Details for: ASGR1

Gene ID: 432

Symbol: ASGR1

Ensembl ID: ENSG00000141505

Description: asialoglycoprotein receptor 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 3.32
    Marker Score: 5,110
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 2.92
    Marker Score: 15,694
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.28
    Marker Score: 127,635
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2.25
    Marker Score: 7,376
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.21
    Marker Score: 5,508
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.17
    Marker Score: 13,954
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 2.07
    Marker Score: 8,936
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.74
    Marker Score: 648
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.62
    Marker Score: 3,152
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.36
    Marker Score: 2,763
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.32
    Marker Score: 1,593
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.24
    Marker Score: 14,445
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.22
    Marker Score: 833
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.21
    Marker Score: 1,143
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.21
    Marker Score: 5,011
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.15
    Marker Score: 1,236
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.04
    Marker Score: 1,059
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,779
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1
    Marker Score: 2,598
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,798
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,022
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,406
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.97
    Marker Score: 1,399
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.97
    Marker Score: 366
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 500
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 455
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,411
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.95
    Marker Score: 5,746
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.94
    Marker Score: 1,070
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,281
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.92
    Marker Score: 1,872
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,734
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 320
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,296
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.81
    Marker Score: 335
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.78
    Marker Score: 3,279
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,269
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 597
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.78
    Marker Score: 1,875
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.77
    Marker Score: 754
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.77
    Marker Score: 19,662
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 700
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.77
    Marker Score: 721
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 390
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 300
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.7
    Marker Score: 697
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.65
    Marker Score: 8,588
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.64
    Marker Score: 216
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.63
    Marker Score: 1,199
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.63
    Marker Score: 185
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.62
    Marker Score: 162
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.61
    Marker Score: 942
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.6
    Marker Score: 223
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.59
    Marker Score: 945
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.56
    Marker Score: 729
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.55
    Marker Score: 1,357
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 437
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.54
    Marker Score: 299
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.54
    Marker Score: 131
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.54
    Marker Score: 233
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 170
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.5
    Marker Score: 563
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.49
    Marker Score: 177
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.49
    Marker Score: 249
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.49
    Marker Score: 7,641
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.48
    Marker Score: 167
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.48
    Marker Score: 132
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.47
    Marker Score: 252
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.47
    Marker Score: 322
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.46
    Marker Score: 296
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.45
    Marker Score: 1,061
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.44
    Marker Score: 203
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.44
    Marker Score: 909
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.44
    Marker Score: 136
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.44
    Marker Score: 225
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.43
    Marker Score: 101
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.43
    Marker Score: 178
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.4
    Marker Score: 175
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.39
    Marker Score: 118
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.39
    Marker Score: 283
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.39
    Marker Score: 200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.38
    Marker Score: 219
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.38
    Marker Score: 253
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.38
    Marker Score: 657
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.37
    Marker Score: 245
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.37
    Marker Score: 228
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.36
    Marker Score: 258
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.36
    Marker Score: 231
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.36
    Marker Score: 88
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.35
    Marker Score: 171
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.35
    Marker Score: 320
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.35
    Marker Score: 211
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.34
    Marker Score: 193
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.34
    Marker Score: 378
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.33
    Marker Score: 180
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.33
    Marker Score: 72
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.33
    Marker Score: 256
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.33
    Marker Score: 683

