htl | FBgn0010389 | NCBI 42160

Details for: htl

Gene ID: 42160

Symbol: htl

Ensembl ID: FBgn0010389

Description: heartless

Associated with

Betaklotho-mediated ligand binding
(R-DME-1307965)
Downstream signaling of activated fgfr2
(R-DME-5654696)
Downstream signaling of activated fgfr3
(R-DME-5654708)
Downstream signaling of activated fgfr4
(R-DME-5654716)
Fgfr2 ligand binding and activation
(R-DME-190241)
Fgfr2b ligand binding and activation
(R-DME-190377)
Fgfr2c ligand binding and activation
(R-DME-190375)
Fgfr3 ligand binding and activation
(R-DME-190239)
Fgfr3b ligand binding and activation
(R-DME-190371)
Fgfr3c ligand binding and activation
(R-DME-190372)
Fgfr4 ligand binding and activation
(R-DME-190322)
Frs-mediated fgfr2 signaling
(R-DME-5654700)
Frs-mediated fgfr3 signaling
(R-DME-5654706)
Frs-mediated fgfr4 signaling
(R-DME-5654712)
Igf1r signaling cascade
(R-DME-2428924)
Insulin receptor signalling cascade
(R-DME-74751)
Intracellular signaling by second messengers
(R-DME-9006925)
Irs-mediated signalling
(R-DME-112399)
Irs-related events triggered by igf1r
(R-DME-2428928)
Mapk1/mapk3 signaling
(R-DME-5684996)
Mapk family signaling cascades
(R-DME-5683057)
Negative regulation of fgfr2 signaling
(R-DME-5654727)
Negative regulation of fgfr3 signaling
(R-DME-5654732)
Negative regulation of fgfr4 signaling
(R-DME-5654733)
Negative regulation of the pi3k/akt network
(R-DME-199418)
Phospholipase c-mediated cascade; fgfr2
(R-DME-5654221)
Phospholipase c-mediated cascade; fgfr3
(R-DME-5654227)
Phospholipase c-mediated cascade; fgfr4
(R-DME-5654228)
Pi-3k cascade:fgfr2
(R-DME-5654695)
Pi-3k cascade:fgfr3
(R-DME-5654710)
Pi-3k cascade:fgfr4
(R-DME-5654720)
Pi3k cascade
(R-DME-109704)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-DME-6811558)
Pip3 activates akt signaling
(R-DME-1257604)
Raf/map kinase cascade
(R-DME-5673001)
Shc-mediated cascade:fgfr2
(R-DME-5654699)
Shc-mediated cascade:fgfr3
(R-DME-5654704)
Shc-mediated cascade:fgfr4
(R-DME-5654719)
Signaling by fgfr
(R-DME-190236)
Signaling by fgfr2
(R-DME-5654738)
Signaling by fgfr3
(R-DME-5654741)
Signaling by fgfr4
(R-DME-5654743)
Signaling by insulin receptor
(R-DME-74752)
Signaling by receptor tyrosine kinases
(R-DME-9006934)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-DME-2404192)
Signal transduction
(R-DME-162582)
Atp binding
(GO:0005524)
Cardioblast differentiation
(GO:0010002)
Central nervous system development
(GO:0007417)
Defense response to gram-negative bacterium
(GO:0050829)
Endodermal cell fate determination
(GO:0007493)
Fibroblast growth factor receptor activity
(GO:0005007)
Fibroblast growth factor receptor signaling pathway
(GO:0008543)
Germ cell migration
(GO:0008354)
Glial cell development
(GO:0021782)
Glial cell differentiation
(GO:0010001)
Glial cell growth
(GO:0042065)
Glial cell migration
(GO:0008347)
Glial cell projection elongation
(GO:0106091)
Gonadal mesoderm development
(GO:0007506)
Heart development
(GO:0007507)
Larval visceral muscle development
(GO:0007523)
Lymph gland crystal cell differentiation
(GO:0035170)
Lymph gland development
(GO:0048542)
Lymph gland plasmatocyte differentiation
(GO:0035169)
Mesodermal cell fate commitment
(GO:0001710)
Mesodermal cell fate determination
(GO:0007500)
Mesodermal cell migration
(GO:0008078)
Mesoderm migration involved in gastrulation
(GO:0007509)
Multicellular organism development
(GO:0007275)
Muscle cell development
(GO:0055001)
Myoblast fate specification
(GO:0048626)
Myotube cell migration
(GO:0110122)
Pericardial nephrocyte differentiation
(GO:0061320)
Plasma membrane
(GO:0005886)
Pole cell migration
(GO:0007280)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of glial cell migration
(GO:1903977)
Positive regulation of innate immune response
(GO:0045089)
Positive regulation of kinase activity
(GO:0033674)
Positive regulation of synaptic assembly at neuromuscular junction
(GO:0045887)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein tyrosine kinase activity
(GO:0004713)
Regulation of cell shape
(GO:0008360)
Salivary gland development
(GO:0007431)
Somatic muscle development
(GO:0007525)
Transmembrane receptor protein tyrosine kinase activity
(GO:0004714)
Transmembrane receptor protein tyrosine kinase signaling pathway
(GO:0007169)
Ventral cord development
(GO:0007419)
Visceral muscle development
(GO:0007522)

