Details for: ART1

Gene ID: 417

Symbol: ART1

Ensembl ID: ENSG00000129744

Description: ADP-ribosyltransferase 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 7.84
    Marker Score: 4342
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 4.68
    Marker Score: 30189
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 3.32
    Marker Score: 1885
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.98
    Marker Score: 2209
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.73
    Marker Score: 911
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 1.5
    Marker Score: 4817
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.5
    Marker Score: 2068
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.38
    Marker Score: 578
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.11
    Marker Score: 7393
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71815
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48039
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5353
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5286
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.81
    Marker Score: 1125.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.76
    Marker Score: 11922
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.69
    Marker Score: 457
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.68
    Marker Score: 397
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.67
    Marker Score: 1070
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.6
    Marker Score: 481
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.59
    Marker Score: 660
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.51
    Marker Score: 299
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.51
    Marker Score: 960
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.43
    Marker Score: 437
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.41
    Marker Score: 847
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.4
    Marker Score: 126
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.38
    Marker Score: 446
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.38
    Marker Score: 417
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.32
    Marker Score: 129
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.29
    Marker Score: 735
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.27
    Marker Score: 558
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.26
    Marker Score: 249
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.26
    Marker Score: 446
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.26
    Marker Score: 3411
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.25
    Marker Score: 149
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.23
    Marker Score: 120
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.22
    Marker Score: 69
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.22
    Marker Score: 396
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.21
    Marker Score: 188
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.17
    Marker Score: 81
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.16
    Marker Score: 70
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.13
    Marker Score: 45
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.13
    Marker Score: 87
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.13
    Marker Score: 2809
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.12
    Marker Score: 31
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.12
    Marker Score: 72
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 0.12
    Marker Score: 36
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.11
    Marker Score: 88.5
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.11
    Marker Score: 36
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.11
    Marker Score: 34
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.11
    Marker Score: 35
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.11
    Marker Score: 31
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.1
    Marker Score: 101
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.1
    Marker Score: 26
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.1
    Marker Score: 26
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.1
    Marker Score: 34
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.1
    Marker Score: 35
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.09
    Marker Score: 33
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.09
    Marker Score: 36
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.09
    Marker Score: 270
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.09
    Marker Score: 31
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.08
    Marker Score: 31
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.08
    Marker Score: 190
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.08
    Marker Score: 54
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.08
    Marker Score: 26
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.08
    Marker Score: 22
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.07
    Marker Score: 29
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.07
    Marker Score: 57
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.07
    Marker Score: 42
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.07
    Marker Score: 35
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.07
    Marker Score: 29
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.07
    Marker Score: 34
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.07
    Marker Score: 30
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.07
    Marker Score: 31
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.07
    Marker Score: 22.5
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.07
    Marker Score: 35
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.07
    Marker Score: 37
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.07
    Marker Score: 37
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.07
    Marker Score: 32
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.07
    Marker Score: 30
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.07
    Marker Score: 35
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.06
    Marker Score: 39
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.06
    Marker Score: 53
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.06
    Marker Score: 61
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.06
    Marker Score: 35
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.06
    Marker Score: 41
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.06
    Marker Score: 34
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.06
    Marker Score: 35
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.05
    Marker Score: 27
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.05
    Marker Score: 36
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.05
    Marker Score: 37
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.05
    Marker Score: 32.5
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.05
    Marker Score: 199
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.05
    Marker Score: 57
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.05
    Marker Score: 28

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Other Information

**Key characteristics:** * It is a membrane-bound protein. * It is expressed in a variety of cell types, including erythrocytes, progenitor cells, megakaryocytes, plasma cells, hematopoietic stem cells, amacrine cells, double-negative thymocytes, megakaryocyte-erythroid progenitor cells, goblet cells, and cerebral cortex GABAergic interneurons. * It is a highly conserved protein, with a similar sequence found in organisms from yeast to humans. * It is a heterodimeric protein, with two identical subunits that come together to form a functional dimer. **Pathways and functions:** * ART1 is involved in the synthesis of antimicrobial peptides, including defensins and cathelicidin. * It is also involved in the regulation of cell surface molecules, such as E-cadherin and CD59. * It is involved in the activation of the innate immune system, by facilitating the production of antimicrobial peptides in response to infection. * It is also involved in the regulation of inflammation and cell migration. **Clinical significance:** * Mutations in the ART1 gene have been linked to several human diseases, including inflammatory bowel disease, asthma, and sepsis. * ART1 inhibitors are being investigated as potential treatments for these diseases.

Genular Protein ID: 1059495894

Symbol: NAR1_HUMAN

Name: GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1

UniProtKB Accession Codes:

P52961 Q6NTD2 Q96KT9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 2 EMBL 5 Ensembl 1 GO 7 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 3 Rhea 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 7947688

Title: Immunological and structural conservation of mammalian skeletal muscle glycosylphosphatidylinositol-linked ADP-ribosyltransferases.

PubMed ID: 7947688

DOI: 10.1021/bi00209a014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20106667

Title: Toward a unified nomenclature for mammalian ADP-ribosyltransferases.

PubMed ID: 20106667

DOI: 10.1016/j.tibs.2009.12.003

PubMed ID: 21901419

Title: Glucagon like-peptide-1 receptor is covalently modified by endogenous mono-ADP-ribosyltransferase.

PubMed ID: 21901419

DOI: 10.1007/s11033-011-1225-0

Sequence Information:

  • Length: 327
  • Mass: 36335
  • Checksum: 8FDC568197031EA5
  • Sequence:
    • MQMPAMMSLL LVSVGLMEAL QAQSHPITRR DLFSQEIQLD MALASFDDQY AGCAAAMTAA 
LPDLNHTEFQ ANQVYADSWT LASSQWQERQ ARWPEWSLSP TRPSPPPLGF RDEHGVALLA 
YTANSPLHKE FNAAVREAGR SRAHYLHHFS FKTLHFLLTE ALQLLGSGQR PPRCHQVFRG 
VHGLRFRPAG PRATVRLGGF ASASLKHVAA QQFGEDTFFG IWTCLGAPIK GYSFFPGEEE 
VLIPPFETFQ VINASRLAQG PARIYLRALG KHSTYNCEYI KDKKCKSGPC HLDNSAMGQS 
PLSAVWSLLL LLWFLVVRAF PDGPGLL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.