Details for: ASIP

Gene ID: 434

Symbol: ASIP

Ensembl ID: ENSG00000101440

Description: agouti signaling protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 42.6885
    Cell Significance Index: -6.6400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 26.2179
    Cell Significance Index: -6.6500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.6878
    Cell Significance Index: -6.6600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8459
    Cell Significance Index: 167.8700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.4855
    Cell Significance Index: 8.3200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.4770
    Cell Significance Index: 10.2000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.4059
    Cell Significance Index: 2.7500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3672
    Cell Significance Index: 253.9400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3257
    Cell Significance Index: 24.9900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.2829
    Cell Significance Index: 7.2700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.2495
    Cell Significance Index: 5.1800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2359
    Cell Significance Index: 32.4000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2195
    Cell Significance Index: 4.6000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2109
    Cell Significance Index: 5.6500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1657
    Cell Significance Index: 4.6300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1198
    Cell Significance Index: 15.3600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0967
    Cell Significance Index: 19.4000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0717
    Cell Significance Index: 25.7200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0604
    Cell Significance Index: 10.8800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.0598
    Cell Significance Index: 1.4600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0535
    Cell Significance Index: 3.0000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0246
    Cell Significance Index: 3.5700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0222
    Cell Significance Index: 0.2800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0185
    Cell Significance Index: 0.2200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0095
    Cell Significance Index: 0.6400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0086
    Cell Significance Index: 13.2100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0053
    Cell Significance Index: 7.1600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0049
    Cell Significance Index: 9.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0047
    Cell Significance Index: 8.7800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0039
    Cell Significance Index: 0.2400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0020
    Cell Significance Index: 0.9200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0017
    Cell Significance Index: 0.0500
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0012
    Cell Significance Index: -0.1500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0028
    Cell Significance Index: -1.7600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0050
    Cell Significance Index: -0.8600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0080
    Cell Significance Index: -5.9000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0087
    Cell Significance Index: -2.5000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0088
    Cell Significance Index: -6.5500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0108
    Cell Significance Index: -5.8800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0124
    Cell Significance Index: -6.9700
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: -0.0145
    Cell Significance Index: -0.1400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0185
    Cell Significance Index: -0.8100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0208
    Cell Significance Index: -0.9200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0231
    Cell Significance Index: -0.4500
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: -0.0280
    Cell Significance Index: -0.2900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0322
    Cell Significance Index: -1.2200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0376
    Cell Significance Index: -7.9200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0379
    Cell Significance Index: -0.8300
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.0417
    Cell Significance Index: -0.3700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0459
    Cell Significance Index: -5.9300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0470
    Cell Significance Index: -4.8000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0513
    Cell Significance Index: -6.0600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0546
    Cell Significance Index: -6.3700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0576
    Cell Significance Index: -0.8500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0583
    Cell Significance Index: -6.0800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0587
    Cell Significance Index: -0.8400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0589
    Cell Significance Index: -0.8700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0594
    Cell Significance Index: -3.8300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0596
    Cell Significance Index: -6.8300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0672
    Cell Significance Index: -1.8000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0699
    Cell Significance Index: -1.1800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0730
    Cell Significance Index: -0.6000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0735
    Cell Significance Index: -5.4800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0744
    Cell Significance Index: -5.9000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0894
    Cell Significance Index: -4.2000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0917
    Cell Significance Index: -2.6300
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.1016
    Cell Significance Index: -1.6400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1060
    Cell Significance Index: -6.6800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1066
    Cell Significance Index: -4.9700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1066
    Cell Significance Index: -5.5400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1084
    Cell Significance Index: -3.8100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1086
    Cell Significance Index: -3.1000
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.1163
    Cell Significance Index: -1.4100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1200
    Cell Significance Index: -3.2100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1205
    Cell Significance Index: -1.7300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1288
    Cell Significance Index: -3.1200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1352
    Cell Significance Index: -6.1300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1355
    Cell Significance Index: -3.2500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1429
    Cell Significance Index: -4.6800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1435
    Cell Significance Index: -1.3600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1457
    Cell Significance Index: -4.6400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1561
    Cell Significance Index: -5.4700
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1685
    Cell Significance Index: -1.0000
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.1711
    Cell Significance Index: -1.0100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1749
    Cell Significance Index: -6.4200
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1809
    Cell Significance Index: -2.1100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1855
    Cell Significance Index: -2.8700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1906
    Cell Significance Index: -4.7600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1910
    Cell Significance Index: -5.2000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1946
    Cell Significance Index: -4.1300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1947
    Cell Significance Index: -3.2800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1960
    Cell Significance Index: -1.8100
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.1981
    Cell Significance Index: -2.0500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2001
    Cell Significance Index: -6.3300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2006
    Cell Significance Index: -5.9100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2013
    Cell Significance Index: -4.3500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2032
    Cell Significance Index: -4.0800
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.2088
    Cell Significance Index: -2.4600
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.2088
    Cell Significance Index: -2.9700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Alternative splicing:** ASIP undergoes alternative splicing, resulting in multiple isoforms of the protein. These isoforms have distinct functions and are expressed in different tissues. 2. **Tissue specificity:** ASIP is expressed in multiple cell types, including retinal cells, cardiac cells, and immune cells. The expression pattern of ASIP is tissue-specific, with some isoforms being more abundant in certain tissues. 3. **Regulation of melanin biosynthesis:** ASIP is involved in the regulation of melanin biosynthesis, which is critical for skin and hair pigmentation. ASIP also regulates the expression of other genes involved in melanin biosynthesis. 4. **Hormone-mediated signaling:** ASIP is involved in hormone-mediated signaling pathways, including the melanocortin receptor pathway. This pathway is critical for regulating energy homeostasis and body weight. **Pathways and Functions:** 1. **Melanin biosynthetic process:** ASIP regulates the expression of genes involved in melanin biosynthesis, including tyrosinase and tyrosinase-related protein 1. 2. **Hormone-mediated signaling pathway:** ASIP is involved in the melanocortin receptor pathway, which regulates energy homeostasis and body weight. 3. **Cell-cell signaling:** ASIP is involved in cell-cell signaling pathways, including the Wnt/β-catenin pathway and the Notch signaling pathway. 4. **Epigenetic programming:** ASIP is involved in epigenetic programming in the zygotic pronuclei, which is critical for embryonic development. 5. **Neurotransmitter regulation:** ASIP regulates the expression of neurotransmitter receptors, including GABA receptors, which are involved in regulating neuronal activity. **Clinical Significance:** 1. **Obesity and metabolic syndrome:** ASIP has been implicated in obesity and metabolic syndrome, which are complex disorders characterized by insulin resistance, hyperglycemia, and dyslipidemia. 2. **Melanoma:** ASIP has been identified as a potential oncogene in melanoma, a type of skin cancer. 3. **Neurological disorders:** ASIP has been implicated in neurological disorders, including Parkinson's disease and Alzheimer's disease. 4. **Immune system dysfunction:** ASIP has been implicated in immune system dysfunction, including autoimmune diseases and immunodeficiency disorders. In conclusion, the Agouti signaling protein (ASIP) is a multifaceted gene that plays a critical role in various developmental and metabolic processes in the human body. ASIP's involvement in hormone-mediated signaling, cell-cell signaling, and epigenetic programming makes it a key regulator of gene expression and cellular function. The clinical significance of ASIP has been established in various diseases and disorders, including obesity, metabolic syndrome, melanoma, and neurological disorders. Further research is needed to fully elucidate the functions and mechanisms of ASIP in human health and disease.

