His2Av | FBgn0001197 | NCBI 43229

Details for: His2Av

Gene ID: 43229

Symbol: His2Av

Ensembl ID: FBgn0001197

Description: Histone H2A variant

Associated with

Activated pkn1 stimulates transcription of ar (androgen receptor) regulated genes klk2 and klk3
(R-DME-5625886)
Assembly of the orc complex at the origin of replication
(R-DME-68616)
Assembly of the pre-replicative complex
(R-DME-68867)
Cell cycle
(R-DME-1640170)
Cell cycle, mitotic
(R-DME-69278)
Cellular responses to stimuli
(R-DME-8953897)
Cellular responses to stress
(R-DME-2262752)
Cellular senescence
(R-DME-2559583)
Chromatin modifying enzymes
(R-DME-3247509)
Chromatin organization
(R-DME-4839726)
Condensation of prophase chromosomes
(R-DME-2299718)
Dna replication
(R-DME-69306)
Dna replication pre-initiation
(R-DME-69002)
Epigenetic regulation by wdr5-containing histone modifying complexes
(R-DME-9917777)
Epigenetic regulation of adipogenesis genes by mll3 and mll4 complexes
(R-DME-9851695)
Epigenetic regulation of gene expression
(R-DME-212165)
Epigenetic regulation of gene expression by mll3 and mll4 complexes
(R-DME-9818564)
Esr-mediated signaling
(R-DME-8939211)
Estrogen-dependent gene expression
(R-DME-9018519)
Formation of the beta-catenin:tcf transactivating complex
(R-DME-201722)
Gene expression (transcription)
(R-DME-74160)
Generic transcription pathway
(R-DME-212436)
Gene silencing by rna
(R-DME-211000)
Mitotic prophase
(R-DME-68875)
Mll4 and mll3 complexes regulate expression of pparg target genes in adipogenesis and hepatic steatosis
(R-DME-9841922)
M phase
(R-DME-68886)
Negative epigenetic regulation of rrna expression
(R-DME-5250941)
Norc negatively regulates rrna expression
(R-DME-427413)
Oxidative stress induced senescence
(R-DME-2559580)
Prc2 methylates histones and dna
(R-DME-212300)
Regulation of endogenous retroelements
(R-DME-9842860)
Regulation of endogenous retroelements by krab-zfp proteins
(R-DME-9843940)
Rho gtpase effectors
(R-DME-195258)
Rho gtpases activate pkns
(R-DME-5625740)
Rmts methylate histone arginines
(R-DME-3214858)
Rna polymerase ii transcription
(R-DME-73857)
Rna polymerase i promoter clearance
(R-DME-73854)
Rna polymerase i promoter escape
(R-DME-73772)
Rna polymerase i transcription
(R-DME-73864)
Runx1 regulates genes involved in megakaryocyte differentiation and platelet function
(R-DME-8936459)
Senescence-associated secretory phenotype (sasp)
(R-DME-2559582)
Signaling by nuclear receptors
(R-DME-9006931)
Signaling by rho gtpases
(R-DME-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-DME-9716542)
Signaling by wnt
(R-DME-195721)
Signal transduction
(R-DME-162582)
Sirt1 negatively regulates rrna expression
(R-DME-427359)
Tcf dependent signaling in response to wnt
(R-DME-201681)
Transcriptional regulation by runx1
(R-DME-8878171)
Transcriptional regulation by small rnas
(R-DME-5578749)
Chromosome
(GO:0005694)
Dna binding
(GO:0003677)
Euchromatin
(GO:0000791)
Heterochromatin formation
(GO:0031507)
Male germ-line stem cell population maintenance
(GO:0036098)
Negative regulation of peptidoglycan recognition protein signaling pathway
(GO:0061060)
Nucleosome
(GO:0000786)
Nucleus
(GO:0005634)
Polytene chromosome
(GO:0005700)
Polytene chromosome chromocenter
(GO:0005701)
Protein-containing complex binding
(GO:0044877)
Protein heterodimerization activity
(GO:0046982)
Protein localization to chromatin
(GO:0071168)
Site of double-strand break
(GO:0035861)
Somatic stem cell population maintenance
(GO:0035019)
Structural constituent of chromatin
(GO:0030527)

Other Information

Proteins

Histone H2A.v

Genular Protein ID: 3262979914

Symbol: H2AV_DROME

Name: Histone H2A.v

UniProtKB Accession Codes:

P08985 A0ANX7 A0ANX8 A0ANY0 A0ANY3 C0MJB2 C0MJB9 Q26252 Q540X2 Q9VBB1

Database IDs:

Citations:

PubMed ID: 3137528

Title: Drosophila has a single copy of the gene encoding a highly conserved histone H2A variant of the H2A.F/Z type.

