Details for: Rel

Gene ID: 41087

Symbol: Rel

Ensembl ID: FBgn0014018

Description: Relish

Associated with

  • Antiviral innate immune response
    (GO:0140374)
  • Canonical nf-kappab signal transduction
    (GO:0007249)
  • Cellular response to amino acid starvation
    (GO:0034198)
  • Cellular response to stress
    (GO:0033554)
  • Cgas/sting signaling pathway
    (GO:0140896)
  • Cytoplasm
    (GO:0005737)
  • Cytosol
    (GO:0005829)
  • Defense response to bacterium
    (GO:0042742)
  • Defense response to gram-negative bacterium
    (GO:0050829)
  • Defense response to virus
    (GO:0051607)
  • Dendrite morphogenesis
    (GO:0048813)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Dna damage response
    (GO:0006974)
  • Euchromatin
    (GO:0000791)
  • Immune response
    (GO:0006955)
  • Innate immune response
    (GO:0045087)
  • Negative regulation of receptor signaling pathway via jak-stat
    (GO:0046426)
  • Negative regulation of stem cell proliferation
    (GO:2000647)
  • Non-canonical nf-kappab signal transduction
    (GO:0038061)
  • Nucleus
    (GO:0005634)
  • Peptidoglycan recognition protein signaling pathway
    (GO:0061057)
  • Peripheral nervous system neuron development
    (GO:0048935)
  • Positive regulation of antibacterial peptide biosynthetic process
    (GO:0006963)
  • Positive regulation of antifungal peptide biosynthetic process
    (GO:0006967)
  • Positive regulation of antimicrobial peptide production
    (GO:0002225)
  • Positive regulation of biosynthetic process of antibacterial peptides active against gram-negative bacteria
    (GO:0006964)
  • Positive regulation of defense response to virus by host
    (GO:0002230)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of innate immune response
    (GO:0045089)
  • Positive regulation of nitric oxide biosynthetic process
    (GO:0045429)
  • Positive regulation of phagocytosis
    (GO:0050766)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of innate immune response
    (GO:0045088)
  • Response to bacterium
    (GO:0009617)
  • Response to cytokine
    (GO:0034097)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Signaling receptor inhibitor activity
    (GO:0030547)

Other Information

Genular Protein ID: 405636132

Symbol: NFKB1_DROME

Name: Nuclear factor NF-kappa-B p110 subunit

UniProtKB Accession Codes:

Q94527 A4V2K3 Q9U435 Q9U436 Q9U437 Q9U438 Q9U439 Q9U440 Q9U6H3 Q9U6H4 Q9U6H5 Q9VHI0

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CDD 2 CTD 1 DIP 1 DNASU 1 EMBL 17 EnsemblMetazoa 4 ExpressionAtlas 1 FlyBase 2 GO 39 Gene3D 3 GeneTree 1 Genevisible 1 GenomeRNAi 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MINT 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PaxDb 1 Pfam 3 PhylomeDB 1 Proteomes 1 Reactome 19 RefSeq 4 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 8816802

Title: Origins of immunity: Relish, a compound Rel-like gene in the antibacterial defense of Drosophila.

PubMed ID: 8816802

DOI: 10.1073/pnas.93.19.10343

PubMed ID: 10619029

Title: Relish, a central factor in the control of humoral, but not cellular immunity in Drosophila.

PubMed ID: 10619029

DOI: 10.1016/s1097-2765(00)80392-5

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537569

Title: A Drosophila full-length cDNA resource.

PubMed ID: 12537569

DOI: 10.1186/gb-2002-3-12-research0080

PubMed ID: 10757765

Title: Adaptive evolution of relish, a Drosophila NF-kappaB/IkappaB protein.

PubMed ID: 10757765

DOI: 10.1093/genetics/154.3.1231

PubMed ID: 11269501

Title: Activation of the Drosophila NF-kappaB factor Relish by rapid endoproteolytic cleavage.

PubMed ID: 11269501

DOI: 10.1093/embo-reports/kvd072

PubMed ID: 11269502

Title: The Drosophila caspase Dredd is required to resist Gram-negative bacterial infection.

PubMed ID: 11269502

DOI: 10.1093/embo-reports/kvd073

PubMed ID: 11018014

Title: A Drosophila IkappaB kinase complex required for Relish cleavage and antibacterial immunity.

PubMed ID: 11018014

DOI: 10.1101/gad.817800

PubMed ID: 11872802

Title: Requirement for a peptidoglycan recognition protein (PGRP) in Relish activation and antibacterial immune responses in Drosophila.

PubMed ID: 11872802

DOI: 10.1126/science.1070216

PubMed ID: 18000549

Title: NF-kappaB/Rel-mediated regulation of the neural fate in Drosophila.

PubMed ID: 18000549

DOI: 10.1371/journal.pone.0001178

PubMed ID: 18327897

Title: Phosphoproteome analysis of Drosophila melanogaster embryos.

