Details for: ASCL2

Gene ID: 430

Symbol: ASCL2

Ensembl ID: ENSG00000183734

Description: achaete-scute family bHLH transcription factor 2

Associated with

  • Bhlh transcription factor binding
    (GO:0043425)
  • Chorionic trophoblast cell development
    (GO:0060719)
  • Chromatin
    (GO:0000785)
  • Cytoplasm
    (GO:0005737)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • E-box binding
    (GO:0070888)
  • Negative regulation of schwann cell proliferation
    (GO:0010626)
  • Negative regulation of t-helper 1 cell differentiation
    (GO:0045626)
  • Negative regulation of t-helper 2 cell differentiation
    (GO:0045629)
  • Negative regulation of t-helper 17 cell differentiation
    (GO:2000320)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Neuron differentiation
    (GO:0030182)
  • Nucleus
    (GO:0005634)
  • Placenta development
    (GO:0001890)
  • Positive regulation of t cell migration
    (GO:2000406)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein dimerization activity
    (GO:0046983)
  • Regulation of neurogenesis
    (GO:0050767)
  • Response to hypoxia
    (GO:0001666)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulator complex
    (GO:0090575)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sensory organ development
    (GO:0007423)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Somatic stem cell population maintenance
    (GO:0035019)
  • Spongiotrophoblast layer development
    (GO:0060712)
  • T follicular helper cell differentiation
    (GO:0061470)

Other Information

Genular Protein ID: 2514949866

Symbol: ASCL2_HUMAN

Name: Achaete-scute homolog 2

UniProtKB Accession Codes:

Q99929 Q6PEY9 Q9UM68

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 GO 30 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9175731

Title: The human Achaete-Scute homologue 2 (ASCL2,HASH2) maps to chromosome 11p15.5, close to IGF2 and is expressed in extravillus trophoblasts.

PubMed ID: 9175731

DOI: 10.1093/hmg/6.6.859

PubMed ID: 11440538

Title: The human Achaete Scute homolog 2 gene contains two promotors, generating overlapping transcripts and encoding two proteins with different nuclear localization.

PubMed ID: 11440538

DOI: 10.1053/plac.2001.0695

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8751384

Title: Genomic cloning and localization to chromosome 11p15.5 of the human achaete-scute homolog 2 (ASCL2).

PubMed ID: 8751384

DOI: 10.1159/000134364

PubMed ID: 12099555

Title: The human ASCL2 gene escaping genomic imprinting and its expression pattern.

PubMed ID: 12099555

DOI: 10.1023/a:1015362903486

PubMed ID: 24463518

Title: Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development.

PubMed ID: 24463518

DOI: 10.1038/nature12910

Sequence Information:

  • Length: 193
  • Mass: 20185
  • Checksum: E59A71342E6D46C8
  • Sequence:
    • MDGGTLPRSA PPAPPVPVGC AARRRPASPE LLRCSRRRRP ATAETGGGAA AVARRNERER 
NRVKLVNLGF QALRQHVPHG GASKKLSKVE TLRSAVEYIR ALQRLLAEHD AVRNALAGGL 
RPQAVRPSAP RGPPGTTPVA ASPSRASSSP GRGGSSEPGS PRSAYSSDDS GCEGALSPAE 
RELLDFSSWL GGY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.