Gene ASCL1 - ENSG00000139352 | NCBI Gene ID: 429

Details for: ASCL1

Gene ID: 429

Symbol: ASCL1

Ensembl ID: ENSG00000139352

Description: achaete-scute family bHLH transcription factor 1

Associated with

Ngf-stimulated transcription
(R-HSA-9031628)
Nuclear events (kinase and transcription factor activation)
(R-HSA-198725)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrks
(R-HSA-166520)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Adrenal chromaffin cell differentiation
(GO:0061104)
Bhlh transcription factor binding
(GO:0043425)
Carotid body glomus cell differentiation
(GO:0061103)
Cell maturation
(GO:0048469)
Cellular response to magnetism
(GO:0071259)
Central nervous system neuron development
(GO:0021954)
Cerebral cortex development
(GO:0021987)
Cerebral cortex gabaergic interneuron differentiation
(GO:0021892)
Chromatin
(GO:0000785)
Chromatin binding
(GO:0003682)
Commitment of neuronal cell to specific neuron type in forebrain
(GO:0021902)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
E-box binding
(GO:0070888)
Heart development
(GO:0007507)
Identical protein binding
(GO:0042802)
Lung epithelial cell differentiation
(GO:0060487)
Lung neuroendocrine cell differentiation
(GO:0061100)
Motor neuron migration
(GO:0097475)
Musculoskeletal movement, spinal reflex action
(GO:0050883)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of neuron differentiation
(GO:0045665)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neuroblast fate determination
(GO:0007400)
Neuroblast proliferation
(GO:0007405)
Neurogenesis
(GO:0022008)
Neuronal cell body
(GO:0043025)
Neuron development
(GO:0048666)
Neuron differentiation
(GO:0030182)
Neuron fate commitment
(GO:0048663)
Neuron fate specification
(GO:0048665)
Noradrenergic neuron development
(GO:0003358)
Noradrenergic neuron fate commitment
(GO:0003359)
Notch signaling pathway
(GO:0007219)
Nucleic acid binding
(GO:0003676)
Nucleus
(GO:0005634)
Olfactory pit development
(GO:0060166)
Oligodendrocyte development
(GO:0014003)
Peripheral nervous system neuron development
(GO:0048935)
Positive regulation of cell cycle
(GO:0045787)
Positive regulation of neural precursor cell proliferation
(GO:2000179)
Positive regulation of neurogenesis
(GO:0050769)
Positive regulation of neuron apoptotic process
(GO:0043525)
Positive regulation of neuron differentiation
(GO:0045666)
Positive regulation of notch signaling pathway
(GO:0045747)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Protein dimerization activity
(GO:0046983)
Regulation of epithelial cell differentiation
(GO:0030856)
Regulation of gene expression
(GO:0010468)
Regulation of mitotic cell cycle
(GO:0007346)
Regulation of neurogenesis
(GO:0050767)
Regulation of timing of subpallium neuron differentiation
(GO:0060165)
Response to epidermal growth factor
(GO:0070849)
Response to folic acid
(GO:0051593)
Response to retinoic acid
(GO:0032526)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulator complex
(GO:0090575)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sensory organ development
(GO:0007423)
Sequence-specific double-stranded dna binding
(GO:1990837)
Spinal cord association neuron differentiation
(GO:0021527)
Spinal cord oligodendrocyte cell fate specification
(GO:0021530)
Stomach neuroendocrine cell differentiation
(GO:0061102)
Subpallium neuron fate commitment
(GO:0060163)
Sympathetic ganglion development
(GO:0061549)
Sympathetic nervous system development
(GO:0048485)
Ventral spinal cord interneuron fate commitment
(GO:0060579)
Vestibular nucleus development
(GO:0021750)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 3.23
Marker Score: 2031
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 2.47
Marker Score: 2323
Cell Name: neural crest cell (CL0011012)
Fold Change: 2.39
Marker Score: 2552
Cell Name: motor neuron (CL0000100)
Fold Change: 2.17
Marker Score: 1286
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 2.14
Marker Score: 2150.5
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 2.1
Marker Score: 2355
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 2
Marker Score: 1993
Cell Name: inhibitory motor neuron (CL0008015)
Fold Change: 1.87
Marker Score: 882
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 1.68
Marker Score: 6217
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.61
Marker Score: 1168
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 1.52
Marker Score: 2496
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 1.39
Marker Score: 5395
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 1.39
Marker Score: 1718
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.37
Marker Score: 870
Cell Name: megakaryocyte (CL0000556)
Fold Change: 1.25
Marker Score: 707.5
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 1.17
Marker Score: 618
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.15
Marker Score: 4812
Cell Name: goblet cell (CL0000160)
Fold Change: 1.12
Marker Score: 7474
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.09
Marker Score: 503
Cell Name: glial cell (CL0000125)
Fold Change: 1.05
Marker Score: 1150
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251803
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71820
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48045
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.99
Marker Score: 412
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.99
Marker Score: 509
