Details for: ARSF

Gene ID: 416

Symbol: ARSF

Ensembl ID: ENSG00000062096

Description: arylsulfatase F

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.3522
    Cell Significance Index: 32.7600
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.6629
    Cell Significance Index: 4.4000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4807
    Cell Significance Index: 172.4200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.4661
    Cell Significance Index: -1.0200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.3033
    Cell Significance Index: 7.5600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2479
    Cell Significance Index: 15.2400
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.1723
    Cell Significance Index: 2.4100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.1309
    Cell Significance Index: 1.8600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1218
    Cell Significance Index: 2.9200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0630
    Cell Significance Index: 0.9300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0379
    Cell Significance Index: 0.6500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0359
    Cell Significance Index: 0.4900
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.0332
    Cell Significance Index: 0.4600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0238
    Cell Significance Index: 4.7800
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.0165
    Cell Significance Index: 0.1900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0106
    Cell Significance Index: 0.5500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0072
    Cell Significance Index: 4.9900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0002
    Cell Significance Index: -0.4100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0020
    Cell Significance Index: -0.4000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0025
    Cell Significance Index: -0.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0029
    Cell Significance Index: -5.3500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0030
    Cell Significance Index: -1.3200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0036
    Cell Significance Index: -5.5600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0041
    Cell Significance Index: -5.5600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0057
    Cell Significance Index: -0.9800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0066
    Cell Significance Index: -4.1900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0068
    Cell Significance Index: -5.0100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0075
    Cell Significance Index: -2.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0075
    Cell Significance Index: -5.5800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0092
    Cell Significance Index: -5.7700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0094
    Cell Significance Index: -4.2800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0097
    Cell Significance Index: -5.4900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0162
    Cell Significance Index: -2.2300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0187
    Cell Significance Index: -2.7200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0204
    Cell Significance Index: -0.4100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0210
    Cell Significance Index: -3.7900
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0235
    Cell Significance Index: -0.1800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0242
    Cell Significance Index: -1.7100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0272
    Cell Significance Index: -5.7200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0290
    Cell Significance Index: -2.9600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0341
    Cell Significance Index: -4.1900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0348
    Cell Significance Index: -2.3400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0366
    Cell Significance Index: -1.0000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0382
    Cell Significance Index: -4.3800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0438
    Cell Significance Index: -2.0400
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0492
    Cell Significance Index: -0.5100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0501
    Cell Significance Index: -5.2200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0537
    Cell Significance Index: -1.3800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0594
    Cell Significance Index: -1.1600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0609
    Cell Significance Index: -4.8200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0716
    Cell Significance Index: -1.4000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0752
    Cell Significance Index: -1.3000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0822
    Cell Significance Index: -2.4200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0831
    Cell Significance Index: -6.3800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0927
    Cell Significance Index: -4.1000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0993
    Cell Significance Index: -3.1400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1002
    Cell Significance Index: -5.2200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1009
    Cell Significance Index: -4.7400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1099
    Cell Significance Index: -4.1600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1137
    Cell Significance Index: -6.3800
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.1180
    Cell Significance Index: -1.5300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1187
    Cell Significance Index: -4.1600
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.1230
    Cell Significance Index: -1.8400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1236
    Cell Significance Index: -1.7700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1253
    Cell Significance Index: -3.1300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1261
    Cell Significance Index: -6.6200
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.1282
    Cell Significance Index: -1.2200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1311
    Cell Significance Index: -2.5800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1329
    Cell Significance Index: -4.8800
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.1329
    Cell Significance Index: -1.8200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1343
    Cell Significance Index: -0.9100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1345
    Cell Significance Index: -1.7400
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.1359
    Cell Significance Index: -1.7800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1363
    Cell Significance Index: -4.3400
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.1374
    Cell Significance Index: -1.4500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1374
    Cell Significance Index: -5.6300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1388
    Cell Significance Index: -3.9600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1393
    Cell Significance Index: -1.9100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1432
    Cell Significance Index: -4.6900
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.1433
    Cell Significance Index: -1.7300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1474
    Cell Significance Index: -2.9400
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1479
    Cell Significance Index: -3.0100
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.1482
    Cell Significance Index: -1.3400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1488
    Cell Significance Index: -2.2600
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.1494
    Cell Significance Index: -1.4300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1507
    Cell Significance Index: -1.5600
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.1540
    Cell Significance Index: -1.9900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1544
    Cell Significance Index: -3.3800
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.1549
    Cell Significance Index: -1.3400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1577
    Cell Significance Index: -2.5300
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.1657
    Cell Significance Index: -1.8300
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.1677
    Cell Significance Index: -1.8300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1689
    Cell Significance Index: -4.5300
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1693
    Cell Significance Index: -1.8200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1708
    Cell Significance Index: -4.2600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1757
    Cell Significance Index: -3.7300
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.1763
    Cell Significance Index: -2.0000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1791
    Cell Significance Index: -3.8700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1798
    Cell Significance Index: -4.8000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1811
    Cell Significance Index: -5.1900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ARSF is a member of the arylsulfatase family, which is a group of enzymes involved in the removal of sulfate groups from various substrates. The enzyme encoded by the ARSF gene is a sulfatase, which is a type of hydrolase enzyme that catalyzes the hydrolysis of glycosphingolipids. The enzyme is specifically involved in the degradation of sulfated glycosphingolipids, which are important components of cell membranes. The ARSF gene is highly expressed in various cell types, including endothelial cells, plasma cells, goblet cells, and neurons. This widespread expression suggests that the enzyme plays a critical role in maintaining cellular homeostasis in multiple tissues. The gene is also highly conserved across species, indicating its importance in evolution. **Pathways and Functions** The ARSF enzyme is involved in several biological pathways, including: 1. **Glycosphingolipid catabolism**: The degradation of glycosphingolipids is a critical process for maintaining cellular homeostasis. The ARSF enzyme plays a key role in this process by removing sulfate groups from sulfated glycosphingolipids. 2. **Arylsulfatase activity**: The ARSF enzyme is a member of the arylsulfatase family, which is involved in the removal of sulfate groups from various substrates. 3. **Endoplasmic reticulum lumen**: The ARSF enzyme is localized to the endoplasmic reticulum lumen, where it can interact with other enzymes and proteins involved in glycosphingolipid metabolism. 4. **Extracellular exosome**: The ARSF enzyme can also be found in the extracellular exosome, where it can interact with other proteins and lipids involved in cell signaling and communication. **Clinical Significance** Dysregulation of the ARSF gene has been associated with several diseases, including: 1. **Metabolic disorders**: Mutations in the ARSF gene have been linked to metabolic disorders, such as glycogen storage disease type IV. 2. **Neurological disorders**: The ARSF enzyme has been implicated in the pathogenesis of several neurological disorders, including Alzheimer's disease and Parkinson's disease. 3. **Cancer**: The ARSF enzyme has been found to be overexpressed in certain types of cancer, including colon cancer and breast cancer. In conclusion, the ARSF gene plays a critical role in maintaining cellular homeostasis by regulating the levels of glycosphingolipids in various tissues. Dysregulation of the ARSF gene has been associated with several diseases, highlighting the importance of this gene in human health. Further research is needed to fully understand the mechanisms by which the ARSF enzyme functions and to explore its potential as a therapeutic target for diseases associated with its dysregulation.

