Details for: wfs1

Gene ID: 42679

Symbol: wfs1

Ensembl ID: FBgn0039003

Description: wolfram syndrome 1

Associated with

  • Metabolism of proteins
    (R-DME-392499)
  • Post-translational protein modification
    (R-DME-597592)
  • Post-translational protein phosphorylation
    (R-DME-8957275)
  • Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
    (R-DME-381426)
  • Adult locomotory behavior
    (GO:0008344)
  • Calcium ion homeostasis
    (GO:0055074)
  • Endoplasmic reticulum membrane
    (GO:0005789)
  • Endoplasmic reticulum unfolded protein response
    (GO:0030968)
  • Negative regulation of gene expression
    (GO:0010629)
  • Ubiquitin protein ligase binding
    (GO:0031625)

Other Information

Genular Protein ID: 614208374

Symbol: WFS1_DROME

Name: N/A

UniProtKB Accession Codes:

Q8IMZ9 A0A0B4JDG5 Q8MS19

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID-ORCS 1 CTD 1 EMBL 3 EnsemblMetazoa 2 ExpressionAtlas 1 FlyBase 1 GO 7 Gene3D 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 HOGENOM 1 InParanoid 1 InterPro 6 KEGG 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PaxDb 1 Pfam 4 PhylomeDB 1 Proteomes 1 Reactome 2 RefSeq 2 SMR 1 STRING 1 TCDB 1 UCSC 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537569

Title: A Drosophila full-length cDNA resource.

PubMed ID: 12537569

DOI: 10.1186/gb-2002-3-12-research0080

PubMed ID: 29357349

Title: Knockdown of wfs1, a fly homolog of Wolfram syndrome 1, in the nervous system increases susceptibility to age- and stress-induced neuronal dysfunction and degeneration in Drosophila.

PubMed ID: 29357349

DOI: 10.1371/journal.pgen.1007196

Sequence Information:

  • Length: 853
  • Mass: 96789
  • Checksum: 9296402B5EDD4886
  • Sequence:
    • MATWTQNEPT GVTKRRRWNL EDRASLNKLK HHIAEEGCPQ MQYDLAKELL DNSIVEPNLA 
KGNQSQKAVN WLVSAAHNGH EDAVKLLRQC YNDGSGITAE NTDEVRRCLA MTPGERAARK 
AARELFACLS NGNEHITPKQ LERKMRRIYN LQRKRRRRDD DRSSSSSEGE QEPECEPLED 
VPTIDLANVE RRRLITEAHL VSAASNYSAG QMPSVNDALT LSVPDPRSLD HVPCFYRMIF 
HPLIFFTLFY HRLLNLIVSI PNVIPLSVRC SVLVAISWWS SRHMLPLVSY YLSLGIMIWA 
TCKMLKTKQQ FVDFRIWSGL FLSYGDQNIE ADIAEHRFLR NNMKPYLYFF CAFICNLIVY 
PLVTDAWLPH SELTIISGAL TFITMCVSMY ASSHQLPDWL VIVSFAVNVL AKYPYEMDEV 
VSTRWRFLDL RVPTFSSFVI GNGIEFCLNC RTALYLFIPV LLIMMAKRSR WHGVYTFLIP 
HCVTLSWLQV CIATSQSSTV FGVMRAALGL AGIVLFLPLF GIVALLVPVF VAIDSLGLAS 
EQLRWGSTAL ACGLVVVLSC ILALNRATQK YITMLQLITA ITTACLLVLP YMTSSFKDTP 
RFNAMPRAGL HSLSETNTLP WDRFHALCAQ PVHEQPNKIK AQLRCSLLNG MPVIWEGSVT 
KVEISRVSNF LEDTIANYLP VWLGRMLRCL HGENISQHFK CDPKLDAQCE EWRSVFKTFN 
AQSGSCTLQR WNRYEYELLV KVGTKRSGRL LGRSTTTDVI LRAHHDFGNF TRLLSEGDVV 
LFYGILHNSR LLADNVQVKL KTIECVECRS RDLGTASIER VVAASPMDAR LQDLMRGIKY 
LLNALLNPLI TFK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.