Details for: ACHE

Gene ID: 43

Symbol: ACHE

Ensembl ID: ENSG00000087085

Description: acetylcholinesterase (Yt blood group)

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.99
    Marker Score: 1242.5
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.72
    Marker Score: 3503
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.59
    Marker Score: 533
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169565.5
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.42
    Marker Score: 14710
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.37
    Marker Score: 5088
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.25
    Marker Score: 1408
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.22
    Marker Score: 1478
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.18
    Marker Score: 2449.5
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.13
    Marker Score: 1068
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 1.03
    Marker Score: 512
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71820
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48045
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 503
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.97
    Marker Score: 1966
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 456
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.96
    Marker Score: 1571
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5332
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 320
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.87
    Marker Score: 1652
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5283
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.81
    Marker Score: 617
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8
    Marker Score: 12533
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.76
    Marker Score: 607
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 391.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 565
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.72
    Marker Score: 538
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 652
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2987
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.69
    Marker Score: 277
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.68
    Marker Score: 433
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.65
    Marker Score: 1142
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.62
    Marker Score: 2506.5
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.61
    Marker Score: 877
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.6
    Marker Score: 133
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.59
    Marker Score: 282
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.56
    Marker Score: 335
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 440
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.55
    Marker Score: 258
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.54
    Marker Score: 228
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.54
    Marker Score: 20341
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.52
    Marker Score: 273
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.51
    Marker Score: 2451
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.51
    Marker Score: 305
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.5
    Marker Score: 241
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.48
    Marker Score: 1496
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.46
    Marker Score: 114
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.45
    Marker Score: 1107
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.43
    Marker Score: 1644
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.41
    Marker Score: 637
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.41
    Marker Score: 2641
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.4
    Marker Score: 1866
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.4
    Marker Score: 621.5
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.4
    Marker Score: 575
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4
    Marker Score: 836
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.39
    Marker Score: 267
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.38
    Marker Score: 98
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.36
    Marker Score: 99
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.36
    Marker Score: 850
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.36
    Marker Score: 503
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.36
    Marker Score: 3352
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.34
    Marker Score: 4635
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.34
    Marker Score: 2956
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.33
    Marker Score: 140
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.33
    Marker Score: 20476
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.33
    Marker Score: 145
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.32
    Marker Score: 180
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.32
    Marker Score: 1338
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.32
    Marker Score: 93
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.32
    Marker Score: 316
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.32
    Marker Score: 6282
  • Cell Name: visceromotor neuron (CL0005025)
    Fold Change: 0.31
    Marker Score: 91
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.3
    Marker Score: 289
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.3
    Marker Score: 2296
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.3
    Marker Score: 96
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3
    Marker Score: 674
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.29
    Marker Score: 4368
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.29
    Marker Score: 403
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.29
    Marker Score: 308
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.29
    Marker Score: 82
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.28
    Marker Score: 275
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.28
    Marker Score: 95
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.27
    Marker Score: 111
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.27
    Marker Score: 560
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.27
    Marker Score: 170
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.27
    Marker Score: 132
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.26
    Marker Score: 1567
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.26
    Marker Score: 269
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.25
    Marker Score: 78
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.25
    Marker Score: 58
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.25
    Marker Score: 420
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.25
    Marker Score: 78
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.24
    Marker Score: 48
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.24
    Marker Score: 946
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.24
    Marker Score: 140

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Other Information

## Summary The ACHE gene encodes for acetylcholinesterase, an enzyme involved in the hydrolysis of acetylcholine, a neurotransmitter in the central nervous system. It is encoded by a single gene with an Ensembl ID of ENSG00000087085. ## Key characteristics * Human ACHE is a glycoprotein with a molecular weight of approximately 170 kD. * It is expressed in a variety of cell types, including endothelial cells, neurons, and immune cells. * ACHE is a highly regulated enzyme, with its activity being influenced by a number of factors, including calcium, magnesium, and pH. * Mutations in the ACHE gene have been linked to a number of neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. ## Pathways and functions * ACHE is involved in a variety of cellular processes, including: * Acetylcholine signaling * Neurotransmitter release * Cell migration * Cell adhesion * Inflammation * It is also involved in the regulation of blood pressure and blood sugar levels. ## Clinical significance * Mutations in the ACHE gene have been linked to a number of neurological disorders, including: * Alzheimer's disease * Parkinson's disease * Amyotrophic lateral sclerosis * Stiff neck syndrome * Diabetic retinopathy * ACHE inhibitors are being investigated as potential treatments for these disorders. ## Additional notes * The ACHE gene is also involved in the regulation of inflammation and immune responses. * It is a well-studied gene, with a number of inhibitors and activators available for research purposes.