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30408
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.98
Marker Score: 462
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2412
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5349
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.93
Marker Score: 374
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2738
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 325
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5285
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.85
Marker Score: 649
Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 709
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1260
Cell Name: neural cell (CL0002319)
Fold Change: 0.77
Marker Score: 371
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.77
Marker Score: 397
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.76
Marker Score: 1442
Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 0.75
Marker Score: 252
Cell Name: mast cell (CL0000097)
Fold Change: 0.74
Marker Score: 429
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.72
Marker Score: 462
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.7
Marker Score: 179
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.64
Marker Score: 423
Cell Name: Schwann cell precursor (CL0002375)
Fold Change: 0.63
Marker Score: 156
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 0.6
Marker Score: 328
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.58
Marker Score: 462
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.57
Marker Score: 238
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.57
Marker Score: 1155
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.56
Marker Score: 148
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.55
Marker Score: 174
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.49
Marker Score: 475
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 0.46
Marker Score: 236
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.45
Marker Score: 271
Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.43
Marker Score: 189
Cell Name: GABAergic neuron (CL0000617)
Fold Change: 0.42
Marker Score: 1755
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.4
Marker Score: 400
Cell Name: epithelial cell of thymus (CL0002293)
Fold Change: 0.4
Marker Score: 129
Cell Name: photoreceptor cell (CL0000210)
Fold Change: 0.39
Marker Score: 297
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.38
Marker Score: 785
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.37
Marker Score: 5755
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.36
Marker Score: 244.5
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.34
Marker Score: 2019
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 0.33
Marker Score: 894
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.32
Marker Score: 326
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.32
Marker Score: 2779
Cell Name: lung neuroendocrine cell (CL1000223)
Fold Change: 0.32
Marker Score: 91
Cell Name: mature astrocyte (CL0002627)
Fold Change: 0.31
Marker Score: 205
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.31
Marker Score: 492
Cell Name: T cell (CL0000084)
Fold Change: 0.3
Marker Score: 523
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.3
Marker Score: 2995
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.3
Marker Score: 6343
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.29
Marker Score: 4284
Cell Name: enteric neuron (CL0007011)
Fold Change: 0.28
Marker Score: 148
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.26
Marker Score: 90
Cell Name: astrocyte (CL0000127)
Fold Change: 0.26
Marker Score: 223
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.26
Marker Score: 152.5
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.24
Marker Score: 108
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 0.24
Marker Score: 207
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.24
Marker Score: 941.5
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.23
Marker Score: 112
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.23
Marker Score: 65
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.23
Marker Score: 234.5
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.21
Marker Score: 70
Cell Name: male germ cell (CL0000015)
Fold Change: 0.19
Marker Score: 56
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.19
Marker Score: 77
Cell Name: exhausted T cell (CL0011025)
Fold Change: 0.19
Marker Score: 108
Cell Name: ependymal cell (CL0000065)
Fold Change: 0.19
Marker Score: 65
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.18
Marker Score: 178
Cell Name: erythrocyte (CL0000232)
Fold Change: 0.18
Marker Score: 98.5
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.18
Marker Score: 43.5
Cell Name: monocyte (CL0000576)
Fold Change: 0.17
Marker Score: 226.5
Cell Name: neuron (CL0000540)
Fold Change: 0.17
Marker Score: 705
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.17
Marker Score: 180
Cell Name: Mueller cell (CL0000636)
Fold Change: 0.17
Marker Score: 229
Cell Name: ionocyte (CL0005006)
Fold Change: 0.16
Marker Score: 50
Cell Name: germ cell (CL0000586)
Fold Change: 0.16
Marker Score: 281
Cell Name: chromaffin cell (CL0000166)
Fold Change: 0.16
Marker Score: 222
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.15
Marker Score: 1186
Cell Name: neuroendocrine cell (CL0000165)
Fold Change: 0.14
Marker Score: 56

