Details for: ART3

Gene ID: 419

Symbol: ART3

Ensembl ID: ENSG00000156219

Description: ADP-ribosyltransferase 3 (inactive)

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 28.8988
    Cell Significance Index: -7.3300
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 8.8137
    Cell Significance Index: 142.2100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 4.7962
    Cell Significance Index: 117.0300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 3.7254
    Cell Significance Index: 95.7600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.1025
    Cell Significance Index: 84.6100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7376
    Cell Significance Index: 147.9600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7302
    Cell Significance Index: 138.9700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6203
    Cell Significance Index: 61.3600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.4677
    Cell Significance Index: 7.4200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4471
    Cell Significance Index: 403.7200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4397
    Cell Significance Index: 19.4500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3821
    Cell Significance Index: 14.4700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3550
    Cell Significance Index: 7.5600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.3526
    Cell Significance Index: 8.5400
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.3193
    Cell Significance Index: 4.4300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3128
    Cell Significance Index: 50.8700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.2846
    Cell Significance Index: 4.6900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2525
    Cell Significance Index: 27.4600
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: 0.2288
    Cell Significance Index: 3.0500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.2161
    Cell Significance Index: 3.1900
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.1787
    Cell Significance Index: 2.3400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1412
    Cell Significance Index: 7.9300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1064
    Cell Significance Index: 7.3600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0988
    Cell Significance Index: 5.9300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0753
    Cell Significance Index: 1.2900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0718
    Cell Significance Index: 9.2000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0596
    Cell Significance Index: 21.4000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0227
    Cell Significance Index: 0.6600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0110
    Cell Significance Index: 4.8700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0106
    Cell Significance Index: 1.2100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0060
    Cell Significance Index: 0.2100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0057
    Cell Significance Index: 3.9700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0042
    Cell Significance Index: 0.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0019
    Cell Significance Index: -3.5100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0024
    Cell Significance Index: -1.0900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0028
    Cell Significance Index: -0.0900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0029
    Cell Significance Index: -5.3000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0039
    Cell Significance Index: -6.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0045
    Cell Significance Index: -6.1700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0083
    Cell Significance Index: -4.5500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0093
    Cell Significance Index: -5.9200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0096
    Cell Significance Index: -0.2400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0103
    Cell Significance Index: -7.6100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0111
    Cell Significance Index: -8.4100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0134
    Cell Significance Index: -7.5700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0149
    Cell Significance Index: -2.6900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0163
    Cell Significance Index: -2.7800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0214
    Cell Significance Index: -2.4900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0224
    Cell Significance Index: -6.4400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0224
    Cell Significance Index: -4.4400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0277
    Cell Significance Index: -1.7000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0301
    Cell Significance Index: -0.9600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0325
    Cell Significance Index: -2.0500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0355
    Cell Significance Index: -1.6100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0369
    Cell Significance Index: -0.5600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0372
    Cell Significance Index: -5.4100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0376
    Cell Significance Index: -0.7800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0380
    Cell Significance Index: -8.0100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0387
    Cell Significance Index: -3.9500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0414
    Cell Significance Index: -5.0900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0419
    Cell Significance Index: -0.6100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0419
    Cell Significance Index: -1.1700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0510
    Cell Significance Index: -7.0100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0513
    Cell Significance Index: -3.4500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0526
    Cell Significance Index: -6.8000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0580
    Cell Significance Index: -0.8300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0590
    Cell Significance Index: -2.7500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0677
    Cell Significance Index: -7.0500
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0812
    Cell Significance Index: -0.8900
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0872
    Cell Significance Index: -1.3100
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0912
    Cell Significance Index: -1.1700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0936
    Cell Significance Index: -1.4100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0962
    Cell Significance Index: -3.3700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1012
    Cell Significance Index: -7.5400
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1142
    Cell Significance Index: -1.6000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1157
    Cell Significance Index: -7.1100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1172
    Cell Significance Index: -6.0900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1177
    Cell Significance Index: -6.1300
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.1210
    Cell Significance Index: -1.7000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1279
    Cell Significance Index: -5.5600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1366
    Cell Significance Index: -7.1700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1380
    Cell Significance Index: -5.6500
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.1394
    Cell Significance Index: -1.8600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1432
    Cell Significance Index: -6.7300
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1551
    Cell Significance Index: -1.8100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1583
    Cell Significance Index: -3.4200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1598
    Cell Significance Index: -2.2700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1646
    Cell Significance Index: -5.3900
  • Cell Name: secondary lymphoid organ macrophage (CL0000867)
    Fold Change: -0.1771
    Cell Significance Index: -1.3000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1825
    Cell Significance Index: -9.2200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1860
    Cell Significance Index: -1.2600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1882
    Cell Significance Index: -2.0500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1937
    Cell Significance Index: -2.2000
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.2049
    Cell Significance Index: -2.3600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2065
    Cell Significance Index: -7.5800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2068
    Cell Significance Index: -4.3900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2125
    Cell Significance Index: -5.3000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2168
    Cell Significance Index: -5.9000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2224
    Cell Significance Index: -5.5500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2265
    Cell Significance Index: -6.4700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ART3 exhibits several key characteristics that distinguish it from other genes in the ADP-ribosyltransferase family. Its inactive nature, as indicated by its designation, suggests that ART3 may not be directly involved in the classical ADP-ribosyltransferase activity. Instead, its expression in specific cell types and tissues implies a more specialized function. The gene's association with various cellular processes, including metabolism, protein modification, and signaling pathways, underscores its potential importance in maintaining cellular homeostasis. **Pathways and Functions:** ART3's involvement in multiple pathways and functions is a testament to its versatility and complexity. The gene's expression in skeletal muscle and cardiac myocytes suggests a role in muscle development and function. Its presence in kidney epithelial cells and the gastrointestinal tract implies a potential involvement in renal and intestinal homeostasis. Furthermore, ART3's association with post-translational protein modification, particularly the synthesis of GPI-anchored proteins, highlights its potential role in cellular differentiation and function. One of the most intriguing aspects of ART3 is its potential involvement in signaling pathways. The gene's expression in cerebral cortex GABAergic interneurons suggests a role in neuronal function and development. The presence of ART3 in other tissues, including the gastrointestinal tract, implies a potential involvement in intestinal homeostasis and the maintenance of the gut-brain axis. **Clinical Significance:** The clinical significance of ART3 is an area that warrants further investigation. While the gene's expression in various tissues and cell types suggests a potential role in maintaining cellular homeostasis, its involvement in specific diseases or disorders remains unclear. However, the gene's association with muscle development and function raises questions about its potential involvement in muscular dystrophies or other muscle-related disorders. Furthermore, ART3's expression in the gastrointestinal tract and its potential involvement in intestinal homeostasis suggest a potential role in gastrointestinal disorders, such as inflammatory bowel disease or irritable bowel syndrome. The gene's presence in cerebral cortex GABAergic interneurons also raises questions about its potential involvement in neurological disorders, such as epilepsy or Alzheimer's disease. In conclusion, ART3 is a gene with a complex and multifaceted role in various cellular processes. Its expression in specific tissues and cell types, combined with its involvement in post-translational protein modification and signaling pathways, highlights its potential importance in maintaining cellular homeostasis. Further investigation is necessary to fully elucidate the clinical significance of ART3 and its potential role in various diseases and disorders.

