Details for: spz

Gene ID: 43256

Symbol: spz

Ensembl ID: FBgn0003495

Description: spatzle

Associated with

Other Information

Genular Protein ID: 2616558380

Symbol: SPZ_DROME

Name: Protein spaetzle

UniProtKB Accession Codes:

P48607 Q95SU5 Q9VB84

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CTD 1 ComplexPortal 1 DIP 1 DNASU 1 EMBL 18 EnsemblMetazoa 5 EvolutionaryTrace 1 ExpressionAtlas 1 FlyBase 1 GO 31 Gene3D 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 4 PIR 1 PRO 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PhylomeDB 1 Proteomes 1 Reactome 7 RefSeq 5 SAM 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 8124709

Title: The spatzle gene encodes a component of the extracellular signaling pathway establishing the dorsal-ventral pattern of the Drosophila embryo.

PubMed ID: 8124709

DOI: 10.1016/0092-8674(94)90507-x

PubMed ID: 11212919

Title: Multiple isoforms of the Drosophila spatzle protein are encoded by alternatively spliced maternal mRNAs in the precellular blastoderm embryo.

PubMed ID: 11212919

DOI: 10.1007/s004380000350

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537569

Title: A Drosophila full-length cDNA resource.

PubMed ID: 12537569

DOI: 10.1186/gb-2002-3-12-research0080

PubMed ID: 9533958

Title: Proteolytic processing of the Drosophila Spatzle protein by easter generates a dimeric NGF-like molecule with ventralising activity.

PubMed ID: 9533958

DOI: 10.1016/s0925-4773(98)00024-0

PubMed ID: 8808632

Title: The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults.

PubMed ID: 8808632

DOI: 10.1016/s0092-8674(00)80172-5

PubMed ID: 12872120

Title: Binding of the Drosophila cytokine Spatzle to Toll is direct and establishes signaling.

PubMed ID: 12872120

DOI: 10.1038/ni955

PubMed ID: 16399077

Title: A Spatzle-processing enzyme required for toll signaling activation in Drosophila innate immunity.

PubMed ID: 16399077

DOI: 10.1016/j.devcel.2005.11.013

PubMed ID: 18790733

Title: Biophysical characterization of refolded Drosophila Spatzle, a cystine knot protein, reveals distinct properties of three isoforms.

PubMed ID: 18790733

DOI: 10.1074/jbc.m801815200

PubMed ID: 24282309

Title: Cytokine Spatzle binds to the Drosophila immunoreceptor Toll with a neurotrophin-like specificity and couples receptor activation.

PubMed ID: 24282309

DOI: 10.1073/pnas.1317002110

PubMed ID: 24733933

Title: Structure of the Toll-Spatzle complex, a molecular hub in Drosophila development and innate immunity.

PubMed ID: 24733933

DOI: 10.1073/pnas.1320678111

Sequence Information:

  • Length: 326
  • Mass: 37447
  • Checksum: 3252389129CFB1E0
  • Sequence:
    • MMTPMWISLF KVLLLLFAFF ATYEAKEYER IIKELFTITN DEGVVLFNTS ADSAPFMPIP 
TQHDDPTQKQ KQNQNQSPIP ETNRHYHQYH SLIQPDQYFK VQRSPNGKLN LVFNDTFVSL 
QRTDTEVQSE QPIPPRHPSD TFVFPDSPIA KYRPPQSPAR PLRNDTKEHN PCAKDESQHL 
RNFCTNVDDY PDLSGLTHKL KNNFAKFFSN DLQPTDVSSR VGGSDERFLC RSIRKLVYPK 
KGLRADDTWQ LIVNNDEYKQ AIQIEECEGA DQPCDFAANF PQSYNPICKQ HYTQQTLASI 
KSDGELDVVQ NSFKIPSCCK CALKTG

Genular Protein ID: 3480677876

Symbol: Q8IG88_DROME

Name: N/A

UniProtKB Accession Codes:

Q8IG88

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 4 EnsemblMetazoa 1 ExpressionAtlas 1 FlyBase 2 GO 2 Gene3D 1 GeneTree 1 GenomeRNAi 1 InterPro 2 NCBI Taxonomy 1 PANTHER 2 PeptideAtlas 1 Pfam 2 Proteomes 2 RefSeq 1 SAM 2 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537568

Title: Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence.