Hover over a box to see details here...

**Key characteristics:** * ASCL1 is a basic helix-loop-helix transcription factor. * It is a key regulator of neural crest cell development and survival. * It is also involved in the development of the blood-brain barrier. **Pathways and functions:** * ASCL1 is a key regulator of neural crest cell development. * It is essential for the survival of neural crest cells, which are a type of stem cell that is responsible for the formation of the brain and spinal cord. * ASCL1 also plays a role in the development of the blood-brain barrier. * It is involved in the regulation of cell cycle, apoptosis, and differentiation. **Clinical significance:** * Mutations in the ASCL1 gene have been linked to a number of human diseases, including autism, schizophrenia, and cancer. * In one study, mutations in ASCL1 were found in 20% of cases of autism spectrum disorder. * The ASCL1 gene has also been linked to the development of a number of other diseases, including colon cancer, breast cancer, and leukemia. **Additional notes:** * ASCL1 is a highly conserved gene, with a similar gene found in mice. * It is a member of the BHLH family of transcription factors. * ASCL1 is a key regulator of neural crest cell development and survival. * It is also involved in the development of the blood-brain barrier.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

ASCL1_HUMAN

Genular Protein ID: 3459854380

Symbol: ASCL1_HUMAN

Name: N/A

UniProtKB Accession Codes:

P50553 A8K3C4 Q9BQ30

Database IDs:

Citations:

PubMed ID: 8390674

Title: Identification of a human achaete-scute homolog highly expressed in neuroendocrine tumors.

PubMed ID: 8390674

DOI: 10.1073/pnas.90.12.5648

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10903890

Title: HASH-1 and E2-2 are expressed in human neuroblastoma cells and form a functional complex.

PubMed ID: 10903890

DOI: 10.1006/bbrc.2000.3090

Sequence Information:

Length: 236
Mass: 25454
Checksum: A7D784329305B49A
Sequence:

MESSAKMESG GAGQQPQPQP QQPFLPPAAC FFATAAAAAA AAAAAAAQSA QQQQQQQQQQ 
QQAPQLRPAA DGQPSGGGHK SAPKQVKRQR SSSPELMRCK RRLNFSGFGY SLPQQQPAAV 
ARRNERERNR VKLVNLGFAT LREHVPNGAA NKKMSKVETL RSAVEYIRAL QQLLDEHDAV 
SAAFQAGVLS PTISPNYSND LNSMAGSPVS SYSSDEGSYD PLSPEEQELL DFTNWF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: ASCL1

Associated with

Cells (max top 100)

Other Information

Identification of a human achaete-scute homolog highly expressed in neuroendocrine tumors. PubMed ID: 8390674

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

HASH-1 and E2-2 are expressed in human neuroblastoma cells and form a functional complex. PubMed ID: 10903890

Database document:

PubMed ID: 8390674

PubMed ID: 14702039

PubMed ID: 15489334

PubMed ID: 10903890