tefu | FBgn0045035 | NCBI 41839

Details for: tefu

Gene ID: 41839

Symbol: tefu

Ensembl ID: FBgn0045035

Description: telomere fusion

Associated with

Autophagy
(R-DME-9612973)
Cell cycle
(R-DME-1640170)
Cell cycle checkpoints
(R-DME-69620)
Cellular responses to stimuli
(R-DME-8953897)
Cellular responses to stress
(R-DME-2262752)
Cellular senescence
(R-DME-2559583)
Dna damage/telomere stress induced senescence
(R-DME-2559586)
Dna double-strand break repair
(R-DME-5693532)
Dna double strand break response
(R-DME-5693606)
G1/s dna damage checkpoints
(R-DME-69615)
G2/m checkpoints
(R-DME-69481)
G2/m dna damage checkpoint
(R-DME-69473)
Gene expression (transcription)
(R-DME-74160)
Generic transcription pathway
(R-DME-212436)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-DME-5693567)
Homology directed repair
(R-DME-5693538)
Macroautophagy
(R-DME-1632852)
P53-dependent g1 dna damage response
(R-DME-69563)
P53-dependent g1/s dna damage checkpoint
(R-DME-69580)
Pexophagy
(R-DME-9664873)
Processing of dna double-strand break ends
(R-DME-5693607)
Recruitment and atm-mediated phosphorylation of repair and signaling proteins at dna double strand breaks
(R-DME-5693565)
Regulation of tp53 activity
(R-DME-5633007)
Regulation of tp53 activity through phosphorylation
(R-DME-6804756)
Rna polymerase ii transcription
(R-DME-73857)
Selective autophagy
(R-DME-9663891)
Sensing of dna double strand breaks
(R-DME-5693548)
Stabilization of p53
(R-DME-69541)
Tp53 regulates transcription of caspase activators and caspases
(R-DME-6803207)
Tp53 regulates transcription of cell death genes
(R-DME-5633008)
Tp53 regulates transcription of genes involved in cytochrome c release
(R-DME-6803204)
Transcriptional regulation by tp53
(R-DME-3700989)
Chromosome organization
(GO:0051276)
Dna damage checkpoint signaling
(GO:0000077)
Dna damage response
(GO:0006974)
Dna repair
(GO:0006281)
Histone kinase activity
(GO:0035173)
Intrinsic apoptotic signaling pathway in response to dna damage
(GO:0008630)
Kinase activity
(GO:0016301)
Meiotic dna double-strand break processing
(GO:0000706)
Mitotic g2 dna damage checkpoint signaling
(GO:0007095)
Negative regulation of g1/s transition of mitotic cell cycle
(GO:2000134)
Negative regulation of glial cell apoptotic process
(GO:0034351)
Negative regulation of innate immune response
(GO:0045824)
Negative regulation of torc1 signaling
(GO:1904262)
Nucleus
(GO:0005634)
Oocyte karyosome formation
(GO:0030717)
Photoreceptor cell maintenance
(GO:0045494)
Post-translational protein modification
(GO:0043687)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Subtelomeric heterochromatin formation
(GO:0031509)
Telomere maintenance
(GO:0000723)

Other Information

Proteins

Serine/threonine-protein kinase ATM

Genular Protein ID: 3976725236

Symbol: ATM_DROME

Name: Serine/threonine-protein kinase ATM

UniProtKB Accession Codes:

Q5EAK6 Q0KI71 Q6TKQ1 Q8MZG4 Q9VFB1

Database IDs:

Citations:

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 14729967

Title: Drosophila melanogaster MNK/Chk2 and p53 regulate multiple DNA repair and apoptotic pathways following DNA damage.

PubMed ID: 14729967

DOI: 10.1128/mcb.24.3.1219-1231.2004

PubMed ID: 12537569

Title: A Drosophila full-length cDNA resource.

PubMed ID: 12537569

DOI: 10.1186/gb-2002-3-12-research0080

PubMed ID: 15296750

Title: ATM is required for telomere maintenance and chromosome stability during Drosophila development.

PubMed ID: 15296750

DOI: 10.1016/j.cub.2004.06.056

PubMed ID: 15296751

Title: Telomere protection without a telomerase; the role of ATM and Mre11 in Drosophila telomere maintenance.

PubMed ID: 15296751

DOI: 10.1016/j.cub.2004.06.063

PubMed ID: 15296752

Title: The Drosophila ATM ortholog, dATM, mediates the response to ionizing radiation and to spontaneous DNA damage during development.