PubMed ID: 12537568

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537573

Title: The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective.

PubMed ID: 12537573

PubMed ID: 12537574

Title: Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.

PubMed ID: 12537574

PubMed ID: 16110336

Title: Combined evidence annotation of transposable elements in genome sequences.

PubMed ID: 16110336

DOI: 10.1371/journal.pcbi.0010022

PubMed ID: 17569856

Title: The Release 5.1 annotation of Drosophila melanogaster heterochromatin.

PubMed ID: 17569856

DOI: 10.1126/science.1139815

PubMed ID: 17569867

Title: Sequence finishing and mapping of Drosophila melanogaster heterochromatin.

PubMed ID: 17569867

DOI: 10.1126/science.1139816

PubMed ID: 26109357

Title: Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.

PubMed ID: 26109357

DOI: .1534/g3.115.018929

PubMed ID: 26109356

Title: Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.

PubMed ID: 26109356

DOI: .1534/g3.115.018937

PubMed ID: 25589440

Title: The Release 6 reference sequence of the Drosophila melanogaster genome.

PubMed ID: 25589440

Sequence Information:

  • Length: 290
  • Mass: 33014
  • Checksum: 044C107E999A53E4
  • Sequence:
    • MMTPMWISLF KVLLLLFAFF ATIVYINIEL TKRHEAEVRA EKTVADYKAL LATINNGGPG 
KSASNHLQYE AKEYERIIKE LFTITNDEGV VLFNRTDTEV QSEQPIPPRH PSDTKYRPPQ 
SPARPLRNDT KEHNPCAKDE SQHLRNFCTN VDDYPDLSGL THKLKNNFAK FFSNDLQPTD 
VSSRVGGSDE RFLCRSIRKL VYPKKGLRAD DTWQLIVNND EYKQAIQIEE CEGADQPCDF 
AANFPQSYNP ICKQHYTQQT LASIKSDGEL DVVQNSFKIP SCCKCALKTG

Genular Protein ID: 3505062936

Symbol: B5RIR9_DROME

Name: N/A

UniProtKB Accession Codes:

B5RIR9

Database IDs:

AlphaFoldDB 1 Bgee 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 EnsemblMetazoa 1 ExpressionAtlas 1 GO 1 Gene3D 1 Genevisible 1 GenomeRNAi 1 HOGENOM 1 InterPro 2 NCBI Taxonomy 1 PANTHER 2 Pfam 2 RefSeq 1 SAM 2 SMR 1 SUPFAM 1 VEuPathDB 1

Sequence Information:

  • Length: 300
  • Mass: 34331
  • Checksum: 32BCE90FA9789B2D
  • Sequence:
    • MMTPMWISLF KVLLLLFAFF ATTSADSAPF MPIPTQHDDP TQKQKQNQNQ SPIPETNRHY 
HQYHSLIQPD QYFKVQRSPN GKLNLVFNDT FVSLQRTDTE VQSEQPIPPR HPSDTFVFPD 
SPIAKYRPPQ SPARPLRNDT KEHNPCAKDE SQHLRNFCTN VDDYPDLSGL THKLKNNFAK 
FFSNDLQPTD VSSRVGGSDE RFLCRSIRKL VYPKKGLRAD DTWQLIVNND EYKQAIQIEE 
CEGADQPCDF AANFPQSYNP ICKQHYTQQT LASIKSDGEL DVVQNSFKIP SCCKCALKTG

Genular Protein ID: 4227538298

Symbol: Q8IMP8_DROME

Name: N/A

UniProtKB Accession Codes:

Q8IMP8

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 EnsemblMetazoa 1 ExpressionAtlas 1 FlyBase 2 GO 1 Gene3D 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 InterPro 2 NCBI Taxonomy 1 PANTHER 2 PeptideAtlas 1 Pfam 2 Proteomes 2 RefSeq 1 SAM 2 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537568

Title: Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence.

