Details for: SPE

Gene ID: 42791

Symbol: SPE

Ensembl ID: FBgn0039102

Description: Spatzle-Processing Enzyme

Associated with

  • Defense response to fungus
    (GO:0050832)
  • Defense response to gram-negative bacterium
    (GO:0050829)
  • Defense response to gram-positive bacterium
    (GO:0050830)
  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • Innate immune response
    (GO:0045087)
  • Positive regulation of antifungal peptide production
    (GO:0002804)
  • Positive regulation of antimicrobial peptide production
    (GO:0002225)
  • Positive regulation of biosynthetic process of antibacterial peptides active against gram-positive bacteria
    (GO:0006965)
  • Proteolysis
    (GO:0006508)
  • Response to fungus
    (GO:0009620)
  • Serine-type endopeptidase activity
    (GO:0004252)
  • Serine hydrolase activity
    (GO:0017171)
  • Toll receptor ligand protein activation cascade
    (GO:0160032)

Other Information

Genular Protein ID: 4249695014

Symbol: SPE_DROME

Name: N/A

UniProtKB Accession Codes:

Q9VCJ8

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 4 ChiTaRS 1 DNASU 1 EMBL 2 EnsemblMetazoa 1 FlyBase 1 GO 14 Gene3D 2 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 HOGENOM 1 InParanoid 1 InterPro 9 KEGG 1 MEROPS 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 4 PaxDb 1 Pfam 2 PhylomeDB 1 Proteomes 1 Reactome 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537569

Title: A Drosophila full-length cDNA resource.

PubMed ID: 12537569

DOI: 10.1186/gb-2002-3-12-research0080

PubMed ID: 16631589

Title: Drosophila immunity: a large-scale in vivo RNAi screen identifies five serine proteases required for Toll activation.

PubMed ID: 16631589

DOI: 10.1016/j.cub.2006.03.020

PubMed ID: 16399077

Title: A Spatzle-processing enzyme required for toll signaling activation in Drosophila innate immunity.

PubMed ID: 16399077

DOI: 10.1016/j.devcel.2005.11.013

PubMed ID: 16996061

Title: Expression and regulation of Spaetzle-processing enzyme in Drosophila.

PubMed ID: 16996061

DOI: 10.1016/j.febslet.2006.09.009

PubMed ID: 18724373

Title: Sensing of 'danger signals' and pathogen-associated molecular patterns defines binary signaling pathways 'upstream' of Toll.

PubMed ID: 18724373

DOI: 10.1038/ni.1643

PubMed ID: 26843333

Title: Spaetzle-processing enzyme-independent activation of the toll pathway in Drosophila innate immunity.

PubMed ID: 26843333

DOI: 10.1247/csf.16002

Sequence Information:

  • Length: 400
  • Mass: 43947
  • Checksum: E4492A4BC7316582
  • Sequence:
    • MASTERNFLL LSLVVSALSG LVHRSDAAEI SFGSCTPQQS DERGQCVHIT SCPYLANLLM 
VEPKTPAQRI LLSKSQCGLD NRVEGLVNRI LVCCPQSMRG NIMDSEPTPS TRDALQQGDV 
LPGNDVCGFL FADRIFGGTN TTLWEFPWMV LLQYKKLFSE TYTFNCGGAL LNSRYVLTAG 
HCLASRELDK SGAVLHSVRL GEWDTRTDPD CTTQMNGQRI CAPKHIDIEV EKGIIHEMYA 
PNSVDQRNDI ALVRLKRIVS YTDYVRPICL PTDGLVQNNF VDYGMDVAGW GLTENMQPSA 
IKLKITVNVW NLTSCQEKYS SFKVKLDDSQ MCAGGQLGVD TCGGDSGGPL MVPISTGGRD 
VFYIAGVTSY GTKPCGLKGW PGVYTRTGAF IDWIKQKLEP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.