Details for: SAK

Gene ID: 40384

Symbol: SAK

Ensembl ID: FBgn0026371

Description: Sak kinase

Associated with

Other Information

Genular Protein ID: 1152782531

Symbol: PLK4_DROME

Name: Serine/threonine-protein kinase PLK4

UniProtKB Accession Codes:

O97143 Q86NL8

Database IDs:

AGR 1 AlphaFoldDB 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CDD 4 CTD 1 ChEBI 12 ChiTaRS 1 DIP 1 DNASU 1 EC 3 ELM 1 EMBL 4 EnsemblMetazoa 1 FlyBase 1 GO 15 Gene3D 4 GeneTree 1 Genevisible 1 GenomeRNAi 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 4 PRO 1 PROSITE 5 PROSITE-ProRule 4 PaxDb 1 Pfam 3 PhylomeDB 1 Proteomes 1 RefSeq 1 Rhea 6 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 16326102

Title: SAK/PLK4 is required for centriole duplication and flagella development.

PubMed ID: 16326102

DOI: 10.1016/j.cub.2005.11.042

PubMed ID: 17463247

Title: Revisiting the role of the mother centriole in centriole biogenesis.

PubMed ID: 17463247

DOI: 10.1126/science.1142950

PubMed ID: 18555779

Title: Centrosome amplification can initiate tumorigenesis in flies.

PubMed ID: 18555779

DOI: 10.1016/j.cell.2008.05.039

PubMed ID: 19171756

Title: The SCF Slimb ubiquitin ligase regulates Plk4/Sak levels to block centriole reduplication.

PubMed ID: 19171756

DOI: 10.1083/jcb.200808049

PubMed ID: 19084407

Title: The SCF/Slimb ubiquitin ligase limits centrosome amplification through degradation of SAK/PLK4.

PubMed ID: 19084407

DOI: 10.1016/j.cub.2008.11.037

PubMed ID: 20946984

Title: Patronin regulates the microtubule network by protecting microtubule minus ends.

PubMed ID: 20946984

DOI: 10.1016/j.cell.2010.09.022

PubMed ID: 32965218

Title: Alstrom syndrome gene is a stem-cell-specific regulator of centriole duplication in the Drosophila testis.

PubMed ID: 32965218

DOI: 10.7554/elife.59368

Sequence Information:

  • Length: 769
  • Mass: 85887
  • Checksum: F050BF60A5D94AA4
  • Sequence:
    • MLSNRAFGET IEDYEVQHLL GKGGFATVYK ARCLHTHQDV AIKMIDKKLI QGTGLTNRVR 
QEVEIHSRLK HPSVLQLYTF FQDANYVYLV LELAHNGELH RYMNHIARPF TETEAASILK 
QVVAGLLYLH SHNIMHRDIS LSNLLLSREM HVKIADFGLA TQLKRPDERH MTMCGTPNYI 
SPEVVSRTSH GLPADVWSVG CMLYTLLVGR PPFETDAVQS TLNKVVMSEY IMPAHLSYEA 
QDLINKLLKK LPHERITLEA VLCHPFMLKC SNGGHSAPGA LNVFSQSMES GDSGIITFAS 
SDSRNSQQIR SVENSGPQQV LPQIREEFKQ VHHKLPYEQT GLFGQASTGL AEPNWPGAAK 
SSAFCMEAGN VPNSKQASLK EDRISVPPLN TKRLLPTRYK TKNAIMSILR NGEVVLEFLK 
FRPTYNEDRI NDICRISDDG QRIIIYQPDP GRGLPVREQP PDLQIPSGDC VYNYDNLPSK 
HWKKYIYGAR FVGLVKSKTP KVTYFSTLGK CQLMETMTDF EIRFYSGAKL LKTPSEGLKV 
YDRNGMLLSD YSCSESRSLI EHGNECFTHC VNISNALEVA QTKDNSCFPV TIGRRPITDV 
QPAQRLDGLR DTTNIAFSTP KSNQGSINFS LSTISSTRNT SDFGTNCSRS NMLAAHQNIP 
IKRINVPEIG IATELSHGVV QVQFYDGSVV SVIPSMQGGG ITYTQPNGTS THFGKGDDLP 
FPVRDRVGQI PNIQLKLKTA PLLGSGRKTD YNNAMTPKTT TPYYNRMLL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.