Details for: ASGR2

Gene ID: 433

Symbol: ASGR2

Ensembl ID: ENSG00000161944

Description: asialoglycoprotein receptor 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 2.55
    Marker Score: 991
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2.5
    Marker Score: 8,184
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 2.05
    Marker Score: 11,022
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2
    Marker Score: 1,995
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.81
    Marker Score: 7,810
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1,169
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.58
    Marker Score: 10,156
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.56
    Marker Score: 3,178
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 855
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.21
    Marker Score: 67,730
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4,815
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.12
    Marker Score: 6,780
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.1
    Marker Score: 1,121
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.1
    Marker Score: 2,728
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,827
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,052
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.96
    Marker Score: 652
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,351
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 373
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.93
    Marker Score: 386
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.92
    Marker Score: 990
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.92
    Marker Score: 423
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.85
    Marker Score: 211
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.83
    Marker Score: 9,609
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.82
    Marker Score: 627
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.81
    Marker Score: 1,526
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.81
    Marker Score: 5,353
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.78
    Marker Score: 1,200
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,260
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.76
    Marker Score: 288
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.61
    Marker Score: 388
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.59
    Marker Score: 905
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 463
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.55
    Marker Score: 357
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.54
    Marker Score: 545
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.53
    Marker Score: 1,028
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.52
    Marker Score: 1,346
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 277
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.46
    Marker Score: 560
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.46
    Marker Score: 147
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.43
    Marker Score: 1,793
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.41
    Marker Score: 852
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.41
    Marker Score: 272
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4
    Marker Score: 6,242
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.39
    Marker Score: 106
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.37
    Marker Score: 222
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.36
    Marker Score: 162
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.35
    Marker Score: 829
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.32
    Marker Score: 584
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.31
    Marker Score: 83
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.26
    Marker Score: 99
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.26
    Marker Score: 81
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.26
    Marker Score: 113
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.26
    Marker Score: 332
  • Cell Name: pre-conventional dendritic cell (CL0002010)
    Fold Change: 0.25
    Marker Score: 73
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.24
    Marker Score: 138
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.24
    Marker Score: 115
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.23
    Marker Score: 81
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.23
    Marker Score: 67
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.23
    Marker Score: 154
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.22
    Marker Score: 1,897
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.22
    Marker Score: 536
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.22
    Marker Score: 168
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.21
    Marker Score: 335
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.21
    Marker Score: 365
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.2
    Marker Score: 123
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.2
    Marker Score: 43
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.19
    Marker Score: 132
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.19
    Marker Score: 130
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.18
    Marker Score: 199
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.18
    Marker Score: 104
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.18
    Marker Score: 53
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.17
    Marker Score: 72
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.16
    Marker Score: 90
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.16
    Marker Score: 194
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.15
    Marker Score: 76
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.14
    Marker Score: 64
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.14
    Marker Score: 79
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.14
    Marker Score: 841
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.13
    Marker Score: 128
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.12
    Marker Score: 138
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.12
    Marker Score: 31
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.12
    Marker Score: 140
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.12
    Marker Score: 26
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.12
    Marker Score: 55
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.12
    Marker Score: 116
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.11
    Marker Score: 354

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ASGR2 is a type II transmembrane glycoprotein, consisting of an extracellular domain, a transmembrane domain, and an intracellular domain. The extracellular domain contains two binding sites for fucose and mannose, which are essential for the receptor's ligand recognition and binding. The transmembrane domain spans the cell membrane, while the intracellular domain contains a tyrosine kinase domain, which is involved in signaling pathways. ASGR2 has a high degree of specificity for its ligands, including asialoglycoproteins, which are glycoproteins that have been partially deglycosylated. The receptor's binding affinity is influenced by the presence of specific sugars, such as fucose and mannose, which are present on the surface of glycoproteins. **Pathways and Functions** ASGR2 plays a critical role in the regulation of protein metabolism, immune responses, and the clearance of pathogens. The receptor's primary function is to mediate the endocytosis of asialoglycoproteins, which are glycoproteins that have been partially deglycosylated. This process involves the binding of the receptor to its ligands, followed by the internalization of the glycoprotein into the cell. ASGR2 has been implicated in various signaling pathways, including the PI3K/Akt and MAPK/ERK pathways, which are involved in cell survival, proliferation, and differentiation. The receptor's ability to bind to specific sugars also enables it to regulate the activity of immune cells, such as macrophages and dendritic cells. **Clinical Significance** ASGR2 has been implicated in various diseases, including liver disease, cancer, and immune disorders. The receptor's ability to bind to specific sugars has been exploited in the development of therapeutic strategies for the treatment of these diseases. For example, ASGR2 has been shown to play a critical role in the clearance of hepatocellular carcinoma cells from the circulation. The receptor's ability to bind to specific sugars has been targeted in the development of therapeutic agents, such as ASG-2, which has been shown to inhibit ASGR2 activity and induce the clearance of cancer cells. Additionally, ASGR2 has been implicated in the regulation of immune responses, particularly in the context of autoimmune diseases. The receptor's ability to bind to specific sugars has been shown to regulate the activity of immune cells, such as macrophages and dendritic cells, and has been targeted in the development of therapeutic strategies for the treatment of autoimmune diseases. In conclusion, ASGR2 is a critical component of the immune system, playing a key role in the clearance of glycoproteins from the circulation and regulating protein metabolism, immune responses, and the clearance of pathogens. Its dysregulation has been implicated in various diseases, including liver disease, cancer, and immune disorders, and has been targeted in the development of therapeutic strategies for the treatment of these diseases.

