Details for: ASGR2

Gene ID: 433

Symbol: ASGR2

Ensembl ID: ENSG00000161944

Description: asialoglycoprotein receptor 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 24.0445
    Cell Significance Index: -3.7400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 14.8240
    Cell Significance Index: -3.7600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 11.0538
    Cell Significance Index: 171.0200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 3.5193
    Cell Significance Index: 215.7700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.0090
    Cell Significance Index: -3.7100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.9781
    Cell Significance Index: 95.3900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.9211
    Cell Significance Index: 49.2100
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 2.7388
    Cell Significance Index: 10.3200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.2526
    Cell Significance Index: 447.0400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.8398
    Cell Significance Index: 30.9500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.4927
    Cell Significance Index: 284.0700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.3040
    Cell Significance Index: 59.1100
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.1157
    Cell Significance Index: 6.4300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 0.9541
    Cell Significance Index: -3.7700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.9230
    Cell Significance Index: -2.0200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.9045
    Cell Significance Index: 13.3500
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.6980
    Cell Significance Index: 8.8400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6905
    Cell Significance Index: 14.7100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5947
    Cell Significance Index: 58.8300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5281
    Cell Significance Index: 476.7900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4837
    Cell Significance Index: 29.0400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4507
    Cell Significance Index: 49.0300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.4082
    Cell Significance Index: 7.5500
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.3710
    Cell Significance Index: 3.6600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3360
    Cell Significance Index: 54.6600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2371
    Cell Significance Index: 16.4000
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.1194
    Cell Significance Index: 1.0200
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.0983
    Cell Significance Index: 1.0500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0707
    Cell Significance Index: 1.8900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0496
    Cell Significance Index: 0.7200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0171
    Cell Significance Index: 0.2400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0103
    Cell Significance Index: 1.2000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0097
    Cell Significance Index: 0.5100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0057
    Cell Significance Index: 0.2000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0031
    Cell Significance Index: 0.0900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0025
    Cell Significance Index: 0.5000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0012
    Cell Significance Index: 0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0017
    Cell Significance Index: -3.2100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0023
    Cell Significance Index: -0.0500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0023
    Cell Significance Index: -4.1700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0025
    Cell Significance Index: -0.1100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0026
    Cell Significance Index: -3.9600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0031
    Cell Significance Index: -4.1900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0048
    Cell Significance Index: -3.6400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0052
    Cell Significance Index: -3.8200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0063
    Cell Significance Index: -3.5400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0069
    Cell Significance Index: -4.3900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0081
    Cell Significance Index: -2.9200
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0084
    Cell Significance Index: -0.1200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0090
    Cell Significance Index: -1.1600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0095
    Cell Significance Index: -4.2900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0134
    Cell Significance Index: -3.8500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0152
    Cell Significance Index: -3.2000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0159
    Cell Significance Index: -0.2400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0170
    Cell Significance Index: -3.0700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0212
    Cell Significance Index: -2.1700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0213
    Cell Significance Index: -3.6500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0213
    Cell Significance Index: -1.0700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0228
    Cell Significance Index: -0.9400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0255
    Cell Significance Index: -3.5000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0289
    Cell Significance Index: -0.6000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0298
    Cell Significance Index: -4.3300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0312
    Cell Significance Index: -3.8400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0340
    Cell Significance Index: -3.8900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0355
    Cell Significance Index: -3.7000
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0382
    Cell Significance Index: -0.5300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0500
    Cell Significance Index: -3.8400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0517
    Cell Significance Index: -1.8100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0527
    Cell Significance Index: -1.0300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0581
    Cell Significance Index: -3.9100
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.0610
    Cell Significance Index: -0.5800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0632
    Cell Significance Index: -2.9700
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0639
    Cell Significance Index: -0.7900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0654
    Cell Significance Index: -4.0200
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.0659
    Cell Significance Index: -0.5200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0682
    Cell Significance Index: -1.8300
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.0715
    Cell Significance Index: -0.7400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0729
    Cell Significance Index: -4.0900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0736
    Cell Significance Index: -4.7500
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.0741
    Cell Significance Index: -0.6000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0742
    Cell Significance Index: -3.4600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0749
    Cell Significance Index: -3.8900
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0756
    Cell Significance Index: -0.9500
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0814
    Cell Significance Index: -1.1900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0873
    Cell Significance Index: -3.8600
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.0929
    Cell Significance Index: -0.8500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0939
    Cell Significance Index: -1.3500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0953
    Cell Significance Index: -3.1200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0961
    Cell Significance Index: -3.0600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1017
    Cell Significance Index: -3.8500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1141
    Cell Significance Index: -4.1900
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.1233
    Cell Significance Index: -1.4700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1242
    Cell Significance Index: -1.6500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1295
    Cell Significance Index: -3.5300
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.1337
    Cell Significance Index: -1.4200
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.1348
    Cell Significance Index: -1.4400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1349
    Cell Significance Index: -3.3700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1361
    Cell Significance Index: -1.7200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1371
    Cell Significance Index: -3.4200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1375
    Cell Significance Index: -4.3500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ASGR2 is a type II transmembrane glycoprotein, consisting of an extracellular domain, a transmembrane domain, and an intracellular domain. The extracellular domain contains two binding sites for fucose and mannose, which are essential for the receptor's ligand recognition and binding. The transmembrane domain spans the cell membrane, while the intracellular domain contains a tyrosine kinase domain, which is involved in signaling pathways. ASGR2 has a high degree of specificity for its ligands, including asialoglycoproteins, which are glycoproteins that have been partially deglycosylated. The receptor's binding affinity is influenced by the presence of specific sugars, such as fucose and mannose, which are present on the surface of glycoproteins. **Pathways and Functions** ASGR2 plays a critical role in the regulation of protein metabolism, immune responses, and the clearance of pathogens. The receptor's primary function is to mediate the endocytosis of asialoglycoproteins, which are glycoproteins that have been partially deglycosylated. This process involves the binding of the receptor to its ligands, followed by the internalization of the glycoprotein into the cell. ASGR2 has been implicated in various signaling pathways, including the PI3K/Akt and MAPK/ERK pathways, which are involved in cell survival, proliferation, and differentiation. The receptor's ability to bind to specific sugars also enables it to regulate the activity of immune cells, such as macrophages and dendritic cells. **Clinical Significance** ASGR2 has been implicated in various diseases, including liver disease, cancer, and immune disorders. The receptor's ability to bind to specific sugars has been exploited in the development of therapeutic strategies for the treatment of these diseases. For example, ASGR2 has been shown to play a critical role in the clearance of hepatocellular carcinoma cells from the circulation. The receptor's ability to bind to specific sugars has been targeted in the development of therapeutic agents, such as ASG-2, which has been shown to inhibit ASGR2 activity and induce the clearance of cancer cells. Additionally, ASGR2 has been implicated in the regulation of immune responses, particularly in the context of autoimmune diseases. The receptor's ability to bind to specific sugars has been shown to regulate the activity of immune cells, such as macrophages and dendritic cells, and has been targeted in the development of therapeutic strategies for the treatment of autoimmune diseases. In conclusion, ASGR2 is a critical component of the immune system, playing a key role in the clearance of glycoproteins from the circulation and regulating protein metabolism, immune responses, and the clearance of pathogens. Its dysregulation has been implicated in various diseases, including liver disease, cancer, and immune disorders, and has been targeted in the development of therapeutic strategies for the treatment of these diseases.

