Details for: ART4

Gene ID: 420

Symbol: ART4

Ensembl ID: ENSG00000111339

Description: ADP-ribosyltransferase 4 (inactive) (Dombrock blood group)

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 14.9028
    Cell Significance Index: -3.7800
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 5.3658
    Cell Significance Index: 76.8900
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 1.4723
    Cell Significance Index: 5.5500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.3307
    Cell Significance Index: 22.4200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 1.2653
    Cell Significance Index: -1.5600
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.0383
    Cell Significance Index: 9.8700
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.9392
    Cell Significance Index: 5.5500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.4412
    Cell Significance Index: 6.4300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.3816
    Cell Significance Index: 12.0700
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.3404
    Cell Significance Index: 1.9600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.2906
    Cell Significance Index: 4.1800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.2862
    Cell Significance Index: 4.1100
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.2597
    Cell Significance Index: 2.0500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1576
    Cell Significance Index: 3.4200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.1446
    Cell Significance Index: 2.1400
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.1150
    Cell Significance Index: 0.4000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1017
    Cell Significance Index: 16.5400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0985
    Cell Significance Index: 3.1600
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.0837
    Cell Significance Index: 0.5200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0666
    Cell Significance Index: 4.2000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0660
    Cell Significance Index: 5.0700
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.0642
    Cell Significance Index: 0.6700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0509
    Cell Significance Index: 10.1100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0496
    Cell Significance Index: 2.9800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0398
    Cell Significance Index: 5.7900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0145
    Cell Significance Index: 26.7800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0108
    Cell Significance Index: 20.2500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0103
    Cell Significance Index: 15.9200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0081
    Cell Significance Index: 10.9700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0078
    Cell Significance Index: 4.9500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0068
    Cell Significance Index: 1.3600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0064
    Cell Significance Index: 2.3000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0063
    Cell Significance Index: 0.0700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0061
    Cell Significance Index: 1.7600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0023
    Cell Significance Index: 0.0600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0004
    Cell Significance Index: 0.0700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0013
    Cell Significance Index: -0.2400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0031
    Cell Significance Index: -0.0900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0047
    Cell Significance Index: -3.4500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0047
    Cell Significance Index: -3.4600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0049
    Cell Significance Index: -3.7300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0053
    Cell Significance Index: -2.9200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0067
    Cell Significance Index: -3.0200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0067
    Cell Significance Index: -3.8000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0127
    Cell Significance Index: -0.5500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0131
    Cell Significance Index: -1.4300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0180
    Cell Significance Index: -2.0600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0183
    Cell Significance Index: -1.1300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0183
    Cell Significance Index: -3.8500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0184
    Cell Significance Index: -3.1400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0221
    Cell Significance Index: -2.5700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0222
    Cell Significance Index: -0.4600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0257
    Cell Significance Index: -3.3200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0259
    Cell Significance Index: -3.1900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0259
    Cell Significance Index: -0.3900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0272
    Cell Significance Index: -3.7400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0281
    Cell Significance Index: -1.2800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0281
    Cell Significance Index: -1.9400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0291
    Cell Significance Index: -2.8800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0337
    Cell Significance Index: -3.4400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0342
    Cell Significance Index: -1.7300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0344
    Cell Significance Index: -3.5800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0369
    Cell Significance Index: -1.6300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0403
    Cell Significance Index: -2.7100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0405
    Cell Significance Index: -0.7900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0422
    Cell Significance Index: -0.7100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0431
    Cell Significance Index: -3.2100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0436
    Cell Significance Index: -1.6500
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0459
    Cell Significance Index: -0.5200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0460
    Cell Significance Index: -0.9800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0497
    Cell Significance Index: -2.7900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0548
    Cell Significance Index: -0.4600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0558
    Cell Significance Index: -1.4900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0567
    Cell Significance Index: -3.6600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0586
    Cell Significance Index: -3.0500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0610
    Cell Significance Index: -0.9000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0632
    Cell Significance Index: -3.3200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0636
    Cell Significance Index: -2.9900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0638
    Cell Significance Index: -1.5900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0663
    Cell Significance Index: -3.0900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0769
    Cell Significance Index: -1.6100
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: -0.0770
    Cell Significance Index: -0.7600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0791
    Cell Significance Index: -2.7700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0852
    Cell Significance Index: -1.2200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0855
    Cell Significance Index: -2.0500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0875
    Cell Significance Index: -1.5000
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0912
    Cell Significance Index: -1.1700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0931
    Cell Significance Index: -1.1100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0947
    Cell Significance Index: -3.0200
  • Cell Name: surface ectodermal cell (CL0000114)
    Fold Change: -0.0950
    Cell Significance Index: -0.7500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0967
    Cell Significance Index: -3.1700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0968
    Cell Significance Index: -2.6000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0977
    Cell Significance Index: -2.6600
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0985
    Cell Significance Index: -1.2400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0994
    Cell Significance Index: -2.6600
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.1007
    Cell Significance Index: -1.1600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1009
    Cell Significance Index: -3.5100
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.1023
    Cell Significance Index: -1.0600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1027
    Cell Significance Index: -2.9500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1052
    Cell Significance Index: -3.1000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Intracellular localization:** ART4 is primarily localized to the plasma membrane, where it is involved in the regulation of immune cell function and tissue homeostasis. 2. **Arginine metabolic process:** ART4 is involved in the arginine metabolic process, which is crucial for the regulation of various cellular functions, including immune responses. 3. **NAD+-protein-arginine adp-ribosyltransferase activity:** ART4 exhibits NAD+-protein-arginine adp-ribosyltransferase activity, which is essential for the modification of proteins and regulation of cellular signaling pathways. 4. **Significantly expressed cells:** ART4 is highly expressed in various cell types, including immune cells (e.g., conventional dendritic cells, granulocyte monocyte progenitor cells), epithelial cells (e.g., enterocytes, goblet cells), and endothelial cells. **Pathways and Functions:** 1. **Arginine metabolic process:** ART4 is involved in the regulation of arginine metabolism, which is crucial for the synthesis of nitric oxide, a key molecule in immune responses. 2. **NAD+-protein-arginine adp-ribosyltransferase activity:** ART4's enzymatic activity is essential for the modification of proteins, regulating cellular signaling pathways, and maintaining cellular homeostasis. 3. **Post-translational modification:** ART4 is involved in the synthesis of GPI-anchored proteins, which are essential for the regulation of immune cell function and tissue homeostasis. 4. **Nucleotidyltransferase activity:** ART4 exhibits nucleotidyltransferase activity, which is involved in the regulation of nucleotide metabolism and cellular homeostasis. **Clinical Significance:** 1. **Immune regulation:** ART4's involvement in immune cell function and regulation highlights its potential as a target for the treatment of immune-related disorders, such as autoimmune diseases and cancer. 2. **Tissue homeostasis:** ART4's role in maintaining tissue homeostasis emphasizes the importance of this gene in the regulation of various cellular processes, including cell growth, differentiation, and survival. 3. **Disease association:** Further studies are necessary to determine the association between ART4 and various diseases, including cancer, autoimmune diseases, and cardiovascular disorders. 4. **Therapeutic potential:** ART4's involvement in arginine metabolic process and protein modification pathways highlights its potential as a therapeutic target for the treatment of various diseases. In conclusion, ART4 is a multifunctional gene that plays a crucial role in regulating immune responses, cellular homeostasis, and maintaining tissue integrity. Further studies are necessary to elucidate the mechanisms of ART4's action and to explore its therapeutic potential in various diseases.