PubMed ID: 15296752

DOI: 10.1016/j.cub.2004.06.064

PubMed ID: 15256487

Title: Drosophila atm/telomere fusion is required for telomeric localization of HP1 and telomere position effect.

PubMed ID: 15256487

DOI: 10.1101/gad.1202504

PubMed ID: 16020777

Title: Drosophila ATM and Mre11 are essential for the G2/M checkpoint induced by low-dose irradiation.

PubMed ID: 16020777

DOI: 10.1534/genetics.105.047720

PubMed ID: 16203987

Title: Drosophila ATM and ATR checkpoint kinases control partially redundant pathways for telomere maintenance.

PubMed ID: 16203987

DOI: 10.1073/pnas.0504981102

PubMed ID: 22964637

Title: The tumor suppressor Caliban regulates DNA damage-induced apoptosis through p53-dependent and -independent activity.

PubMed ID: 22964637

DOI: 10.1038/onc.2012.395

Sequence Information:

Length: 2767
Mass: 317991
Checksum: F354E55FA1B35570
Sequence:

MSALLNEIQR ILGDLQSGKA ASRNKGIQQL DEKLSSCRED LDKLFLSKTS DISWTTIFEA 
SKEALFKQAG NLEDVNEKVF KTLAGKNYLY DNVLEKITQF NLEAGSQTSG NGHFLAKTSI 
FSAFEDGIKM RVVVKYFGDR ILSLLEKGIY SSVSYVRDLK INEYSRILSY LFELNVDMDE 
VLRTRILKCI TRTVSLAKDR VQLHVDLVEY LPELSSFALS AFGARKTEIV RVYLIFASEL 
AVNYNHQLNV HMQEILPKLC EYHDEDAFRD DTRNLFFQCV SKSLHSMYLK MDMCDFNTLG 
VPVHEKWPQT LLRLKTIVNV EIRKNSWARC KNALLSNNKF SDPFIKMSAL AMYIVLWHLE 
TKKADENGEG DAPKKIPKPA DKMETIFSLI DKKENTFNDV WLAIFTEILQ LSSVILNVAN 
YQMALTTVAE IMQMYGNAKN LRNLRLCLAH LLTKEQELLH SKSIREDFLG ELWSQMANQL 
ISETTTNSEE IKEKQLVLQM LIRHNKLNQK LSSTLLNNII SNEMLKRNEC LATIREIFIH 
ADKCGQDKAS ADLEPIIAWA YGSADRFIAA QMIHNIDSID AQLQADTFAI SIINFLDVQQ 
LRQISQSEHI VPSTERNLLA YKYNEQLICF DKDYATPFES ITHIQSETKN CLIQSNYDCL 
MRGLNFEIAK ENKPAAIIKN LNSLLKLICT MERLLHYKVF DADTYTGCPL IKRIGLYLSH 
IEFQLKANGA EILDKSDLPE ILRLEIYVLD VFRTNLVLLD YLERQPIEML VEFVGAALKL 
HSMQRERSVD ADHGTITRLC LNILAGLCAY NSHRDEAFEH IVKVTMRWHP QDVLIVTKML 
CSCQTISEAS SSWLVSKLKT LFQQHHQDAE LMDKVVQHMP TIFYFVRHKE NHLDDMLMAL 
NSLLRIAIKK SYTSNLTAKI VRCVGLIAQR CPDIYLLENF AVICKSTAKF ITMPTLEVRF 
ATLFTFTILL ESNCVTSDAI GHSRTHWDFC QELYESIEFK KLTYNNEDAI QNSNALIVQM 
LIAIFLRSSF HQEIALKELL HHCALRRLTE REFISLQSMS SCHRQTVRDL IRPFAAILLH 
HWSSKRWPIS KFPYFLCYST KSEFRKTHAS EIMAYTFLYG KTEDIERCSK SISEELALPI 
LASFLLIKNS SCSESEGQNF KEHLQLLSEN LSYSQLNATD VDLDLDILCY VISMLHDPQE 
MMRLFGSLAI CNRTASWYSL SGESLFKCLN FHIDPEMRPS MDSRIQSMTT LQTKHSRVLV 
DIFGRLKTNC YSASFSSQAL HDFFLYCEVA DAVYDAARKN ETIVTQCSFF VRDIWFFVVR 
LLIHTKFIRV QMAALTFLEL LLNKHNFRLD DYQNHFGDIA KLLSNFQLCC EAKEVREKTM 
SIVMYILESK KGHINLNSFL EETTDCEFLK PLREDCKSSQ PNIDRADVAN YLRSFLLSPT 
PERLRDLRTY IAEHKDKVQE HEKLLFGVIN KLIQMTRDAH NKTTSIDSLK CLAQIGPLKI 
STVSYYFQTD FEAFEKSNGE PMEAFLGVVC HSLDTSLFQF DPKTHEGLVS VAIQVVNSKP 
GSNIMERYKN LRIFADKSTA STFLHSNKQI RRIDWLSILK ATKSLSYEPW MCAFVSKVFQ 
MCGWLGFDKL AATSFAFAKT CLLPFIKLLL ENSLEHVESL SQMLDYFFEG FTSSTAPNSQ 
EIFRNKRAIK KFLHICEYIR IFNNWTIPIN LSNVVMASNH CQAYFLSIMY LELWACSESP 
KSKADFLDNE CFQDGAKKAY ESIGCLDAIP GFVNPMRSRL DFLGHGSNLS TILLESDHLD 
RASGQLCIDI MKGNGLWSFA KLQQHQNIEP DYEIFWRLGQ WDSLTDPKHQ QNQTVVRTSL 
DLEQEFKRHH FVALRSIGQR EEENSLSAIE QAYSCVRDIL MEISVECLQS VYKYLTWLCS 
LQQAEDFCQI QFGTQLDPAS TTKIFRKWQT ELELKYGNFS CKEYVIAHQI ALLKLAGTRA 
SRRMSEFYQK DPISTYLMKG IEECKSAGKL NLAAKYTATL RELPNIRESI KISVLLEDAE 
INLKMGNQQI AKAILDYVTN NNEFVYCVQR VPALRMQGEF LLDCNAETLS WVQSHKFNNS 
LKLIDDFVQH RQTLSEKYRD IFDWHQLDAY ASKQRTAAYA TIAKYADREY QQLHDYRHSQ 
EYQTLKDIIE QNRQTAEKVT QRENQDRRVI SVQMKRYASL DEQQLNQIEE KLTEYLRLAL 
TNYMAYCRLD SGFSSAAIYR IISLWFTNAT SKQCQECIKD EILTVPSYKF ICAANQLTAR 
LNSKNTSLLK GLTDLLVQCG KDHPYHTFYQ LYPLVFAHLD GENSNTERSG IARKIIAMIC 
EKNGTAGECS KQLESLLPAL ITFANEGKTN DNRPVSDSVR NKQFDKVRRW RNLNAVHCPT 
LELPVMPSKE YSIISVVKWT NETTQCGGLN APVKIMCVCS DGKIRAQLVK GKDDLRQDAV 
MQQVFGIVNE LLNQDSEFIE RKLKLRTYKV TPLSMRSGIL EWCTNSVPVG HYLVVEGKGG 
AHARYRPNDW NNNKCRKLSS DHLKSPKETR YAIYKKICEN IKPVFHYFLL EKFPIPGVWF 
ERRLAYTNSV ATTSMVGYVL GLGDRHTQNI LVDQQTAEVI HIDFGIAFEQ GKIQTTPETV 
PFRLTRDFVA PMGICGTKGV FAKSCEATMH ILRRYKSVFT TILEVLLYDP LFIWGVLKKK 
QSPQQSGEES VNLVAQRALL LVQNKLDGRE AGTMGDSNVE AQVERLINEA TLPSNLCMLF 
PGWDPHL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: tefu

