Details for: MIR139

Gene ID: 406931

Symbol: MIR139

Ensembl ID: ENSG00000272036

Description: microRNA 139

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MIR139 is a 22-nucleotide long non-coding RNA that belongs to the microRNA family. It is highly conserved across species, suggesting its essential role in fundamental biological processes. MIR139 is primarily expressed in cells of the nervous system, cardiovascular system, and immune cells, where it regulates the expression of target genes involved in cell differentiation, survival, and immune responses. **Pathways and Functions:** MIR139 is involved in several cellular pathways, including: 1. **Mirna-mediated post-transcriptional gene silencing:** MIR139 binds to target mRNAs, leading to their degradation or repression of translation, thereby regulating gene expression. 2. **mRNA 3'-UTR binding:** MIR139 binds to the 3'-untranslated region (3'-UTR) of target mRNAs, influencing their stability and translation. 3. **mRNA base-pairing translational repressor activity:** MIR139 interacts with target mRNAs through base pairing, preventing their translation into proteins. 4. **RISC complex:** MIR139 is part of the RNA-induced silencing complex (RISC), which is essential for microRNA-mediated gene silencing. **Clinical Significance:** MIR139 has been implicated in various diseases and disorders, including: 1. **Cardiovascular disease:** MIR139 has been associated with cardiac hypertrophy, fibrosis, and cardiac arrhythmias, highlighting its potential role in the development of cardiovascular disease. 2. **Neurological disorders:** MIR139 has been linked to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where it may play a role in regulating gene expression involved in neuronal function and survival. 3. **Immune disorders:** MIR139 has been implicated in immune responses, including the regulation of immune cell development and function, which may be relevant to autoimmune diseases and cancer. 4. **Cancer:** MIR139 has been found to be downregulated in various types of cancer, suggesting its potential role as a tumor suppressor gene. In conclusion, MIR139 is a critical regulator of cellular processes, including development, differentiation, and immune responses. Its dysregulation has been implicated in various diseases and disorders, highlighting the need for further research into the molecular mechanisms underlying its functions and potential therapeutic applications.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.