Details for: dsx

Gene ID: 40940

Symbol: dsx

Ensembl ID: FBgn0000504

Description: doublesex

Associated with

  • Axon midline choice point recognition
    (GO:0016199)
  • Courtship behavior
    (GO:0007619)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Female analia development
    (GO:0045497)
  • Female sex differentiation
    (GO:0046660)
  • Female somatic sex determination
    (GO:0019101)
  • Genital disc development
    (GO:0035215)
  • Imaginal disc-derived female genitalia development
    (GO:0007486)
  • Imaginal disc-derived male genitalia development
    (GO:0007485)
  • Male analia development
    (GO:0045496)
  • Male courtship behavior
    (GO:0008049)
  • Male courtship behavior, veined wing generated song production
    (GO:0045433)
  • Male sex differentiation
    (GO:0046661)
  • Negative regulation of developmental pigmentation
    (GO:0048086)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Nucleus
    (GO:0005634)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Protein homodimerization activity
    (GO:0042803)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sex-specific pigmentation
    (GO:0048071)
  • Sex comb development
    (GO:0045498)
  • Sex determination
    (GO:0007530)
  • Sex differentiation
    (GO:0007548)
  • Somatic sex determination
    (GO:0018993)
  • Zinc ion binding
    (GO:0008270)

Other Information

Genular Protein ID: 1843641142

Symbol: DSX_DROME

Name: Protein doublesex

UniProtKB Accession Codes:

P23023 P23022 Q0KIA7 Q95TA5 Q9VHY0

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CTD 1 DIP 1 DNASU 1 EMBL 7 EnsemblMetazoa 5 EvolutionaryTrace 1 ExpressionAtlas 1 FlyBase 1 GO 30 Gene3D 2 Genevisible 1 GenomeRNAi 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OMA 1 PANTHER 2 PDB 7 PDBsum 4 PIR 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 Pfam 2 PhylomeDB 1 Proteomes 1 RefSeq 5 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 2493994

Title: Drosophila doublesex gene controls somatic sexual differentiation by producing alternatively spliced mRNAs encoding related sex-specific polypeptides.

PubMed ID: 2493994

DOI: 10.1016/0092-8674(89)90633-8

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537569

Title: A Drosophila full-length cDNA resource.

PubMed ID: 12537569

DOI: 10.1186/gb-2002-3-12-research0080

PubMed ID: 1907913

Title: The doublesex proteins of Drosophila melanogaster bind directly to a sex-specific yolk protein gene enhancer.

PubMed ID: 1907913

DOI: 10.1002/j.1460-2075.1991.tb07798.x

PubMed ID: 8440242

Title: The Drosophila doublesex proteins share a novel zinc finger related DNA binding domain.

PubMed ID: 8440242

DOI: 10.1002/j.1460-2075.1993.tb05684.x

PubMed ID: 12435630

Title: The Drosophila takeout gene is regulated by the somatic sex-determination pathway and affects male courtship behavior.

PubMed ID: 12435630

DOI: 10.1101/gad.1010302

Sequence Information:

  • Length: 549
  • Mass: 57409
  • Checksum: 3C1B92724E4CE083
  • Sequence:
    • MVSEENWNSD TMSDSDMIDS KNDVCGGASS SSGSSISPRT PPNCARCRNH GLKITLKGHK 
RYCKFRYCTC EKCRLTADRQ RVMALQTALR RAQAQDEQRA LHMHEVPPAN PAATTLLSHH 
HHVAAPAHVH AHHVHAHHAH GGHHSHHGHV LHHQQAAAAA AAAPSAPASH LGGSSTAASS 
IHGHAHAHHV HMAAAAAASV AQHQHQSHPH SHHHHHQNHH QHPHQQPATQ TALRSPPHSD 
HGGSVGPATS SSGGGAPSSS NAAAATSSNG SSGGGGGGGG GSSGGGAGGG RSSGTSVITS 
ADHHMTTVPT PAQSLEGSCD SSSPSPSSTS GAAILPISVS VNRKNGANVP LGQDVFLDYC 
QKLLEKFRYP WELMPLMYVI LKDADANIEE ASRRIEEARV EINRTVAQIY YNYYTPMALV 
NGAPMYLTYP SIEQGRYGAH FTHLPLTQIC PPTPEPLALS RSPSSPSGPS AVHNQKPSRP 
GSSNGTVHSA ASPTMVTTMA TTSSTPTLSR RQRSRSATPT TPPPPPPAHS SSNGAYHHGH 
HLVSSTAAT

Genular Protein ID: 2116195466

Symbol: A0A0B4LGS9_DROME

Name: N/A

UniProtKB Accession Codes:

A0A0B4LGS9

Database IDs:

AGR 1 ARBA 3 AlphaFoldDB 1 Bgee 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 EnsemblMetazoa 3 ExpressionAtlas 1 FlyBase 2 GO 4 Gene3D 2 GenomeRNAi 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 Pfam 2 PhylomeDB 1 Proteomes 2 RefSeq 3 SAM 1 SMART 2 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537568

Title: Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence.

