Details for: E2f1

Gene ID: 42550

Symbol: E2f1

Ensembl ID: FBgn0011766

Description: E2F transcription factor 1

Associated with

  • Cellular response to gamma radiation
    (GO:0071480)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription factor binding
    (GO:0140297)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dna binding
    (GO:0003677)
  • Dna endoreduplication
    (GO:0042023)
  • Eggshell chorion gene amplification
    (GO:0007307)
  • G1/s transition of mitotic cell cycle
    (GO:0000082)
  • Larval lymph gland hemopoiesis
    (GO:0035167)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleus
    (GO:0005634)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of dna endoreduplication
    (GO:0032877)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of nurse cell apoptotic process
    (GO:0045850)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Protein dimerization activity
    (GO:0046983)
  • Rb-e2f complex
    (GO:0035189)
  • Regulation of cell cycle
    (GO:0051726)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of execution phase of apoptosis
    (GO:1900117)
  • Regulation of gene expression
    (GO:0010468)
  • Regulation of hemocyte proliferation
    (GO:0035206)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulator complex
    (GO:0090575)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific dna binding
    (GO:0043565)
  • Transcription regulator complex
    (GO:0005667)
  • Ventral cord development
    (GO:0007419)

Other Information

Genular Protein ID: 1497843631

Symbol: E2F1_DROME

Name: Transcription factor E2f1

UniProtKB Accession Codes:

Q27368 O77035 Q5U0Z6

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DIP 1 ELM 1 EMBL 7 EnsemblMetazoa 4 ExpressionAtlas 1 FlyBase 2 GO 29 Gene3D 2 GeneTree 1 Genevisible 1 GenomeRNAi 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 NCBI Taxonomy 1 PANTHER 2 PIR 1 PRO 1 PaxDb 1 Pfam 2 PhylomeDB 1 Proteomes 1 Reactome 3 RefSeq 4 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 8114698

Title: Functional properties of a Drosophila homolog of the E2F1 gene.

PubMed ID: 8114698

DOI: 10.1128/mcb.14.3.1603-1612.1994

PubMed ID: 8022787

Title: DNA-binding and trans-activation properties of Drosophila E2F and DP proteins.

PubMed ID: 8022787

DOI: 10.1073/pnas.91.14.6359

PubMed ID: 9858578

Title: Specification of regions of DNA replication initiation during embryogenesis in the 65-kilobase DNApolalpha-dE2F locus of Drosophila melanogaster.

PubMed ID: 9858578

DOI: 10.1128/mcb.19.1.547

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 8537434

Title: Functional conservation of the cell cycle-regulating transcription factor DRTF1/E2F and its pathway of control in Drosophila melanogaster.

PubMed ID: 8537434

DOI: 10.1242/jcs.108.9.2945

PubMed ID: 9271122

Title: Mutations in Drosophila DP and E2F distinguish G1-S progression from an associated transcriptional program.

PubMed ID: 9271122

DOI: 10.1101/gad.11.15.1999

PubMed ID: 9418862

Title: Mutations of the Drosophila dDP, dE2F, and cyclin E genes reveal distinct roles for the E2F-DP transcription factor and cyclin E during the G1-S transition.

PubMed ID: 9418862

DOI: 10.1128/mcb.18.1.141

PubMed ID: 14526388

Title: The Drosophila wing differentiation factor vestigial-scalloped is required for cell proliferation and cell survival at the dorso-ventral boundary of the wing imaginal disc.

PubMed ID: 14526388

DOI: 10.1038/sj.cdd.4401321

PubMed ID: 19081076

Title: Intrinsic negative cell cycle regulation provided by PIP box- and Cul4Cdt2-mediated destruction of E2f1 during S phase.

PubMed ID: 19081076

DOI: 10.1016/j.devcel.2008.10.003

PubMed ID: 18327897

Title: Phosphoproteome analysis of Drosophila melanogaster embryos.

PubMed ID: 18327897

DOI: 10.1021/pr700696a

Sequence Information:

