Details for: foxo

Gene ID: 41709

Symbol: foxo

Ensembl ID: FBgn0038197

Description: forkhead box, sub-group O

Associated with

  • Cellular response to amino acid starvation
    (GO:0034198)
  • Cellular response to oxidative stress
    (GO:0034599)
  • Cellular response to starvation
    (GO:0009267)
  • Circadian rhythm
    (GO:0007623)
  • Compound eye morphogenesis
    (GO:0001745)
  • Cytoplasm
    (GO:0005737)
  • Cytosol
    (GO:0005829)
  • Dendrite morphogenesis
    (GO:0048813)
  • Determination of adult lifespan
    (GO:0008340)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Female germ-line stem cell population maintenance
    (GO:0036099)
  • Glucose homeostasis
    (GO:0042593)
  • Insulin receptor signaling pathway
    (GO:0008286)
  • Locomotor rhythm
    (GO:0045475)
  • Lymph gland development
    (GO:0048542)
  • Negative regulation of cell growth
    (GO:0030308)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of cell size
    (GO:0045792)
  • Negative regulation of fat cell proliferation
    (GO:0070345)
  • Negative regulation of innate immune response
    (GO:0045824)
  • Negative regulation of insulin receptor signaling pathway
    (GO:0046627)
  • Negative regulation of lipid storage
    (GO:0010888)
  • Negative regulation of multicellular organism growth
    (GO:0040015)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Negative regulation of wound healing
    (GO:0061045)
  • Nucleus
    (GO:0005634)
  • Peptidoglycan recognition protein signaling pathway
    (GO:0061057)
  • Positive regulation of autophagy
    (GO:0010508)
  • Positive regulation of entry into reproductive diapause
    (GO:0061965)
  • Positive regulation of feeding behavior
    (GO:2000253)
  • Positive regulation of octopamine signaling pathway
    (GO:2000130)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of triglyceride catabolic process
    (GO:0010898)
  • Protein binding
    (GO:0005515)
  • Regulation of autophagy
    (GO:0010506)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of growth
    (GO:0040008)
  • Regulation of hemocyte proliferation
    (GO:0035206)
  • Regulation of lipid metabolic process
    (GO:0019216)
  • Regulation of macroautophagy
    (GO:0016241)
  • Regulation of organ growth
    (GO:0046620)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Response to bacterium
    (GO:0009617)
  • Response to oxidative stress
    (GO:0006979)
  • Response to starvation
    (GO:0042594)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific dna binding
    (GO:0043565)

Other Information

Genular Protein ID: 2944408339

Symbol: FOXO_DROME

Name: Protein FKHR

UniProtKB Accession Codes:

Q95V55 Q7KF42 Q95TK1 Q9VFN8

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 EMBL 13 EnsemblMetazoa 2 ExpressionAtlas 1 FlyBase 1 GO 49 Gene3D 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 Pfam 1 PhylomeDB 1 Proteomes 1 Reactome 11 RefSeq 4 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 2 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 12893776

Title: Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway.

PubMed ID: 12893776

DOI: 10.1101/gad.1098703

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537569

Title: A Drosophila full-length cDNA resource.

PubMed ID: 12537569

DOI: 10.1186/gb-2002-3-12-research0080

PubMed ID: 12908874

Title: The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling.

PubMed ID: 12908874

DOI: 10.1186/1475-4924-2-20

PubMed ID: 15175753

Title: Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body.

PubMed ID: 15175753

DOI: 10.1038/nature02549

PubMed ID: 16054033

Title: Drosophila Melted modulates FOXO and TOR activity.

PubMed ID: 16054033

DOI: 10.1016/j.devcel.2005.07.004

PubMed ID: 18234213

Title: dFOXO regulates transcription of a Drosophila acid lipase.

PubMed ID: 18234213

DOI: 10.1016/j.jmb.2007.12.042

PubMed ID: 18327897

Title: Phosphoproteome analysis of Drosophila melanogaster embryos.

