Details for: nAChRalpha1

Gene ID: 42918

Symbol: nAChRalpha1

Ensembl ID: FBgn0000036

Description: nicotinic Acetylcholine Receptor alpha1

Associated with

  • Acetylcholine binding and downstream events
    (R-DME-181431)
  • Highly calcium permeable nicotinic acetylcholine receptors
    (R-DME-629597)
  • Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
    (R-DME-629594)
  • Highly sodium permeable postsynaptic acetylcholine nicotinic receptors
    (R-DME-629587)
  • Immune system
    (R-DME-168256)
  • Innate immune system
    (R-DME-168249)
  • Neuronal system
    (R-DME-112316)
  • Neurotransmitter receptors and postsynaptic signal transmission
    (R-DME-112314)
  • Neutrophil degranulation
    (R-DME-6798695)
  • Postsynaptic nicotinic acetylcholine receptors
    (R-DME-622327)
  • Presynaptic nicotinic acetylcholine receptors
    (R-DME-622323)
  • Transmission across chemical synapses
    (R-DME-112315)
  • Acetylcholine-gated channel complex
    (GO:0005892)
  • Acetylcholine-gated monoatomic cation-selective channel activity
    (GO:0022848)
  • Acetylcholine receptor activity
    (GO:0015464)
  • Chemical synaptic transmission
    (GO:0007268)
  • Excitatory extracellular ligand-gated monoatomic ion channel activity
    (GO:0005231)
  • Monoatomic cation transmembrane transport
    (GO:0098655)
  • Monoatomic ion transmembrane transport
    (GO:0034220)
  • Neuron projection
    (GO:0043005)
  • Plasma membrane
    (GO:0005886)
  • Postsynaptic membrane
    (GO:0045211)
  • Regulation of membrane potential
    (GO:0042391)
  • Response to insecticide
    (GO:0017085)
  • Synapse
    (GO:0045202)
  • Synaptic transmission, cholinergic
    (GO:0007271)
  • Transmembrane signaling receptor activity
    (GO:0004888)
  • Transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
    (GO:1904315)

Other Information

Genular Protein ID: 75887643

Symbol: ACH1_DROME

Name: Acetylcholine receptor subunit alpha-like 1

UniProtKB Accession Codes:

P09478 Q9VC74

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEMBL 1 EMBL 2 EnsemblMetazoa 2 ExpressionAtlas 1 FlyBase 1 GO 12 Gene3D 2 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 HOGENOM 1 InParanoid 1 InterPro 8 KEGG 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PaxDb 1 Pfam 2 PhylomeDB 1 Proteomes 1 Reactome 4 RefSeq 2 SMR 1 STRING 1 SUPFAM 2 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 2840281

Title: Conservation of neural nicotinic acetylcholine receptors from Drosophila to vertebrate central nervous systems.

PubMed ID: 2840281

DOI: 10.1002/j.1460-2075.1988.tb02854.x

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

Sequence Information:

  • Length: 567
  • Mass: 64019
  • Checksum: 08E1F721FB2A92AC
  • Sequence:
    • MGSVLFAAVF IALHFATGGL ANPDAKRLYD DLLSNYNRLI RPVGNNSDRL TVKMGLRLSQ 
LIDVNLKNQI MTTNVWVEQE WNDYKLKWNP DDYGGVDTLH VPSEHIWLPD IVLYNNADGN 
YEVTIMTKAI LHHTGKVVWK PPAIYKSFCE IDVEYFPFDE QTCFMKFGSW TYDGYMVDLR 
HLKQTADSDN IEVGIDLQDY YISVEWDIMR VPAVRNEKFY SCCEEPYLDI VFNLTLRRKT 
LFYTVNLIIP CVGISFLSVL VFYLPSDSGE KISLCISILL SLTVFFLLLA EIIPPTSLTV 
PLLGKYLLFT MMLVTLSVVV TIAVLNVNFR SPVTHRMAPW VQRLFIQILP KLLCIERPKK 
EEPEEDQPPE VLTDVYHLPP DVDKFVNYDS KRFSGDYGIP ALPASHRFDL AAAGGISAHC 
FAEPPLPSSL PLPGADDDLF SPSGLNGDIS PGCCPAAAAA AAADLSPTFE KPYAREMEKT 
IEGSRFIAQH VKNKDKFESV EEDWKYVAMV LDRMFLWIFA IACVVGTALI ILQAPSLYDQ 
SQPIDILYSK IAKKKFELLK MGSENTL

Genular Protein ID: 4078931084

Symbol: A0A0B4KGU3_DROME

Name: N/A

UniProtKB Accession Codes:

A0A0B4KGU3

Database IDs:

AGR 1 ARBA 18 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 EMBL 2 EnsemblMetazoa 1 ExpressionAtlas 1 FlyBase 2 GO 3 Gene3D 2 GeneTree 1 InterPro 8 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 1 Pfam 4 PhylomeDB 1 Proteomes 2 RefSeq 1 RuleBase 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537568

Title: Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence.

PubMed ID: 12537568

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537573

Title: The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective.

PubMed ID: 12537573

PubMed ID: 12537574

Title: Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.

PubMed ID: 12537574

PubMed ID: 16110336

Title: Combined evidence annotation of transposable elements in genome sequences.

PubMed ID: 16110336

DOI: 10.1371/journal.pcbi.0010022

PubMed ID: 17569856

Title: The Release 5.1 annotation of Drosophila melanogaster heterochromatin.

PubMed ID: 17569856

DOI: 10.1126/science.1139815

PubMed ID: 17569867

Title: Sequence finishing and mapping of Drosophila melanogaster heterochromatin.

PubMed ID: 17569867

DOI: 10.1126/science.1139816

Sequence Information:

  • Length: 597
  • Mass: 67388
  • Checksum: 076CAB1B67EBEEB6
  • Sequence:
    • MGSVLFAAVF IALHFATGGL ANPDAKRLYD DLLSNYNRLI RPVGNNSDRL TVKMGLRLSQ 
LIDVNLKNQI MTTNVWVEQE WNDYKLKWNP DDYGGVDTLH VPSEHIWLPD IVLYNNADGN 
YEVTIMTKAI LHHTGKVVWK PPAIYKSFCE IDVEYFPFDE QTCFMKFGSW TYDGYMVDLR 
HLKQTADSDN IEVGIDLQDY YISVEWDIMR VPAVRNEKFY SCCEEPYLDI VFNLTLRRKT 
LFYTVNLIIP CVGISFLSVL VFYLPSDSGE KISLCISILL SLTVFFLLLA EIIPPTSLTV 
PLLGKYLLFT MMLVTLSVVV TIAVLNVNFR SPVTHRMAPW VQRLFIQILP KLLCIERPKK 
EEPEEDQPPE VLTDVYHLPP DVDKFVNYDS KRFSGDYGIP ALPASHRFDL AAAGGISAHC 
FAEPPLPSSL PLPGADDDLF SPSGLNGDIS PGCCPAAAAA AAADLSPTFE KPYAREMEKT 
IEGSRFIAQH VKNKDKFESV EEDWKYVAMV LDRMFLWIFA IACVVGTALI ILQAPSLYDQ 
SQPIDILYSK IAKKKFELLK MGSENTLXRP LGFAAGWWNL IISSLRTLFA ARDDDRG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.