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transmembrane Receptor:** ASGR1 is a type of transmembrane receptor that spans the plasma membrane, with an extracellular domain responsible for ligand binding and an intracellular domain involved in signaling and endocytosis. 2. **Glycoprotein Binding:** ASGR1 exhibits affinity for fucose and mannose, suggesting its role in regulating glycoprotein metabolism and recognition. 3. **Cellular Expression:** ASGR1 is highly expressed in enterocytes, hepatocytes, and immune cells, indicating its involvement in various physiological processes, including digestion, metabolism, and immune response. 4. **Signaling Pathways:** ASGR1 is involved in multiple signaling pathways, including receptor-mediated endocytosis, cellular response to extracellular stimuli, and protein binding. **Pathways and Functions:** 1. **Glycoprotein Metabolism:** ASGR1 regulates the metabolism of glycoproteins, including asialoglycoprotein, by mediating their endocytosis and degradation. 2. **Interspecies Interaction:** ASGR1 plays a crucial role in interspecies interaction between organisms, particularly in the context of gut-associated lymphoid tissue (GALT) and the immune system. 3. **Cellular Response to Extracellular Stimuli:** ASGR1 is involved in the cellular response to extracellular stimuli, including the recognition of pathogens and the regulation of immune responses. 4. **Protein Binding:** ASGR1 exhibits affinity for various proteins, including asialoglycoprotein, and regulates their binding and function. **Clinical Significance:** 1. **Gastrointestinal Disorders:** ASGR1 dysfunction has been implicated in various gastrointestinal disorders, including liver disease, inflammatory bowel disease, and cancer. 2. **Immune System Dysregulation:** ASGR1 plays a crucial role in regulating the immune system, and its dysfunction has been linked to autoimmune diseases and immunodeficiency disorders. 3. **Cancer Metastasis:** ASGR1 has been shown to be overexpressed in various cancers, including colon cancer, and is involved in the regulation of metastasis and tumor progression. 4. **Diabetes and Metabolic Disorders:** ASGR1 has been implicated in the regulation of glucose metabolism and insulin signaling, and its dysfunction has been linked to diabetes and metabolic disorders. In conclusion, ASGR1 is a multifunctional gene that plays a crucial role in regulating glycoprotein metabolism, interspecies interaction, and cellular response to extracellular stimuli. Its dysregulation has been implicated in various diseases, including gastrointestinal disorders, immune system dysregulation, cancer, and metabolic disorders. Further research is needed to fully understand the functions of ASGR1 and its potential therapeutic applications.

Genular Protein ID: 822300778

Symbol: ASGR1_HUMAN

Name: Asialoglycoprotein receptor 1

UniProtKB Accession Codes:

P07306 I3L1X1

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 ELM 1 EMBL 5 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 4 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 3 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniLectin 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2982798

Title: Sequence of human asialoglycoprotein receptor cDNA. An internal signal sequence for membrane insertion.

PubMed ID: 2982798

DOI: 10.1016/s0021-9258(18)89497-2

PubMed ID: 3753585

Title: An internal signal sequence: the asialoglycoprotein receptor membrane anchor.

PubMed ID: 3753585

DOI: 10.1016/0092-8674(86)90496-4

PubMed ID: 20886072

Title: A new splice variant of the major subunit of human asialoglycoprotein receptor encodes a secreted form in hepatocytes.

PubMed ID: 20886072

DOI: 10.1371/journal.pone.0012934

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8943311

Title: Fatty acylation of the rat and human asialoglycoprotein receptors. A conserved cytoplasmic cysteine residue is acylated in all receptor subunits.

PubMed ID: 8943311

DOI: 10.1074/jbc.271.50.32454

PubMed ID: 11543633

Title: Cloning, mapping, and characterization of a human homologue of the yeast longevity assurance gene LAG1.

PubMed ID: 11543633

DOI: 10.1006/geno.2001.6614

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27155063

Title: Asialoglycoprotein receptor facilitates infection of PLC/PRF/5 cells by HEV through interaction with ORF2.

PubMed ID: 27155063

DOI: 10.1002/jmv.24570

PubMed ID: 10891274

Title: Crystal structure of the carbohydrate recognition domain of the H1 subunit of the asialoglycoprotein receptor.

PubMed ID: 10891274

DOI: 10.1006/jmbi.2000.3853

Sequence Information:

  • Length: 291
  • Mass: 33186
  • Checksum: 9B825527B2FC1FD0
  • Sequence:
    • MTKEYQDLQH LDNEESDHHQ LRKGPPPPQP LLQRLCSGPR LLLLSLGLSL LLLVVVCVIG 
SQNSQLQEEL RGLRETFSNF TASTEAQVKG LSTQGGNVGR KMKSLESQLE KQQKDLSEDH 
SSLLLHVKQF VSDLRSLSCQ MAALQGNGSE RTCCPVNWVE HERSCYWFSR SGKAWADADN 
YCRLEDAHLV VVTSWEEQKF VQHHIGPVNT WMGLHDQNGP WKWVDGTDYE TGFKNWRPEQ 
PDDWYGHGLG GGEDCAHFTD DGRWNDDVCQ RPYRWVCETE LDKASQEPPL L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.