Genular Protein ID: 846854115

Symbol: ASGR2_HUMAN

Name: Asialoglycoprotein receptor 2

UniProtKB Accession Codes:

P07307 A6NLV8 A8MT12 D3DTM9 D3DTN0 O00448 Q03969

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CPTAC 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 9 Ensembl 3 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 10 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3863106

Title: Sequence of a second human asialoglycoprotein receptor: conservation of two receptor genes during evolution.

PubMed ID: 3863106

DOI: 10.1073/pnas.82.19.6465

PubMed ID: 1371982

Title: Differences in the abundance of variably spliced transcripts for the second asialoglycoprotein receptor polypeptide, H2, in normal and transformed human liver.

PubMed ID: 1371982

DOI: 10.1002/hep.1840150307

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11543633

Title: Cloning, mapping, and characterization of a human homologue of the yeast longevity assurance gene LAG1.

PubMed ID: 11543633

DOI: 10.1006/geno.2001.6614

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27155063

Title: Asialoglycoprotein receptor facilitates infection of PLC/PRF/5 cells by HEV through interaction with ORF2.

PubMed ID: 27155063

DOI: 10.1002/jmv.24570

Sequence Information:

  • Length: 311
  • Mass: 35092
  • Checksum: C86D2247FFF604DC
  • Sequence:
    • MAKDFQDIQQ LSSEENDHPF HQGEGPGTRR LNPRRGNPFL KGPPPAQPLA QRLCSMVCFS 
LLALSFNILL LVVICVTGSQ SEGHGGAQLQ AELRSLKEAF SNFSSSTLTE VQAISTHGGS 
VGDKITSLGA KLEKQQQDLK ADHDALLFHL KHFPVDLRFV ACQMELLHSN GSQRTCCPVN 
WVEHQGSCYW FSHSGKAWAE AEKYCQLENA HLVVINSWEE QKFIVQHTNP FNTWIGLTDS 
DGSWKWVDGT DYRHNYKNWA VTQPDNWHGH ELGGSEDCVE VQPDGRWNDD FCLQVYRWVC 
EKRRNATGEV A

Genular Protein ID: 3136938886

Symbol: Q7Z4G9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q7Z4G9

Database IDs:

ARBA 2 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 Ensembl 2 GO 6 Gene3D 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 InterPro 5 MANE-Select 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 2 Proteomes 2 RefSeq 1 SAM 2 SMART 1 SUPFAM 1

Citations:

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 306
  • Mass: 34655
  • Checksum: F53B06C41AE80D03
  • Sequence:
    • MAKDFQDIQQ LSSEENDHPF HQGEGPGTRR LNPRRGNPFL KGPPPAQPLA QRLCSMVCFS 
LLALSFNILL LVVICVTGSQ SAQLQAELRS LKEAFSNFSS STLTEVQAIS THGGSVGDKI 
TSLGAKLEKQ QQDLKADHDA LLFHLKHFPV DLRFVACQME LLHSNGSQRT CCPVNWVEHQ 
GSCYWFSHSG KAWAEAEKYC QLENAHLVVI NSWEEQKFIV QHTNPFNTWI GLTDSDGSWK 
WVDGTDYRHN YKNWAVTQPD NWHGHELGGS EDCVEVQPDG RWNDDFCLQV YRWVCEKRRN 
ATGEVA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.