Genular Protein ID: 2857362054

Symbol: ASIP_HUMAN

Name: Agouti-signaling protein

UniProtKB Accession Codes:

P42127 Q3SXL2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 EvolutionaryTrace 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 4 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7937887

Title: Molecular structure and chromosomal mapping of the human homolog of the agouti gene.

PubMed ID: 7937887

DOI: 10.1073/pnas.91.21.9760

PubMed ID: 7757071

Title: Structure and function of ASP, the human homolog of the mouse agouti gene.

PubMed ID: 7757071

DOI: 10.1093/hmg/4.2.223

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15701517

Title: Structures of the agouti signaling protein.

PubMed ID: 15701517

DOI: 10.1016/j.jmb.2004.12.030

PubMed ID: 11833005

Title: A polymorphism in the agouti signaling protein gene is associated with human pigmentation.

PubMed ID: 11833005

DOI: 10.1086/339076

PubMed ID: 36536132

Title: Aberrant expression of agouti signaling protein (ASIP) as a cause of monogenic severe childhood obesity.

PubMed ID: 36536132

DOI: 10.1038/s42255-022-00703-9

Sequence Information:

  • Length: 132
  • Mass: 14515
  • Checksum: AF82CC3C747F2BE6
  • Sequence:
    • MDVTRLLLAT LLVFLCFFTA NSHLPPEEKL RDDRSLRSNS SVNLLDVPSV SIVALNKKSK 
QIGRKAAEKK RSSKKEASMK KVVRPRTPLS APCVATRNSC KPPAPACCDP CASCQCRFFR 
SACSCRVLSL NC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.