Details for: Cpsf73

Gene ID: 42240

Symbol: Cpsf73

Ensembl ID: FBgn0261065

Description: Cleavage and polyadenylation specificity factor 73

Associated with

  • Gene expression (transcription)
    (R-DME-74160)
  • Metabolism of rna
    (R-DME-8953854)
  • Mrna 3'-end processing
    (R-DME-72187)
  • Processing of capped intron-containing pre-mrna
    (R-DME-72203)
  • Processing of capped intronless pre-mrna
    (R-DME-75067)
  • Processing of intronless pre-mrnas
    (R-DME-77595)
  • Rna polymerase ii transcription
    (R-DME-73857)
  • Rna polymerase ii transcription termination
    (R-DME-73856)
  • Transport of mature mrna derived from an intronless transcript
    (R-DME-159231)
  • Transport of mature mrnas derived from intronless transcripts
    (R-DME-159234)
  • Transport of mature transcript to cytoplasm
    (R-DME-72202)
  • 5'-3' rna exonuclease activity
    (GO:0004534)
  • Co-transcriptional mrna 3'-end processing, cleavage and polyadenylation pathway
    (GO:0180010)
  • Mrna 3'-end processing by stem-loop binding and cleavage
    (GO:0006398)
  • Mrna cleavage and polyadenylation specificity factor complex
    (GO:0005847)
  • Protein binding
    (GO:0005515)
  • Rna binding
    (GO:0003723)
  • Rna endonuclease activity
    (GO:0004521)

Other Information

Genular Protein ID: 1207815684

Symbol: CPSF3_DROME

Name: N/A

UniProtKB Accession Codes:

Q9VE51

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 9 ChiTaRS 1 ComplexPortal 1 DNASU 1 EMBL 2 EnsemblMetazoa 1 FlyBase 1 GO 7 Gene3D 2 GeneTree 1 GenomeRNAi 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRO 1 PaxDb 1 Pfam 4 PhylomeDB 1 Proteomes 1 Reactome 5 RefSeq 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 UCSC 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537569

Title: A Drosophila full-length cDNA resource.

PubMed ID: 12537569

DOI: 10.1186/gb-2002-3-12-research0080

PubMed ID: 18042462

Title: A genome-wide RNA interference screen reveals that variant histones are necessary for replication-dependent histone pre-mRNA processing.

PubMed ID: 18042462

DOI: 10.1016/j.molcel.2007.10.009

PubMed ID: 19450530

Title: A core complex of CPSF73, CPSF100, and Symplekin may form two different cleavage factors for processing of poly(A) and histone mRNAs.

PubMed ID: 19450530

DOI: 10.1016/j.molcel.2009.04.024

PubMed ID: 19854135

Title: FLASH, a proapoptotic protein involved in activation of caspase-8, is essential for 3' end processing of histone pre-mRNAs.

PubMed ID: 19854135

DOI: 10.1016/j.molcel.2009.08.016

PubMed ID: 21078872

Title: A subset of Drosophila integrator proteins is essential for efficient U7 snRNA and spliceosomal snRNA 3'-end formation.

PubMed ID: 21078872

DOI: 10.1128/mcb.00943-10

Sequence Information:

  • Length: 684
  • Mass: 76826
  • Checksum: F059330C06BFEC53
  • Sequence:
    • MTQATGDARM PDEESDLLQI KPLGAGQEVG RSCIMLEFKG KKIMLDCGIH PGLSGMDALP 
YVDLIEADEI DLLFISHFHL DHCGALPWFL MKTSFKGRCF MTHATKAIYR WMLSDYIKIS 
NISTEQMLYT EADLEASMEK IETINFHEER DVMGVRFCAY IAGHVLGAAM FMIEIAGIKI 
LYTGDFSRQE DRHLMAAEVP PMKPDVLITE STYGTHIHEK REDRENRFTS LVQKIVQQGG 
RCLIPVFALG RAQELLLILD EFWSQNPDLH EIPIYYASSL AKKCMAVYQT YINAMNDRIR 
RQIAVNNPFV FRHISNLKGI DHFEDIGPCV IMASPGMMQS GLSRELFESW CTDPKNGVII 
AGYCVEGTLA KAVLSEPEEI TTLSGQKLPL NMSVDYISFS AHTDYQQTSE FIRLLKPTHV 
VLVHGEQNEM SRLKLALQRE YEADASTDIK FYNPRNTHAV DLYFRGEKTA KVMGSLAAKN 
SEVGSKLSGV LVKRDFKYHL LAPSDLGKYT DMSMSVVTQR QSIPWGSSLS TLELLLDRIG 
AGCVEVLEAE RKLRVFGCIE LTVEQKIIVM EWQATHVNDV YADAVLACIM QSELGGTNLK 
GATKQTKSED SRFRECLIET LQDTFGDNCV PKMFEGDLLP VTVSGKRAEI NLETLAISCA 
EDDVLRQMLN TTVQKLHQTL VSAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.