Details for: spas

Gene ID: 42846

Symbol: spas

Ensembl ID: FBgn0039141

Description: spastin

Associated with

Other Information

Genular Protein ID: 3325831133

Symbol: SPAST_DROME

Name: D-Spastin

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537569

Title: A Drosophila full-length cDNA resource.

PubMed ID: 12537569

DOI: 10.1186/gb-2002-3-12-research0080

PubMed ID: 12908108

Title: Identification of the Drosophila melanogaster homolog of the human spastin gene.

PubMed ID: 12908108

DOI: 10.1007/s00427-003-0340-x

PubMed ID: 15242610

Title: The hereditary spastic paraplegia gene, spastin, regulates microtubule stability to modulate synaptic structure and function.

PubMed ID: 15242610

DOI: 10.1016/j.cub.2004.06.058

PubMed ID: 15562320

Title: Drosophila spastin regulates synaptic microtubule networks and is required for normal motor function.

PubMed ID: 15562320

DOI: 10.1371/journal.pbio.0020429

PubMed ID: 15823537

Title: The Drosophila homologue of the hereditary spastic paraplegia protein, spastin, severs and disassembles microtubules.

PubMed ID: 15823537

DOI: 10.1016/j.cub.2005.02.029

PubMed ID: 16276413

Title: Disease-related phenotypes in a Drosophila model of hereditary spastic paraplegia are ameliorated by treatment with vinblastine.

PubMed ID: 16276413

DOI: 10.1172/jci24694

PubMed ID: 17452528

Title: Three microtubule severing enzymes contribute to the 'Pacman-flux' machinery that moves chromosomes.

PubMed ID: 17452528

DOI: 10.1083/jcb.200612011

PubMed ID: 18327897

Title: Phosphoproteome analysis of Drosophila melanogaster embryos.

PubMed ID: 18327897

DOI: 10.1021/pr700696a

PubMed ID: 19341724

Title: Drosophila Atlastin regulates the stability of muscle microtubules and is required for synapse development.

PubMed ID: 19341724

DOI: 10.1016/j.ydbio.2009.03.019

PubMed ID: 23122959

Title: Normal spastin gene dosage is specifically required for axon regeneration.

PubMed ID: 23122959

DOI: 10.1016/j.celrep.2012.09.032

PubMed ID: 25875445

Title: Spastin binds to lipid droplets and affects lipid metabolism.

PubMed ID: 25875445

DOI: 10.1371/journal.pgen.1005149

PubMed ID: 26744324

Title: Conserved pharmacological rescue of hereditary spastic paraplegia-related phenotypes across model organisms.

PubMed ID: 26744324

DOI: 10.1093/hmg/ddv632

PubMed ID: 18202664

Title: Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin.

PubMed ID: 18202664

DOI: 10.1038/nature06482

Sequence Information:

  • Length: 758
  • Mass: 82749
  • Checksum: 406D075DCBD2A9CD
  • Sequence:
  • MVRTKNQSSS SSASSSSTKS PIKSSSGAGS SGGGLGGRQS THRSSSASNV AAVVAGGSSA 
    AGGGSSSNRR SPGSSPDGDD DTTTTDDLTP TTCSPRSGHH HSYGGYSSSV HKQNLYVVSF 
    PIIFLFNVLR SLIYQLFCIF RYLYGASTKV IYRPHRRDCN IEIVVQNSSK EQQQSLNHPS 
    ELNREGDGQE QQLSNQPQRF RPIQPLEMAA NRPGGGYSPG PGDPLLAKQK HHHRRAFEYI 
    SKALKIDEEN EGHKELAIEL YRKGIKELED GIAVDCWSGR GDVWDRAQRL HDKMQTNLSM 
    ARDRLHFLAL REQDLQMQRL SLKEKQKEEA QSKPQKTREP MLAGMTNEPM KLRVRSSGYG 
    PKATTSAQPT ASGRKLTIGS KRPVNLAVAN KSQTLPRNLG SKTSVGAVQR QPAKTAATPP 
    AVRRQFSSGR NTPPQRSRTP INNNGPSGSG ASTPVVSVKG VEQKLVQLIL DEIVEGGAKV 
    EWTDIAGQDV AKQALQEMVI LPSVRPELFT GLRAPAKGLL LFGPPGNGKT LLARAVATEC 
    SATFLNISAA SLTSKYVGDG EKLVRALFAV ARHMQPSIIF IDEVDSLLSE RSSSEHEASR 
    RLKTEFLVEF DGLPGNPDGD RIVVLAATNR PQELDEAALR RFTKRVYVSL PDEQTRELLL 
    NRLLQKQGSP LDTEALRRLA KITDGYSGSD LTALAKDAAL EPIRELNVEQ VKCLDISAMR 
    AITEQDFHSS LKRIRRSVAP QSLNSYEKWS QDYGDITI

