Details for: ASIC1

Gene ID: 41

Symbol: ASIC1

Ensembl ID: ENSG00000110881

Description: acid sensing ion channel subunit 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.1751
    Cell Significance Index: 25.7300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6069
    Cell Significance Index: 8.2800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.5806
    Cell Significance Index: 13.9300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5314
    Cell Significance Index: 32.6600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.4705
    Cell Significance Index: 15.0700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4147
    Cell Significance Index: 148.7300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3511
    Cell Significance Index: 70.4400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3308
    Cell Significance Index: 228.7900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2369
    Cell Significance Index: 10.4800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2340
    Cell Significance Index: 46.4400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.1795
    Cell Significance Index: 2.5500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1790
    Cell Significance Index: 6.7800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1717
    Cell Significance Index: 32.6700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.1095
    Cell Significance Index: 6.7200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0350
    Cell Significance Index: 31.6000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0341
    Cell Significance Index: 1.5900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0316
    Cell Significance Index: 0.9100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0245
    Cell Significance Index: 0.4200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0242
    Cell Significance Index: 2.3900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.0076
    Cell Significance Index: 0.1300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0049
    Cell Significance Index: 0.8100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0010
    Cell Significance Index: -0.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0062
    Cell Significance Index: -11.6600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0096
    Cell Significance Index: -5.2300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0110
    Cell Significance Index: -20.3500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0117
    Cell Significance Index: -0.4100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0128
    Cell Significance Index: -19.7700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0139
    Cell Significance Index: -0.2800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0154
    Cell Significance Index: -20.9300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0171
    Cell Significance Index: -1.8600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0177
    Cell Significance Index: -7.8300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0197
    Cell Significance Index: -12.5000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0228
    Cell Significance Index: -17.2500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0258
    Cell Significance Index: -19.1100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0307
    Cell Significance Index: -13.9500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0325
    Cell Significance Index: -18.3400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0370
    Cell Significance Index: -23.1000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0460
    Cell Significance Index: -2.7600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0480
    Cell Significance Index: -3.2300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0493
    Cell Significance Index: -14.2000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0574
    Cell Significance Index: -1.3900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0741
    Cell Significance Index: -3.3600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0751
    Cell Significance Index: -9.6300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0776
    Cell Significance Index: -13.9900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0830
    Cell Significance Index: -10.7300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0833
    Cell Significance Index: -12.1100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0912
    Cell Significance Index: -19.2000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1045
    Cell Significance Index: -12.1800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1070
    Cell Significance Index: -14.7000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1086
    Cell Significance Index: -18.5500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1147
    Cell Significance Index: -14.1000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1299
    Cell Significance Index: -13.2700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1336
    Cell Significance Index: -3.3400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1393
    Cell Significance Index: -9.6300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1472
    Cell Significance Index: -16.8600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1594
    Cell Significance Index: -16.6000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1814
    Cell Significance Index: -3.9300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1958
    Cell Significance Index: -23.0900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1978
    Cell Significance Index: -15.6700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2036
    Cell Significance Index: -5.6900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2054
    Cell Significance Index: -4.2600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2092
    Cell Significance Index: -15.6000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2304
    Cell Significance Index: -17.6800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2434
    Cell Significance Index: -3.4900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2503
    Cell Significance Index: -13.1400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2513
    Cell Significance Index: -16.2100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2732
    Cell Significance Index: -12.8400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2784
