Details for: ARVCF

Gene ID: 421

Symbol: ARVCF

Ensembl ID: ENSG00000099889

Description: ARVCF delta catenin family member

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 82.7734
    Cell Significance Index: -12.8800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 54.2888
    Cell Significance Index: -13.7700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 26.0180
    Cell Significance Index: -10.5700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.6346
    Cell Significance Index: -14.3500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 11.0396
    Cell Significance Index: -10.5400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.9723
    Cell Significance Index: -13.3200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.7126
    Cell Significance Index: -14.6500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7989
    Cell Significance Index: 79.0300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6190
    Cell Significance Index: 558.9200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4141
    Cell Significance Index: 67.3500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3887
    Cell Significance Index: 42.2800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2732
    Cell Significance Index: 16.4000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2683
    Cell Significance Index: 53.8300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2252
    Cell Significance Index: 4.9300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2244
    Cell Significance Index: 44.5300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.2149
    Cell Significance Index: 292.1800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2053
    Cell Significance Index: 142.0000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1610
    Cell Significance Index: 57.7400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1581
    Cell Significance Index: 10.9300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1394
    Cell Significance Index: 4.9000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1365
    Cell Significance Index: 7.6600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1353
    Cell Significance Index: 10.3800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1127
    Cell Significance Index: 5.8700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1090
    Cell Significance Index: 13.9700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1045
    Cell Significance Index: 1.7900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0822
    Cell Significance Index: 15.6400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0802
    Cell Significance Index: 2.3100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0794
    Cell Significance Index: 146.4400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0784
    Cell Significance Index: 120.6300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0761
    Cell Significance Index: 3.4500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0754
    Cell Significance Index: 3.9600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0673
    Cell Significance Index: 36.7500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0584
    Cell Significance Index: 2.0300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0573
    Cell Significance Index: 2.6700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0445
    Cell Significance Index: 83.7900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0434
    Cell Significance Index: 0.9400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0373
    Cell Significance Index: 2.2900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0285
    Cell Significance Index: 12.6000
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.0200
    Cell Significance Index: 0.2300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0113
    Cell Significance Index: 7.1500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0050
    Cell Significance Index: 0.9000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0011
    Cell Significance Index: 0.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0105
    Cell Significance Index: -7.7600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0143
    Cell Significance Index: -10.5200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0167
    Cell Significance Index: -12.6100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0184
    Cell Significance Index: -10.3800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0187
    Cell Significance Index: -3.1900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0225
    Cell Significance Index: -1.4200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0249
    Cell Significance Index: -11.3200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0261
    Cell Significance Index: -16.2800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0271
    Cell Significance Index: -3.5000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0306
    Cell Significance Index: -0.6400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0371
    Cell Significance Index: -10.6800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0382
    Cell Significance Index: -2.8500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0388
    Cell Significance Index: -5.6500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0403
    Cell Significance Index: -4.9600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0413
    Cell Significance Index: -0.8800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0416
    Cell Significance Index: -4.7700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0496
    Cell Significance Index: -5.7800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0512
    Cell Significance Index: -7.0300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0529
    Cell Significance Index: -1.4400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0692
    Cell Significance Index: -4.2400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0709
    Cell Significance Index: -14.9300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0761
    Cell Significance Index: -1.0900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0764
    Cell Significance Index: -7.8100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0819
    Cell Significance Index: -3.8500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0855
    Cell Significance Index: -2.7400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0906
    Cell Significance Index: -6.4100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1097
    Cell Significance Index: -12.9400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1114
    Cell Significance Index: -2.9300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1159
    Cell Significance Index: -6.0200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1161
    Cell Significance Index: -3.4200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1311
    Cell Significance Index: -3.3700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1336
    Cell Significance Index: -13.9100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1390
    Cell Significance Index: -2.9100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1417
    Cell Significance Index: -9.5300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1517
    Cell Significance Index: -9.7900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1528
    Cell Significance Index: -12.1000
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1533
    Cell Significance Index: -0.9100
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.1847
    Cell Significance Index: -1.1600
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.1905
    Cell Significance Index: -2.8500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2222
    Cell Significance Index: -5.3300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2226
    Cell Significance Index: -3.7300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2229
    Cell Significance Index: -9.8600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2261
    Cell Significance Index: -3.9100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2644
    Cell Significance Index: -8.4200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2736
    Cell Significance Index: -10.3600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2776
    Cell Significance Index: -9.0900
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.2811
    Cell Significance Index: -4.5200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2849
    Cell Significance Index: -9.9800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2878
    Cell Significance Index: -5.6900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2926
    Cell Significance Index: -4.4100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3043
    Cell Significance Index: -9.6300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3108
    Cell Significance Index: -8.8700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3116
    Cell Significance Index: -7.9600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3168
    Cell Significance Index: -6.3600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3261
    Cell Significance Index: -4.8200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3288
    Cell Significance Index: -8.7800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3323
    Cell Significance Index: -7.1800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.3346
    Cell Significance Index: -8.1100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cell-cell adhesion**: ARVCF is a key component of adherens junctions, which are essential for maintaining cell-cell adhesion and tissue structure. 2. **Delta catenin family member**: ARVCF is a member of the delta catenin family, which is characterized by its ability to interact with cadherins and other adhesion molecules. 3. **Expression in various tissues**: ARVCF is widely expressed in tissues such as the lens, heart, brain, and immune cells, highlighting its importance in maintaining tissue homeostasis. 4. **Regulation of immune responses**: ARVCF has been implicated in the regulation of immune responses, particularly in the context of innate lymphoid cell development. **Pathways and Functions:** 1. **Adherens junction formation**: ARVCF interacts with cadherins and other adhesion molecules to form adherens junctions, which are essential for maintaining cell-cell adhesion and tissue structure. 2. **Cell signaling**: ARVCF modulates cell signaling pathways, including the Wnt/β-catenin pathway, to regulate cellular homeostasis and immune responses. 3. **RNA processing**: ARVCF is involved in RNA processing, including splicing and mRNA stability, which is critical for maintaining cellular homeostasis. 4. **Protein binding**: ARVCF interacts with various proteins, including cadherins, E-cadherin, and N-cadherin, to regulate cell-cell adhesion and tissue structure. **Clinical Significance:** 1. **Lens disorders**: Mutations in ARVCF have been associated with lens disorders, such as cataracts and glaucoma, highlighting its role in maintaining lens cell adhesion and function. 2. **Cardiac disorders**: ARVCF has been implicated in cardiac disorders, including arrhythmias and cardiac hypertrophy, suggesting its importance in maintaining cardiac cell-cell adhesion and function. 3. **Immune disorders**: ARVCF has been linked to immune disorders, including autoimmune diseases and cancer, highlighting its role in regulating immune responses and tissue homeostasis. 4. **Cancer progression**: ARVCF has been implicated in cancer progression, particularly in the context of epithelial-to-mesenchymal transition (EMT), suggesting its potential as a therapeutic target. In conclusion, ARVCF is a critical component of adherens junctions, regulating cell-cell adhesion and tissue integrity. Its involvement in various cellular processes, including immune responses and tissue development, highlights its clinical significance in maintaining tissue homeostasis and preventing disorders. Further research is necessary to fully elucidate the role of ARVCF in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 3991344715

