Details for: MIR196A2

Gene ID: 406973

Symbol: MIR196A2

Ensembl ID: ENSG00000207924

Description: microRNA 196a-2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 5.39
    Marker Score: 2388
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 4.99
    Marker Score: 2381
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 3.93
    Marker Score: 2363
  • Cell Name: pericyte (CL0000669)
    Fold Change: 3.81
    Marker Score: 2228
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 2.47
    Marker Score: 1969
  • Cell Name: brush cell (CL0002204)
    Fold Change: 1.83
    Marker Score: 1668
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 1.48
    Marker Score: 2397
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.44
    Marker Score: 9556
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.17
    Marker Score: 2215
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.09
    Marker Score: 2207
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.06
    Marker Score: 3176
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.04
    Marker Score: 6321
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30330
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.87
    Marker Score: 2207
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.81
    Marker Score: 4612
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.32
    Marker Score: 1923
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.08
    Marker Score: 1267

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key Characteristics** MIR196A2 is a 22-nucleotide long microRNA that is highly conserved across species. It is encoded by a single gene, MIR196A2, which is located on chromosome 4q21.3 in humans. The microRNA is processed by the Drosha-Dgcr8 complex and is released into the cytoplasm, where it binds to specific messenger RNA (mRNA) targets, leading to their degradation or inhibition of translation. MIR196A2 has been shown to play a crucial role in regulating the expression of genes involved in immune cell development, differentiation, and function. **Pathways and Functions** MIR196A2 is involved in several key pathways, including: 1. **Mirna-mediated post-transcriptional gene silencing**: MIR196A2 regulates gene expression at the post-transcriptional level by binding to specific mRNAs, leading to their degradation or inhibition of translation. 2. **RISC complex**: MIR196A2 is a component of the RNA-induced silencing complex (RISC), which is responsible for the recognition and degradation of target mRNAs. 3. **Immune cell development and differentiation**: MIR196A2 regulates the expression of genes involved in immune cell development, differentiation, and function, including T cell receptor genes and cytokine genes. 4. **Cell proliferation and survival**: MIR196A2 has been shown to regulate cell proliferation and survival by modulating the expression of genes involved in these processes. **Clinical Significance** Dysregulation of MIR196A2 has been implicated in various diseases, including: 1. **Autoimmune disorders**: MIR196A2 has been shown to play a role in the development of autoimmune disorders, such as multiple sclerosis and type 1 diabetes, by regulating the expression of genes involved in immune cell development and function. 2. **Cancer**: MIR196A2 has been implicated in the development and progression of various cancers, including breast cancer and lung cancer, by regulating the expression of genes involved in cell proliferation and survival. 3. **Infectious diseases**: MIR196A2 has been shown to play a role in the development of infectious diseases, such as HIV and tuberculosis, by regulating the expression of genes involved in immune cell development and function. In conclusion, MIR196A2 is a critical regulator of immune cell development, differentiation, and function. Its dysregulation has been implicated in various diseases, including autoimmune disorders, cancer, and infectious diseases. Further research is needed to fully understand the role of MIR196A2 in human disease and to explore its potential as a therapeutic target.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.