Genular Protein ID: 2566058833

Symbol: A0A126GV13_DROME

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537568

Title: Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence.

PubMed ID: 12537568

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537573

Title: The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective.

PubMed ID: 12537573

PubMed ID: 12537574

Title: Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.

PubMed ID: 12537574

PubMed ID: 16110336

Title: Combined evidence annotation of transposable elements in genome sequences.

PubMed ID: 16110336

DOI: 10.1371/journal.pcbi.0010022

PubMed ID: 17569856

Title: The Release 5.1 annotation of Drosophila melanogaster heterochromatin.

PubMed ID: 17569856

DOI: 10.1126/science.1139815

PubMed ID: 17569867

Title: Sequence finishing and mapping of Drosophila melanogaster heterochromatin.

PubMed ID: 17569867

DOI: 10.1126/science.1139816

Sequence Information:

  • Length: 489
  • Mass: 53654
  • Checksum: DAA7800A2648CEFC
  • Sequence:
  • MAANRPGGGY SPGPGDPLLA KQKHHHRRAF EYISKALKID EENEGHKELA IELYRKGIKE 
    LEDGIAVDCW SGRGDVWDRA QRLHDKMQTN LSMARDRLHF LASGRKLTIG SKRPVNLAVA 
    NKSQTLPRNL GSKTSVGAVQ RQPAKTAATP PAVRRQFSSG RNTPPQRSRT PINNNGPSGS 
    GASTPVVSVK GVEQKLVQLI LDEIVEGGAK VEWTDIAGQD VAKQALQEMV ILPSVRPELF 
    TGLRAPAKGL LLFGPPGNGK TLLARAVATE CSATFLNISA ASLTSKYVGD GEKLVRALFA 
    VARHMQPSII FIDEVDSLLS ERSSSEHEAS RRLKTEFLVE FDGLPGNPDG DRIVVLAATN 
    RPQELDEAAL RRFTKRVYVS LPDEQTRELL LNRLLQKQGS PLDTEALRRL AKITDGYSGS 
    DLTALAKDAA LEPIRELNVE QVKCLDISAM RAITEQDFHS SLKRIRRSVA PQSLNSYEKW 
    SQDYGDITI

Genular Protein ID: 2380861002

Symbol: A0A0B4LHJ5_DROME

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537568

Title: Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence.

PubMed ID: 12537568

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537573

Title: The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective.

PubMed ID: 12537573

PubMed ID: 12537574

Title: Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.

PubMed ID: 12537574

PubMed ID: 16110336

Title: Combined evidence annotation of transposable elements in genome sequences.

PubMed ID: 16110336

DOI: 10.1371/journal.pcbi.0010022

PubMed ID: 17569856

Title: The Release 5.1 annotation of Drosophila melanogaster heterochromatin.

PubMed ID: 17569856

DOI: 10.1126/science.1139815

PubMed ID: 17569867

Title: Sequence finishing and mapping of Drosophila melanogaster heterochromatin.

PubMed ID: 17569867

DOI: 10.1126/science.1139816

PubMed ID: 26109357

Title: Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.

PubMed ID: 26109357

DOI: .1534/g3.115.018929

PubMed ID: 26109356

Title: Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.

PubMed ID: 26109356

DOI: .1534/g3.115.018937

PubMed ID: 25589440

Title: The Release 6 reference sequence of the Drosophila melanogaster genome.

PubMed ID: 25589440

PubMed ID: 31285604

Title: An allosteric network in spastin couples multiple activities required for microtubule severing.

