Details for: E spl m8 HLH

Gene ID: 43161

Symbol: E spl m8 HLH

Ensembl ID: FBgn0000591

Description: Enhancer of split m8, helix-loop-helix

Associated with

  • Anterior/posterior pattern specification
    (GO:0009952)
  • Compound eye development
    (GO:0048749)
  • Dendrite morphogenesis
    (GO:0048813)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dna binding
    (GO:0003677)
  • Mesoderm development
    (GO:0007498)
  • Negative regulation of gene expression
    (GO:0010629)
  • Nucleus
    (GO:0005634)
  • Protein dimerization activity
    (GO:0046983)
  • Protein heterodimerization activity
    (GO:0046982)
  • Protein homodimerization activity
    (GO:0042803)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of neurogenesis
    (GO:0050767)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sensory organ precursor cell fate determination
    (GO:0016360)
  • Sequence-specific dna binding
    (GO:0043565)

Other Information

Genular Protein ID: 1929029838

Symbol: ESM8_DROME

Name: Enhancer of split m8 protein

UniProtKB Accession Codes:

P13098 Q0IGQ3 Q2XYK0 Q5S426 Q5S462 Q5S474 Q5S4H0 Q5S4I2 Q9VBI5

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DIP 1 ELM 1 EMBL 23 EnsemblMetazoa 1 FlyBase 2 GO 15 Gene3D 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MINT 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 2 PaxDb 1 Pfam 2 PhylomeDB 1 Proteomes 1 RefSeq 1 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 2540957

Title: Closely related transcripts encoded by the neurogenic gene complex enhancer of split of Drosophila melanogaster.

PubMed ID: 2540957

DOI: 10.1002/j.1460-2075.1989.tb03365.x

PubMed ID: 15537803

Title: Identifying signatures of selection at the enhancer of split neurogenic gene complex in Drosophila.

PubMed ID: 15537803

DOI: 10.1093/molbev/msi046

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 16120803

Title: Intragenic Hill-Robertson interference influences selection intensity on synonymous mutations in Drosophila.

PubMed ID: 16120803

DOI: 10.1093/molbev/msi246

PubMed ID: 8001118

Title: Groucho is required for Drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy-related bHLH proteins.

PubMed ID: 8001118

DOI: 10.1016/0092-8674(94)90070-1

PubMed ID: 22357926

Title: bHLH-O proteins are crucial for Drosophila neuroblast self-renewal and mediate Notch-induced overproliferation.

PubMed ID: 22357926

DOI: 10.1242/dev.071779

Sequence Information:

  • Length: 179
  • Mass: 20303
  • Checksum: 017B139DE0C328B4
  • Sequence:
    • MEYTTKTQIY QKVKKPMLER QRRARMNKCL DNLKTLVAEL RGDDGILRMD KAEMLESAVI 
FMRQQKTPKK VAQEEQSLPL DSFKNGYMNA VNEVSRVMAS TPGMSVDLGK SVMTHLGRVY 
KNLQQFHEAQ SAADFIQNSM DCSSMDKAPL SPASSGYHSD CDSPAPSPQP MQQPLWRPW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.