Details for: ASCL2

Gene ID: 430

Symbol: ASCL2

Ensembl ID: ENSG00000183734

Description: achaete-scute family bHLH transcription factor 2

Associated with

  • Bhlh transcription factor binding
    (GO:0043425)
  • Chorionic trophoblast cell development
    (GO:0060719)
  • Chromatin
    (GO:0000785)
  • Cytoplasm
    (GO:0005737)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • E-box binding
    (GO:0070888)
  • Negative regulation of schwann cell proliferation
    (GO:0010626)
  • Negative regulation of t-helper 1 cell differentiation
    (GO:0045626)
  • Negative regulation of t-helper 2 cell differentiation
    (GO:0045629)
  • Negative regulation of t-helper 17 cell differentiation
    (GO:2000320)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Neuron differentiation
    (GO:0030182)
  • Nucleus
    (GO:0005634)
  • Placenta development
    (GO:0001890)
  • Positive regulation of t cell migration
    (GO:2000406)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein dimerization activity
    (GO:0046983)
  • Regulation of neurogenesis
    (GO:0050767)
  • Response to hypoxia
    (GO:0001666)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulator complex
    (GO:0090575)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sensory organ development
    (GO:0007423)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Somatic stem cell population maintenance
    (GO:0035019)
  • Spongiotrophoblast layer development
    (GO:0060712)
  • T follicular helper cell differentiation
    (GO:0061470)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 42.1099
    Cell Significance Index: -6.5500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 22.6302
    Cell Significance Index: -5.7400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 14.2403
    Cell Significance Index: -7.3300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.3368
    Cell Significance Index: -6.5800
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 4.7494
    Cell Significance Index: 29.5100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.7773
    Cell Significance Index: -7.4400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.1962
    Cell Significance Index: 131.8500
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 2.1377
    Cell Significance Index: 21.5700
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.8222
    Cell Significance Index: 15.0700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.7250
    Cell Significance Index: 49.7000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.5726
    Cell Significance Index: 255.7600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.4988
    Cell Significance Index: 77.8600
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.2068
    Cell Significance Index: 12.8400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.0687
    Cell Significance Index: 49.8300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.0139
    Cell Significance Index: 70.1200
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.9492
    Cell Significance Index: 2.1400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9406
    Cell Significance Index: 93.0500
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.7617
    Cell Significance Index: 5.3600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6186
    Cell Significance Index: 8.4400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.6130
    Cell Significance Index: 11.3300
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.5665
    Cell Significance Index: 6.5900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.5382
    Cell Significance Index: 11.1700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.5176
    Cell Significance Index: 7.8000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4818
    Cell Significance Index: 10.2600
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 0.4512
    Cell Significance Index: 9.4100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.3723
    Cell Significance Index: 9.9600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3283
    Cell Significance Index: 23.2200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.2743
    Cell Significance Index: 4.4000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2671
    Cell Significance Index: 48.1500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2414
    Cell Significance Index: 10.9400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2237
    Cell Significance Index: 27.5000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2017
    Cell Significance Index: 89.1600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1967
    Cell Significance Index: 5.3600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1902
    Cell Significance Index: 36.2000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1748
    Cell Significance Index: 5.6000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1723
    Cell Significance Index: 94.0700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.1541
    Cell Significance Index: 2.3400
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 0.1132
    Cell Significance Index: 0.6300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0724
    Cell Significance Index: 2.5500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0598
    Cell Significance Index: 11.8700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0413
    Cell Significance Index: 0.9000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0317
    Cell Significance Index: 3.6300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0233
    Cell Significance Index: 0.6500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0041
    Cell Significance Index: 0.1100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0034
    Cell Significance Index: -6.3100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0047
    Cell Significance Index: -3.5800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0049
    Cell Significance Index: -3.6600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0056
    Cell Significance Index: -0.0800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0060
    Cell Significance Index: -3.4000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0070
    Cell Significance Index: -5.1600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0092
    Cell Significance Index: -1.2700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0114
    Cell Significance Index: -7.1500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0119
    Cell Significance Index: -3.4200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0138
    Cell Significance Index: -1.4100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0150
    Cell Significance Index: -0.7100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0152
    Cell Significance Index: -5.4600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0190
    Cell Significance Index: -8.6400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0272
    Cell Significance Index: -5.4600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0276
    Cell Significance Index: -3.5400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0280
    Cell Significance Index: -0.7000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0280
    Cell Significance Index: -5.8900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0311
    Cell Significance Index: -3.6300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0319
    Cell Significance Index: -5.4500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0378
    Cell Significance Index: -2.4400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0392
    Cell Significance Index: -0.8500
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0399
    Cell Significance Index: -0.2900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0423
    Cell Significance Index: -4.9900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0459
    Cell Significance Index: -0.4800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0467
    Cell Significance Index: -1.2000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0481
    Cell Significance Index: -6.9900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0567
    Cell Significance Index: -7.3200
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: -0.0570
    Cell Significance Index: -0.4900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0572
    Cell Significance Index: -4.2600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0725
    Cell Significance Index: -3.6600
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: -0.0752
    Cell Significance Index: -0.5800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0871
    Cell Significance Index: -5.4900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0872
    Cell Significance Index: -6.9100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0889
    Cell Significance Index: -6.8200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0950
    Cell Significance Index: -1.5900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1080
    Cell Significance Index: -6.6200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1086
    Cell Significance Index: -7.3000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1104
    Cell Significance Index: -6.2000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1132
    Cell Significance Index: -6.9600
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1133
    Cell Significance Index: -1.5900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1178
    Cell Significance Index: -1.0900
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.1190
    Cell Significance Index: -1.1300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1204
    Cell Significance Index: -6.2700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1259
    Cell Significance Index: -1.4300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1307
    Cell Significance Index: -6.8600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1417
    Cell Significance Index: -5.2000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1453
    Cell Significance Index: -6.3200
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.1525
    Cell Significance Index: -1.2400
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.1600
    Cell Significance Index: -1.6500
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.1623
    Cell Significance Index: -0.8500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1632
    Cell Significance Index: -7.2200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1675
    Cell Significance Index: -2.3900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1727
    Cell Significance Index: -6.0500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1848
    Cell Significance Index: -6.0500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1864
    Cell Significance Index: -5.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ASCL2 is a transcription factor that belongs to the bHLH (basic helix-loop-helix) family of proteins. It contains a bHLH domain, which is responsible for DNA binding and transcriptional activation. ASCL2 is a dimerization partner of other bHLH transcription factors, such as ASCL1, and forms a heterodimer that binds to specific DNA sequences. ASCL2 is also a transcriptional repressor, as it can bind to the same DNA sequences as transcriptional activators, such as ASCL1, and inhibit their activity. ASCL2 has been shown to interact with other transcription factors and co-regulators, such as TCF/LEF-1 and p300, to regulate gene expression. **Pathways and Functions** ASCL2 is involved in several signaling pathways and regulatory networks, including: 1. **Neurogenesis**: ASCL2 is a key transcription factor in the development of the nervous system, where it regulates the differentiation of neural progenitor cells into neurons and glial cells. 2. **Sensory organ development**: ASCL2 is involved in the development of sensory organs, such as the eye and ear, where it regulates the differentiation of sensory cells. 3. **Immune system function**: ASCL2 is expressed in immune cells, such as T cells and B cells, and regulates their development and function. 4. **Cell cycle regulation**: ASCL2 can regulate cell cycle progression by inhibiting the activity of cell cycle regulators, such as E2F1. 5. **Apoptosis**: ASCL2 can regulate apoptosis by interacting with pro-apoptotic proteins, such as BAX. **Clinical Significance** Dysregulation of ASCL2 has been implicated in several human diseases, including: 1. **Neurodevelopmental disorders**: Mutations in ASCL2 have been associated with neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. 2. **Cancer**: ASCL2 has been shown to be overexpressed in certain types of cancer, including lung cancer and breast cancer. 3. **Immune system disorders**: ASCL2 has been implicated in immune system disorders, such as rheumatoid arthritis and multiple sclerosis. 4. **Placental development**: ASCL2 is involved in placental development, and dysregulation of ASCL2 has been associated with pregnancy complications, such as preeclampsia. In conclusion, ASCL2 is a critical transcription factor involved in various developmental processes, including neurogenesis, sensory organ development, and immune system function. Its dysregulation has been implicated in several human diseases, highlighting the importance of ASCL2 in maintaining tissue homeostasis and preventing disease.

