Details for: ASIC1

Gene ID: 41

Symbol: ASIC1

Ensembl ID: ENSG00000110881

Description: acid sensing ion channel subunit 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 2.15
    Marker Score: 3,089
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.03
    Marker Score: 1,068
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1,170
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.51
    Marker Score: 1,510
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 1.47
    Marker Score: 1,461
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 870
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.34
    Marker Score: 51,023
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.32
    Marker Score: 2,738
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.12
    Marker Score: 5,883
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.03
    Marker Score: 431
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.02
    Marker Score: 7,807
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,823
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,048
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.94
    Marker Score: 298
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,351
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.94
    Marker Score: 1,906
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 373
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,739
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.91
    Marker Score: 3,526
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.91
    Marker Score: 1,124
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.9
    Marker Score: 3,658
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.88
    Marker Score: 406
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.88
    Marker Score: 2,065
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,286
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.84
    Marker Score: 28,242
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.83
    Marker Score: 482
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.82
    Marker Score: 1,558
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 610
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.79
    Marker Score: 12,413
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,262
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.77
    Marker Score: 2,597
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.75
    Marker Score: 3,162
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.75
    Marker Score: 3,111
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.74
    Marker Score: 645
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.68
    Marker Score: 395
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.67
    Marker Score: 10,040
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.65
    Marker Score: 311
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.62
    Marker Score: 22,830
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.61
    Marker Score: 5,746
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.61
    Marker Score: 5,762
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.61
    Marker Score: 6,262
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.6
    Marker Score: 11,890
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.59
    Marker Score: 5,083
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.59
    Marker Score: 378
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.59
    Marker Score: 906
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.57
    Marker Score: 3,077
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 448
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.54
    Marker Score: 2,511
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.54
    Marker Score: 357
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.53
    Marker Score: 32,681
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.53
    Marker Score: 409
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.52
    Marker Score: 294
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.5
    Marker Score: 160
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.5
    Marker Score: 1,707
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.49
    Marker Score: 187
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.42
    Marker Score: 132
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.41
    Marker Score: 976
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.4
    Marker Score: 190
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.39
    Marker Score: 313
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.39
    Marker Score: 162
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.39
    Marker Score: 438
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.38
    Marker Score: 136
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.37
    Marker Score: 7,970
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 371
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.34
    Marker Score: 207
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.32
    Marker Score: 143
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.32
    Marker Score: 378
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.32
    Marker Score: 1,316
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.3
    Marker Score: 197
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.3
    Marker Score: 688
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.29
    Marker Score: 353
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.29
    Marker Score: 2,198
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.29
    Marker Score: 194
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.28
    Marker Score: 513
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.28
    Marker Score: 73
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.28
    Marker Score: 284
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.27
    Marker Score: 92
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.27
    Marker Score: 2,316
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.26
    Marker Score: 148
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.26
    Marker Score: 123
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.26
    Marker Score: 736
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.25
    Marker Score: 146
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.25
    Marker Score: 236
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.24
    Marker Score: 946
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.22
    Marker Score: 107
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.22
    Marker Score: 202
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.2
    Marker Score: 60
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.2
    Marker Score: 70

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ASIC1 is a transmembrane protein that forms a trimeric channel complex with other ASIC subunits. It is characterized by its ability to sense acidic pH and activate the channel in response to a decrease in pH. ASIC1 is highly expressed in tissues that are sensitive to acidic pH, such as the nervous system, and is involved in the regulation of neurotransmitter secretion and synaptic plasticity. The channel is also activated by other ligands, such as amphetamine, and has been implicated in the regulation of pain perception and sensory perception of sour taste. **Pathways and Functions:** ASIC1 plays a crucial role in the regulation of cellular response to acidic pH and neurotransmission. The channel is activated by the presence of acidic pH, which triggers a rapid increase in intracellular calcium levels. This increase in calcium levels leads to the activation of various signaling pathways, including the phospholipase C (PLC) pathway, which regulates neurotransmitter secretion and synaptic plasticity. ASIC1 has also been implicated in the regulation of pain perception and sensory perception of sour taste, and has been shown to interact with other ion channels and receptors, such as the NMDA receptor, to modulate neuronal excitability. **Clinical Significance:** ASIC1 has been implicated in the development of various diseases, including cancer, neurological disorders, and metabolic disorders. For example, ASIC1 has been shown to be overexpressed in certain types of cancer, such as lung and breast cancer, and has been implicated in the regulation of tumor growth and metastasis. ASIC1 has also been implicated in the development of neurological disorders, such as Parkinson's disease and epilepsy, and has been shown to interact with other ion channels and receptors to modulate neuronal excitability. Additionally, ASIC1 has been implicated in metabolic disorders, such as diabetes and obesity, and has been shown to interact with other ion channels and receptors to regulate glucose metabolism. In conclusion, ASIC1 is a crucial component of the acid-sensing ion channel family, which plays a vital role in the regulation of cellular response to acidic pH and neurotransmission. Its dysregulation has been implicated in the development of various diseases, including cancer, neurological disorders, and metabolic disorders. Further research is needed to fully understand the mechanisms by which ASIC1 regulates cellular response to acidic pH and neurotransmission, and to explore its potential as a therapeutic target for the treatment of various diseases. **Implications for Future Research:** Future research should focus on the following areas: 1. The molecular mechanisms by which ASIC1 regulates cellular response to acidic pH and neurotransmission. 2. The role of ASIC1 in the development of various diseases, including cancer, neurological disorders, and metabolic disorders. 3. The potential of ASIC1 as a therapeutic target for the treatment of various diseases. 4. The interactions between ASIC1 and other ion channels and receptors, and the implications for neuronal excitability and synaptic plasticity. Overall, ASIC1 is a complex protein that plays a crucial role in the regulation of cellular response to acidic pH and neurotransmission. Further research is needed to fully understand its mechanisms of action and to explore its potential as a therapeutic target for the treatment of various diseases.