Genular Protein ID: 4149212719

Symbol: NAR3_HUMAN

Name: Ecto-ADP-ribosyltransferase 3

UniProtKB Accession Codes:

Q13508 Q53XW3 Q6FHT7 Q8WVJ7 Q93069 Q96HL1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChEBI 7 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 7 Ensembl 3 ExpressionAtlas 1 GO 7 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 2 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 3 Rhea 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8605984

Title: Human testis specifically expresses a homologue of the rodent T lymphocytes RT6 mRNA.

PubMed ID: 8605984

DOI: 10.1016/0014-5793(96)00183-4

PubMed ID: 9119374

Title: Two novel human members of an emerging mammalian gene family related to mono-ADP-ribosylating bacterial toxins.

PubMed ID: 9119374

DOI: 10.1006/geno.1996.4520

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20106667

Title: Toward a unified nomenclature for mammalian ADP-ribosyltransferases.

PubMed ID: 20106667

DOI: 10.1016/j.tibs.2009.12.003

PubMed ID: 22171320

Title: Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD.

PubMed ID: 22171320

DOI: 10.1074/mcp.m111.013649

PubMed ID: 28718531

Title: Next-generation sequencing for patients with non-obstructive azoospermia: implications for significant roles of monogenic/oligogenic mutations.

PubMed ID: 28718531

DOI: 10.1111/andr.12378

Sequence Information:

  • Length: 389
  • Mass: 43923
  • Checksum: EE1311304BB2F41D
  • Sequence:
    • MKTGHFEIVT MLLATMILVD IFQVKAEVLD MADNAFDDEY LKCTDRMEIK YVPQLLKEEK 
ASHQQLDTVW ENAKAKWAAR KTQIFLPMNF KDNHGIALMA YISEAQEQTP FYHLFSEAVK 
MAGQSREDYI YGFQFKAFHF YLTRALQLLR KPCEASSKTV VYRTSQGTSF TFGGLNQARF 
GHFTLAYSAK PQAANDQLTV LSIYTCLGVD IENFLDKESE RITLIPLNEV FQVSQEGAGN 
NLILQSINKT CSHYECAFLG GLKTENCIEN LEYFQPIYVY NPGEKNQKLE DHSEKNWKLE 
DHGEKNQKLE DHGVKILEPT QIPGMKIPEP FPLPEDKSQG NINNPTPGPV PVPGPKSHPS 
ASSGKLLLPQ FGMVIILISV SAINLFVAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.