Symbol: ARVC_HUMAN

Name: N/A

UniProtKB Accession Codes:

O00192 B7WNV2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9126485

Title: Identification of a new human catenin gene family member (ARVCF) from the region deleted in velo-cardio-facial syndrome.

PubMed ID: 9126485

DOI: 10.1006/geno.1997.4627

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 10725230

Title: ARVCF localizes to the nucleus and adherens junction and is mutually exclusive with p120(ctn) in E-cadherin complexes.

PubMed ID: 10725230

DOI: 10.1242/jcs.113.8.1481

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19706687

Title: PDZ-domain-directed basolateral targeting of the peripheral membrane protein FRMPD2 in epithelial cells.

PubMed ID: 19706687

DOI: 10.1242/jcs.046854

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24644279

Title: Nuclear ARVCF protein binds splicing factors and contributes to the regulation of alternative splicing.

PubMed ID: 24644279

DOI: 10.1074/jbc.m113.530717

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25009281

Title: DIPA-family coiled-coils bind conserved isoform-specific head domain of p120-catenin family: potential roles in hydrocephalus and heterotopia.

PubMed ID: 25009281

DOI: 10.1091/mbc.e13-08-0492

PubMed ID: 29034528

Title: Patients with a new variant of endemic pemphigus foliaceus have autoantibodies against arrector pili muscle, colocalizing with MYZAP, p0071, desmoplakins 1 and 2 and ARVCF.

PubMed ID: 29034528

DOI: 10.1111/ced.13214

PubMed ID: 30479852

Title: Subclinical oral involvement in patients with endemic pemphigus foliaceus.

PubMed ID: 30479852

DOI: 10.5826/dpc.0804a02

Sequence Information:

  • Length: 962
  • Mass: 104642
  • Checksum: 74A1814A022FF2B1
  • Sequence:
    • MEDCNVHSAA SILASVKEQE ARFERLTRAL EQERRHVALQ LERAQQPGMV SGGMGSGQPL 
PMAWQQLVLQ EQSPGSQASL ATMPEAPDVL EETVTVEEDP GTPTSHVSIV TSEDGTTRRT 
ETKVTKTVKT VTTRTVRQVP VGPDGLPLLD GGPPLGPFAD GALDRHFLLR GGGPVATLSR 
AYLSSGGGFP EGPEPRDSPS YGSLSRGLGM RPPRAGPLGP GPGDGCFTLP GHREAFPVGP 
EPGPPGGRSL PERFQAEPYG LEDDTRSLAA DDEGGPELEP DYGTATRRRP ECGRGLHTRA 
YEDTADDGGE LADERPAFPM VTAPLAQPER GSMGSLDRLV RRSPSVDSAR KEPRWRDPEL 
PEVLAMLRHP VDPVKANAAA YLQHLCFENE GVKRRVRQLR GLPLLVALLD HPRAEVRRRA 
CGALRNLSYG RDTDNKAAIR DCGGVPALVR LLRAARDNEV RELVTGTLWN LSSYEPLKMV 
IIDHGLQTLT HEVIVPHSGW EREPNEDSKP RDAEWTTVFK NTSGCLRNVS SDGAEARRRL 
RECEGLVDAL LHALQSAVGR KDTDNKSVEN CVCIMRNLSY HVHKEVPGAD RYQEAEPGPL 
GSAVGSQRRR RDDASCFGGK KAKEEWFHQG KKDGEMDRNF DTLDLPKRTE AAKGFELLYQ 
PEVVRLYLSL LTESRNFNTL EAAAGALQNL SAGNWMWATY IRATVRKERG LPVLVELLQS 
ETDKVVRAVA IALRNLSLDR RNKDLIGSYA MAELVRNVRN AQAPPRPGAC LEEDTVVAVL 
NTIHEIVSDS LDNARSLLQA RGVPALVALV ASSQSVREAK AASHVLQTVW SYKELRGTLQ 
KDGWTKARFQ SAAATAKGPK GALSPGGFDD STLPLVDKSL EGEKTGSRDV IPMDALGPDG 
YSTVDRRERR PRGASSAGEA SEKEPLKLDP SRKAPPPGPS RPAVRLVDAV GDAKPQPVDS 
WV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.