PubMed ID: 18327897

DOI: 10.1021/pr700696a

Sequence Information:

  • Length: 613
  • Mass: 67413
  • Checksum: B472822ACA169BF9
  • Sequence:
    • MMDGYAQEWP RLTHTDNGLA MDQLGGDLPL DVGFEPQTRA RSNTWPCPRP ENFVEPTDEL 
DSTKASNQQL APGDSQQAIQ NANAAKKNSS RRNAWGNLSY ADLITHAIGS ATDKRLTLSQ 
IYEWMVQNVP YFKDKGDSNS SAGWKNSIRH NLSLHNRFMR VQNEGTGKSS WWMLNPEAKP 
GKSVRRRAAS METSRYEKRR GRAKKRVEAL RQAGVVGLND ATPSPSSSVS EGLDHFPESP 
LHSGGGFQLS PDFRQRASSN ASSCGRLSPI RAQDLEPDWG FPVDYQNTTM TQAHAQALEE 
LTGTMADELT LCNQQQQGFS AASGLPSQPP PPPYQPPQHQ QAQQQQQQQS PYALNGPASG 
YNTLQPQSQC LLHRSLNCSC MHNARDGLSP NSVTTTMSPA YPNSEPSSDS LNTYSNVVLD 
GPADTAALMV QQQQQQQQQQ QLSASLEGQC LEVLNNEAQP IDEFNLENFP VGNLECNVEE 
LLQQEMSYGG LLDINIPLAT VNTNLVNSSS GPLSISNISN LSNISSNSGS SLSLNQLQAQ 
LQQQQQQQQA QQQQQAQQQQ QQHQQHQQQL LLNNNNNSSS SLELATQTAT TNLNARVQYS 
QPSVVTSPPS WVH

Genular Protein ID: 3003235222

Symbol: A0A0B4KGN1_DROME

Name: N/A

UniProtKB Accession Codes:

A0A0B4KGN1

Database IDs:

AGR 1 ARBA 11 AlphaFoldDB 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 EMBL 2 EnsemblMetazoa 2 ExpressionAtlas 1 FlyBase 2 GO 3 Gene3D 1 GeneTree 1 GenomeRNAi 1 InterPro 4 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PROSITE-ProRule 1 Pfam 1 PhylomeDB 1 Proteomes 2 RefSeq 2 SAM 2 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537568

Title: Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence.

PubMed ID: 12537568

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537573

Title: The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective.

PubMed ID: 12537573

PubMed ID: 12537574

Title: Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.

PubMed ID: 12537574

PubMed ID: 16110336

Title: Combined evidence annotation of transposable elements in genome sequences.

PubMed ID: 16110336

DOI: 10.1371/journal.pcbi.0010022

PubMed ID: 17569856

Title: The Release 5.1 annotation of Drosophila melanogaster heterochromatin.

PubMed ID: 17569856

DOI: 10.1126/science.1139815

PubMed ID: 17569867

Title: Sequence finishing and mapping of Drosophila melanogaster heterochromatin.

PubMed ID: 17569867

DOI: 10.1126/science.1139816

Sequence Information:

  • Length: 622
  • Mass: 68345
  • Checksum: 1BA72D9E25615A97
  • Sequence:
    • MMDGYAQEWP RLTHTDNGLA MDQLGGDLPL DVGFEPQTRA RSNTWPCPRP ENFVEPTDEL 
DSTKASNQQL APGDSQQAIQ NANAAKKNSS RRNAWGNLSY ADLITHAIGS ATDKRLTLSQ 
IYEWMVQNVP YFKDKGDSNS SAGWKNSIRH NLSLHNRFMR VQNEGTGKSS WWMLNPEAKP 
GKSVRRRAAS METSRYEKRR GRAKKRVEAL RQAGVVGLND ATPSPSSSVS EGLDHFPESP 
LHSGGGFQLS PDFRQRASSN ASSCGRLSPI RAQDLEPDWG FPVDYQNTTM TQAHAQALEE 
LTGTMADELT LCNQQQQGFS AASGLPSQPP PPPYQPPQHQ QAQQQQQQQS PYALNGPASG 
YNTLQPQSQC LLHRSLNCSC MHNARDGLSP NSVTTTMSPA YPNSEPSSDS LNTYSNVVLD 
GPADTAALMV QQQQQQQQQQ QLSASLEDNN CASTLIGQCL EVLNNEAQPI DEFNLENFPV 
GNLECNVEEL LQQEMSYGGL LDINIPLATV NTNLVNSSSG PLSISNISNL SNISSNSGSS 
LSLNQLQAQL QQQQQQQQAQ QQQQAQQQQQ QHQQHQQQLL LNNNNNSSSS LELATQTATT 
NLNARVQYSQ PSVVTSPPSW VH

Genular Protein ID: 1701609249

Symbol: A0A126GUT4_DROME

Name: N/A

UniProtKB Accession Codes:

A0A126GUT4

Database IDs:

AGR 1 ARBA 11 AlphaFoldDB 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 EMBL 2 EnsemblMetazoa 1 ExpressionAtlas 1 FlyBase 2 GO 3 Gene3D 1 GeneTree 1 GenomeRNAi 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PROSITE-ProRule 1 Pfam 1 Proteomes 2 RefSeq 1 SAM 2 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537568

Title: Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence.

PubMed ID: 12537568

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537573

Title: The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective.

PubMed ID: 12537573

PubMed ID: 12537574

Title: Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.

PubMed ID: 12537574

PubMed ID: 16110336

Title: Combined evidence annotation of transposable elements in genome sequences.

PubMed ID: 16110336

DOI: 10.1371/journal.pcbi.0010022

PubMed ID: 17569856

Title: The Release 5.1 annotation of Drosophila melanogaster heterochromatin.

PubMed ID: 17569856

DOI: 10.1126/science.1139815

PubMed ID: 17569867

Title: Sequence finishing and mapping of Drosophila melanogaster heterochromatin.

PubMed ID: 17569867

DOI: 10.1126/science.1139816

Sequence Information:

  • Length: 619
  • Mass: 68150
  • Checksum: 8F48F0C3FEE1DA80
  • Sequence:
    • MMDGYAQEWP RLTHTDNGLA MDQLGGDLPL DVGFEPQTRA RSNTWPCPRP ENFVEPTDEL 
DSTKASNQQL APGDSQQAIQ NANAAKKNSS RRNAWGNLSY ADLITHAIGS ATDKRLTLSQ 
IYEWMVQNVP YFKDKGDSNS SAGWKNSIRH NLSLHNRFMR VQNEGTGKSS WWMLNPEAKP 
GKSVRRRAAS METSRYEKRR GRAKKRVEAL RQAGVVGLND ATPSPSSSVS EGLDHFPESP 
LHSGGGFQLS PDFRQRASSN ASSCGRLSPI RAQDLEPDWG FPVDYQNTTM TQAHAQALEE 
LTGTMADELT LCNQQQQGSY GWSRFSAASG LPSQPPPPPY QPPQHQQAQQ QQQQQSPYAL 
NGPASGYNTL QPQSQCLLHR SLNCSCMHNA RDGLSPNSVT TTMSPAYPNS EPSSDSLNTY 
SNVVLDGPAD TAALMVQQQQ QQQQQQQLSA SLEGQCLEVL NNEAQPIDEF NLENFPVGNL 
ECNVEELLQQ EMSYGGLLDI NIPLATVNTN LVNSSSGPLS ISNISNLSNI SSNSGSSLSL 
NQLQAQLQQQ QQQQQAQQQQ QAQQQQQQHQ QHQQQLLLNN NNNSSSSLEL ATQTATTNLN 
ARVQYSQPSV VTSPPSWVH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.