Details for: ASIC1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: Purkinje cell (CL0000121)
Fold Change: 1.1751
Cell Significance Index: 25.7300 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.6069
Cell Significance Index: 8.2800 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.5806
Cell Significance Index: 13.9300 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.5314
Cell Significance Index: 32.6600 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.4705
Cell Significance Index: 15.0700 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.4147
Cell Significance Index: 148.7300 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.3511
Cell Significance Index: 70.4400 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.3308
Cell Significance Index: 228.7900 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.2369
Cell Significance Index: 10.4800 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.2340
Cell Significance Index: 46.4400 - Cell Name: helper T cell (CL0000912)
Fold Change: 0.1795
Cell Significance Index: 2.5500 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.1790
Cell Significance Index: 6.7800 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1717
Cell Significance Index: 32.6700 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.1095
Cell Significance Index: 6.7200 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.0350
Cell Significance Index: 31.6000 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0341
Cell Significance Index: 1.5900 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0316
Cell Significance Index: 0.9100 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0245
Cell Significance Index: 0.4200 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0242
Cell Significance Index: 2.3900 - Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.0076
Cell Significance Index: 0.1300 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.0049
Cell Significance Index: 0.8100 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0010
Cell Significance Index: -0.0500 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0062
Cell Significance Index: -11.6600 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0096
Cell Significance Index: -5.2300 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0110
Cell Significance Index: -20.3500 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0117
Cell Significance Index: -0.4100 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0128
Cell Significance Index: -19.7700 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.0139
Cell Significance Index: -0.2800 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0154
Cell Significance Index: -20.9300 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.0171
Cell Significance Index: -1.8600 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0177
Cell Significance Index: -7.8300 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0197
Cell Significance Index: -12.5000 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0228
Cell Significance Index: -17.2500 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0258
Cell Significance Index: -19.1100 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0307
Cell Significance Index: -13.9500 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0325
Cell Significance Index: -18.3400 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0370
Cell Significance Index: -23.1000 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.0460
Cell Significance Index: -2.7600 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0480
Cell Significance Index: -3.2300 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0493
Cell Significance Index: -14.2000 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.0574
Cell Significance Index: -1.3900 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0741
Cell Significance Index: -3.3600 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0751
Cell Significance Index: -9.6300 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0776
Cell Significance Index: -13.9900 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0830
Cell Significance Index: -10.7300 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0833
Cell Significance Index: -12.1100 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0912
Cell Significance Index: -19.2000 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1045
Cell Significance Index: -12.1800 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.1070
Cell Significance Index: -14.7000 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1086
Cell Significance Index: -18.5500 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.1147
Cell Significance Index: -14.1000 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1299
Cell Significance Index: -13.2700 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.1336
Cell Significance Index: -3.3400 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.1393
Cell Significance Index: -9.6300 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1472
Cell Significance Index: -16.8600 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1594
Cell Significance Index: -16.6000 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.1814
Cell Significance Index: -3.9300 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1958
Cell Significance Index: -23.0900 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1978
Cell Significance Index: -15.6700 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.2036
Cell Significance Index: -5.6900 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.2054
Cell Significance Index: -4.2600 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2092
Cell Significance Index: -15.6000 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.2304
Cell Significance Index: -17.6800 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.2434
Cell Significance Index: -3.4900 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2503
Cell Significance Index: -13.1400 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.2513
Cell Significance Index: -16.2100 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.2732
Cell Significance Index: -12.8400 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.2784
Cell Significance Index: -14.5000 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.2885
Cell Significance Index: -16.1900 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.3033
Cell Significance Index: -4.5700 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.3331
Cell Significance Index: -7.1000 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.3375
Cell Significance Index: -10.7500 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.3494
Cell Significance Index: -9.9700 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.3537
Cell Significance Index: -11.5800 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.3593
Cell Significance Index: -8.9600 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.3626
Cell Significance Index: -7.1700 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.3677
Cell Significance Index: -19.1000 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.3694
Cell Significance Index: -7.8400 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.3828
Cell Significance Index: -8.2700 - Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: -0.3869
Cell Significance Index: -5.4100 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.3965
Cell Significance Index: -13.8900 - Cell Name: hippocampal interneuron (CL1001569)
Fold Change: -0.4033
Cell Significance Index: -5.2300 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.4042
Cell Significance Index: -6.7700 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.4296
Cell Significance Index: -14.9300 - Cell Name: keratocyte (CL0002363)
Fold Change: -0.4330
Cell Significance Index: -6.8700 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.4419
Cell Significance Index: -9.2500 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.4524
Cell Significance Index: -11.6300 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.4605
Cell Significance Index: -9.6100 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.4877
Cell Significance Index: -12.1700 - Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: -0.5076
Cell Significance Index: -5.6400 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.5147
Cell Significance Index: -14.0100 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.5222
Cell Significance Index: -15.3800 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.5222
Cell Significance Index: -14.9700 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.5280
Cell Significance Index: -9.1300 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -0.5365
Cell Significance Index: -10.5600 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.5416
Cell Significance Index: -10.5700 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.5432
Cell Significance Index: -19.9400 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.5517
Cell Significance Index: -14.7300 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.5540
Cell Significance Index: -16.2700 - Cell Name: neuron (CL0000540)
Fold Change: -0.5591
Cell Significance Index: -5.3000
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3290352283
Symbol: ASIC1_HUMAN
Name: Amiloride-sensitive cation channel 2, neuronal
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9037075
Title: BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels.
