Details for: ASGR1

Gene ID: 432

Symbol: ASGR1

Ensembl ID: ENSG00000141505

Description: asialoglycoprotein receptor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 80.6196
    Cell Significance Index: -12.5400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 41.6727
    Cell Significance Index: -10.5700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 27.8391
    Cell Significance Index: -14.3200
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 10.7754
    Cell Significance Index: 28.4300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 10.5818
    Cell Significance Index: 178.2500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.1139
    Cell Significance Index: -12.4700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 3.8104
    Cell Significance Index: 756.1900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.2209
    Cell Significance Index: -12.7100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.8465
    Cell Significance Index: 52.6100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.0586
    Cell Significance Index: 31.8500
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.6835
    Cell Significance Index: 9.7000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.1222
    Cell Significance Index: 8.6500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.9180
    Cell Significance Index: 48.2000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.9072
    Cell Significance Index: 13.3900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.7353
    Cell Significance Index: 15.3900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6772
    Cell Significance Index: 67.0000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5291
    Cell Significance Index: 477.7300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5204
    Cell Significance Index: 31.2400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4662
    Cell Significance Index: 88.7200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3734
    Cell Significance Index: 60.7400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3015
    Cell Significance Index: 35.1400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2335
    Cell Significance Index: 16.1500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.2288
    Cell Significance Index: 6.1200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.1525
    Cell Significance Index: 2.1400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1523
    Cell Significance Index: 9.3600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1234
    Cell Significance Index: 7.7800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1061
    Cell Significance Index: 21.2900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0911
    Cell Significance Index: 4.7300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0823
    Cell Significance Index: 3.7300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0766
    Cell Significance Index: 0.8700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0512
    Cell Significance Index: 1.8000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0507
    Cell Significance Index: 1.4600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0382
    Cell Significance Index: 13.7100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0370
    Cell Significance Index: 0.8100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0252
    Cell Significance Index: 0.3000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0136
    Cell Significance Index: 0.2900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0075
    Cell Significance Index: 0.9600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0060
    Cell Significance Index: 0.1000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0009
    Cell Significance Index: 0.5700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0012
    Cell Significance Index: -0.6800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0032
    Cell Significance Index: -2.3800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0034
    Cell Significance Index: -2.3600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0035
    Cell Significance Index: -6.5900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0075
    Cell Significance Index: -13.8800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0088
    Cell Significance Index: -13.5900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0095
    Cell Significance Index: -1.7100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0100
    Cell Significance Index: -7.5800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0114
    Cell Significance Index: -15.5400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0120
    Cell Significance Index: -5.3100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0125
    Cell Significance Index: -0.2100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0155
    Cell Significance Index: -8.7500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0170
    Cell Significance Index: -1.0400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0170
    Cell Significance Index: -2.3400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0189
    Cell Significance Index: -13.8600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0190
    Cell Significance Index: -12.0900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0206
    Cell Significance Index: -4.3300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0260
    Cell Significance Index: -3.2000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0271
    Cell Significance Index: -4.6300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0301
    Cell Significance Index: -13.6800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0311
    Cell Significance Index: -8.9600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0412
    Cell Significance Index: -4.2100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0500
    Cell Significance Index: -1.6000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0578
    Cell Significance Index: -0.9900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0759
    Cell Significance Index: -2.1200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0762
    Cell Significance Index: -11.0700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0814
    Cell Significance Index: -10.5200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0846
    Cell Significance Index: -9.6600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0854
    Cell Significance Index: -9.7800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0868
    Cell Significance Index: -1.8800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0911
    Cell Significance Index: -1.8900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1116
    Cell Significance Index: -6.2600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1162
    Cell Significance Index: -13.7000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1181
    Cell Significance Index: -12.3000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1398
    Cell Significance Index: -1.5200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1422
    Cell Significance Index: -3.7400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1508
    Cell Significance Index: -7.0300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1512
    Cell Significance Index: -10.1700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1604
    Cell Significance Index: -1.9900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1606
    Cell Significance Index: -11.9700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1718
    Cell Significance Index: -13.1800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1760
    Cell Significance Index: -13.9400
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.1862
    Cell Significance Index: -1.6400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1885
    Cell Significance Index: -4.5200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1904
    Cell Significance Index: -8.9500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1972
    Cell Significance Index: -12.7200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2069
    Cell Significance Index: -7.1900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2150
    Cell Significance Index: -3.2400
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.2151
    Cell Significance Index: -0.8100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2247
    Cell Significance Index: -9.9400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2268
    Cell Significance Index: -4.4400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2394
    Cell Significance Index: -12.4700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2429
    Cell Significance Index: -2.5200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2461
    Cell Significance Index: -8.6200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2502
    Cell Significance Index: -5.3100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2572
    Cell Significance Index: -6.6100
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.2625
    Cell Significance Index: -3.6400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2715
    Cell Significance Index: -7.2500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2791
    Cell Significance Index: -10.5700
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.2843
    Cell Significance Index: -1.7800
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.2863
    Cell Significance Index: -3.4700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transmembrane Receptor:** ASGR1 is a type of transmembrane receptor that spans the plasma membrane, with an extracellular domain responsible for ligand binding and an intracellular domain involved in signaling and endocytosis. 2. **Glycoprotein Binding:** ASGR1 exhibits affinity for fucose and mannose, suggesting its role in regulating glycoprotein metabolism and recognition. 3. **Cellular Expression:** ASGR1 is highly expressed in enterocytes, hepatocytes, and immune cells, indicating its involvement in various physiological processes, including digestion, metabolism, and immune response. 4. **Signaling Pathways:** ASGR1 is involved in multiple signaling pathways, including receptor-mediated endocytosis, cellular response to extracellular stimuli, and protein binding. **Pathways and Functions:** 1. **Glycoprotein Metabolism:** ASGR1 regulates the metabolism of glycoproteins, including asialoglycoprotein, by mediating their endocytosis and degradation. 2. **Interspecies Interaction:** ASGR1 plays a crucial role in interspecies interaction between organisms, particularly in the context of gut-associated lymphoid tissue (GALT) and the immune system. 3. **Cellular Response to Extracellular Stimuli:** ASGR1 is involved in the cellular response to extracellular stimuli, including the recognition of pathogens and the regulation of immune responses. 4. **Protein Binding:** ASGR1 exhibits affinity for various proteins, including asialoglycoprotein, and regulates their binding and function. **Clinical Significance:** 1. **Gastrointestinal Disorders:** ASGR1 dysfunction has been implicated in various gastrointestinal disorders, including liver disease, inflammatory bowel disease, and cancer. 2. **Immune System Dysregulation:** ASGR1 plays a crucial role in regulating the immune system, and its dysfunction has been linked to autoimmune diseases and immunodeficiency disorders. 3. **Cancer Metastasis:** ASGR1 has been shown to be overexpressed in various cancers, including colon cancer, and is involved in the regulation of metastasis and tumor progression. 4. **Diabetes and Metabolic Disorders:** ASGR1 has been implicated in the regulation of glucose metabolism and insulin signaling, and its dysfunction has been linked to diabetes and metabolic disorders. In conclusion, ASGR1 is a multifunctional gene that plays a crucial role in regulating glycoprotein metabolism, interspecies interaction, and cellular response to extracellular stimuli. Its dysregulation has been implicated in various diseases, including gastrointestinal disorders, immune system dysregulation, cancer, and metabolic disorders. Further research is needed to fully understand the functions of ASGR1 and its potential therapeutic applications.