Other Information

Proteins

Fibroblast growth factor receptor homolog 1

Genular Protein ID: 3659428230

Symbol: FGFR1_DROME

Name: Fibroblast growth factor receptor homolog 1

UniProtKB Accession Codes:

Q07407 A4V320 O18371 Q26294 Q9VED5

Database IDs:

Citations:

PubMed ID: 8330538

Title: Two FGF-receptor homologues of Drosophila: one is expressed in mesodermal primordium in early embryos.

PubMed ID: 8330538

DOI: 10.1242/dev.117.2.751

PubMed ID: 8112607

Title: Alternative splicing generates two distinct transcripts for the Drosophila melanogaster fibroblast growth factor receptor homolog.

PubMed ID: 8112607

DOI: 10.1016/0378-1119(94)90758-7

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537569

Title: A Drosophila full-length cDNA resource.

PubMed ID: 12537569

DOI: 10.1186/gb-2002-3-12-research0080

PubMed ID: 1915852

Title: Identification of seven novel protein-tyrosine kinase genes of Drosophila by the polymerase chain reaction.

PubMed ID: 1915852

DOI: 10.1016/0014-5793(91)81078-m

PubMed ID: 9731193

Title: Sampling the genomic pool of protein tyrosine kinase genes using the polymerase chain reaction with genomic DNA.

PubMed ID: 9731193

DOI: 10.1006/bbrc.1998.9003

Sequence Information:

Length: 729
Mass: 82586
Checksum: 199166043EC87386
Sequence:

MAAAWSWRAS HSTITMTSGS LVVLFLLLSI WQPAVQVEGR RQMANSQEMI KDHLGARSQN 
KTPAITNNAN QSSTSSADLD DGAADDDDNK ADLPVNVSSK PYWRNPKKMS FLQTRPSGSL 
LTLNCHALGN PEPNITWYRN GTVDWTRGYG SLKRNRWTLT MEDLVPGDCG NYTCKVCNSL 
GCIRHDTQVI VSDRVNHKPI LMTGPLNLTL VVNSTGSMHC KYLSDLTSKK AWIFVPCHGM 
TNCSNNRSII AEDKDQLDFV NVRMEQEGWY TCVESNSLGQ SNSTAYLRVV RSLHVLEAGV 
ASGSLHSTSF VYIFVFGGLI FIFMTTLFVF YAIRKMKHEK VLKQRIETVH QWTKKVIIFK 
PEGGGDSSGS MDTMIMPVVR IQKQRTTVLQ NGNEPAPFNE YEFPLDSNWE LPRSHLVLGA 
TLGEGAFGRV VMAEVNNAIV AVKMVKEGHT DDDIASLVRE MEVMKIIGRH INIINLLGCC 
SQNGPLYVIV EYAPHGNLKD FLYKNRPFGR DQDRDSSQPP PSPPAHVITE KDLIKFAHQI 
ARGMDYLASR RCIHRDLAAR NVLVSDDYVL KIADFGLARD IQSTDYYRKN TNGRLPIKWM 
APESLQEKFY DSKSDVWSYG ILLWEIMTYG QQPYPTIMSA EELYTYLMSG QRMEKPAKCS 
MNIYILMRQC WHFNADDRPP FTEIVEYMDK LLQTKEDYLD VDIANLDTPP STSDEEEDET 
DNLQKWCNY

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: htl

Associated with

Other Information

Two FGF-receptor homologues of Drosophila: one is expressed in mesodermal primordium in early embryos. PubMed ID: 8330538

Alternative splicing generates two distinct transcripts for the Drosophila melanogaster fibroblast growth factor receptor homolog. PubMed ID: 8112607

The genome sequence of Drosophila melanogaster. PubMed ID: 10731132

Annotation of the Drosophila melanogaster euchromatic genome: a systematic review. PubMed ID: 12537572

A Drosophila full-length cDNA resource. PubMed ID: 12537569

Identification of seven novel protein-tyrosine kinase genes of Drosophila by the polymerase chain reaction. PubMed ID: 1915852

Sampling the genomic pool of protein tyrosine kinase genes using the polymerase chain reaction with genomic DNA. PubMed ID: 9731193