Details for: ASCL2

Gene ID: 430

Symbol: ASCL2

Ensembl ID: ENSG00000183734

Description: achaete-scute family bHLH transcription factor 2

Associated with

  • Bhlh transcription factor binding
    (GO:0043425)
  • Chorionic trophoblast cell development
    (GO:0060719)
  • Chromatin
    (GO:0000785)
  • Cytoplasm
    (GO:0005737)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • E-box binding
    (GO:0070888)
  • Negative regulation of schwann cell proliferation
    (GO:0010626)
  • Negative regulation of t-helper 1 cell differentiation
    (GO:0045626)
  • Negative regulation of t-helper 2 cell differentiation
    (GO:0045629)
  • Negative regulation of t-helper 17 cell differentiation
    (GO:2000320)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Neuron differentiation
    (GO:0030182)
  • Nucleus
    (GO:0005634)
  • Placenta development
    (GO:0001890)
  • Positive regulation of t cell migration
    (GO:2000406)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein dimerization activity
    (GO:0046983)
  • Regulation of neurogenesis
    (GO:0050767)
  • Response to hypoxia
    (GO:0001666)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulator complex
    (GO:0090575)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sensory organ development
    (GO:0007423)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Somatic stem cell population maintenance
    (GO:0035019)
  • Spongiotrophoblast layer development
    (GO:0060712)
  • T follicular helper cell differentiation
    (GO:0061470)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 10.11
    Marker Score: 14518
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 3.31
    Marker Score: 9343
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.47
    Marker Score: 585
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.4
    Marker Score: 5180
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.35
    Marker Score: 697
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.33
    Marker Score: 2516
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.22
    Marker Score: 2473
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.17
    Marker Score: 439
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.01
    Marker Score: 7523
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71803
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48028
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.99
    Marker Score: 15497
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.98
    Marker Score: 2873
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 498
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.96
    Marker Score: 1417
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 452
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2737
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.91
    Marker Score: 2159
  • Cell Name: epithelial fate stem cell (CL0000036)
    Fold Change: 0.9
    Marker Score: 258
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5121
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 318
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5284
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 0.87
    Marker Score: 316.5
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.86
    Marker Score: 756.5
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.85
    Marker Score: 367
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.79
    Marker Score: 1167
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 592.5
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.76
    Marker Score: 1740
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.75
    Marker Score: 1312
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 388
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.75
    Marker Score: 763
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.74
    Marker Score: 295.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.7
    Marker Score: 421
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2884
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.64
    Marker Score: 1660
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.63
    Marker Score: 794
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 0.62
    Marker Score: 140
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.61
    Marker Score: 34209
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.61
    Marker Score: 1916
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.6
    Marker Score: 174
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.6
    Marker Score: 312
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.59
    Marker Score: 409
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.56
    Marker Score: 122
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 436
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.52
    Marker Score: 1175
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.49
    Marker Score: 206
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.48
    Marker Score: 429
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.47
    Marker Score: 221
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.46
    Marker Score: 252
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.45
    Marker Score: 270
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.45
    Marker Score: 411
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.45
    Marker Score: 582
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.44
    Marker Score: 244
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.42
    Marker Score: 134
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.41
    Marker Score: 808
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.41
    Marker Score: 409
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.41
    Marker Score: 411
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4
    Marker Score: 253
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.38
    Marker Score: 102
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.38
    Marker Score: 279
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.38
    Marker Score: 1496
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.38
    Marker Score: 158
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.38
    Marker Score: 74
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.38
    Marker Score: 289
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.37
    Marker Score: 330
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.37
    Marker Score: 603
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.36
    Marker Score: 117
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.35
    Marker Score: 92
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.35
    Marker Score: 868
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.35
    Marker Score: 169
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.35
    Marker Score: 144
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.34
    Marker Score: 141
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.34
    Marker Score: 853
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.34
    Marker Score: 116
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.33
    Marker Score: 159
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.33
    Marker Score: 345
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.33
    Marker Score: 314
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.31
    Marker Score: 84
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.31
    Marker Score: 76
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.3
    Marker Score: 261
  • Cell Name: brush cell of trachebronchial tree (CL0002075)
    Fold Change: 0.3
    Marker Score: 93
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.3
    Marker Score: 411
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.3
    Marker Score: 94
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3
    Marker Score: 10274
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.3
    Marker Score: 75
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.29
    Marker Score: 372
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.28
    Marker Score: 688
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.27
    Marker Score: 659
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.27
    Marker Score: 435
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.27
    Marker Score: 124
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.27
    Marker Score: 280
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.27
    Marker Score: 268
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.27
    Marker Score: 423
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.26
    Marker Score: 115
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.26
    Marker Score: 119
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.26
    Marker Score: 442

