Mcm2 | FBgn0014861 | NCBI 40973

Details for: Mcm2

Gene ID: 40973

Symbol: Mcm2

Ensembl ID: FBgn0014861

Description: Minichromosome maintenance 2

Associated with

Activation of atr in response to replication stress
(R-DME-176187)
Activation of the pre-replicative complex
(R-DME-68962)
Assembly of the pre-replicative complex
(R-DME-68867)
Cell cycle
(R-DME-1640170)
Cell cycle, mitotic
(R-DME-69278)
Cell cycle checkpoints
(R-DME-69620)
Dna replication pre-initiation
(R-DME-69002)
G1/s transition
(R-DME-69206)
G2/m checkpoints
(R-DME-69481)
Mitotic g1 phase and g1/s transition
(R-DME-453279)
Orc1 removal from chromatin
(R-DME-68949)
S phase
(R-DME-69242)
Switching of origins to a post-replicative state
(R-DME-69052)
Synthesis of dna
(R-DME-69239)
3'-5' dna helicase activity
(GO:0043138)
Atp binding
(GO:0005524)
Chromosome condensation
(GO:0030261)
Cmg complex
(GO:0071162)
Dna binding
(GO:0003677)
Dna duplex unwinding
(GO:0032508)
Dna replication
(GO:0006260)
Dna replication initiation
(GO:0006270)
Dna unwinding involved in dna replication
(GO:0006268)
Double-strand break repair via break-induced replication
(GO:0000727)
Mcm complex
(GO:0042555)
Mitotic dna replication initiation
(GO:1902975)
Nucleus
(GO:0005634)
Single-stranded dna binding
(GO:0003697)
Single-stranded dna helicase activity
(GO:0017116)

Other Information

Proteins

DNA replication licensing factor Mcm2

Genular Protein ID: 2914087385

Symbol: MCM2_DROME

Name: DNA replication licensing factor Mcm2

UniProtKB Accession Codes:

P49735 Q9VHU2

Database IDs:

Citations:

PubMed ID: 7622035

Title: Cell proliferation and DNA replication defects in a Drosophila MCM2 mutant.

PubMed ID: 7622035

DOI: 10.1101/gad.9.14.1709

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537569

Title: A Drosophila full-length cDNA resource.

PubMed ID: 12537569

DOI: 10.1186/gb-2002-3-12-research0080

PubMed ID: 11854416

Title: Drosophila minichromosome maintenance 6 is required for chorion gene amplification and genomic replication.

PubMed ID: 11854416

DOI: 10.1091/mbc.01-08-0400

PubMed ID: 12808023

Title: Drosophila MCM10 interacts with members of the prereplication complex and is required for proper chromosome condensation.

PubMed ID: 12808023

DOI: 10.1091/mbc.e02-11-0706

PubMed ID: 16798881

Title: Isolation of the Cdc45/Mcm2-7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase.

PubMed ID: 16798881

DOI: 10.1073/pnas.0602400103

PubMed ID: 17372656

Title: An integrated chemical, mass spectrometric and computational strategy for (quantitative) phosphoproteomics: application to Drosophila melanogaster Kc167 cells.

PubMed ID: 17372656

DOI: 10.1039/b617545g

PubMed ID: 18327897

Title: Phosphoproteome analysis of Drosophila melanogaster embryos.

PubMed ID: 18327897

DOI: 10.1021/pr700696a

PubMed ID: 20122406

Title: Activation of the MCM2-7 helicase by association with Cdc45 and GINS proteins.

PubMed ID: 20122406

DOI: 10.1016/j.molcel.2009.12.030

Sequence Information:

Length: 887
Mass: 100415
Checksum: 26A7092109F09CBE
Sequence:

MDNPSSPPPN TPSDAAERRD LRAAMTSPVG DFEPFENEDE ILGDQTVRDE AEEEDGEELF 
GDNMENDYRP MPELDHYDPA LLDDEDDFSE MSQGDRFAAE SEMRRRDRAA GIHRDDRDLG 
FGQSDDEDDV GPRAKRRAGE KAAVGEVEDT EMVESIENLE DTKGHSTKEW VSMLGPRTEI 
ANRFQSFLRT FVDERGAYTY RDRIRRMCEQ NMSSFVVSYT DLANKEHVLA YFLPEAPFQM 
LEIFDKVAKD MVLSIFPTYE RVTTEIHVRI SELPLIEELR TFRKLHLNQL VRTLGVVTAT 
TGVLPQLSVI KYDCVKCGYV LGPFVQSQNT EIKPGSCPEC QSTGPFSINM EQTLYRNYQK 
ITLQESPGRI PAGRIPRSKD VILLADLCDQ CKPGDELEVT GIYTNNYDGS LNTDQGFPVF 
ATVIIANHVV VKDSKQVVQS LTDEDIATIQ KLSKDPRIVE RVVASMAPSI YGHDYIKRAL 
ALALFGGESK NPGEKHKVRG DINLLICGDP GTAKSQFLKY TEKVAPRAVF TTGQGASAVG 
LTAYVRRNPV SREWTLEAGA LVLADQGVCL IDEFDKMNDQ DRTSIHEAME QQSISISKAG 
IVTSLQARCT VIAAANPIGG RYDPSMTFSE NVNLSEPILS RFDVLCVVKD EFDPMQDQQL 
AKFVVHSHMK HHPSEEEQPE LEEPQLKTVD EIPQDLLRQY IVYAKENIRP KLTNIDEDKI 
AKMYAQLRQE SFATGSLPIT VRHIESVIRM SEAHARMHLR ENVMEADVSM AIRMMLESFI 
EAQKFSVMKK MRSTFQKYLS FQKDHSELLF FILRQLTLDQ LAYIRCKDGP GATHVEIMER 
DLIERAKQLD IVNLKPFYES DLFRTNGFSY DPKRRIILQI VVDGNTA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Mcm2

Associated with

Other Information

Cell proliferation and DNA replication defects in a Drosophila MCM2 mutant. PubMed ID: 7622035

The genome sequence of Drosophila melanogaster. PubMed ID: 10731132

Annotation of the Drosophila melanogaster euchromatic genome: a systematic review. PubMed ID: 12537572

A Drosophila full-length cDNA resource. PubMed ID: 12537569

Drosophila minichromosome maintenance 6 is required for chorion gene amplification and genomic replication. PubMed ID: 11854416

Drosophila MCM10 interacts with members of the prereplication complex and is required for proper chromosome condensation. PubMed ID: 12808023

Isolation of the Cdc45/Mcm2-7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase. PubMed ID: 16798881

An integrated chemical, mass spectrometric and computational strategy for (quantitative) phosphoproteomics: application to Drosophila melanogaster Kc167 cells. PubMed ID: 17372656

Phosphoproteome analysis of Drosophila melanogaster embryos. PubMed ID: 18327897

Activation of the MCM2-7 helicase by association with Cdc45 and GINS proteins. PubMed ID: 20122406