Genular Protein ID: 3290352283

Symbol: ASIC1_HUMAN

Name: Amiloride-sensitive cation channel 2, neuronal

UniProtKB Accession Codes:

P78348 A3KN86 E5KBL7 P78349 Q96CV2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EMBL 8 EMDB 3 Ensembl 3 ExpressionAtlas 1 GO 22 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 5 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9037075

Title: BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels.

PubMed ID: 9037075

DOI: 10.1073/pnas.94.4.1459

PubMed ID: 21036899

Title: Identification of a calcium permeable human acid-sensing ion channel 1 transcript variant.

PubMed ID: 21036899

DOI: 10.1074/jbc.m110.171330

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10798398

Title: Neuropeptide FF and FMRFamide potentiate acid-evoked currents from sensory neurons and proton-gated DEG/ENaC channels.

PubMed ID: 10798398

DOI: 10.1016/s0896-6273(00)81144-7

PubMed ID: 11802773

Title: Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel).

PubMed ID: 11802773

DOI: 10.1042/0264-6021:3610443

PubMed ID: 12244121

Title: Protein kinase C isoform antagonism controls BNaC2 (ASIC1) function.

PubMed ID: 12244121

DOI: 10.1074/jbc.m208995200

PubMed ID: 12578970

Title: cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1.

PubMed ID: 12578970

DOI: 10.1073/pnas.252782799

PubMed ID: 15247234

Title: Selective regulation of acid-sensing ion channel 1 by serine proteases.

PubMed ID: 15247234

DOI: 10.1074/jbc.m407381200

PubMed ID: 19654327

Title: Identification of protein domains that control proton and calcium sensitivity of ASIC1a.

PubMed ID: 19654327

DOI: 10.1074/jbc.m109.029009

PubMed ID: 23034652

Title: Black mamba venom peptides target acid-sensing ion channels to abolish pain.

PubMed ID: 23034652

DOI: 10.1038/nature11494

PubMed ID: 22760635

Title: Structure of the acid-sensing ion channel 1 in complex with the gating modifier Psalmotoxin 1.

PubMed ID: 22760635

DOI: 10.1038/ncomms1917

PubMed ID: 28327374

Title: Discovery and molecular interaction studies of a highly stable, tarantula peptide modulator of acid-sensing ion channel 1.

PubMed ID: 28327374

DOI: 10.1016/j.neuropharm.2017.03.020

Sequence Information:

  • Length: 528
  • Mass: 59909
  • Checksum: 9E998F711C208450
  • Sequence:
    • MELKAEEEEV GGVQPVSIQA FASSSTLHGL AHIFSYERLS LKRALWALCF LGSLAVLLCV 
CTERVQYYFH YHHVTKLDEV AASQLTFPAV TLCNLNEFRF SQVSKNDLYH AGELLALLNN 
RYEIPDTQMA DEKQLEILQD KANFRSFKPK PFNMREFYDR AGHDIRDMLL SCHFRGEVCS 
AEDFKVVFTR YGKCYTFNSG RDGRPRLKTM KGGTGNGLEI MLDIQQDEYL PVWGETDETS 
FEAGIKVQIH SQDEPPFIDQ LGFGVAPGFQ TFVACQEQRL IYLPPPWGTC KAVTMDSDLD 
FFDSYSITAC RIDCETRYLV ENCNCRMVHM PGDAPYCTPE QYKECADPAL DFLVEKDQEY 
CVCEMPCNLT RYGKELSMVK IPSKASAKYL AKKFNKSEQY IGENILVLDI FFEVLNYETI 
EQKKAYEIAG LLGDIGGQMG LFIGASILTV LELFDYAYEV IKHKLCRRGK CQKEAKRSSA 
DKGVALSLDD VKRHNPCESL RGHPAGMTYA ANILPHHPAR GTFEDFTC

Genular Protein ID: 2131883218

Symbol: A8K1U5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K1U5

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 3 GenomeRNAi 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 1 RefSeq 2

Sequence Information:

  • Length: 528
  • Mass: 59863
  • Checksum: 08CD0D39AA74164C
  • Sequence:
    • MELKAEEEEV GGVQPVSIQA FASSSTLHGL AHIFSYERLS LKRALWALCF LGSLAVLLCV 
CTERVQYYFH YHHVTKLDEV AASQLTFPAV TLCNLNEFRF SQVSKNDLYH AGELLALLNN 
RYEIPDTQMA DEKQLEILQD KANFRSFKPK PFNMREFYDR AGHDIRDMLL SCHFRGEVCS 
AEDFKVVFTR YGKCYTFNSG RDGRPRLKTM KGGTGNGLEI MLDIQQDEYL PVWGETDETS 
FEAGIKVQIH SQDEPPFIDQ LGFGVAPGFQ TFVACQEQRL IYLPPPWGTC KAVTMDSDLD 
FFDSYSITAC RIDCETRYLV ENCNCRMLHM PGDAPYCTPE QYKECADPAL DFLVEKDQEY 
CVCEMPCNLT RYGKELSMVK IPSKASAKYL AKKFNKSEQY IGENILVLDI FFEVLNYETI 
EQKKAYEIAG LLGDIGGQMG LFIGASILTV LELFDYAYEV IKHKLCRRGK CQKEAKRSSA 
DKGVALSLDD VKRHNPCESL RGHPAGMTYA ANILPHHPAR GTFEDSTC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.