ACHE | ENSG00000087085 | NCBI 43

Details for: ACHE

Gene ID: 43

Symbol: ACHE

Ensembl ID: ENSG00000087085

Description: acetylcholinesterase (Yt blood group)

Associated with

Glycerophospholipid biosynthesis
(R-HSA-1483206)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Metabolism of proteins
(R-HSA-392499)
Neuronal system
(R-HSA-112316)
Neurotransmitter clearance
(R-HSA-112311)
Peptide hormone metabolism
(R-HSA-2980736)
Phospholipid metabolism
(R-HSA-1483257)
Synthesis, secretion, and deacylation of ghrelin
(R-HSA-422085)
Synthesis of pc
(R-HSA-1483191)
Transmission across chemical synapses
(R-HSA-112315)
Acetylcholine binding
(GO:0042166)
Acetylcholine catabolic process
(GO:0006581)
Acetylcholine catabolic process in synaptic cleft
(GO:0001507)
Acetylcholine receptor signaling pathway
(GO:0095500)
Acetylcholinesterase activity
(GO:0003990)
Amyloid-beta binding
(GO:0001540)
Amyloid precursor protein metabolic process
(GO:0042982)
Basement membrane
(GO:0005604)
Cell adhesion
(GO:0007155)
Cell surface
(GO:0009986)
Cholinesterase activity
(GO:0004104)
Collagen binding
(GO:0005518)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Golgi apparatus
(GO:0005794)
Hydrolase activity
(GO:0016787)
Laminin binding
(GO:0043236)
Membrane
(GO:0016020)
Negative regulation of synaptic transmission, cholinergic
(GO:0032223)
Nervous system development
(GO:0007399)
Neuromuscular junction
(GO:0031594)
Nucleus
(GO:0005634)
Osteoblast development
(GO:0002076)
Perinuclear region of cytoplasm
(GO:0048471)
Plasma membrane
(GO:0005886)
Positive regulation of cold-induced thermogenesis
(GO:0120162)
Positive regulation of protein secretion
(GO:0050714)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein self-association
(GO:0043621)
Receptor internalization
(GO:0031623)
Regulation of receptor recycling
(GO:0001919)
Retina development in camera-type eye
(GO:0060041)
Serine hydrolase activity
(GO:0017171)
Side of membrane
(GO:0098552)
Synapse
(GO:0045202)
Synapse assembly
(GO:0007416)
Synaptic cleft
(GO:0043083)

Other Information

Proteins

ACES_HUMAN

Genular Protein ID: 4107082016

Symbol: ACES_HUMAN

Name: N/A

UniProtKB Accession Codes:

P22303 A4D2E2 B7ZKZ0 D6W5X7 Q16169 Q29S23 Q2M324 Q504V3 Q53F46 Q86TM9 Q86YX9 Q9BXP7

Database IDs:

Citations:

PubMed ID: 2263619

Title: Molecular cloning and construction of the coding region for human acetylcholinesterase reveals a G + C-rich attenuating structure.

PubMed ID: 2263619

DOI: 10.1073/pnas.87.24.9688

PubMed ID: 8299725

Title: Expression of three alternative acetylcholinesterase messenger RNAs in human tumor cell lines of different tissue origins.

PubMed ID: 8299725

DOI: 10.1006/excr.1994.1039

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11239002

Title: Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5.

PubMed ID: 11239002

DOI: 10.1093/nar/29.6.1352

PubMed ID: 2714437

Title: Purification and partial amino acid sequence analysis of human erythrocyte acetylcholinesterase.

PubMed ID: 2714437

DOI: 10.1016/0014-5793(89)81352-3

PubMed ID: 1748670

Title: The effect of elimination of intersubunit disulfide bonds on the activity, assembly, and secretion of recombinant human acetylcholinesterase. Expression of acetylcholinesterase Cys-580-->Ala mutant.

PubMed ID: 1748670

DOI: 10.1016/s0021-9258(18)54380-5

PubMed ID: 1517212

Title: Mutagenesis of human acetylcholinesterase. Identification of residues involved in catalytic activity and in polypeptide folding.

PubMed ID: 1517212

DOI: 10.1016/s0021-9258(19)37091-7

PubMed ID: 11985878

Title: Increased expression of intranuclear AChE involved in apoptosis of SK-N-SH cells.

PubMed ID: 11985878

DOI: 10.1016/s0168-0102(02)00005-6

PubMed ID: 9640563

Title: External and internal electrostatic potentials of cholinesterase models.

