Details for: ART1

Gene ID: 417

Symbol: ART1

Ensembl ID: ENSG00000129744

Description: ADP-ribosyltransferase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.8589
    Cell Significance Index: 48.8700
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 2.3426
    Cell Significance Index: 32.1300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 1.7520
    Cell Significance Index: 22.6700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.2092
    Cell Significance Index: 29.2900
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.9131
    Cell Significance Index: 9.7000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.5014
    Cell Significance Index: 5.1900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.4226
    Cell Significance Index: -0.9300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.3484
    Cell Significance Index: 4.9900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.3206
    Cell Significance Index: 8.2400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.3033
    Cell Significance Index: 7.4000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.1284
    Cell Significance Index: 2.0800
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.1202
    Cell Significance Index: 1.9400
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.1178
    Cell Significance Index: 1.4900
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.0916
    Cell Significance Index: 1.2700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0654
    Cell Significance Index: 0.9500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0637
    Cell Significance Index: 0.9400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0369
    Cell Significance Index: 0.9200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0272
    Cell Significance Index: 2.0900
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.0263
    Cell Significance Index: 0.3500
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.0194
    Cell Significance Index: 0.2900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0152
    Cell Significance Index: 3.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0090
    Cell Significance Index: 1.8100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0075
    Cell Significance Index: 0.2000
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.0062
    Cell Significance Index: 0.0800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0057
    Cell Significance Index: 1.6300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0037
    Cell Significance Index: 0.6700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0028
    Cell Significance Index: 0.9900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0021
    Cell Significance Index: 0.3100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0018
    Cell Significance Index: 0.0400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0010
    Cell Significance Index: 0.0700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0006
    Cell Significance Index: 0.9100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0003
    Cell Significance Index: 0.6100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0000
    Cell Significance Index: -0.0300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0005
    Cell Significance Index: -0.7400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0011
    Cell Significance Index: -0.1300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0011
    Cell Significance Index: -0.6800
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0012
    Cell Significance Index: -0.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0015
    Cell Significance Index: -0.7000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0017
    Cell Significance Index: -1.2500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0021
    Cell Significance Index: -1.1700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0022
    Cell Significance Index: -1.2300
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0031
    Cell Significance Index: -0.0400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0036
    Cell Significance Index: -0.0600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0047
    Cell Significance Index: -0.8000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0054
    Cell Significance Index: -0.0900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0062
    Cell Significance Index: -0.0900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0072
    Cell Significance Index: -0.3400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0095
    Cell Significance Index: -0.1400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0097
    Cell Significance Index: -1.1100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0109
    Cell Significance Index: -1.1400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0165
    Cell Significance Index: -0.7300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0190
    Cell Significance Index: -0.6000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0197
    Cell Significance Index: -1.2100
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0201
    Cell Significance Index: -0.2400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0210
    Cell Significance Index: -1.1800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0211
    Cell Significance Index: -0.8000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0216
    Cell Significance Index: -0.5500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0224
    Cell Significance Index: -0.6400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0228
    Cell Significance Index: -0.3900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0244
    Cell Significance Index: -0.8000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0245
    Cell Significance Index: -0.7800
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0263
    Cell Significance Index: -0.3500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0268
    Cell Significance Index: -0.9400
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0279
    Cell Significance Index: -0.2700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0287
    Cell Significance Index: -1.0100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0287
    Cell Significance Index: -0.4800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0311
    Cell Significance Index: -0.8700
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0326
    Cell Significance Index: -0.4200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0329
    Cell Significance Index: -1.6600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0330
    Cell Significance Index: -0.9500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0338
    Cell Significance Index: -0.6600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0345
    Cell Significance Index: -0.9200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0362
    Cell Significance Index: -0.7500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0367
    Cell Significance Index: -1.5000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0369
    Cell Significance Index: -0.9200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0384
    Cell Significance Index: -0.8300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0384
    Cell Significance Index: -1.1000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0391
    Cell Significance Index: -0.8300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0405
    Cell Significance Index: -0.8000
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0413
    Cell Significance Index: -0.5500
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0419
    Cell Significance Index: -0.4300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0432
    Cell Significance Index: -1.0800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0441
    Cell Significance Index: -0.8900
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0467
    Cell Significance Index: -0.9500
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.0474
    Cell Significance Index: -0.5000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0475
    Cell Significance Index: -0.4500
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.0496
    Cell Significance Index: -0.6000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0503
    Cell Significance Index: -1.0500
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0512
    Cell Significance Index: -0.6900
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0516
    Cell Significance Index: -0.4900
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0521
    Cell Significance Index: -0.7800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0532
    Cell Significance Index: -0.6600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0538
    Cell Significance Index: -1.2900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0539
    Cell Significance Index: -1.0600
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0549
    Cell Significance Index: -0.6400
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0553
    Cell Significance Index: -0.7100
  • Cell Name: endothelial stalk cell (CL0002671)
    Fold Change: -0.0562
    Cell Significance Index: -0.6300
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0571
    Cell Significance Index: -0.7700
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: -0.0589
    Cell Significance Index: -0.6100
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0597
    Cell Significance Index: -0.6100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ART1 is a member of the ADP-ribosyltransferase family, which is characterized by its ability to catalyze the transfer of ADP-ribose groups to protein substrates. The ART1 gene encodes a protein with a GPI (glycosylphosphatidylinositol) anchor, which is a type of lipid anchor that attaches the protein to the plasma membrane. This anchor is essential for the protein's function and localization. ART1 is also known to be involved in various cellular processes, including cell signaling, membrane trafficking, and protein degradation. **Pathways and Functions:** The ART1 gene is involved in several key pathways, including: 1. **Innate Immunity:** ART1 is a key player in the regulation of innate immune responses, particularly in the context of antimicrobial peptides and alpha-defensins. Its expression is induced by various stimuli, including pathogens and cytokines, and it plays a crucial role in the activation of immune cells, such as neutrophils and macrophages. 2. **Cell Surface Signaling:** ART1 is involved in cell surface signaling, particularly in the context of G-protein coupled receptor (GPCR) signaling. Its expression is induced by various stimuli, including growth factors and cytokines, and it plays a crucial role in the regulation of cell growth, differentiation, and survival. 3. **NAD+-dependent Metabolism:** ART1 is also involved in NAD+-dependent metabolism, particularly in the context of DNA repair and epigenetic regulation. Its expression is induced by various stimuli, including DNA damage and epigenetic modifications, and it plays a crucial role in the regulation of gene expression and cellular metabolism. **Clinical Significance:** The clinical significance of ART1 is still largely unknown, but its dysregulation may have far-reaching consequences for our understanding of immune-related disorders. Some potential clinical applications of ART1 include: 1. **Immunodeficiency Disorders:** ART1 may play a crucial role in the regulation of immune responses in individuals with immunodeficiency disorders, such as HIV/AIDS and autoimmune diseases. 2. **Cancer:** ART1 may be involved in the regulation of cancer cell growth, differentiation, and survival, and its dysregulation may contribute to the development of cancer. 3. **Neurological Disorders:** ART1 may play a crucial role in the regulation of neuronal function and behavior, and its dysregulation may contribute to the development of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, ART1 is a gene that plays a crucial role in the regulation of immune responses, particularly in the context of innate immunity. Its expression is widespread, and its dysregulation may have far-reaching consequences for our understanding of immune-related disorders. Further research is needed to fully elucidate the role of ART1 in human disease and to explore its potential clinical applications.

