Details for: Dcr 1

Gene ID: 42693

Symbol: Dcr 1

Ensembl ID: FBgn0039016

Description: Dicer-1

Associated with

Other Information

Genular Protein ID: 3735142862

Symbol: DCR1_DROME

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537569

Title: A Drosophila full-length cDNA resource.

PubMed ID: 12537569

DOI: 10.1186/gb-2002-3-12-research0080

PubMed ID: 11201747

Title: Role for a bidentate ribonuclease in the initiation step of RNA interference.

PubMed ID: 11201747

DOI: 10.1038/35053110

PubMed ID: 11498593

Title: Argonaute2, a link between genetic and biochemical analyses of RNAi.

PubMed ID: 11498593

DOI: 10.1126/science.1064023

PubMed ID: 12368261

Title: A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins.

PubMed ID: 12368261

DOI: 10.1101/gad.1022002

PubMed ID: 15066283

Title: Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways.

PubMed ID: 15066283

DOI: 10.1016/s0092-8674(04)00261-2

PubMed ID: 15985611

Title: Dicer-1 and R3D1-L catalyze microRNA maturation in Drosophila.

PubMed ID: 15985611

DOI: 10.1101/gad.1334005

PubMed ID: 15918769

Title: Processing of pre-microRNAs by the Dicer-1-Loquacious complex in Drosophila cells.

PubMed ID: 15918769

DOI: 10.1371/journal.pbio.0030235

PubMed ID: 16949822

Title: The role of PIWI and the miRNA machinery in Drosophila germline determination.

PubMed ID: 16949822

DOI: 10.1016/j.cub.2006.08.051

PubMed ID: 17666393

Title: Functional anatomy of the Drosophila microRNA-generating enzyme.

PubMed ID: 17666393

DOI: 10.1074/jbc.m705208200

PubMed ID: 17928574

Title: Dicer-1, but not Loquacious, is critical for assembly of miRNA-induced silencing complexes.

PubMed ID: 17928574

DOI: 10.1261/rna.723707

PubMed ID: 18327897

Title: Phosphoproteome analysis of Drosophila melanogaster embryos.

PubMed ID: 18327897

DOI: 10.1021/pr700696a

PubMed ID: 19451544

Title: Characterization of the miRNA-RISC loading complex and miRNA-RISC formed in the Drosophila miRNA pathway.

PubMed ID: 19451544

DOI: 10.1261/rna.1541209

PubMed ID: 19635780

Title: Processing of Drosophila endo-siRNAs depends on a specific Loquacious isoform.

PubMed ID: 19635780

DOI: 10.1261/rna.1611309

PubMed ID: 21419681

Title: Phosphate and R2D2 restrict the substrate specificity of Dicer-2, an ATP-driven ribonuclease.

PubMed ID: 21419681

DOI: 10.1016/j.molcel.2011.03.002

PubMed ID: 21926993

Title: Recognition of the pre-miRNA structure by Drosophila Dicer-1.

PubMed ID: 21926993

DOI: 10.1038/nsmb.2125

PubMed ID: 23063653

Title: Dicer partner proteins tune the length of mature miRNAs in flies and mammals.

PubMed ID: 23063653

DOI: 10.1016/j.cell.2012.09.027

PubMed ID: 24488111

Title: Inorganic phosphate blocks binding of pre-miRNA to Dicer-2 via its PAZ domain.

PubMed ID: 24488111

DOI: 10.1002/embj.201387176

PubMed ID: 36182693

Title: Structural basis of microRNA biogenesis by Dicer-1 and its partner protein Loqs-PB.

PubMed ID: 36182693

DOI: 10.1016/j.molcel.2022.09.002

Sequence Information:

