Details for: pnt

Gene ID: 42757

Symbol: pnt

Ensembl ID: FBgn0003118

Description: pointed

Associated with

  • Cellular responses to stimuli
    (R-DME-8953897)
  • Cellular responses to stress
    (R-DME-2262752)
  • Cellular senescence
    (R-DME-2559583)
  • Oncogene induced senescence
    (R-DME-2559585)
  • Cell dedifferentiation
    (GO:0043697)
  • Cell differentiation
    (GO:0030154)
  • Compound eye photoreceptor cell differentiation
    (GO:0001751)
  • Determination of adult lifespan
    (GO:0008340)
  • Determination of genital disc primordium
    (GO:0035225)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Epidermal growth factor receptor signaling pathway
    (GO:0007173)
  • Epithelial cell migration, open tracheal system
    (GO:0007427)
  • Epithelial cell proliferation involved in malpighian tubule morphogenesis
    (GO:0061331)
  • Eye-antennal disc morphogenesis
    (GO:0007455)
  • Fibroblast growth factor receptor signaling pathway
    (GO:0008543)
  • Imaginal disc-derived wing morphogenesis
    (GO:0007476)
  • Leg disc proximal/distal pattern formation
    (GO:0007479)
  • Lymph gland crystal cell differentiation
    (GO:0035170)
  • Lymph gland plasmatocyte differentiation
    (GO:0035169)
  • Maintenance of epithelial cell apical/basal polarity
    (GO:0045199)
  • Muscle cell development
    (GO:0055001)
  • Negative regulation of apoptotic signaling pathway
    (GO:2001234)
  • Negative regulation of cardioblast cell fate specification
    (GO:0009997)
  • Nucleus
    (GO:0005634)
  • Oenocyte differentiation
    (GO:0001742)
  • Ommatidial rotation
    (GO:0016318)
  • Open tracheal system development
    (GO:0007424)
  • Pericardial nephrocyte differentiation
    (GO:0061320)
  • Photoreceptor cell development
    (GO:0042461)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of neuron differentiation
    (GO:0045666)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Primary branching, open tracheal system
    (GO:0007428)
  • Protein binding
    (GO:0005515)
  • R3/r4 cell fate commitment
    (GO:0007464)
  • R7 cell fate commitment
    (GO:0007465)
  • Regulation of establishment of planar polarity
    (GO:0090175)
  • Regulation of neuroblast proliferation
    (GO:1902692)
  • Regulation of neurogenesis
    (GO:0050767)
  • Regulation of neuron differentiation
    (GO:0045664)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Secondary branching, open tracheal system
    (GO:0007429)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sevenless signaling pathway
    (GO:0045500)
  • Terminal cell fate specification, open tracheal system
    (GO:0035154)
  • Trachea development
    (GO:0060438)
  • Transcription cis-regulatory region binding
    (GO:0000976)
  • Wing disc dorsal/ventral pattern formation
    (GO:0048190)

Other Information

Genular Protein ID: 3765392390

Symbol: PNT_DROME

Name: N/A

UniProtKB Accession Codes:

P51023 A0A0B4KH96 B9EQV8 H8F4R1 P19420 P51022 Q29R53 Q8IG92 Q8IMZ1 Q9VCN2

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 DisProt 1 EMBL 12 EnsemblMetazoa 4 ExpressionAtlas 1 FlyBase 1 GO 45 Gene3D 2 GeneTree 1 GenomeRNAi 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MINT 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 2 PRINTS 1 PRO 1 PROSITE 4 PaxDb 1 Pfam 2 PhylomeDB 1 Proteomes 1 Reactome 1 RefSeq 4 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 8223245

Title: The Drosophila gene pointed encodes two ETS-like proteins which are involved in the development of the midline glial cells.

PubMed ID: 8223245

DOI: 10.1242/dev.117.1.163

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537569

Title: A Drosophila full-length cDNA resource.