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Other Information

**Key characteristics:** * ASCL2 is a bHLH transcription factor, which are a family of transcription factors that are highly expressed in neural tissue. * It is a key regulator of neuron differentiation, as it is expressed in neurons and is essential for their survival and function. * It is also involved in the regulation of placental development, as it is expressed in cells that are responsible for the development of the placenta. * ASCL2 is a negative regulator of inflammation, as it inhibits the expression of inflammatory genes. * It is also involved in the regulation of tissue homeostasis, as it is expressed in cells that are responsible for maintaining tissue integrity. **Pathways and functions:** * ASCL2 binds to DNA sequences known as E-boxes and regulates the expression of genes that are involved in neuron differentiation, placental development, and inflammation. * It also binds to DNA sequences in the rna polymerase ii region of the genome, which is involved in the regulation of transcription by RNA polymerase ii. * ASCL2 is a key regulator of neurogenesis, as it is expressed in cells that are committed to becoming neurons. * It is also involved in the regulation of placental development, as it is expressed in cells that are responsible for the development of the placenta. **Clinical significance:** Mutations in the ASCL2 gene have been linked to a number of human diseases, including autism, schizophrenia, and epilepsy. These mutations can lead to the loss of ASCL2 function, which can result in a variety of developmental and neurological problems.

Genular Protein ID: 2514949866

Symbol: ASCL2_HUMAN

Name: Achaete-scute homolog 2

UniProtKB Accession Codes:

Q99929 Q6PEY9 Q9UM68

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 GO 30 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9175731

Title: The human Achaete-Scute homologue 2 (ASCL2,HASH2) maps to chromosome 11p15.5, close to IGF2 and is expressed in extravillus trophoblasts.

PubMed ID: 9175731

DOI: 10.1093/hmg/6.6.859

PubMed ID: 11440538

Title: The human Achaete Scute homolog 2 gene contains two promotors, generating overlapping transcripts and encoding two proteins with different nuclear localization.

PubMed ID: 11440538

DOI: 10.1053/plac.2001.0695

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8751384

Title: Genomic cloning and localization to chromosome 11p15.5 of the human achaete-scute homolog 2 (ASCL2).

PubMed ID: 8751384

DOI: 10.1159/000134364

PubMed ID: 12099555

Title: The human ASCL2 gene escaping genomic imprinting and its expression pattern.

PubMed ID: 12099555

DOI: 10.1023/a:1015362903486

PubMed ID: 24463518

Title: Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development.

PubMed ID: 24463518

DOI: 10.1038/nature12910

Sequence Information:

  • Length: 193
  • Mass: 20185
  • Checksum: E59A71342E6D46C8
  • Sequence:
    • MDGGTLPRSA PPAPPVPVGC AARRRPASPE LLRCSRRRRP ATAETGGGAA AVARRNERER 
NRVKLVNLGF QALRQHVPHG GASKKLSKVE TLRSAVEYIR ALQRLLAEHD AVRNALAGGL 
RPQAVRPSAP RGPPGTTPVA ASPSRASSSP GRGGSSEPGS PRSAYSSDDS GCEGALSPAE 
RELLDFSSWL GGY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.