Details for: eIF3a

Gene ID: 40563

Symbol: eIF3a

Ensembl ID: FBgn0037249

Description: eukaryotic translation initiation factor 3 subunit a

Associated with

  • Activation of the mrna upon binding of the cap-binding complex and eifs, and subsequent binding to 43s
    (R-DME-72662)
  • Cap-dependent translation initiation
    (R-DME-72737)
  • Eukaryotic translation initiation
    (R-DME-72613)
  • Formation of a pool of free 40s subunits
    (R-DME-72689)
  • Formation of the ternary complex, and subsequently, the 43s complex
    (R-DME-72695)
  • L13a-mediated translational silencing of ceruloplasmin expression
    (R-DME-156827)
  • Metabolism of proteins
    (R-DME-392499)
  • Ribosomal scanning and start codon recognition
    (R-DME-72702)
  • Translation
    (R-DME-72766)
  • Translation initiation complex formation
    (R-DME-72649)
  • Cytosol
    (GO:0005829)
  • Eukaryotic translation initiation factor 3 complex
    (GO:0005852)
  • Eukaryotic translation initiation factor 3 complex, eif3e
    (GO:0071540)
  • Eukaryotic translation initiation factor 3 complex, eif3m
    (GO:0071541)
  • Formation of cytoplasmic translation initiation complex
    (GO:0001732)
  • Mrna binding
    (GO:0003729)
  • Multi-eif complex
    (GO:0043614)
  • Regulation of translational initiation
    (GO:0006446)
  • Translational initiation
    (GO:0006413)
  • Translation initiation factor activity
    (GO:0003743)
  • Translation reinitiation
    (GO:0002188)

Other Information

Genular Protein ID: 1986036955

Symbol: EIF3A_DROME

Name: N/A

UniProtKB Accession Codes:

Q9VN25 Q0KID1 Q494J3 Q8IH03 Q8SYE5

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 EMBL 4 EnsemblMetazoa 2 FlyBase 2 GO 13 Gene3D 2 GeneTree 1 Genevisible 1 GenomeRNAi 1 HAMAP 1 HAMAP-Rule 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MINT 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PaxDb 1 Pfam 1 PhylomeDB 1 Proteomes 1 Reactome 5 RefSeq 2 SAM 1 SMR 1 STRING 1 SignaLink 1 UCSC 2 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537569

Title: A Drosophila full-length cDNA resource.

PubMed ID: 12537569

DOI: 10.1186/gb-2002-3-12-research0080

PubMed ID: 17392269

Title: The essential Drosophila ATP-binding cassette domain protein, pixie, binds the 40 S ribosome in an ATP-dependent manner and is required for translation initiation.

PubMed ID: 17392269

DOI: 10.1074/jbc.m701361200

PubMed ID: 18327897

Title: Phosphoproteome analysis of Drosophila melanogaster embryos.

PubMed ID: 18327897

DOI: 10.1021/pr700696a

Sequence Information:

  • Length: 1140
  • Mass: 133880
  • Checksum: E249F68B8861B6DC
  • Sequence:
    • MARYTQRPEN ALKRANEFIE VGKPLRALDT LQEVFRNKRW NYAYSETVIE PLMFKYLYLC 
VELKKSHIAK EGLFQYRNMF QLVNVNSLEN VIRGYLKMAE EHTEAAQAQS SAAVAVLELD 
DLDNIATPES ILMSAVCGED AQDRSDRTIL LPWVKFLWES YCQCLELLRV NTHCEALYHD 
IARMAFQFCL KYNRKSEFRR LCDKLRKHLE DICKSSNQTT GVSINKVETQ QLCLDTRLYL 
LDSAIQMELW QEAYKAIEDI HGLMALSKKT PVPKTMANYY QKLAMVFSKA GNQLFHAAAL 
LKLFQLTREL KKNLTKDDLQ RMAAHVLLAT LSIPLPSAHP EFDRFIEADK SPLEKAQKLA 
VLLGLPQPPT RVSLIREVVR LNVPQLVSED FRNLYNWLEV DFNPLNLCKR IQSIVDFIEN 
GPENALLTPY IQSLKDVTIM RLIRQISQVY ESIKFQRLLQ LASFCNIFEL EKLLVESVRH 
NDMQIRIDHQ KNSIYFGTDL TESQREYRPD GPALQSMPSE QIRSQLVNMS TVLTRAVSIV 
YPNRERDQRA KLRNQMVNHY HEIKDREHQR ILQRQKIIED RKEYIEKQNN AREEEEARRQ 
EEESRKAKLA EQKRLEQEQE ERERKRHQNE IQAIREKSLK EKVQQISQTA HGKKMLSKLD 
EEGIKKLDAE QIAKRESEEL QREAKELQSK LKSQEKKIDY FERAKRLEEI PLFEKYLAEK 
QVKDKEFWEA TEKTRIENAI AERKDAVAQQ ERLKRMYPDR DEFLEALKKE RASLYVEKLK 
KFEAALEAER KKRLADRIIR RREERRQAFL REKEEERLRK EEEIRLAQAA EERAAAEARR 
LEREAEDEKR RAQYEKQRAK EEEAERKIKE DRDRLSRELA SERERTEKDR DTWRPRGGDR 
PSASNGGSSE WRRAAPAASE RNDRGGERIE RGGERIERGG ERLERGGERI ERGGDRDRKD 
NEGADSSWRV RREPDSQRAA APKDSGAPQS RDDKWRRGGE RDRDFRIDGA RRDRDDGPRR 
DRDDGPRRDR DDERGGFRRA DGARRTDEPQ RETGGNWRDA PRHADRETRR PAERRDRDVR 
ETRGDQRGSA PKEAASGGVG GNWRTAPATR EEKPAAKRDQ AQEKENKAGD DGEWTSVKRR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.