Details for: nAChRalpha2

Gene ID: 42919

Symbol: nAChRalpha2

Ensembl ID: FBgn0000039

Description: nicotinic Acetylcholine Receptor alpha2

Associated with

  • Acetylcholine binding and downstream events
    (R-DME-181431)
  • Highly calcium permeable nicotinic acetylcholine receptors
    (R-DME-629597)
  • Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
    (R-DME-629594)
  • Highly sodium permeable postsynaptic acetylcholine nicotinic receptors
    (R-DME-629587)
  • Immune system
    (R-DME-168256)
  • Innate immune system
    (R-DME-168249)
  • Neuronal system
    (R-DME-112316)
  • Neurotransmitter receptors and postsynaptic signal transmission
    (R-DME-112314)
  • Neutrophil degranulation
    (R-DME-6798695)
  • Postsynaptic nicotinic acetylcholine receptors
    (R-DME-622327)
  • Presynaptic nicotinic acetylcholine receptors
    (R-DME-622323)
  • Transmission across chemical synapses
    (R-DME-112315)
  • Acetylcholine-gated channel complex
    (GO:0005892)
  • Acetylcholine-gated monoatomic cation-selective channel activity
    (GO:0022848)
  • Acetylcholine receptor activity
    (GO:0015464)
  • Chemical synaptic transmission
    (GO:0007268)
  • Excitatory extracellular ligand-gated monoatomic ion channel activity
    (GO:0005231)
  • Monoatomic cation transmembrane transport
    (GO:0098655)
  • Monoatomic ion transmembrane transport
    (GO:0034220)
  • Neuron projection
    (GO:0043005)
  • Plasma membrane
    (GO:0005886)
  • Postsynaptic membrane
    (GO:0045211)
  • Regulation of membrane potential
    (GO:0042391)
  • Synapse
    (GO:0045202)
  • Synaptic transmission, cholinergic
    (GO:0007271)
  • Transmembrane signaling receptor activity
    (GO:0004888)
  • Transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
    (GO:1904315)

Other Information

Genular Protein ID: 2223526719

Symbol: ACH2_DROME

Name: Acetylcholine receptor subunit alpha-like 2

UniProtKB Accession Codes:

P17644 Q0KI18 Q9VC73

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEMBL 1 DIP 1 DNASU 1 EMBL 4 EnsemblMetazoa 2 FlyBase 1 GO 11 Gene3D 2 GenomeRNAi 1 GlyCosmos 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PaxDb 1 Pfam 2 PhylomeDB 1 Proteomes 1 Reactome 4 RefSeq 2 SMR 1 STRING 1 SUPFAM 2 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 2117557

Title: Structure and developmental expression of the D alpha 2 gene encoding a novel nicotinic acetylcholine receptor protein of Drosophila melanogaster.

PubMed ID: 2117557

DOI: 10.1016/0014-5793(90)81170-s

PubMed ID: 1697262

Title: Heterogeneity of Drosophila nicotinic acetylcholine receptors: SAD, a novel developmentally regulated alpha-subunit.

PubMed ID: 1697262

DOI: 10.1002/j.1460-2075.1990.tb07452.x

PubMed ID: 2114015

Title: Sequence of D alpha 2, a novel alpha-like subunit of Drosophila nicotinic acetylcholine receptors.

PubMed ID: 2114015

DOI: 10.1093/nar/18.12.3640

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537569

Title: A Drosophila full-length cDNA resource.

PubMed ID: 12537569

DOI: 10.1186/gb-2002-3-12-research0080

Sequence Information:

  • Length: 576
  • Mass: 65506
  • Checksum: 97D6A46CADC3F42F
  • Sequence:
    • MAPGCCTTRP RPIALLAHIW RHCKPLCLLL VLLLLCETVQ ANPDAKRLYD DLLSNYNRLI 
RPVSNNTDTV LVKLGLRLSQ LIDLNLKDQI LTTNVWLEHE WQDHKFKWDP SEYGGVTELY 
VPSEHIWLPD IVLYNNADGE YVVTTMTKAI LHYTGKVVWT PPAIFKSSCE IDVRYFPFDQ 
QTCFMKFGSW TYDGDQIDLK HISQKNDKDN KVEIGIDLRE YYPSVEWDIL GVPAERHEKY 
YPCCAEPYPD IFFNITLRRK TLFYTVNLII PCVGISYLSV LVFYLPADSG EKIALCISIL 
LSQTMFFLLI SEIIPSTSLA LPLLGKYLLF TMLLVGLSVV ITIIILNIHY RKPSTHKMRP 
WIRSFFIKRL PKLLLMRVPK DLLRDLAANK INYGLKFSKT KFGQALMDEM QMNSGGSSPD 
SLRRMQGRVG AGGCNGMHVT TATNRFSGLV GALGGGLSTL SGYNGLPSVL SGLDDSLSDV 
AARKKYPFEL EKAIHNVMFI QHHMQRQDEF NAEDQDWGFV AMVMDRLFLW LFMIASLVGT 
FVILGEAPSL YDDTKAIDVQ LSDVAKQIYN LTEKKN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.