PubMed ID: 9640563

DOI: 10.1016/s1093-3263(98)00005-9

PubMed ID: 11053835

Title: Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II.

PubMed ID: 11053835

DOI: 10.1107/s0907444900010659

PubMed ID: 15526038

Title: The synaptic acetylcholinesterase tetramer assembles around a polyproline II helix.

PubMed ID: 15526038

DOI: 10.1038/sj.emboj.7600425

PubMed ID: 20408548

Title: Structural evidence that human acetylcholinesterase inhibited by tabun ages through O-dealkylation.

PubMed ID: 20408548

DOI: 10.1021/jm901853b

PubMed ID: 23035744

Title: Structures of human acetylcholinesterase in complex with pharmacologically important ligands.

PubMed ID: 23035744

DOI: 10.1021/jm300871x

PubMed ID: 23679855

Title: Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase.

PubMed ID: 23679855

DOI: 10.1042/bj20130013

PubMed ID: 8488842

Title: Mutation at codon 322 in the human acetylcholinesterase (ACHE) gene accounts for YT blood group polymorphism.

PubMed ID: 8488842

Sequence Information:

Length: 614
Mass: 67796
Checksum: B9AA84C77831C302
Sequence:

MRPPQCLLHT PSLASPLLLL LLWLLGGGVG AEGREDAELL VTVRGGRLRG IRLKTPGGPV 
SAFLGIPFAE PPMGPRRFLP PEPKQPWSGV VDATTFQSVC YQYVDTLYPG FEGTEMWNPN 
RELSEDCLYL NVWTPYPRPT SPTPVLVWIY GGGFYSGASS LDVYDGRFLV QAERTVLVSM 
NYRVGAFGFL ALPGSREAPG NVGLLDQRLA LQWVQENVAA FGGDPTSVTL FGESAGAASV 
GMHLLSPPSR GLFHRAVLQS GAPNGPWATV GMGEARRRAT QLAHLVGCPP GGTGGNDTEL 
VACLRTRPAQ VLVNHEWHVL PQESVFRFSF VPVVDGDFLS DTPEALINAG DFHGLQVLVG 
VVKDEGSYFL VYGAPGFSKD NESLISRAEF LAGVRVGVPQ VSDLAAEAVV LHYTDWLHPE 
DPARLREALS DVVGDHNVVC PVAQLAGRLA AQGARVYAYV FEHRASTLSW PLWMGVPHGY 
EIEFIFGIPL DPSRNYTAEE KIFAQRLMRY WANFARTGDP NEPRDPKAPQ WPPYTAGAQQ 
YVSLDLRPLE VRRGLRAQAC AFWNRFLPKL LSATDTLDEA ERQWKAEFHR WSSYMVHWKN 
QFDHYSKQDR CSDL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ACHE

Associated with

Other Information

Molecular cloning and construction of the coding region for human acetylcholinesterase reveals a G + C-rich attenuating structure. PubMed ID: 2263619

Expression of three alternative acetylcholinesterase messenger RNAs in human tumor cell lines of different tissue origins. PubMed ID: 8299725

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence of human chromosome 7. PubMed ID: 12853948

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5. PubMed ID: 11239002

Purification and partial amino acid sequence analysis of human erythrocyte acetylcholinesterase. PubMed ID: 2714437

The effect of elimination of intersubunit disulfide bonds on the activity, assembly, and secretion of recombinant human acetylcholinesterase. Expression of acetylcholinesterase Cys-580--&gt;Ala mutant. PubMed ID: 1748670

Mutagenesis of human acetylcholinesterase. Identification of residues involved in catalytic activity and in polypeptide folding. PubMed ID: 1517212

Increased expression of intranuclear AChE involved in apoptosis of SK-N-SH cells. PubMed ID: 11985878

External and internal electrostatic potentials of cholinesterase models. PubMed ID: 9640563

Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II. PubMed ID: 11053835

The synaptic acetylcholinesterase tetramer assembles around a polyproline II helix. PubMed ID: 15526038

Structural evidence that human acetylcholinesterase inhibited by tabun ages through O-dealkylation. PubMed ID: 20408548

Structures of human acetylcholinesterase in complex with pharmacologically important ligands. PubMed ID: 23035744

Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase. PubMed ID: 23679855

Mutation at codon 322 in the human acetylcholinesterase (ACHE) gene accounts for YT blood group polymorphism. PubMed ID: 8488842