PubMed ID: 12537568

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537573

Title: The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective.

PubMed ID: 12537573

PubMed ID: 12537574

Title: Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.

PubMed ID: 12537574

PubMed ID: 16110336

Title: Combined evidence annotation of transposable elements in genome sequences.

PubMed ID: 16110336

DOI: 10.1371/journal.pcbi.0010022

PubMed ID: 17569856

Title: The Release 5.1 annotation of Drosophila melanogaster heterochromatin.

PubMed ID: 17569856

DOI: 10.1126/science.1139815

PubMed ID: 17569867

Title: Sequence finishing and mapping of Drosophila melanogaster heterochromatin.

PubMed ID: 17569867

DOI: 10.1126/science.1139816

Sequence Information:

  • Length: 244
  • Mass: 27998
  • Checksum: 10509AA7E0E83C0E
  • Sequence:
    • MMTPMWISLF KVLLLLFAFF ATYEAKEYER IIKELFTITN DEGVVLFNRT DTEVQSEQPI 
PPRHPSDTKY RPPQSPARPL RNDTKEHNPC AKDESQHLRN FCTNVDDYPD LSGLTHKLKN 
NFAKFFSNDL QPTDVSSRVG GSDERFLCRS IRKLVYPKKG LRADDTWQLI VNNDEYKQAI 
QIEECEGADQ PCDFAANFPQ SYNPICKQHY TQQTLASIKS DGELDVVQNS FKIPSCCKCA 
LKTG

Genular Protein ID: 4186182342

Symbol: A1Z0H7_DROME

Name: N/A

UniProtKB Accession Codes:

A1Z0H7

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 4 EnsemblMetazoa 1 ExpressionAtlas 1 FlyBase 2 GO 1 Gene3D 1 GeneTree 1 GenomeRNAi 1 InterPro 2 NCBI Taxonomy 1 PANTHER 2 PeptideAtlas 1 Pfam 2 Proteomes 2 RefSeq 1 SAM 2 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537568

Title: Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence.

PubMed ID: 12537568

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537573

Title: The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective.

PubMed ID: 12537573

PubMed ID: 12537574

Title: Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.

PubMed ID: 12537574

PubMed ID: 16110336

Title: Combined evidence annotation of transposable elements in genome sequences.

PubMed ID: 16110336

DOI: 10.1371/journal.pcbi.0010022

PubMed ID: 17324925

Title: Role of the Spatzle Pro-domain in the generation of an active toll receptor ligand.

PubMed ID: 17324925

DOI: 10.1074/jbc.M700068200

PubMed ID: 17569856

Title: The Release 5.1 annotation of Drosophila melanogaster heterochromatin.

PubMed ID: 17569856

DOI: 10.1126/science.1139815

PubMed ID: 17569867

Title: Sequence finishing and mapping of Drosophila melanogaster heterochromatin.

PubMed ID: 17569867

DOI: 10.1126/science.1139816

PubMed ID: 26109357

Title: Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.

PubMed ID: 26109357

DOI: .1534/g3.115.018929

PubMed ID: 26109356

Title: Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.

PubMed ID: 26109356

DOI: .1534/g3.115.018937

PubMed ID: 25589440

Title: The Release 6 reference sequence of the Drosophila melanogaster genome.

PubMed ID: 25589440

Sequence Information:

  • Length: 270
  • Mass: 30998
  • Checksum: 6269E09F1C36F7E5
  • Sequence:
    • MMTPMWISLF KVLLLLFAFF ATTSADSAPF MPIPTQHDDP TQKQKQNQNQ SPIPETNRHY 
HQYHSLIQPD QYFKRTDTEV QSEQPIPPRH PSDTKYRPPQ SPARPLRNDT KEHNPCAKDE 
SQHLRNFCTN VDDYPDLSGL THKLKNNFAK FFSNDLQPTD VSSRVGGSDE RFLCRSIRKL 
VYPKKGLRAD DTWQLIVNND EYKQAIQIEE CEGADQPCDF AANFPQSYNP ICKQHYTQQT 
LASIKSDGEL DVVQNSFKIP SCCKCALKTG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.