Details for: Akt

Gene ID: 41957

Symbol: Akt

Ensembl ID: FBgn0010379

Description: Akt kinase

Associated with

Other Information

Genular Protein ID: 1649538764

Symbol: AKT1_DROME

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8302573

Title: The SH2-like Akt homology (AH) domain of c-akt is present in multiple copies in the genome of vertebrate and invertebrate eucaryotes. Cloning and characterisation of the Drosophila melanogaster c-akt homolog Dakt1.

PubMed ID: 8302573

PubMed ID: 7876156

Title: Developmental regulation of expression and activity of multiple forms of the Drosophila RAC protein kinase.

PubMed ID: 7876156

DOI: 10.1074/jbc.270.8.4066

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537569

Title: A Drosophila full-length cDNA resource.

PubMed ID: 12537569

DOI: 10.1186/gb-2002-3-12-research0080

PubMed ID: 9601646

Title: Genetic analysis of protein kinase B (AKT) in Drosophila.

PubMed ID: 9601646

DOI: 10.1016/s0960-9822(98)70231-3

PubMed ID: 10587646

Title: Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB.

PubMed ID: 10587646

DOI: 10.1038/70293

PubMed ID: 10962553

Title: The conserved PI3'K/PTEN/Akt signaling pathway regulates both cell size and survival in Drosophila.

PubMed ID: 10962553

DOI: 10.1038/sj.onc.1203739

PubMed ID: 11740943

Title: Regulation of Drosophila tracheal system development by protein kinase B.

PubMed ID: 11740943

DOI: 10.1016/s1534-5807(01)00090-9

PubMed ID: 11344272

Title: Drosophila phosphoinositide-dependent kinase-1 regulates apoptosis and growth via the phosphoinositide 3-kinase-dependent signaling pathway.

PubMed ID: 11344272

DOI: 10.1073/pnas.101596998

PubMed ID: 11752451

Title: PDK1 regulates growth through Akt and S6K in Drosophila.

PubMed ID: 11752451

DOI: 10.1073/pnas.011318098

PubMed ID: 12172554

Title: Akt regulates growth by directly phosphorylating Tsc2.

PubMed ID: 12172554

DOI: 10.1038/ncb840

PubMed ID: 11872800

Title: Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB.

PubMed ID: 11872800

DOI: 10.1126/science.1068094

PubMed ID: 14525946

Title: Coordinated functions of Akt/PKB and ETS1 in tubule formation.

PubMed ID: 14525946

DOI: 10.1096/fj.03-0040fje

PubMed ID: 12893776

Title: Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway.

PubMed ID: 12893776

DOI: 10.1101/gad.1098703

PubMed ID: 15466161

Title: Tsc2 is not a critical target of Akt during normal Drosophila development.

PubMed ID: 15466161

DOI: 10.1101/gad.1240504

PubMed ID: 15712201

Title: dAkt kinase controls follicle cell size during Drosophila oogenesis.

PubMed ID: 15712201

DOI: 10.1002/dvdy.20333

PubMed ID: 15808505

Title: PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth.

PubMed ID: 15808505

DOI: 10.1016/j.molcel.2005.03.008

PubMed ID: 15718470

Title: Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.

PubMed ID: 15718470

DOI: 10.1126/science.1106148

PubMed ID: 18327897

Title: Phosphoproteome analysis of Drosophila melanogaster embryos.

PubMed ID: 18327897

DOI: 10.1021/pr700696a

PubMed ID: 22493059

Title: LST8 regulates cell growth via target-of-rapamycin complex 2 (TORC2).

PubMed ID: 22493059

DOI: 10.1128/mcb.06474-11

PubMed ID: 24786828

Title: The TORC1 inhibitors Nprl2 and Nprl3 mediate an adaptive response to amino-acid starvation in Drosophila.

PubMed ID: 24786828

DOI: 10.1038/cdd.2014.63

PubMed ID: 24603715

Title: CDP-diacylglycerol synthetase coordinates cell growth and fat storage through phosphatidylinositol metabolism and the insulin pathway.

PubMed ID: 24603715

DOI: 10.1371/journal.pgen.1004172

PubMed ID: 25329475

Title: Drosophila tribbles antagonizes insulin signaling-mediated growth and metabolism via interactions with Akt kinase.

PubMed ID: 25329475

DOI: 10.1371/journal.pone.0109530

PubMed ID: 29025897

Title: A Drosophila model of insulin resistance associated with the human Trib3 Q/R polymorphism.