Genular Protein ID: 716767119

Symbol: NAR4_HUMAN

Name: Ecto-ADP-ribosyltransferase 4

UniProtKB Accession Codes:

Q93070 Q9BZ50 Q9BZ51 Q9HB06

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 8 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 22 Ensembl 1 ExpressionAtlas 1 GO 7 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 2 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11001920

Title: Identification of the Dombrock blood group glycoprotein as a polymorphic member of the ADP-ribosyltransferase gene family.

PubMed ID: 11001920

PubMed ID: 11896313

Title: Insights into the Holley- and Joseph- phenotypes.

PubMed ID: 11896313

DOI: 10.1046/j.1537-2995.2002.00004.x

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9119374

Title: Two novel human members of an emerging mammalian gene family related to mono-ADP-ribosylating bacterial toxins.

PubMed ID: 9119374

DOI: 10.1006/geno.1996.4520

PubMed ID: 11520417

Title: Polymerase chain reaction with sequence-specific primers-based genotyping of the human Dombrock blood group DO1 and DO2 alleles and the DO gene frequencies in Chinese blood donors.

PubMed ID: 11520417

DOI: 10.1046/j.1423-0410.2001.00052.x

PubMed ID: 20106667

Title: Toward a unified nomenclature for mammalian ADP-ribosyltransferases.

PubMed ID: 20106667

DOI: 10.1016/j.tibs.2009.12.003

Sequence Information:

  • Length: 314
  • Mass: 35879
  • Checksum: 1744A8E4B7FD158F
  • Sequence:
    • MGPLINRCKK ILLPTTVPPA TMRIWLLGGL LPFLLLLSGL QRPTEGSEVA IKIDFDFAPG 
SFDDQYQGCS KQVMEKLTQG DYFTKDIEAQ KNYFRMWQKA HLAWLNQGKV LPQNMTTTHA 
VAILFYTLNS NVHSDFTRAM ASVARTPQQY ERSFHFKYLH YYLTSAIQLL RKDSIMENGT 
LCYEVHYRTK DVHFNAYTGA TIRFGQFLST SLLKEEAQEF GNQTLFTIFT CLGAPVQYFS 
LKKEVLIPPY ELFKVINMSY HPRGDWLQLR STGNLSTYNC QLLKASSKKC IPDPIAIASL 
SFLTSVIIFS KSRV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.