Genular Protein ID: 1059495894

Symbol: NAR1_HUMAN

Name: GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1

UniProtKB Accession Codes:

P52961 Q6NTD2 Q96KT9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 2 EMBL 5 Ensembl 1 GO 7 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 3 Rhea 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 7947688

Title: Immunological and structural conservation of mammalian skeletal muscle glycosylphosphatidylinositol-linked ADP-ribosyltransferases.

PubMed ID: 7947688

DOI: 10.1021/bi00209a014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20106667

Title: Toward a unified nomenclature for mammalian ADP-ribosyltransferases.

PubMed ID: 20106667

DOI: 10.1016/j.tibs.2009.12.003

PubMed ID: 21901419

Title: Glucagon like-peptide-1 receptor is covalently modified by endogenous mono-ADP-ribosyltransferase.

PubMed ID: 21901419

DOI: 10.1007/s11033-011-1225-0

Sequence Information:

  • Length: 327
  • Mass: 36335
  • Checksum: 8FDC568197031EA5
  • Sequence:
    • MQMPAMMSLL LVSVGLMEAL QAQSHPITRR DLFSQEIQLD MALASFDDQY AGCAAAMTAA 
LPDLNHTEFQ ANQVYADSWT LASSQWQERQ ARWPEWSLSP TRPSPPPLGF RDEHGVALLA 
YTANSPLHKE FNAAVREAGR SRAHYLHHFS FKTLHFLLTE ALQLLGSGQR PPRCHQVFRG 
VHGLRFRPAG PRATVRLGGF ASASLKHVAA QQFGEDTFFG IWTCLGAPIK GYSFFPGEEE 
VLIPPFETFQ VINASRLAQG PARIYLRALG KHSTYNCEYI KDKKCKSGPC HLDNSAMGQS 
PLSAVWSLLL LLWFLVVRAF PDGPGLL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.