Timp | FBgn0025879 | NCBI 41248

Details for: Timp

Gene ID: 41248

Symbol: Timp

Ensembl ID: FBgn0025879

Description: Tissue inhibitor of metalloproteases

Associated with

Activation of matrix metalloproteinases
(R-DME-1592389)
Degradation of the extracellular matrix
(R-DME-1474228)
Extracellular matrix organization
(R-DME-1474244)
Hemostasis
(R-DME-109582)
Immune system
(R-DME-168256)
Innate immune system
(R-DME-168249)
Metabolism of proteins
(R-DME-392499)
Neutrophil degranulation
(R-DME-6798695)
Platelet activation, signaling and aggregation
(R-DME-76002)
Platelet degranulation
(R-DME-114608)
Post-translational protein modification
(R-DME-597592)
Post-translational protein phosphorylation
(R-DME-8957275)
Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
(R-DME-381426)
Response to elevated platelet cytosolic ca2+
(R-DME-76005)
Basement membrane organization
(GO:0071711)
Cell adhesion
(GO:0007155)
Delamination
(GO:0060232)
Dendrite
(GO:0030425)
Extracellular matrix
(GO:0031012)
Extracellular space
(GO:0005615)
Imaginal disc-derived wing expansion
(GO:0048526)
Metalloendopeptidase inhibitor activity
(GO:0008191)
Negative regulation of endopeptidase activity
(GO:0010951)
Negative regulation of membrane protein ectodomain proteolysis
(GO:0051045)
Phototaxis
(GO:0042331)
Protease binding
(GO:0002020)
Response to organic substance
(GO:0010033)
Tracheal outgrowth, open tracheal system
(GO:0007426)
Tracheal pit formation in open tracheal system
(GO:0035202)
Ventral cord development
(GO:0007419)
Wing disc morphogenesis
(GO:0007472)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

TIMP_DROME

Genular Protein ID: 2279331417

Symbol: TIMP_DROME

Name: N/A

UniProtKB Accession Codes:

Q9VH14 A4V2N5 O96747

Database IDs:

Citations:

PubMed ID: 10198170

Title: Invertebrate tissue inhibitor of metalloproteinase: structure and nested gene organization within the synapsin locus is conserved from Drosophila to human.

PubMed ID: 10198170

DOI: 10.1006/geno.1999.5776

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537569

Title: A Drosophila full-length cDNA resource.

PubMed ID: 12537569

DOI: 10.1186/gb-2002-3-12-research0080

PubMed ID: 14567681

Title: Drosophila TIMP is a potent inhibitor of MMPs and TACE: similarities in structure and function to TIMP-3.

PubMed ID: 14567681

DOI: 10.1021/bi035358x

PubMed ID: 10961449

Title: Inflated wings, tissue autolysis and early death in tissue inhibitor of metalloproteinases mutants of Drosophila.

PubMed ID: 10961449

DOI: 10.1078/0171-9335-00072

PubMed ID: 16962574

Title: Tissue remodeling during maturation of the Drosophila wing.

PubMed ID: 16962574

DOI: 10.1016/j.ydbio.2006.08.011

PubMed ID: 17301221

Title: Basement membrane remodeling is essential for Drosophila disc eversion and tumor invasion.

PubMed ID: 17301221

DOI: 10.1073/pnas.0611666104

PubMed ID: 26808525

Title: ECM-regulator timp is required for stem cell niche organization and cyst production in the Drosophila ovary.

PubMed ID: 26808525

DOI: 10.1371/journal.pgen.1005763

Sequence Information:

Length: 210
Mass: 23980
Checksum: E7F4A7845CB69BD0
Sequence:

MDLRKHLGLL TLLLVAVFAF YGRPADACSC MPSHPQTHFA QADYVVQLRV LRKSDTIEPG 
RTTYKVHIKR TYKATSEARR MLRDGRLSTP QDDAMCGINL DLGKVYIVAG RMPTLNICSY 
YKEYTRMTIT ERHGFSGGYA KATNCTVTPC FGERCFKGRN YADTCKWSPF GKCETNYSAC 
MPHKVQTVNG VISRCRWRRT QLYRKCMSNP

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Timp

Associated with

Other Information

Invertebrate tissue inhibitor of metalloproteinase: structure and nested gene organization within the synapsin locus is conserved from Drosophila to human. PubMed ID: 10198170

The genome sequence of Drosophila melanogaster. PubMed ID: 10731132

Annotation of the Drosophila melanogaster euchromatic genome: a systematic review. PubMed ID: 12537572

A Drosophila full-length cDNA resource. PubMed ID: 12537569

Drosophila TIMP is a potent inhibitor of MMPs and TACE: similarities in structure and function to TIMP-3. PubMed ID: 14567681

Inflated wings, tissue autolysis and early death in tissue inhibitor of metalloproteinases mutants of Drosophila. PubMed ID: 10961449

Tissue remodeling during maturation of the Drosophila wing. PubMed ID: 16962574

Basement membrane remodeling is essential for Drosophila disc eversion and tumor invasion. PubMed ID: 17301221

ECM-regulator timp is required for stem cell niche organization and cyst production in the Drosophila ovary. PubMed ID: 26808525