    Cell Significance Index: -14.5000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2885
    Cell Significance Index: -16.1900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3033
    Cell Significance Index: -4.5700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3331
    Cell Significance Index: -7.1000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3375
    Cell Significance Index: -10.7500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3494
    Cell Significance Index: -9.9700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3537
    Cell Significance Index: -11.5800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3593
    Cell Significance Index: -8.9600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3626
    Cell Significance Index: -7.1700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3677
    Cell Significance Index: -19.1000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3694
    Cell Significance Index: -7.8400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3828
    Cell Significance Index: -8.2700
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.3869
    Cell Significance Index: -5.4100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3965
    Cell Significance Index: -13.8900
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.4033
    Cell Significance Index: -5.2300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4042
    Cell Significance Index: -6.7700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4296
    Cell Significance Index: -14.9300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.4330
    Cell Significance Index: -6.8700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4419
    Cell Significance Index: -9.2500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4524
    Cell Significance Index: -11.6300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.4605
    Cell Significance Index: -9.6100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4877
    Cell Significance Index: -12.1700
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.5076
    Cell Significance Index: -5.6400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.5147
    Cell Significance Index: -14.0100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5222
    Cell Significance Index: -15.3800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5222
    Cell Significance Index: -14.9700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.5280
    Cell Significance Index: -9.1300
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.5365
    Cell Significance Index: -10.5600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.5416
    Cell Significance Index: -10.5700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5432
    Cell Significance Index: -19.9400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.5517
    Cell Significance Index: -14.7300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5540
    Cell Significance Index: -16.2700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.5591
    Cell Significance Index: -5.3000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ASIC1 is a transmembrane protein that forms a trimeric channel complex with other ASIC subunits. It is characterized by its ability to sense acidic pH and activate the channel in response to a decrease in pH. ASIC1 is highly expressed in tissues that are sensitive to acidic pH, such as the nervous system, and is involved in the regulation of neurotransmitter secretion and synaptic plasticity. The channel is also activated by other ligands, such as amphetamine, and has been implicated in the regulation of pain perception and sensory perception of sour taste. **Pathways and Functions:** ASIC1 plays a crucial role in the regulation of cellular response to acidic pH and neurotransmission. The channel is activated by the presence of acidic pH, which triggers a rapid increase in intracellular calcium levels. This increase in calcium levels leads to the activation of various signaling pathways, including the phospholipase C (PLC) pathway, which regulates neurotransmitter secretion and synaptic plasticity. ASIC1 has also been implicated in the regulation of pain perception and sensory perception of sour taste, and has been shown to interact with other ion channels and receptors, such as the NMDA receptor, to modulate neuronal excitability. **Clinical Significance:** ASIC1 has been implicated in the development of various diseases, including cancer, neurological disorders, and metabolic disorders. For example, ASIC1 has been shown to be overexpressed in certain types of cancer, such as lung and breast cancer, and has been implicated in the regulation of tumor growth and metastasis. ASIC1 has also been implicated in the development of neurological disorders, such as Parkinson's disease and epilepsy, and has been shown to interact with other ion channels and receptors to modulate neuronal excitability. Additionally, ASIC1 has been implicated in metabolic disorders, such as diabetes and obesity, and has been shown to interact with other ion channels and receptors to regulate glucose metabolism. In conclusion, ASIC1 is a crucial component of the acid-sensing ion channel family, which plays a vital role in the regulation of cellular response to acidic pH and neurotransmission. Its dysregulation has been implicated in the development of various diseases, including cancer, neurological disorders, and metabolic disorders. Further research is needed to fully understand the mechanisms by which ASIC1 regulates cellular response to acidic pH and neurotransmission, and to explore its potential as a therapeutic target for the treatment of various diseases. **Implications for Future Research:** Future research should focus on the following areas: 1. The molecular mechanisms by which ASIC1 regulates cellular response to acidic pH and neurotransmission. 2. The role of ASIC1 in the development of various diseases, including cancer, neurological disorders, and metabolic disorders. 3. The potential of ASIC1 as a therapeutic target for the treatment of various diseases. 4. The interactions between ASIC1 and other ion channels and receptors, and the implications for neuronal excitability and synaptic plasticity. Overall, ASIC1 is a complex protein that plays a crucial role in the regulation of cellular response to acidic pH and neurotransmission. Further research is needed to fully understand its mechanisms of action and to explore its potential as a therapeutic target for the treatment of various diseases.