Genular Protein ID: 846854115

Symbol: ASGR2_HUMAN

Name: Asialoglycoprotein receptor 2

UniProtKB Accession Codes:

P07307 A6NLV8 A8MT12 D3DTM9 D3DTN0 O00448 Q03969

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CPTAC 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 9 Ensembl 3 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 10 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3863106

Title: Sequence of a second human asialoglycoprotein receptor: conservation of two receptor genes during evolution.

PubMed ID: 3863106

DOI: 10.1073/pnas.82.19.6465

PubMed ID: 1371982

Title: Differences in the abundance of variably spliced transcripts for the second asialoglycoprotein receptor polypeptide, H2, in normal and transformed human liver.

PubMed ID: 1371982

DOI: 10.1002/hep.1840150307

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11543633

Title: Cloning, mapping, and characterization of a human homologue of the yeast longevity assurance gene LAG1.

PubMed ID: 11543633

DOI: 10.1006/geno.2001.6614

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27155063

Title: Asialoglycoprotein receptor facilitates infection of PLC/PRF/5 cells by HEV through interaction with ORF2.

PubMed ID: 27155063

DOI: 10.1002/jmv.24570

Sequence Information:

  • Length: 311
  • Mass: 35092
  • Checksum: C86D2247FFF604DC
  • Sequence:
    • MAKDFQDIQQ LSSEENDHPF HQGEGPGTRR LNPRRGNPFL KGPPPAQPLA QRLCSMVCFS 
LLALSFNILL LVVICVTGSQ SEGHGGAQLQ AELRSLKEAF SNFSSSTLTE VQAISTHGGS 
VGDKITSLGA KLEKQQQDLK ADHDALLFHL KHFPVDLRFV ACQMELLHSN GSQRTCCPVN 
WVEHQGSCYW FSHSGKAWAE AEKYCQLENA HLVVINSWEE QKFIVQHTNP FNTWIGLTDS 
DGSWKWVDGT DYRHNYKNWA VTQPDNWHGH ELGGSEDCVE VQPDGRWNDD FCLQVYRWVC 
EKRRNATGEV A

Genular Protein ID: 3136938886

Symbol: Q7Z4G9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q7Z4G9

Database IDs:

ARBA 3 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 GO 6 Gene3D 1 GeneTree 1 HGNC 1 InterPro 6 MANE-Select 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 2 SMART 1 SUPFAM 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 306
  • Mass: 34655
  • Checksum: F53B06C41AE80D03
  • Sequence:
    • MAKDFQDIQQ LSSEENDHPF HQGEGPGTRR LNPRRGNPFL KGPPPAQPLA QRLCSMVCFS 
LLALSFNILL LVVICVTGSQ SAQLQAELRS LKEAFSNFSS STLTEVQAIS THGGSVGDKI 
TSLGAKLEKQ QQDLKADHDA LLFHLKHFPV DLRFVACQME LLHSNGSQRT CCPVNWVEHQ 
GSCYWFSHSG KAWAEAEKYC QLENAHLVVI NSWEEQKFIV QHTNPFNTWI GLTDSDGSWK 
WVDGTDYRHN YKNWAVTQPD NWHGHELGGS EDCVEVQPDG RWNDDFCLQV YRWVCEKRRN 
ATGEVA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.