Blm | FBgn0002906 | NCBI 41366

Details for: Blm

Gene ID: 41366

Symbol: Blm

Ensembl ID: FBgn0002906

Description: Bloom syndrome helicase

Associated with

Cell cycle
(R-DME-1640170)
Cell cycle checkpoints
(R-DME-69620)
Dna double-strand break repair
(R-DME-5693532)
G2/m checkpoints
(R-DME-69481)
G2/m dna damage checkpoint
(R-DME-69473)
Gene expression (transcription)
(R-DME-74160)
Generic transcription pathway
(R-DME-212436)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-DME-5693567)
Homology directed repair
(R-DME-5693538)
Metabolism of proteins
(R-DME-392499)
Post-translational protein modification
(R-DME-597592)
Processing of dna double-strand break ends
(R-DME-5693607)
Regulation of tp53 activity
(R-DME-5633007)
Regulation of tp53 activity through phosphorylation
(R-DME-6804756)
Rna polymerase ii transcription
(R-DME-73857)
Sumo e3 ligases sumoylate target proteins
(R-DME-3108232)
Sumoylation
(R-DME-2990846)
Sumoylation of dna damage response and repair proteins
(R-DME-3108214)
Transcriptional regulation by tp53
(R-DME-3700989)
3'-5' dna helicase activity
(GO:0043138)
Atp binding
(GO:0005524)
Chromosome
(GO:0005694)
Cytoplasm
(GO:0005737)
Dna/dna annealing activity
(GO:1990814)
Dna damage response
(GO:0006974)
Dna duplex unwinding
(GO:0032508)
Dna helicase activity
(GO:0003678)
Dna recombination
(GO:0006310)
Dna repair
(GO:0006281)
Dna replication
(GO:0006260)
Dna strand displacement
(GO:0000732)
Dna synthesis involved in dna repair
(GO:0000731)
Dna unwinding involved in dna replication
(GO:0006268)
Double-strand break repair
(GO:0006302)
Double-strand break repair involved in meiotic recombination
(GO:1990918)
Double-strand break repair via homologous recombination
(GO:0000724)
Double-strand break repair via nonhomologous end joining
(GO:0006303)
Double-strand break repair via synthesis-dependent strand annealing
(GO:0045003)
Four-way junction helicase activity
(GO:0009378)
Helicase activity
(GO:0004386)
Negative regulation of double-strand break repair via single-strand annealing
(GO:1901291)
Nucleic acid binding
(GO:0003676)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Reciprocal meiotic recombination
(GO:0007131)
Y-form dna binding
(GO:0000403)

Other Information

Proteins

Bloom syndrome helicase ortholog

Genular Protein ID: 999178865

Symbol: BLM_DROME

Name: Bloom syndrome helicase ortholog

UniProtKB Accession Codes:

Q9VGI8 Q9Y062

Database IDs:

Citations:

PubMed ID: 10049920

Title: Evolution of the RECQ family of helicases: a Drosophila homolog, Dmblm, is similar to the human Bloom syndrome gene.

PubMed ID: 10049920

DOI: 10.1093/genetics/151.3.1027

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 18327897

Title: Phosphoproteome analysis of Drosophila melanogaster embryos.

PubMed ID: 18327897

DOI: 10.1021/pr700696a

PubMed ID: 25205745

Title: Drosophila FANCM helicase prevents spontaneous mitotic crossovers generated by the MUS81 and SLX1 nucleases.

PubMed ID: 25205745

DOI: 10.1534/genetics.114.168096

Sequence Information:

Length: 1487
Mass: 166079
Checksum: 07361B8005E29432
Sequence:

MSKKPVAQRK QLTLSSFIGL DGNSQSQPKS RAASVRSKPP AVYNPIFLDA SSSDDETTEI 
SSQSNNGTIA TKKSSRDPRT AKLKKHTYLD LSVSPLAKLS AKKYARDSPK KPTSLDLSVS 
PLAELLAKKS DRDSPKKPVQ NENSYTYRGL SESPVENKSI GDTLRKPPQK ERKTSIVWLS 
DSPEKKVTQN ERKILDSPLQ RFSFEDFPNK ENGNRHHLLT LPDSPPPPQP VKKPEKTMWQ 
NETKTIQDKD SPANPLVSNN LASISTLLDS SRAPNTYKGS SRNLFEDSPE KSGSGEQGYK 
LGSAKENEIP TKPATASLER NSVTSSPSPA APLKPRYSVA FDNSLADYLK DLAQNDNFSI 
DPNKQNTETL KSTLGFFRNT YVELMEKYCS LIDQIPAMHF NEIAGFQPNT FLKLKVMRQK 
FKARTQLVQN SLDKKESQLK AEQEALEKEE IEMQAEQAQQ TVLSSSSPEK SRPIMPLPKV 
QEIKDEKIPN RNQLIHDLCG EPDNFSPPSS PRDTQLIPKR QQLINDLCGE PDDFSPPSKQ 
NDPHLLRKCE ELVHDLCEEP DDYLAQSMML DGDLEEEQLN GPTQGTTTSG MDDDEDDLEG 
LLAEIEDEHQ KMQGRRSEFN GYSYKELEAV KVKEKHKETP INISLDDDGF PEYDEAMFEQ 
MHSQAAANKS RVSSAGPSTS KSVVPTKQTS ALHSQKLSGN FHANVHNDGI TGEFDGQKFE 
HSTRLMHGLS YSFGLKSFRP NQLQVINATL LGNDCFVLMP TGGGKSLCYQ LPAILTEGVT 
IVISPLKSLI FDQINKLASL DICAKSLSGE QKMADVMAIY RDLESQPPMV KLLYVTPEKI 
SSSARFQDTL DTLNSNNYIS RFVIDEAHCV SQWGHDFRPD YKKLGVLKKR FPNVPTIALT 
ATATPRVRLD ILAQLNLKNC KWFLSSFNRS NLRYRVLPKK GVSTLDDISR YIRSKPQHFS 
GIIYCLSRKE CDETSKKMCK DGVRAVSYHA GLTDTDRESR QKDWLTGKMR VICATVAFGM 
GIDKPDVRFV LHYSLPKSIE GYYQEAGRAG RDGDVADCIL YYNYSDMLRI KKMLDSDKAL 
QYNVKKIHVD NLYRIVGYCE NLTDCRRAQQ LDYFGEHFTS EQCLENRETA CDNCINKRAY 
KAVDALEHAR KAARAVKDLC SGRSRFTLLH IADVLKGSKI KKIIDFNHHK TPHHGVLKDW 
DKNDVHRLLR KMVIDGFLRE DLIFTNDFPQ AYLYLGNNIS KLMEGTPNFE FAVTKNAKEA 
KAAVGSVSDG ATSSTADGQS GMREIHERCY TDLLDLCRTI ASQRNVTMAS IMNIQALKSM 
AETLPITEKD MCSIPHVTKA NFDKYGAKLL EITSNYASEK LLMQAVLDEE EEQAAAKQRP 
STSGWNNESV DWDMAVASQG NANTSGASGF NSFRAGKRKK IYKSGASKRY KTSTTSPAAR 
KTTSARGRGG RAGAKRAESS ASSASGWKSK KTGNSFGFDL MPLPGSK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Blm

Associated with

Other Information

Evolution of the RECQ family of helicases: a Drosophila homolog, Dmblm, is similar to the human Bloom syndrome gene. PubMed ID: 10049920

The genome sequence of Drosophila melanogaster. PubMed ID: 10731132

Annotation of the Drosophila melanogaster euchromatic genome: a systematic review. PubMed ID: 12537572