PubMed ID: 12537568

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537573

Title: The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective.

PubMed ID: 12537573

PubMed ID: 12537574

Title: Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.

PubMed ID: 12537574

PubMed ID: 16110336

Title: Combined evidence annotation of transposable elements in genome sequences.

PubMed ID: 16110336

DOI: 10.1371/journal.pcbi.0010022

PubMed ID: 17569856

Title: The Release 5.1 annotation of Drosophila melanogaster heterochromatin.

PubMed ID: 17569856

DOI: 10.1126/science.1139815

PubMed ID: 17569867

Title: Sequence finishing and mapping of Drosophila melanogaster heterochromatin.

PubMed ID: 17569867

DOI: 10.1126/science.1139816

Sequence Information:

  • Length: 427
  • Mass: 44768
  • Checksum: 75143686AC717315
  • Sequence:
    • MVSEENWNSD TMSDSDMIDS KNDVCGGASS SSGSSISPRT PPNCARCRNH GLKITLKGHK 
RYCKFRYCTC EKCRLTADRQ RVMALQTALR RAQAQDEQRA LHMHEVPPAN PAATTLLSHH 
HHVAAPAHVH AHHVHAHHAH GGHHSHHGHV LHHQQAAAAA AAAPSAPASH LGGSSTAASS 
IHGHAHAHHV HMAAAAAASV AQHQHQSHPH SHHHHHQNHH QHPHQQPATQ TALRSPPHSD 
HGGSVGPATS SSGGGAPSSS NAAAATSSNG SSGGGGGGGG GSSGGGAGGG RSSGTSVITS 
ADHHMTTVPT PAQSLEGSCD SSSPSPSSTS GAAILPISVS VNRKNGANVP LGQDVFLDYC 
QKLLEKFRYP WELMPLMYVI LKDADANIEE ASRRIEEGQY VVNEYSRQHN LNIYDGGELR 
NTTRQCG

Genular Protein ID: 3793389255

Symbol: A0A0B4KGR7_DROME

Name: N/A

UniProtKB Accession Codes:

A0A0B4KGR7

Database IDs:

AGR 1 ARBA 3 Bgee 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 EnsemblMetazoa 1 ExpressionAtlas 1 FlyBase 2 GO 4 Gene3D 2 GenomeRNAi 1 InterPro 4 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 Pfam 2 Proteomes 2 RefSeq 1 SAM 2 SMART 2 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537568

Title: Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence.

PubMed ID: 12537568

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537573

Title: The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective.

PubMed ID: 12537573

PubMed ID: 12537574

Title: Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.

PubMed ID: 12537574

PubMed ID: 16110336

Title: Combined evidence annotation of transposable elements in genome sequences.

PubMed ID: 16110336

DOI: 10.1371/journal.pcbi.0010022

PubMed ID: 17569856

Title: The Release 5.1 annotation of Drosophila melanogaster heterochromatin.

PubMed ID: 17569856

DOI: 10.1126/science.1139815

PubMed ID: 17569867

Title: Sequence finishing and mapping of Drosophila melanogaster heterochromatin.

PubMed ID: 17569867

DOI: 10.1126/science.1139816

Sequence Information:

  • Length: 572
  • Mass: 59679
  • Checksum: 04B5A127C8FE93AE
  • Sequence:
    • MVSEENWNSD TMSDSDMIDS KNDVCGGASS SSGSSISPRT PPNCARCRNH GLKITLKGHK 
RYCKFRYCTC EKCRLTADRQ RVMALQTALR RAQAQDEQRA LHMHEVPPAN PAATTLLSHH 
HHVAAPAHVH AHHVHAHHAH GGHHSHHGHV LHHQQAAAAA AAAPSAPASH LGGSSTAASS 
IHGHAHAHHV HMAAAAAASV AQHQHQSHPH SHHHHHQNHH QHPHQQPATQ TALRSPPHSD 
HGGSVGPATS SSGGGAPSSS NAAAATSSNG SSGGGGGGGG GSSGGGAGGG RSSGTSVITS 
ADHHMTTVPT PAQSLEGSCD SSSPSPSSTS GAAILPISVS VNRKNGANVP LGQDVFLDYC 
QKLLEKFRYP WELMPLMYVI LKDADANIEE ASRRIEEARV EINRTVAQIY YNYYTPMALV 
NGAPMYLTYP SIEQGRYGAH FTHLPLTQIC PPTPEPLALS RSPSSPSGPS AVHNQKPSRP 
GSSNGTVHSA ASPTMVTTMA TTSSTPTLSR RQRSRSATPT TPPPPPPAHS SSNGAYHHGH 
HLVSSTAATX QYRNVAAAVA AAAAAAVLFV DN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.