Details for: E spl mgamma HLH

Gene ID: 43151

Symbol: E spl mgamma HLH

Ensembl ID: FBgn0002735

Description: Enhancer of split mgamma, helix-loop-helix

Associated with

  • Anterior/posterior pattern specification
    (GO:0009952)
  • Cis-regulatory region sequence-specific dna binding
    (GO:0000987)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription factor binding
    (GO:0140297)
  • Dna binding
    (GO:0003677)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Neuronal stem cell population maintenance
    (GO:0097150)
  • Nucleus
    (GO:0005634)
  • Positive regulation of neuroblast proliferation
    (GO:0002052)
  • Protein dimerization activity
    (GO:0046983)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of neuroblast proliferation
    (GO:1902692)
  • Regulation of neurogenesis
    (GO:0050767)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Wing disc dorsal/ventral pattern formation
    (GO:0048190)

Other Information

Genular Protein ID: 1503631354

Symbol: ESMC_DROME

Name: Enhancer of split mgamma protein

UniProtKB Accession Codes:

Q01070 Q01898 Q5S4K4

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CDD 1 CTD 1 DIP 1 DNASU 1 ELM 1 EMBL 21 EnsemblMetazoa 1 FlyBase 1 GO 20 Gene3D 2 GeneTree 1 GenomeRNAi 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PaxDb 1 Pfam 2 PhylomeDB 1 Proteomes 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 1427040

Title: Seven genes of the Enhancer of split complex of Drosophila melanogaster encode helix-loop-helix proteins.

PubMed ID: 1427040

DOI: 10.1093/genetics/132.2.505

PubMed ID: 1528887

Title: The Enhancer of split [E(spl)] locus of Drosophila encodes seven independent helix-loop-helix proteins.

PubMed ID: 1528887

DOI: 10.1073/pnas.89.18.8731

PubMed ID: 10790334

Title: Spatially restricted factors cooperate with Notch in the regulation of Enhancer of split genes.

PubMed ID: 10790334

DOI: 10.1006/dbio.2000.9691

PubMed ID: 15537803

Title: Identifying signatures of selection at the enhancer of split neurogenic gene complex in Drosophila.

PubMed ID: 15537803

DOI: 10.1093/molbev/msi046

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 22357926

Title: bHLH-O proteins are crucial for Drosophila neuroblast self-renewal and mediate Notch-induced overproliferation.

PubMed ID: 22357926

DOI: 10.1242/dev.071779

PubMed ID: 24618901

Title: The Brm-HDAC3-Erm repressor complex suppresses dedifferentiation in Drosophila type II neuroblast lineages.

PubMed ID: 24618901

DOI: 10.7554/elife.01906

Sequence Information:

  • Length: 205
  • Mass: 23135
  • Checksum: 4183A35D66DAB7E5
  • Sequence:
    • MSSLQMSEMS KTYQYRKVMK PMLERKRRAR INKCLDELKD LMVATLESEG EHVTRLEKAD 
ILELTVTHLQ KMKQQRQHKR ASGDESLTPA EGFRSGYIHA VNEVSRSLSQ LPGMNVSLGT 
QLMTHLGQRL NQIQPAEKEV LPVTAPLSVH IANRDAYSVP ISPISSYAGS PNSNTSSTSH 
SLLTTIDVTK MEDDSEDEEN VWRPW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.