Genular Protein ID: 1337108659

Symbol: ARSF_HUMAN

Name: Arylsulfatase F

UniProtKB Accession Codes:

P54793 Q8TCC5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 11 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 3 Ensembl 2 GO 4 Gene3D 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 3 Rhea 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9192838

Title: Identification by shotgun sequencing, genomic organization, and functional analysis of a fourth arylsulfatase gene (ARSF) from the Xp22.3 region.

PubMed ID: 9192838

DOI: 10.1006/geno.1997.4716

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7720070

Title: A cluster of sulfatase genes on Xp22.3: mutations in chondrodysplasia punctata (CDPX) and implications for warfarin embryopathy.

PubMed ID: 7720070

DOI: 10.1016/0092-8674(95)90367-4

Sequence Information:

  • Length: 590
  • Mass: 65940
  • Checksum: EA9B7289040AE79A
  • Sequence:
    • MRPRRPLVFM SLVCALLNTC QAHRVHDDKP NIVLIMVDDL GIGDLGCYGN DTMRTPHIDR 
LAREGVRLTQ HISAASLCSP SRSAFLTGRY PIRSGMVSSG NRRVIQNLAV PAGLPLNETT 
LAALLKKQGY STGLIGKWHQ GLNCDSRSDQ CHHPYNYGFD YYYGMPFTLV DSCWPDPSRN 
TELAFESQLW LCVQLVAIAI LTLTFGKLSG WVSVPWLLIF SMILFIFLLG YAWFSSHTSP 
LYWDCLLMRG HEITEQPMKA ERAGSIMVKE AISFLERHSK ETFLLFFSFL HVHTPLPTTD 
DFTGTSKHGL YGDNVEEMDS MVGKILDAID DFGLRNNTLV YFTSDHGGHL EARRGHAQLG 
GWNGIYKGGK GMGGWEGGIR VPGIVRWPGK VPAGRLIKEP TSLMDILPTV ASVSGGSLPQ 
DRVIDGRDLM PLLQGNVRHS EHEFLFHYCG SYLHAVRWIP KDDSGSVWKA HYVTPVFQPP 
ASGGCYVTSL CRCFGEQVTY HNPPLLFDLS RDPSESTPLT PATEPLHDFV IKKVANALKE 
HQETIVPVTY QLSELNQGRT WLKPCCGVFP FCLCDKEEEV SQPRGPNEKR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.