Cdk2 | FBgn0004107 | NCBI 42453

Details for: Cdk2

Gene ID: 42453

Symbol: Cdk2

Ensembl ID: FBgn0004107

Description: Cyclin-dependent kinase 2

Associated with

Activation of atr in response to replication stress
(R-DME-176187)
Activation of the pre-replicative complex
(R-DME-68962)
Apc/c-mediated degradation of cell cycle proteins
(R-DME-174143)
Cdk-mediated phosphorylation and removal of cdc6
(R-DME-69017)
Cell cycle
(R-DME-1640170)
Cell cycle, mitotic
(R-DME-69278)
Cell cycle checkpoints
(R-DME-69620)
Cellular responses to stimuli
(R-DME-8953897)
Cellular responses to stress
(R-DME-2262752)
Cellular senescence
(R-DME-2559583)
Cyclin a:cdk2-associated events at s phase entry
(R-DME-69656)
Cyclin e associated events during g1/s transition
(R-DME-69202)
Developmental biology
(R-DME-1266738)
Dna damage/telomere stress induced senescence
(R-DME-2559586)
Dna double-strand break repair
(R-DME-5693532)
Dna repair
(R-DME-73894)
Dna replication
(R-DME-69306)
Dna replication pre-initiation
(R-DME-69002)
G0 and early g1
(R-DME-1538133)
G1/s dna damage checkpoints
(R-DME-69615)
G1/s transition
(R-DME-69206)
G2 phase
(R-DME-68911)
G2/m checkpoints
(R-DME-69481)
Gene expression (transcription)
(R-DME-74160)
Generic transcription pathway
(R-DME-212436)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-DME-5693567)
Homology directed repair
(R-DME-5693538)
Mitotic g1 phase and g1/s transition
(R-DME-453279)
Mitotic g2-g2/m phases
(R-DME-453274)
Orc1 removal from chromatin
(R-DME-68949)
P53-dependent g1 dna damage response
(R-DME-69563)
P53-dependent g1/s dna damage checkpoint
(R-DME-69580)
Processing of dna double-strand break ends
(R-DME-5693607)
Regulation of apc/c activators between g1/s and early anaphase
(R-DME-176408)
Regulation of mitotic cell cycle
(R-DME-453276)
Regulation of tp53 activity
(R-DME-5633007)
Regulation of tp53 activity through phosphorylation
(R-DME-6804756)
Rna polymerase ii transcription
(R-DME-73857)
Scf(skp2)-mediated degradation of p27/p21
(R-DME-187577)
Senescence-associated secretory phenotype (sasp)
(R-DME-2559582)
S phase
(R-DME-69242)
Switching of origins to a post-replicative state
(R-DME-69052)
Synthesis of dna
(R-DME-69239)
Tp53 regulates transcription of cell cycle genes
(R-DME-6791312)
Tp53 regulates transcription of genes involved in g1 cell cycle arrest
(R-DME-6804116)
Transcriptional regulation by tp53
(R-DME-3700989)
Transcriptional regulation of granulopoiesis
(R-DME-9616222)
Atp binding
(GO:0005524)
Cyclin-dependent protein kinase holoenzyme complex
(GO:0000307)
Cyclin-dependent protein serine/threonine kinase activity
(GO:0004693)
Cyclin binding
(GO:0030332)
Cytoplasm
(GO:0005737)
G1/s transition of mitotic cell cycle
(GO:0000082)
G2/m transition of mitotic cell cycle
(GO:0000086)
Nucleus
(GO:0005634)
Positive regulation of receptor signaling pathway via jak-stat
(GO:0046427)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Regulation of g2/m transition of mitotic cell cycle
(GO:0010389)
Regulation of gene expression
(GO:0010468)
Response to organic substance
(GO:0010033)
Signal transduction
(GO:0007165)

Other Information

Proteins

Cell division control protein 2 cognate

Genular Protein ID: 2425385319

Symbol: CDK2_DROME

Name: Cell division control protein 2 cognate

UniProtKB Accession Codes:

P23573 Q0KI40 Q9TXB2 Q9VDJ4

Database IDs:

Citations:

PubMed ID: 2120045

Title: Drosophila cdc2 homologs: a functional homolog is coexpressed with a cognate variant.

PubMed ID: 2120045

DOI: 10.1002/j.1460-2075.1990.tb07568.x

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537569

Title: A Drosophila full-length cDNA resource.

PubMed ID: 12537569

DOI: 10.1186/gb-2002-3-12-research0080

PubMed ID: 1378625

Title: Primary structure, expression, and signal-dependent tyrosine phosphorylation of a Drosophila homolog of extracellular signal-regulated kinase.

PubMed ID: 1378625

DOI: 10.1073/pnas.89.14.6295

PubMed ID: 18327897

Title: Phosphoproteome analysis of Drosophila melanogaster embryos.

PubMed ID: 18327897

DOI: 10.1021/pr700696a

PubMed ID: 21311225

Title: Drosophila melanogaster Cyclin G coordinates cell growth and cell proliferation.

PubMed ID: 21311225

DOI: 10.4161/cc.10.5.14959

Sequence Information:

Length: 314
Mass: 35888
Checksum: 576A88767F9D35C0
Sequence:

MTTILDNFQR AEKIGEGTYG IVYKARSNST GQDVALKKIR LEGETEGVPS TAIREISLLK 
NLKHPNVVQL FDVVISGNNL YMIFEYLNMD LKKLMDKKKD VFTPQLIKSY MHQILDAVGF 
CHTNRILHRD LKPQNLLVDT AGKIKLADFG LARAFNVPMR AYTHEVVTLW YRAPEILLGT 
KFYSTGVDIW SLGCIFSEMI MRRSLFPGDS EIDQLYRIFR TLSTPDETNW PGVTQLPDFK 
TKFPRWEGTN MPQPITEHEA HELIMSMLCY DPNLRISAKD ALQHAYFRNV QHVDHVALPV 
DPNAGSASRL TRLV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cdk2

Associated with

Other Information

Drosophila cdc2 homologs: a functional homolog is coexpressed with a cognate variant. PubMed ID: 2120045

The genome sequence of Drosophila melanogaster. PubMed ID: 10731132

Annotation of the Drosophila melanogaster euchromatic genome: a systematic review. PubMed ID: 12537572

A Drosophila full-length cDNA resource. PubMed ID: 12537569

Primary structure, expression, and signal-dependent tyrosine phosphorylation of a Drosophila homolog of extracellular signal-regulated kinase. PubMed ID: 1378625

Phosphoproteome analysis of Drosophila melanogaster embryos. PubMed ID: 18327897

Drosophila melanogaster Cyclin G coordinates cell growth and cell proliferation. PubMed ID: 21311225