PubMed ID: 29025897

DOI: 10.1242/dmm.030619

Sequence Information:

  • Length: 611
  • Mass: 68485
  • Checksum: C139380152580934
  • Sequence:
  • MNYLPFVLQR RSTVVASAPA PGSASRIPES PTTTGSNIIN IIYSQSTHPN SSPTSGSAEK 
    FSWQQSWPSR TSAAPTHDSG TMSINTTFDL SSPSVTSGHA LTEQTQVVKE GWLMKRGEHI 
    KNWRQRYFVL HSDGRLMGYR SKPADSASTP SDFLLNNFTV RGCQIMTVDR PKPFTFIIRG 
    LQWTTVIERT FAVESELERQ QWTEAIRNVS SRLIDVGEVA MTPSEQTDMT DVDMATIAED 
    ELSEQFSVQG TTCNSSGVKK VTLENFEFLK VLGKGTFGKV ILCREKATAK LYAIKILKKE 
    VIIQKDEVAH TLTESRVLKS TNHPFLISLK YSFQTNDRLC FVMQYVNGGE LFWHLSHERI 
    FTEDRTRFYG AEIISALGYL HSQGIIYRDL KLENLLLDKD GHIKVADFGL CKEDITYGRT 
    TKTFCGTPEY LAPEVLDDND YGQAVDWWGT GVVMYEMICG RLPFYNRDHD VLFTLILVEE 
    VKFPRNITDE AKNLLAGLLA KDPKKRLGGG KDDVKEIQAH PFFASINWTD LVLKKIPPPF 
    KPQVTSDTDT RYFDKEFTGE SVELTPPDPT GPLGSIAEEP LFPQFSYQGD MASTLGTSSH 
    ISTSTSLASM Q

Genular Protein ID: 3229144431

Symbol: A0A0B4LIA3_DROME

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537568

Title: Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence.

PubMed ID: 12537568

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537573

Title: The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective.

PubMed ID: 12537573

PubMed ID: 12537574

Title: Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.

PubMed ID: 12537574

PubMed ID: 16110336

Title: Combined evidence annotation of transposable elements in genome sequences.

PubMed ID: 16110336

DOI: 10.1371/journal.pcbi.0010022

PubMed ID: 17569856

Title: The Release 5.1 annotation of Drosophila melanogaster heterochromatin.

PubMed ID: 17569856

DOI: 10.1126/science.1139815

PubMed ID: 17569867

Title: Sequence finishing and mapping of Drosophila melanogaster heterochromatin.

PubMed ID: 17569867

DOI: 10.1126/science.1139816

PubMed ID: 26109357

Title: Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.

PubMed ID: 26109357

DOI: .1534/g3.115.018929

PubMed ID: 26109356

Title: Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.

PubMed ID: 26109356

DOI: .1534/g3.115.018937

PubMed ID: 25589440

Title: The Release 6 reference sequence of the Drosophila melanogaster genome.

PubMed ID: 25589440

Sequence Information:

  • Length: 530
  • Mass: 59911
  • Checksum: F7508582C7F4A288
  • Sequence:
  • MSINTTFDLS SPSVTSGHAL TEQTQVVKEG WLMKRGEHIK NWRQRYFVLH SDGRLMGYRS 
    KPADSASTPS DFLLNNFTVR GCQIMTVDRP KPFTFIIRGL QWTTVIERTF AVESELERQQ 
    WTEAIRNVSS RLIDVGEVAM TPSEQTDMTD VDMATIAEDE LSEQFSVQGT TCNSSGVKKV 
    TLENFEFLKV LGKGTFGKVI LCREKATAKL YAIKILKKEV IIQKDEVAHT LTESRVLKST 
    NHPFLISLKY SFQTNDRLCF VMQYVNGGEL FWHLSHERIF TEDRTRFYGA EIISALGYLH 
    SQGIIYRDLK LENLLLDKDG HIKVADFGLC KEDITYGRTT KTFCGTPEYL APEVLDDNDY 
    GQAVDWWGTG VVMYEMICGR LPFYNRDHDV LFTLILVEEV KFPRNITDEA KNLLAGLLAK 
    DPKKRLGGGK DDVKEIQAHP FFASINWTDL VLKKIPPPFK PQVTSDTDTR YFDKEFTGES 
    VELTPPDPTG PLGSIAEEPL FPQFSYQGDM ASTLGTSSHI STSTSLASMQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.