Genular Protein ID: 3290352283

Symbol: ASIC1_HUMAN

Name: Amiloride-sensitive cation channel 2, neuronal

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9037075

Title: BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels.

PubMed ID: 9037075

DOI: 10.1073/pnas.94.4.1459

PubMed ID: 21036899

Title: Identification of a calcium permeable human acid-sensing ion channel 1 transcript variant.

PubMed ID: 21036899

DOI: 10.1074/jbc.m110.171330

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10798398

Title: Neuropeptide FF and FMRFamide potentiate acid-evoked currents from sensory neurons and proton-gated DEG/ENaC channels.

PubMed ID: 10798398

DOI: 10.1016/s0896-6273(00)81144-7

PubMed ID: 11802773

Title: Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel).

PubMed ID: 11802773

DOI: 10.1042/0264-6021:3610443

PubMed ID: 12244121

Title: Protein kinase C isoform antagonism controls BNaC2 (ASIC1) function.

PubMed ID: 12244121

DOI: 10.1074/jbc.m208995200

PubMed ID: 12578970

Title: cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1.

PubMed ID: 12578970

DOI: 10.1073/pnas.252782799

PubMed ID: 15247234

Title: Selective regulation of acid-sensing ion channel 1 by serine proteases.

PubMed ID: 15247234

DOI: 10.1074/jbc.m407381200

PubMed ID: 19654327

Title: Identification of protein domains that control proton and calcium sensitivity of ASIC1a.

PubMed ID: 19654327

DOI: 10.1074/jbc.m109.029009

PubMed ID: 23034652

Title: Black mamba venom peptides target acid-sensing ion channels to abolish pain.

PubMed ID: 23034652

DOI: 10.1038/nature11494

PubMed ID: 22760635

Title: Structure of the acid-sensing ion channel 1 in complex with the gating modifier Psalmotoxin 1.

PubMed ID: 22760635

DOI: 10.1038/ncomms1917

PubMed ID: 28327374

Title: Discovery and molecular interaction studies of a highly stable, tarantula peptide modulator of acid-sensing ion channel 1.

PubMed ID: 28327374

DOI: 10.1016/j.neuropharm.2017.03.020

Sequence Information:

  • Length: 528
  • Mass: 59909
  • Checksum: 9E998F711C208450
  • Sequence:
  • MELKAEEEEV GGVQPVSIQA FASSSTLHGL AHIFSYERLS LKRALWALCF LGSLAVLLCV 
    CTERVQYYFH YHHVTKLDEV AASQLTFPAV TLCNLNEFRF SQVSKNDLYH AGELLALLNN 
    RYEIPDTQMA DEKQLEILQD KANFRSFKPK PFNMREFYDR AGHDIRDMLL SCHFRGEVCS 
    AEDFKVVFTR YGKCYTFNSG RDGRPRLKTM KGGTGNGLEI MLDIQQDEYL PVWGETDETS 
    FEAGIKVQIH SQDEPPFIDQ LGFGVAPGFQ TFVACQEQRL IYLPPPWGTC KAVTMDSDLD 
    FFDSYSITAC RIDCETRYLV ENCNCRMVHM PGDAPYCTPE QYKECADPAL DFLVEKDQEY 
    CVCEMPCNLT RYGKELSMVK IPSKASAKYL AKKFNKSEQY IGENILVLDI FFEVLNYETI 
    EQKKAYEIAG LLGDIGGQMG LFIGASILTV LELFDYAYEV IKHKLCRRGK CQKEAKRSSA 
    DKGVALSLDD VKRHNPCESL RGHPAGMTYA ANILPHHPAR GTFEDFTC

Genular Protein ID: 2131883218

Symbol: A8K1U5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 528
  • Mass: 59863
  • Checksum: 08CD0D39AA74164C
  • Sequence:
  • MELKAEEEEV GGVQPVSIQA FASSSTLHGL AHIFSYERLS LKRALWALCF LGSLAVLLCV 
    CTERVQYYFH YHHVTKLDEV AASQLTFPAV TLCNLNEFRF SQVSKNDLYH AGELLALLNN 
    RYEIPDTQMA DEKQLEILQD KANFRSFKPK PFNMREFYDR AGHDIRDMLL SCHFRGEVCS 
    AEDFKVVFTR YGKCYTFNSG RDGRPRLKTM KGGTGNGLEI MLDIQQDEYL PVWGETDETS 
    FEAGIKVQIH SQDEPPFIDQ LGFGVAPGFQ TFVACQEQRL IYLPPPWGTC KAVTMDSDLD 
    FFDSYSITAC RIDCETRYLV ENCNCRMLHM PGDAPYCTPE QYKECADPAL DFLVEKDQEY 
    CVCEMPCNLT RYGKELSMVK IPSKASAKYL AKKFNKSEQY IGENILVLDI FFEVLNYETI 
    EQKKAYEIAG LLGDIGGQMG LFIGASILTV LELFDYAYEV IKHKLCRRGK CQKEAKRSSA 
    DKGVALSLDD VKRHNPCESL RGHPAGMTYA ANILPHHPAR GTFEDSTC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.