  • Length: 2249
  • Mass: 255330
  • Checksum: D693F0432AC8033D
  • Sequence:
  • MAFHWCDNNL HTTVFTPRDF QVELLATAYE RNTIICLGHR SSKEFIALKL LQELSRRARR 
    HGRVSVYLSC EVGTSTEPCS IYTMLTHLTD LRVWQEQPDM QIPFDHCWTD YHVSILRPEG 
    FLYLLETREL LLSSVELIVL EDCHDSAVYQ RIRPLFENHI MPAPPADRPR ILGLAGPLHS 
    AGCELQQLSA MLATLEQSVL CQIETASDIV TVLRYCSRPH EYIVQCAPFE MDELSLVLAD 
    VLNTHKSFLL DHRYDPYEIY GTDQFMDELK DIPDPKVDPL NVINSLLVVL HEMGPWCTQR 
    AAHHFYQCNE KLKVKTPHER HYLLYCLVST ALIQLYSLCE HAFHRHLGSG SDSRQTIERY 
    SSPKVRRLLQ TLRCFKPEEV HTQADGLRRM RHQVDQADFN RLSHTLESKC RMVDQMDQPP 
    TETRALVATL EQILHTTEDR QTNRSAARVT PTPTPAHAKP KPSSGANTAQ PRTRRRVYTR 
    RHHRDHNDGS DTLCALIYCN QNHTARVLFE LLAEISRRDP DLKFLRCQYT TDRVADPTTE 
    PKEAELEHRR QEEVLKRFRM HDCNVLIGTS VLEEGIDVPK CNLVVRWDPP TTYRSYVQCK 
    GRARAAPAYH VILVAPSYKS PTVGSVQLTD RSHRYICATG DTTEADSDSD DSAMPNSSGS 
    DPYTFGTARG TVKILNPEVF SKQPPTACDI KLQEIQDELP AAAQLDTSNS SDEAVSMSNT 
    SPSESSTEQK SRRFQCELSS LTEPEDTSDT TAEIDTAHSL ASTTKDLVHQ MAQYREIEQM 
    LLSKCANTEP PEQEQSEAER FSACLAAYRP KPHLLTGASV DLGSAIALVN KYCARLPSDT 
    FTKLTALWRC TRNERAGVTL FQYTLRLPIN SPLKHDIVGL PMPTQTLARR LAALQACVEL 
    HRIGELDDQL QPIGKEGFRA LEPDWECFEL EPEDEQIVQL SDEPRPGTTK RRQYYYKRIA 
    SEFCDCRPVA GAPCYLYFIQ LTLQCPIPEE QNTRGRKIYP PEDAQQGFGI LTTKRIPKLS 
    AFSIFTRSGE VKVSLELAKE RVILTSEQIV CINGFLNYTF TNVLRLQKFL MLFDPDSTEN 
    CVFIVPTVKA PAGGKHIDWQ FLELIQANGN TMPRAVPDEE RQAQPFDPQR FQDAVVMPWY 
    RNQDQPQYFY VAEICPHLSP LSCFPGDNYR TFKHYYLVKY GLTIQNTSQP LLDVDHTSAR 
    LNFLTPRYVN RKGVALPTSS EETKRAKREN LEQKQILVPE LCTVHPFPAS LWRTAVCLPC 
    ILYRINGLLL ADDIRKQVSA DLGLGRQQIE DEDFEWPMLD FGWSLSEVLK KSRESKQKES 
    LKDDTINGKD LADVEKKPTS EETQLDKDSK DDKVEKSAIE LIIEGEEKLQ EADDFIEIGT 
    WSNDMADDIA SFNQEDDDED DAFHLPVLPA NVKFCDQQTR YGSPTFWDVS NGESGFKGPK 
    SSQNKQGGKG KAKGPAKPTF NYYDSDNSLG SSYDDDDNAG PLNYMHHNYS SDDDDVADDI 
    DAGRIAFTSK NEAETIETAQ EVEKRQKQLS IIQATNANER QYQQTKNLLI GFNFKHEDQK 
    EPATIRYEES IAKLKTEIES GGMLVPHDQQ LVLKRSDAAE AQVAKVSMME LLKQLLPYVN 
    EDVLAKKLGD RRELLLSDLV ELNADWVARH EQETYNVMGC GDSFDNYNDH HRLNLDEKQL 
    KLQYERIEIE PPTSTKAITS AILPAGFSFD RQPDLVGHPG PSPSIILQAL TMSNANDGIN 
    LERLETIGDS FLKYAITTYL YITYENVHEG KLSHLRSKQV ANLNLYRLGR RKRLGEYMIA 
    TKFEPHDNWL PPCYYVPKEL EKALIEAKIP THHWKLADLL DIKNLSSVQI CEMVREKADA 
    LGLEQNGGAQ NGQLDDSNDS CNDFSCFIPY NLVSQHSIPD KSIADCVEAL IGAYLIECGP 
    RGALLFMAWL GVRVLPITRQ LDGGNQEQRI PGSTKPNAEN VVTVYGAWPT PRSPLLHFAP 
    NATEELDQLL SGFEEFEESL GYKFRDRSYL LQAMTHASYT PNRLTDCYQR LEFLGDAVLD 
    YLITRHLYED PRQHSPGALT DLRSALVNNT IFASLAVRHG FHKFFRHLSP GLNDVIDRFV 
    RIQQENGHCI SEEYYLLSEE ECDDAEDVEV PKALGDVFES IAGAIFLDSN MSLDVVWHVY 
    SNMMSPEIEQ FSNSVPKSPI RELLELEPET AKFGKPEKLA DGRRVRVTVD VFCKGTFRGI 
    GRNYRIAKCT AAKCALRQLK KQGLIAKKD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.