PubMed ID: 18327897

DOI: 10.1021/pr700696a

PubMed ID: 22022271

Title: Toll-8/Tollo negatively regulates antimicrobial response in the Drosophila respiratory epithelium.

PubMed ID: 22022271

DOI: 10.1371/journal.ppat.1002319

PubMed ID: 25180232

Title: Akirin specifies NF-kappaB selectivity of Drosophila innate immune response via chromatin remodeling.

PubMed ID: 25180232

DOI: 10.15252/embj.201488456

PubMed ID: 24947515

Title: The chromatin regulator DMAP1 modulates activity of the nuclear factor B (NF-B) transcription factor Relish in the Drosophila innate immune response.

PubMed ID: 24947515

DOI: 10.1074/jbc.c114.553719

PubMed ID: 25477468

Title: An ancient defense system eliminates unfit cells from developing tissues during cell competition.

PubMed ID: 25477468

DOI: 10.1126/science.1258236

PubMed ID: 29934091

Title: Inflammation-induced, STING-dependent autophagy restricts Zika virus infection in the Drosophila brain.

PubMed ID: 29934091

DOI: 10.1016/j.chom.2018.05.022

PubMed ID: 29924997

Title: Analysis of Drosophila STING reveals an evolutionarily conserved antimicrobial function.

PubMed ID: 29924997

DOI: 10.1016/j.celrep.2018.05.029

PubMed ID: 30119996

Title: The kinase IKKbeta regulates a STING- and NF-kappaB-dependent antiviral response pathway in Drosophila.

PubMed ID: 30119996

DOI: 10.1016/j.immuni.2018.07.013

PubMed ID: 33262294

Title: 2'3'-cGAMP triggers a STING- and NF-kappaB-dependent broad antiviral response in Drosophila.

PubMed ID: 33262294

DOI: 10.1126/scisignal.abc4537

PubMed ID: 34261127

Title: cGAS-like receptors sense RNA and control 3'2'-cGAMP signaling in Drosophila.

PubMed ID: 34261127

DOI: 10.1038/s41586-021-03743-5

PubMed ID: 34261128

Title: Two cGAS-like receptors induce antiviral immunity in Drosophila.

PubMed ID: 34261128

DOI: 10.1038/s41586-021-03800-z

Sequence Information:

  • Length: 971
  • Mass: 109775
  • Checksum: EAF607357381AD32
  • Sequence:
    • MNMNQYYDLD NGKNVMFMND ASSTSGYSSS TSPNSTNRSF SPAHSPKTME LQTDFANLNL 
PGGNSPHQPP MANSPYQNQL LNNGGICQLG ATNLINSTGV SFGVANVTSF GNMYMDHQYF 
VPAPATVPPS QNFGYHQNGL ASDGDIKHVP QLRIVEQPVE KFRFRYKSEM HGTHGSLNGA 
NSKRTPKTFP EVTLCNYDGP AVIRCSLFQT NLDSPHSHQL VVRKDDRDVC DPHDLHVSKE 
RGYVAQFINM GIIHTAKKYI FEELCKKKQD RLVFQMNRRE LSHKQLQELH QETEREAKDM 
NLNQVRLCFE AFKIEDNGAW VPLAPPVYSN AINNRKSAQT GELRIVRLSK PTGGVMGNDE 
LILLVEKVSK KNIKVRFFEE DEDGETVWEA YAKFRESDVH HQYAIVCQTP PYKDKDVDRE 
VNVYIELIRP SDDERSFPAL PFRYKPRSVI VSRKRRRTGS SANSSSSGTE SSNNSLDLPK 
TLGLAQPPNG LPNLSQHDQT ISEEFGREKH LNEFIASEDF RKLIEHNSSD LEKICQLDMG 
ELQHDGHNRA EVPSHRNRTI KCLDDLFEIY KQDRISPIKI SHHKVEKWFI EHALNNYNRD 
TLLHEVISHK KDKLKLAIQT IQVMNYFNLK DVVNSTLNAD GDSALHVACQ QDRAHYIRPL 
LGMGCNPNLK NNAGNTPLHV AVKEEHLSCV ESFLNGVPTV QLDLSLTNDD GLTPLHMAIR 
QNKYDVAKKL ISYDRTSISV ANTMDGNNAL HMAVLEQSVE LLVLILDAQN ENLTDILQAQ 
NAAGHTPLEL AERKANDRVV QLLKNVYPEK GELAMTWIPC KVKEEIDSSS DESSDAGQLE 
IKSEEMDIET KDEDSVELDL SSGPRRQKDE SSRDTEMDNN KLQLLLKNKF IYDRLCSLLN 
QPLGHGSDPQ DRKWMQLARQ THLKQFAFIW LGAEDLLDHV KRKGASVEFS TFARALQAVD 
PQAYALLVNP T

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.