Details for: ARSF

Gene ID: 416

Symbol: ARSF

Ensembl ID: ENSG00000062096

Description: arylsulfatase F

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.13
    Marker Score: 2143
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.83
    Marker Score: 2048
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.11
    Marker Score: 7391.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71809
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48033
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5354
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5278
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.87
    Marker Score: 3357
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.86
    Marker Score: 2034
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.83
    Marker Score: 482
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 705
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.77
    Marker Score: 345
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.71
    Marker Score: 1339
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 462
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.55
    Marker Score: 1110
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.53
    Marker Score: 167
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.45
    Marker Score: 17140
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.41
    Marker Score: 249
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.41
    Marker Score: 453
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.36
    Marker Score: 346
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.36
    Marker Score: 2781
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.33
    Marker Score: 5197
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.33
    Marker Score: 1159
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.32
    Marker Score: 281
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.29
    Marker Score: 175
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.26
    Marker Score: 365
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.26
    Marker Score: 419
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.25
    Marker Score: 352
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.23
    Marker Score: 287
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.21
    Marker Score: 102
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.19
    Marker Score: 4082
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.19
    Marker Score: 41
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.18
    Marker Score: 382
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.18
    Marker Score: 104
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.17
    Marker Score: 279
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.17
    Marker Score: 60
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.17
    Marker Score: 53
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.17
    Marker Score: 68
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.16
    Marker Score: 42
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.16
    Marker Score: 1389
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.16
    Marker Score: 51
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.16
    Marker Score: 41
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.16
    Marker Score: 41
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.15
    Marker Score: 125
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.15
    Marker Score: 36
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.15
    Marker Score: 39
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.15
    Marker Score: 97
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.15
    Marker Score: 40
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.15
    Marker Score: 41
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.14
    Marker Score: 64
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.14
    Marker Score: 38
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.14
    Marker Score: 36
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.14
    Marker Score: 124
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.14
    Marker Score: 89
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 0.13
    Marker Score: 41
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.13
    Marker Score: 39
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.13
    Marker Score: 40
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.13
    Marker Score: 283.5
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.13
    Marker Score: 74
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.13
    Marker Score: 41
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.13
    Marker Score: 40
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.13
    Marker Score: 37
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.12
    Marker Score: 39
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.12
    Marker Score: 151
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.12
    Marker Score: 41
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.12
    Marker Score: 43
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.12
    Marker Score: 1027
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.12
    Marker Score: 1769
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.12
    Marker Score: 38
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.11
    Marker Score: 57
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.11
    Marker Score: 42
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.11
    Marker Score: 454
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.11
    Marker Score: 41
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.11
    Marker Score: 41
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.1
    Marker Score: 33
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.1
    Marker Score: 172
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.1
    Marker Score: 40
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.1
    Marker Score: 773
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.1
    Marker Score: 57
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.1
    Marker Score: 1281
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.1
    Marker Score: 39
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.09
    Marker Score: 64
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.09
    Marker Score: 34
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.09
    Marker Score: 45
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.09
    Marker Score: 89
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.09
    Marker Score: 262
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.09
    Marker Score: 38
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.09
    Marker Score: 33
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.09
    Marker Score: 96
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.09
    Marker Score: 35
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.09
    Marker Score: 91
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.09
    Marker Score: 42
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.09
    Marker Score: 50
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.08
    Marker Score: 225
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.08
    Marker Score: 30

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Other Information

**Key characteristics:** - ARSF is a transmembrane protein with a molecular weight of approximately 150 kDa. - It is a member of the arylsulfatase superfamily of enzymes. - It is highly expressed in brain tissues, particularly in neurons and glial cells. **Pathways and functions:** - ARSF is involved in multiple pathways, including: - Arylsulfatase activity: It catalyzes the deamination of arylamines and aryl sulfoxides, converting them into corresponding alkanes and hydrogen sulfide. - Endoplasmic reticulum lumen: It is involved in the biosynthesis of glycoproteins and glycolipids. - Extracellular exosome: It is a key regulator of immune responses and inflammation. - Gamma carboxylation: It is involved in the metabolism of various molecules, including proteins and lipids. - Hypusinylation: It is involved in the regulation of cell signaling and growth. - Hydroxylation: It catalyzes the oxidation of substrates to produce alcohols. - Arylsulfatase activation: It is a key regulator of the activation of other enzymes, such as CYP3A4. **Clinical significance:** - Mutations in the ARSF gene have been linked to several human diseases, including schizophrenia, autism, and cancer. - ARSF inhibitors are being investigated as potential therapeutic agents for these disorders. - Understanding the role of ARSF in human health and disease is important for the development of new diagnostic and therapeutic strategies.

Genular Protein ID: 1337108659

Symbol: ARSF_HUMAN

Name: Arylsulfatase F

UniProtKB Accession Codes:

P54793 Q8TCC5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 11 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 3 Ensembl 2 GO 4 Gene3D 3 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 3 Rhea 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9192838

Title: Identification by shotgun sequencing, genomic organization, and functional analysis of a fourth arylsulfatase gene (ARSF) from the Xp22.3 region.

PubMed ID: 9192838

DOI: 10.1006/geno.1997.4716

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7720070

Title: A cluster of sulfatase genes on Xp22.3: mutations in chondrodysplasia punctata (CDPX) and implications for warfarin embryopathy.

PubMed ID: 7720070

DOI: 10.1016/0092-8674(95)90367-4

Sequence Information:

  • Length: 590
  • Mass: 65940
  • Checksum: EA9B7289040AE79A
  • Sequence:
    • MRPRRPLVFM SLVCALLNTC QAHRVHDDKP NIVLIMVDDL GIGDLGCYGN DTMRTPHIDR 
LAREGVRLTQ HISAASLCSP SRSAFLTGRY PIRSGMVSSG NRRVIQNLAV PAGLPLNETT 
LAALLKKQGY STGLIGKWHQ GLNCDSRSDQ CHHPYNYGFD YYYGMPFTLV DSCWPDPSRN 
TELAFESQLW LCVQLVAIAI LTLTFGKLSG WVSVPWLLIF SMILFIFLLG YAWFSSHTSP 
LYWDCLLMRG HEITEQPMKA ERAGSIMVKE AISFLERHSK ETFLLFFSFL HVHTPLPTTD 
DFTGTSKHGL YGDNVEEMDS MVGKILDAID DFGLRNNTLV YFTSDHGGHL EARRGHAQLG 
GWNGIYKGGK GMGGWEGGIR VPGIVRWPGK VPAGRLIKEP TSLMDILPTV ASVSGGSLPQ 
DRVIDGRDLM PLLQGNVRHS EHEFLFHYCG SYLHAVRWIP KDDSGSVWKA HYVTPVFQPP 
ASGGCYVTSL CRCFGEQVTY HNPPLLFDLS RDPSESTPLT PATEPLHDFV IKKVANALKE 
HQETIVPVTY QLSELNQGRT WLKPCCGVFP FCLCDKEEEV SQPRGPNEKR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.