Genular Protein ID: 2514949866

Symbol: ASCL2_HUMAN

Name: Achaete-scute homolog 2

UniProtKB Accession Codes:

Q99929 Q6PEY9 Q9UM68

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 GO 30 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9175731

Title: The human Achaete-Scute homologue 2 (ASCL2,HASH2) maps to chromosome 11p15.5, close to IGF2 and is expressed in extravillus trophoblasts.

PubMed ID: 9175731

DOI: 10.1093/hmg/6.6.859

PubMed ID: 11440538

Title: The human Achaete Scute homolog 2 gene contains two promotors, generating overlapping transcripts and encoding two proteins with different nuclear localization.

PubMed ID: 11440538

DOI: 10.1053/plac.2001.0695

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8751384

Title: Genomic cloning and localization to chromosome 11p15.5 of the human achaete-scute homolog 2 (ASCL2).

PubMed ID: 8751384

DOI: 10.1159/000134364

PubMed ID: 12099555

Title: The human ASCL2 gene escaping genomic imprinting and its expression pattern.

PubMed ID: 12099555

DOI: 10.1023/a:1015362903486

PubMed ID: 24463518

Title: Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development.

PubMed ID: 24463518

DOI: 10.1038/nature12910

Sequence Information:

  • Length: 193
  • Mass: 20185
  • Checksum: E59A71342E6D46C8
  • Sequence:
    • MDGGTLPRSA PPAPPVPVGC AARRRPASPE LLRCSRRRRP ATAETGGGAA AVARRNERER 
NRVKLVNLGF QALRQHVPHG GASKKLSKVE TLRSAVEYIR ALQRLLAEHD AVRNALAGGL 
RPQAVRPSAP RGPPGTTPVA ASPSRASSSP GRGGSSEPGS PRSAYSSDDS GCEGALSPAE 
RELLDFSSWL GGY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.