Associated with

Other Information

The genome sequence of Drosophila melanogaster. PubMed ID: 10731132

Annotation of the Drosophila melanogaster euchromatic genome: a systematic review. PubMed ID: 12537572

Drosophila melanogaster MNK/Chk2 and p53 regulate multiple DNA repair and apoptotic pathways following DNA damage. PubMed ID: 14729967

A Drosophila full-length cDNA resource. PubMed ID: 12537569

ATM is required for telomere maintenance and chromosome stability during Drosophila development. PubMed ID: 15296750

Telomere protection without a telomerase; the role of ATM and Mre11 in Drosophila telomere maintenance. PubMed ID: 15296751

The Drosophila ATM ortholog, dATM, mediates the response to ionizing radiation and to spontaneous DNA damage during development. PubMed ID: 15296752

Drosophila atm/telomere fusion is required for telomeric localization of HP1 and telomere position effect. PubMed ID: 15256487

Drosophila ATM and Mre11 are essential for the G2/M checkpoint induced by low-dose irradiation. PubMed ID: 16020777

Drosophila ATM and ATR checkpoint kinases control partially redundant pathways for telomere maintenance. PubMed ID: 16203987

The tumor suppressor Caliban regulates DNA damage-induced apoptosis through p53-dependent and -independent activity. PubMed ID: 22964637