PubMed ID: 3137528

DOI: 10.1093/nar/16.15.7487

PubMed ID: 2111857

Title: Conservation of intron position indicates separation of major and variant H2As is an early event in the evolution of eukaryotes.

PubMed ID: 2111857

DOI: 10.1007/bf02101116

PubMed ID: 16951084

Title: Widespread adaptive evolution of Drosophila genes with sex-biased expression.

PubMed ID: 16951084

DOI: 10.1534/genetics.106.058008

PubMed ID: 19126864

Title: The influence of demography and weak selection on the McDonald-Kreitman test: an empirical study in Drosophila.

PubMed ID: 19126864

DOI: 10.1093/molbev/msn297

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537569

Title: A Drosophila full-length cDNA resource.

PubMed ID: 12537569

DOI: 10.1186/gb-2002-3-12-research0080

PubMed ID: 1498368

Title: A histone variant, H2AvD, is essential in Drosophila melanogaster.

PubMed ID: 1498368

DOI: 10.1091/mbc.3.6.593

PubMed ID: 10385122

Title: Regions of variant histone His2AvD required for Drosophila development.

PubMed ID: 10385122

DOI: 10.1038/21436

PubMed ID: 10801889

Title: Histone H2A.Z is widely but nonrandomly distributed in chromosomes of Drosophila melanogaster.

PubMed ID: 10801889

DOI: 10.1074/jbc.m910206199

PubMed ID: 12202754

Title: DNA double-strand break-induced phosphorylation of Drosophila histone variant H2Av helps prevent radiation-induced apoptosis.

PubMed ID: 12202754

DOI: 10.1093/nar/gkf496

PubMed ID: 15528408

Title: Acetylation by Tip60 is required for selective histone variant exchange at DNA lesions.

PubMed ID: 15528408

DOI: 10.1126/science.1103455

PubMed ID: 15630020

Title: The role of histone H2Av variant replacement and histone H4 acetylation in the establishment of Drosophila heterochromatin.

PubMed ID: 15630020

DOI: 10.1101/gad.1259105

PubMed ID: 36930688

Title: The histone chaperone NASP maintains H3-H4 reservoirs in the early Drosophila embryo.

PubMed ID: 36930688

DOI: 10.1371/journal.pgen.1010682

Sequence Information:

Length: 141
Mass: 14981
Checksum: 0DA41C01F831A5B6
Sequence:

MAGGKAGKDS GKAKAKAVSR SARAGLQFPV GRIHRHLKSR TTSHGRVGAT AAVYSAAILE 
YLTAEVLELA GNASKDLKVK RITPRHLQLA IRGDEELDSL IKATIAGGGV IPHIHKSLIG 
KKEETVQDPQ RKGNVILSQA Y

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: His2Av

Associated with

Other Information

Drosophila has a single copy of the gene encoding a highly conserved histone H2A variant of the H2A.F/Z type. PubMed ID: 3137528

Conservation of intron position indicates separation of major and variant H2As is an early event in the evolution of eukaryotes. PubMed ID: 2111857

Widespread adaptive evolution of Drosophila genes with sex-biased expression. PubMed ID: 16951084

The influence of demography and weak selection on the McDonald-Kreitman test: an empirical study in Drosophila. PubMed ID: 19126864

The genome sequence of Drosophila melanogaster. PubMed ID: 10731132

Annotation of the Drosophila melanogaster euchromatic genome: a systematic review. PubMed ID: 12537572

A Drosophila full-length cDNA resource. PubMed ID: 12537569

A histone variant, H2AvD, is essential in Drosophila melanogaster. PubMed ID: 1498368

Regions of variant histone His2AvD required for Drosophila development. PubMed ID: 10385122

Histone H2A.Z is widely but nonrandomly distributed in chromosomes of Drosophila melanogaster. PubMed ID: 10801889

DNA double-strand break-induced phosphorylation of Drosophila histone variant H2Av helps prevent radiation-induced apoptosis. PubMed ID: 12202754

Acetylation by Tip60 is required for selective histone variant exchange at DNA lesions. PubMed ID: 15528408

The role of histone H2Av variant replacement and histone H4 acetylation in the establishment of Drosophila heterochromatin. PubMed ID: 15630020

The histone chaperone NASP maintains H3-H4 reservoirs in the early Drosophila embryo. PubMed ID: 36930688