Genular Protein ID: 822300778

Symbol: ASGR1_HUMAN

Name: Asialoglycoprotein receptor 1

UniProtKB Accession Codes:

P07306 I3L1X1

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 ELM 1 EMBL 5 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 3 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniLectin 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2982798

Title: Sequence of human asialoglycoprotein receptor cDNA. An internal signal sequence for membrane insertion.

PubMed ID: 2982798

DOI: 10.1016/s0021-9258(18)89497-2

PubMed ID: 3753585

Title: An internal signal sequence: the asialoglycoprotein receptor membrane anchor.

PubMed ID: 3753585

DOI: 10.1016/0092-8674(86)90496-4

PubMed ID: 20886072

Title: A new splice variant of the major subunit of human asialoglycoprotein receptor encodes a secreted form in hepatocytes.

PubMed ID: 20886072

DOI: 10.1371/journal.pone.0012934

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8943311

Title: Fatty acylation of the rat and human asialoglycoprotein receptors. A conserved cytoplasmic cysteine residue is acylated in all receptor subunits.

PubMed ID: 8943311

DOI: 10.1074/jbc.271.50.32454

PubMed ID: 11543633

Title: Cloning, mapping, and characterization of a human homologue of the yeast longevity assurance gene LAG1.

PubMed ID: 11543633

DOI: 10.1006/geno.2001.6614

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27155063

Title: Asialoglycoprotein receptor facilitates infection of PLC/PRF/5 cells by HEV through interaction with ORF2.

PubMed ID: 27155063

DOI: 10.1002/jmv.24570

PubMed ID: 10891274

Title: Crystal structure of the carbohydrate recognition domain of the H1 subunit of the asialoglycoprotein receptor.

PubMed ID: 10891274

DOI: 10.1006/jmbi.2000.3853

Sequence Information:

  • Length: 291
  • Mass: 33186
  • Checksum: 9B825527B2FC1FD0
  • Sequence:
    • MTKEYQDLQH LDNEESDHHQ LRKGPPPPQP LLQRLCSGPR LLLLSLGLSL LLLVVVCVIG 
SQNSQLQEEL RGLRETFSNF TASTEAQVKG LSTQGGNVGR KMKSLESQLE KQQKDLSEDH 
SSLLLHVKQF VSDLRSLSCQ MAALQGNGSE RTCCPVNWVE HERSCYWFSR SGKAWADADN 
YCRLEDAHLV VVTSWEEQKF VQHHIGPVNT WMGLHDQNGP WKWVDGTDYE TGFKNWRPEQ 
PDDWYGHGLG GGEDCAHFTD DGRWNDDVCQ RPYRWVCETE LDKASQEPPL L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.