Genular Protein ID: 4107082016

Symbol: ACES_HUMAN

Name: N/A

UniProtKB Accession Codes:

P22303 A4D2E2 B7ZKZ0 D6W5X7 Q16169 Q29S23 Q2M324 Q504V3 Q53F46 Q86TM9 Q86YX9 Q9BXP7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 15 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 62 DrugCentral 1 EC 1 ELM 1 EMBL 18 ESTHER 1 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 37 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 2 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 93 PDBsum 74 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 3 RefSeq 8 Rhea 2 SABIO-RK 1 SASBDB 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2263619

Title: Molecular cloning and construction of the coding region for human acetylcholinesterase reveals a G + C-rich attenuating structure.

PubMed ID: 2263619

DOI: 10.1073/pnas.87.24.9688

PubMed ID: 8299725

Title: Expression of three alternative acetylcholinesterase messenger RNAs in human tumor cell lines of different tissue origins.

PubMed ID: 8299725

DOI: 10.1006/excr.1994.1039

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11239002

Title: Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5.

PubMed ID: 11239002

DOI: 10.1093/nar/29.6.1352

PubMed ID: 2714437

Title: Purification and partial amino acid sequence analysis of human erythrocyte acetylcholinesterase.

PubMed ID: 2714437

DOI: 10.1016/0014-5793(89)81352-3

PubMed ID: 1748670

Title: The effect of elimination of intersubunit disulfide bonds on the activity, assembly, and secretion of recombinant human acetylcholinesterase. Expression of acetylcholinesterase Cys-580-->Ala mutant.

PubMed ID: 1748670

DOI: 10.1016/s0021-9258(18)54380-5

PubMed ID: 1517212

Title: Mutagenesis of human acetylcholinesterase. Identification of residues involved in catalytic activity and in polypeptide folding.

PubMed ID: 1517212

DOI: 10.1016/s0021-9258(19)37091-7

PubMed ID: 11985878

Title: Increased expression of intranuclear AChE involved in apoptosis of SK-N-SH cells.

PubMed ID: 11985878

DOI: 10.1016/s0168-0102(02)00005-6

PubMed ID: 9640563

Title: External and internal electrostatic potentials of cholinesterase models.

PubMed ID: 9640563

DOI: 10.1016/s1093-3263(98)00005-9

PubMed ID: 11053835

Title: Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II.

PubMed ID: 11053835

DOI: 10.1107/s0907444900010659

PubMed ID: 15526038

Title: The synaptic acetylcholinesterase tetramer assembles around a polyproline II helix.

PubMed ID: 15526038

DOI: 10.1038/sj.emboj.7600425

PubMed ID: 20408548

Title: Structural evidence that human acetylcholinesterase inhibited by tabun ages through O-dealkylation.

PubMed ID: 20408548

DOI: 10.1021/jm901853b

PubMed ID: 23035744

Title: Structures of human acetylcholinesterase in complex with pharmacologically important ligands.

PubMed ID: 23035744

DOI: 10.1021/jm300871x

PubMed ID: 23679855

Title: Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase.

PubMed ID: 23679855

DOI: 10.1042/bj20130013

PubMed ID: 8488842

Title: Mutation at codon 322 in the human acetylcholinesterase (ACHE) gene accounts for YT blood group polymorphism.

PubMed ID: 8488842

Sequence Information:

  • Length: 614
  • Mass: 67796
  • Checksum: B9AA84C77831C302
  • Sequence:
    • MRPPQCLLHT PSLASPLLLL LLWLLGGGVG AEGREDAELL VTVRGGRLRG IRLKTPGGPV 
SAFLGIPFAE PPMGPRRFLP PEPKQPWSGV VDATTFQSVC YQYVDTLYPG FEGTEMWNPN 
RELSEDCLYL NVWTPYPRPT SPTPVLVWIY GGGFYSGASS LDVYDGRFLV QAERTVLVSM 
NYRVGAFGFL ALPGSREAPG NVGLLDQRLA LQWVQENVAA FGGDPTSVTL FGESAGAASV 
GMHLLSPPSR GLFHRAVLQS GAPNGPWATV GMGEARRRAT QLAHLVGCPP GGTGGNDTEL 
VACLRTRPAQ VLVNHEWHVL PQESVFRFSF VPVVDGDFLS DTPEALINAG DFHGLQVLVG 
VVKDEGSYFL VYGAPGFSKD NESLISRAEF LAGVRVGVPQ VSDLAAEAVV LHYTDWLHPE 
DPARLREALS DVVGDHNVVC PVAQLAGRLA AQGARVYAYV FEHRASTLSW PLWMGVPHGY 
EIEFIFGIPL DPSRNYTAEE KIFAQRLMRY WANFARTGDP NEPRDPKAPQ WPPYTAGAQQ 
YVSLDLRPLE VRRGLRAQAC AFWNRFLPKL LSATDTLDEA ERQWKAEFHR WSSYMVHWKN 
QFDHYSKQDR CSDL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.