PubMed ID: 9037075
PubMed ID: 21036899
Title: Identification of a calcium permeable human acid-sensing ion channel 1 transcript variant.
PubMed ID: 21036899
PubMed ID: 16541075
Title: The finished DNA sequence of human chromosome 12.
PubMed ID: 16541075
DOI: 10.1038/nature04569
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10798398
Title: Neuropeptide FF and FMRFamide potentiate acid-evoked currents from sensory neurons and proton-gated DEG/ENaC channels.
PubMed ID: 10798398
PubMed ID: 11802773
Title: Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel).
PubMed ID: 11802773
PubMed ID: 12244121
Title: Protein kinase C isoform antagonism controls BNaC2 (ASIC1) function.
PubMed ID: 12244121
PubMed ID: 12578970
Title: cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1.
PubMed ID: 12578970
PubMed ID: 15247234
Title: Selective regulation of acid-sensing ion channel 1 by serine proteases.
PubMed ID: 15247234
PubMed ID: 19654327
Title: Identification of protein domains that control proton and calcium sensitivity of ASIC1a.
PubMed ID: 19654327
PubMed ID: 23034652
Title: Black mamba venom peptides target acid-sensing ion channels to abolish pain.
PubMed ID: 23034652
DOI: 10.1038/nature11494
PubMed ID: 22760635
Title: Structure of the acid-sensing ion channel 1 in complex with the gating modifier Psalmotoxin 1.
PubMed ID: 22760635
DOI: 10.1038/ncomms1917
PubMed ID: 28327374
Title: Discovery and molecular interaction studies of a highly stable, tarantula peptide modulator of acid-sensing ion channel 1.
PubMed ID: 28327374
Sequence Information:
- Length: 528
- Mass: 59909
- Checksum: 9E998F711C208450
- Sequence:
MELKAEEEEV GGVQPVSIQA FASSSTLHGL AHIFSYERLS LKRALWALCF LGSLAVLLCV CTERVQYYFH YHHVTKLDEV AASQLTFPAV TLCNLNEFRF SQVSKNDLYH AGELLALLNN RYEIPDTQMA DEKQLEILQD KANFRSFKPK PFNMREFYDR AGHDIRDMLL SCHFRGEVCS AEDFKVVFTR YGKCYTFNSG RDGRPRLKTM KGGTGNGLEI MLDIQQDEYL PVWGETDETS FEAGIKVQIH SQDEPPFIDQ LGFGVAPGFQ TFVACQEQRL IYLPPPWGTC KAVTMDSDLD FFDSYSITAC RIDCETRYLV ENCNCRMVHM PGDAPYCTPE QYKECADPAL DFLVEKDQEY CVCEMPCNLT RYGKELSMVK IPSKASAKYL AKKFNKSEQY IGENILVLDI FFEVLNYETI EQKKAYEIAG LLGDIGGQMG LFIGASILTV LELFDYAYEV IKHKLCRRGK CQKEAKRSSA DKGVALSLDD VKRHNPCESL RGHPAGMTYA ANILPHHPAR GTFEDFTC
Genular Protein ID: 2131883218
Symbol: A8K1U5_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 528
- Mass: 59863
- Checksum: 08CD0D39AA74164C
- Sequence:
MELKAEEEEV GGVQPVSIQA FASSSTLHGL AHIFSYERLS LKRALWALCF LGSLAVLLCV CTERVQYYFH YHHVTKLDEV AASQLTFPAV TLCNLNEFRF SQVSKNDLYH AGELLALLNN RYEIPDTQMA DEKQLEILQD KANFRSFKPK PFNMREFYDR AGHDIRDMLL SCHFRGEVCS AEDFKVVFTR YGKCYTFNSG RDGRPRLKTM KGGTGNGLEI MLDIQQDEYL PVWGETDETS FEAGIKVQIH SQDEPPFIDQ LGFGVAPGFQ TFVACQEQRL IYLPPPWGTC KAVTMDSDLD FFDSYSITAC RIDCETRYLV ENCNCRMLHM PGDAPYCTPE QYKECADPAL DFLVEKDQEY CVCEMPCNLT RYGKELSMVK IPSKASAKYL AKKFNKSEQY IGENILVLDI FFEVLNYETI EQKKAYEIAG LLGDIGGQMG LFIGASILTV LELFDYAYEV IKHKLCRRGK CQKEAKRSSA DKGVALSLDD VKRHNPCESL RGHPAGMTYA ANILPHHPAR GTFEDSTC
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.