PubMed ID: 12537569

DOI: 10.1186/gb-2002-3-12-research0080

PubMed ID: 2834248

Title: The Drosophila ets-2 gene: molecular structure, chromosomal localization, and developmental expression.

PubMed ID: 2834248

DOI: 10.1016/0012-1606(88)90187-x

PubMed ID: 1577186

Title: Isolation and characterization of five Drosophila genes that encode an ets-related DNA binding domain.

PubMed ID: 1577186

DOI: 10.1016/0012-1606(92)90225-6

PubMed ID: 8033205

Title: The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by the Ras/MAPK pathway.

PubMed ID: 8033205

DOI: 10.1016/0092-8674(94)90580-0

PubMed ID: 22143802

Title: Ets transcription factor Pointed promotes the generation of intermediate neural progenitors in Drosophila larval brains.

PubMed ID: 22143802

DOI: 10.1073/pnas.1118595109

PubMed ID: 23757412

Title: Sequential activation of ETS proteins provides a sustained transcriptional response to EGFR signaling.

PubMed ID: 23757412

DOI: 10.1242/dev.093138

PubMed ID: 27151950

Title: Notch maintains Drosophila type II neuroblasts by suppressing expression of the Fez transcription factor Earmuff.

PubMed ID: 27151950

DOI: 10.1242/dev.136184

PubMed ID: 27510969

Title: The Ets protein Pointed prevents both premature differentiation and dedifferentiation of Drosophila intermediate neural progenitors.

PubMed ID: 27510969

DOI: 10.1242/dev.137281

PubMed ID: 28899667

Title: bHLH-O proteins balance the self-renewal and differentiation of Drosophila neural stem cells by regulating Earmuff expression.

PubMed ID: 28899667

DOI: 10.1016/j.ydbio.2017.09.011

PubMed ID: 28245922

Title: An Hdac1/Rpd3-poised circuit balances continual self-renewal and rapid restriction of developmental potential during asymmetric stem cell division.

PubMed ID: 28245922

DOI: 10.1016/j.devcel.2017.01.014

Sequence Information:

  • Length: 718
  • Mass: 77683
  • Checksum: FD6AFD0F4BCD69C5
  • Sequence:
    • MELAICKTDL SATKFMLPPA LPSSAAIGSS SAVASTASHF LDKAAHELFQ LNAINGHLFK 
SPASSHLNSV GSPSILSQLN GIGNSGNHSG QVSTMRLKKN RKVTFLSSLV ESKNIFIKEE 
PIHGCKDLCS LSDISDHEAS LEVPTALPPL TPGTNRKVNE VLKASFASWE KEVQKCNITK 
DPREWTEEHV IYWLNWAKNE FSLVSMNLDP FYKMKGRAMV DLGKEKFLAI TPPFTGDILW 
EHLDILQKDC EKPNEDIVHG NSFESATTAS VCGSDHQVAN YPNETHANSN NSSINSRLSM 
DYVTSAGNSD NKNFHRATPH SHNGYNTSNT HDRINNSTPP QQQQSQQPTV NGSGSASSNN 
NNSMLPPAVQ QSNNENNNTS SSNTNNSSNN NNNSGGSNNS NAGSNNNNNN NNNINFMAAA 
AIFQHHLKEE PGTQNGNIGG YGGGSNSQND PTDLSSYGLP AHLAAYGGGS GSGPTGGRSS 
GGGGDESDYH STISAQDHQS QQSSGGNGSG GASGGSTGNS NGYLDSSSEF YGSYAGRNRF 
HDGYPPEFTP YDAQSFQSMG PQPTAMDQWG AAHAHQHPAA YMSTLGLDKG LLGGYTTQGG 
VPCFTGSGPI QLWQFLLELL LDKTCQSFIS WTGDGWEFKL TDPDEVARRW GIRKNKPKMN 
YEKLSRGLRY YYDKNIIHKT AGKRYVYRFV CDLQNLVGHT PEELVAKYDL KIEKKDVD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.