nature04788

PubMed ID: 16672981

Title: Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin.

PubMed ID: 16672981

DOI: 10.1038/nature04779

PubMed ID: 17123504

Title: The Drosophila parkin homologue is required for normal mitochondrial dynamics during spermiogenesis.

PubMed ID: 17123504

DOI: 10.1016/j.ydbio.2006.10.038

PubMed ID: 17456438

Title: Drosophila melanogaster Parkin ubiquitinates peanut and septin1 as an E3 ubiquitin-protein ligase.

PubMed ID: 17456438

DOI: 10.1016/j.ibmb.2007.01.007

PubMed ID: 18957282

Title: PINK1 controls mitochondrial localization of Parkin through direct phosphorylation.

PubMed ID: 18957282

DOI: 10.1016/j.bbrc.2008.10.104

PubMed ID: 19048081

Title: Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson's disease factors Pink1 and Parkin.

PubMed ID: 19048081

DOI: 10.1242/dmm.000109

PubMed ID: 18799731

Title: The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila.

PubMed ID: 18799731

DOI: 10.1073/pnas.0803998105

PubMed ID: 18230723

Title: The PINK1/Parkin pathway regulates mitochondrial morphology.

PubMed ID: 18230723

DOI: 10.1073/pnas.0709336105

PubMed ID: 18443288

Title: Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery.

PubMed ID: 18443288

DOI: 10.1073/pnas.0711845105

PubMed ID: 20496123

Title: Parkin suppresses c-Jun N-terminal kinase-induced cell death via transcriptional regulation in Drosophila.

PubMed ID: 20496123

DOI: 10.1007/s10059-010-0068-1

PubMed ID: 20483372

Title: Extended lifespan of Drosophila parkin mutants through sequestration of redox-active metals and enhancement of anti-oxidative pathways.

PubMed ID: 20483372

DOI: 10.1016/j.nbd.2010.05.011

PubMed ID: 20194754

Title: Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin.

PubMed ID: 20194754

DOI: 10.1073/pnas.0913485107

PubMed ID: 20869429

Title: Diminution of eIF4E activity suppresses parkin mutant phenotypes.

PubMed ID: 20869429

DOI: 10.1016/j.gene.2010.09.003

PubMed ID: 22396657

Title: Parkinson's disease-associated kinase PINK1 regulates Miro protein level and axonal transport of mitochondria.

PubMed ID: 22396657

DOI: 10.1371/journal.pgen.1002537

PubMed ID: 23509287

Title: The PINK1-Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo.

PubMed ID: 23509287

DOI: 10.1073/pnas.1221132110

PubMed ID: 23650379

Title: Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan.

PubMed ID: 23650379

DOI: 10.1073/pnas.1216197110

PubMed ID: 24192653

Title: Mitochondrial contagion induced by Parkin deficiency in Drosophila hearts and its containment by suppressing mitofusin.

PubMed ID: 24192653

DOI: 10.1161/circresaha.114.302734

PubMed ID: 24898855

Title: MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin.

PubMed ID: 24898855

DOI: 10.7554/elife.01958

PubMed ID: 24901221

Title: PINK1-mediated phosphorylation of Parkin boosts Parkin activity in Drosophila.

PubMed ID: 24901221

DOI: 10.1371/journal.pgen.1004391

PubMed ID: 25474007

Title: Phosphorylation of mitochondrial polyubiquitin by PINK1 promotes Parkin mitochondrial tethering.

PubMed ID: 25474007

DOI: 10.1371/journal.pgen.1004861

PubMed ID: 25565208

Title: PINK1 and Parkin control localized translation of respiratory chain component mRNAs on mitochondria outer membrane.

PubMed ID: 25565208

DOI: 10.1016/j.cmet.2014.12.007

PubMed ID: 27906179

Title: PINK1-dependent phosphorylation of PINK1 and Parkin is essential for mitochondrial quality control.

PubMed ID: 27906179

DOI: 10.1038/cddis.2016.396

PubMed ID: 28435104

Title: Drosophila PINK1 and parkin loss-of-function mutants display a range of non-motor Parkinson's disease phenotypes.

PubMed ID: 28435104

DOI: 10.1016/j.nbd.2017.04.014

PubMed ID: 29497364

Title: Vulnerable Parkin Loss-of-Function Drosophila Dopaminergic Neurons Have Advanced Mitochondrial Aging, Mitochondrial Network Loss and Transiently Reduced Autophagosome Recruitment.

PubMed ID: 29497364

DOI: 10.3389/fncel.2018.00039

PubMed ID: 31714929

Title: Overexpression of pink1 or parkin in indirect flight muscles promotes mitochondrial proteostasis and extends lifespan in Drosophila melanogaster.

PubMed ID: 31714929

DOI: 10.1371/journal.pone.0225214

PubMed ID: 32138754

Title: PARIS induced defects in mitochondrial biogenesis drive dopamine neuron loss under conditions of parkin or PINK1 deficiency.

PubMed ID: 32138754

DOI: 10.1186/s13024-020-00363-x

PubMed ID: 32047033

Title: Decision between mitophagy and apoptosis by Parkin via VDAC1 ubiquitination.

PubMed ID: 32047033

DOI: 10.1073/pnas.1909814117

PubMed ID: 23770917

Title: A molecular explanation for the recessive nature of parkin-linked Parkinson's disease.

PubMed ID: 23770917

DOI: 10.1038/ncomms2983

Sequence Information:

  • Length: 482
  • Mass: 54105
  • Checksum: 4A89C695475B213D
  • Sequence:
    • MSFIFKFIAT FVRKMLELLQ FGGKTLTHTL SIYVKTNTGK TLTVNLEPQW DIKNVKELVA 
PQLGLQPDDL KIIFAGKELS DATTIEQCDL GQQSVLHAIR LRPPVQRQKI QSATLEEEEP 
SLSDEASKPL NETLLDLQLE SEERLNITDE ERVRAKAHFF VHCSQCDKLC NGKLRVRCAL 
CKGGAFTVHR DPECWDDVLK SRRIPGHCES LEVACVDNAA GDPPFAEFFF KCAEHVSGGE 
KDFAAPLNLI KNNIKNVPCL ACTDVSDTVL VFPCASQHVT CIDCFRHYCR SRLGERQFMP 
HPDFGYTLPC PAGCEHSFIE EIHHFKLLTR EEYDRYQRFA TEEYVLQAGG VLCPQPGCGM 
GLLVEPDCRK VTCQNGCGYV FCRNCLQGYH IGECLPEGTG ASATNSCEYT VDPNRAAEAR 
WDEASNVTIK VSTKPCPKCR TPTERDGGCM HMVCTRAGCG FEWCWVCQTE WTRDCMGAHW 
FG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.