  • Length: 805
  • Mass: 87460
  • Checksum: BD49C813DDB2A77D
  • Sequence:
    • MSKFFVNVAP INNSNSSSSH TTTSSNTQRH QQHQQHYGGS GTTGHTMVAR RLNYDLHGGT 
TSINNNNNIV IKNESVDLDY DHVLSSSDSN SNGGVAAHLR DHVYISLDKG HNTGAVATAA 
AAATAGHTQQ QLQQQHHHQN QQQRKATGKS NDITNYYKVK RRPHAVSDEI HPKKQAKQSA 
HHQTVYQKHT ASSAPQQLRH SHHQLRHDAD AELDEDVVER VAKPASHHPF SLSTPQQQLA 
ASVASSSSSG DRNRADTSLG ILTKKFVDLL QESPDGVVDL NEASNRLHVQ KRRIYDITNV 
LEGINILEKK SKNNIQWRCG QSMVSQERSR HIEADSLRLE QQENELNKAI DLMRENLAEI 
SQEVENSGGM AYVTQNDLLN VDLFKDQIVI VIKAPPEAKL VLPNTKLPRE IYVKAENSGE 
INVFLCHDTS PENSPIAPGA GYVGAPGAGC VRTATSTRLH PLTNQRLNDP LFNNIDAMST 
KGLFQTPYRS ARNLSKSIEE AAKQSQPEYN NICDIAMGQH HNLNQQQQQQ QQQLLQQPEE 
DDVDVELNQL VPTLTNPVVR THQFQQHQQP SIQELFSSLT ESSPPTPTKR RREAAAAAIA 
AGSSTTATTT LNSHNNRNHS NHSNHSNHSS SNNSKSQPPT IGYGSSQRRS DVPMYNCAME 
GATTTSATAD TTAATSRSAA ASSLQMQFAA VAESNNGSSS GGGGGGGGYG SIAGAGANAD 
PHQPYSHDRN SLPPGVADCD ANSNSSSVTL QGLDALFNDI GSDYFSNDIA FVSINPPDDN 
DYPYALNANE GIDRLFDFGS DAYGP

Genular Protein ID: 3346779395

Symbol: A0A0B4KGM3_DROME

Name: N/A

UniProtKB Accession Codes:

A0A0B4KGM3

Database IDs:

AGR 1 ARBA 3 AlphaFoldDB 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 EMBL 4 EnsemblMetazoa 2 ExpressionAtlas 1 FlyBase 2 GO 5 Gene3D 2 GeneTree 1 GenomeRNAi 1 InterPro 6 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 Pfam 2 Proteomes 2 RefSeq 2 RuleBase 1 SAM 2 SMART 2 SMR 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537568

Title: Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence.

PubMed ID: 12537568

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537573

Title: The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective.

PubMed ID: 12537573

PubMed ID: 12537574

Title: Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.

PubMed ID: 12537574

PubMed ID: 16110336

Title: Combined evidence annotation of transposable elements in genome sequences.

PubMed ID: 16110336

DOI: 10.1371/journal.pcbi.0010022

PubMed ID: 17569856

Title: The Release 5.1 annotation of Drosophila melanogaster heterochromatin.

PubMed ID: 17569856

DOI: 10.1126/science.1139815

PubMed ID: 17569867

Title: Sequence finishing and mapping of Drosophila melanogaster heterochromatin.

PubMed ID: 17569867

DOI: 10.1126/science.1139816

PubMed ID: 26109357

Title: Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.

PubMed ID: 26109357

DOI: .1534/g3.115.018929

PubMed ID: 26109356

Title: Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.

PubMed ID: 26109356

DOI: .1534/g3.115.018937

PubMed ID: 25589440

Title: The Release 6 reference sequence of the Drosophila melanogaster genome.

PubMed ID: 25589440

Sequence Information:

  • Length: 821
  • Mass: 89259
  • Checksum: 8D0DA00A078003AB
  • Sequence:
    • MSKFFVNVAP INNSNSSSSH TTTSSNTQRH QQHQQHYGGS GTTGHTMVAR RLNYDLHGGT 
TSINNNNNIV IKNESVDLDY DHVLSSSDSN SNGGVAAHLR DHVYISLDKG HNTGAVATAA 
AAATAGHTQQ QLQQQHHHQN QQQRKATGKS NDITNYYKVK RRPHAVSDEI HPKKQAKQSA 
HHQTVYQKHT ASSAPQQLRH SHHQLRHDAD AELDEDVVER VAKPASHHPF SLSTPQQQLA 
ASVASSSSSG DRNRADTSLG ILTKKFVDLL QESPDGVVDL NEASNRLHVQ KRRIYDITNV 
LEGINILEKK SKNNIQWRCG QSMVSQERSR HIEADSLRLE QQENELNKAI DLMRENLAEI 
SQEVENSGGM AYVTQNDLLN VDLFKDQIVI VIKAPPEAKL VRSATALKFQ PLPFNLNLPN 
TKLPREIYVK AENSGEINVF LCHDTSPENS PIAPGAGYVG APGAGCVRTA TSTRLHPLTN 
QRLNDPLFNN IDAMSTKGLF QTPYRSARNL SKSIEEAAKQ SQPEYNNICD IAMGQHHNLN 
QQQQQQQQQL LQQPEEDDVD VELNQLVPTL TNPVVRTHQF QQHQQPSIQE LFSSLTESSP 
PTPTKRRREA AAAAIAAGSS TTATTTLNSH NNRNHSNHSN HSNHSSSNNS KSQPPTIGYG 
SSQRRSDVPM YNCAMEGATT TSATADTTAA TSRSAAASSL QMQFAAVAES NNGSSSGGGG 
GGGGYGSIAG AGANADPHQP YSHDRNSLPP GVADCDANSN SSSVTLQGLD ALFNDIGSDY 
FSNDIAFVSI NPPDDNDYPY ALNANEGIDR LFDFGSDAYG P

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.