PubMed ID: 31285604

DOI: 10.1038/s41594-019-0257-3

Sequence Information:

  • Length: 696
  • Mass: 75751
  • Checksum: 3454736CB35D0500
  • Sequence:
  • MVRTKNQSSS SSASSSSTKS PIKSSSGAGS SGGGLGGRQS THRSSSASNV AAVVAGGSSA 
    AGGGSSSNRR SPGSSPDGDD DTTTTDDLTP TTCSPRSGHH HSYGGYSSSV HKQNLYVVSF 
    PIIFLFNVLR SLIYQLFCIF RYLYGASTKV IYRPHRRDCN IEIVVQNSSK EQQQSLNHPS 
    ELNREGDGQE QQLSNQPQRF RPIQPLEMAA NRPGGGYSPG PGDPLLAKQK HHHRRAFEYI 
    SKALKIDEEN EGHKELAIEL YRKGIKELED GIAVDCWSGR GDVWDRAQRL HDKMQTNLSM 
    ARDRLHFLAS GRKLTIGSKR PVNLAVANKS QTLPRNLGSK TSVGAVQRQP AKTAATPPAV 
    RRQFSSGRNT PPQRSRTPIN NNGPSGSGAS TPVVSVKGVE QKLVQLILDE IVEGGAKVEW 
    TDIAGQDVAK QALQEMVILP SVRPELFTGL RAPAKGLLLF GPPGNGKTLL ARAVATECSA 
    TFLNISAASL TSKYVGDGEK LVRALFAVAR HMQPSIIFID EVDSLLSERS SSEHEASRRL 
    KTEFLVEFDG LPGNPDGDRI VVLAATNRPQ ELDEAALRRF TKRVYVSLPD EQTRELLLNR 
    LLQKQGSPLD TEALRRLAKI TDGYSGSDLT ALAKDAALEP IRELNVEQVK CLDISAMRAI 
    TEQDFHSSLK RIRRSVAPQS LNSYEKWSQD YGDITI

Genular Protein ID: 2916070319

Symbol: A0A126GV10_DROME

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537568

Title: Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence.

PubMed ID: 12537568

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537573

Title: The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective.

PubMed ID: 12537573

PubMed ID: 12537574

Title: Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.

PubMed ID: 12537574

PubMed ID: 16110336

Title: Combined evidence annotation of transposable elements in genome sequences.

PubMed ID: 16110336

DOI: 10.1371/journal.pcbi.0010022

PubMed ID: 17569856

Title: The Release 5.1 annotation of Drosophila melanogaster heterochromatin.

PubMed ID: 17569856

DOI: 10.1126/science.1139815

PubMed ID: 17569867

Title: Sequence finishing and mapping of Drosophila melanogaster heterochromatin.

PubMed ID: 17569867

DOI: 10.1126/science.1139816

Sequence Information:

  • Length: 551
  • Mass: 60652
  • Checksum: A994A9DD80167507
  • Sequence:
  • MAANRPGGGY SPGPGDPLLA KQKHHHRRAF EYISKALKID EENEGHKELA IELYRKGIKE 
    LEDGIAVDCW SGRGDVWDRA QRLHDKMQTN LSMARDRLHF LALREQDLQM QRLSLKEKQK 
    EEAQSKPQKT REPMLAGMTN EPMKLRVRSS GYGPKATTSA QPTASGRKLT IGSKRPVNLA 
    VANKSQTLPR NLGSKTSVGA VQRQPAKTAA TPPAVRRQFS SGRNTPPQRS RTPINNNGPS 
    GSGASTPVVS VKGVEQKLVQ LILDEIVEGG AKVEWTDIAG QDVAKQALQE MVILPSVRPE 
    LFTGLRAPAK GLLLFGPPGN GKTLLARAVA TECSATFLNI SAASLTSKYV GDGEKLVRAL 
    FAVARHMQPS IIFIDEVDSL LSERSSSEHE ASRRLKTEFL VEFDGLPGNP DGDRIVVLAA 
    TNRPQELDEA ALRRFTKRVY VSLPDEQTRE LLLNRLLQKQ GSPLDTEALR RLAKITDGYS 
    GSDLTALAKD AALEPIRELN VEQVKCLDIS AMRAITEQDF HSSLKRIRRS VAPQSLNSYE 
    KWSQDYGDIT I

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.