Gene ASIP - ENSG00000101440 | NCBI Gene ID: 434

Details for: ASIP

Gene ID: 434

Symbol: ASIP

Ensembl ID: ENSG00000101440

Description: agouti signaling protein

Associated with

Adult feeding behavior
(GO:0008343)
Cell-cell signaling
(GO:0007267)
Epigenetic programming in the zygotic pronuclei
(GO:0044725)
Extracellular space
(GO:0005615)
Generation of precursor metabolites and energy
(GO:0006091)
Hormone-mediated signaling pathway
(GO:0009755)
Melanin biosynthetic process
(GO:0042438)
Melanocortin receptor binding
(GO:0031779)
Melanosome organization
(GO:0032438)
Melanosome transport
(GO:0032402)
Neuropeptide hormone activity
(GO:0005184)
Positive regulation of melanin biosynthetic process
(GO:0048023)
Signaling receptor binding
(GO:0005102)
Signal transduction
(GO:0007165)
Type 3 melanocortin receptor binding
(GO:0031781)
Type 4 melanocortin receptor binding
(GO:0031782)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: 4.98
Marker Score: 14762.5
Cell Name: retina horizontal cell (CL0000745)
Fold Change: 4.52
Marker Score: 4336
Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 3.41
Marker Score: 28878
Cell Name: retinal cone cell (CL0000573)
Fold Change: 2.39
Marker Score: 6860.5
Cell Name: retinal rod cell (CL0000604)
Fold Change: 2.35
Marker Score: 6700
Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 1.95
Marker Score: 873
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.09
Marker Score: 2063
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.09
Marker Score: 17029
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.06
Marker Score: 2147
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71815
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48039
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30408
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.96
Marker Score: 2258
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2413
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5303
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2740
Cell Name: decidual cell (CL2000002)
Fold Change: 0.91
Marker Score: 3903
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5296
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.8
Marker Score: 610.5
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1263
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.77
Marker Score: 4604
Cell Name: brush cell (CL0002204)
Fold Change: 0.76
Marker Score: 698
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 395
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.72
Marker Score: 1815
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 176
Cell Name: skin fibroblast (CL0002620)
Fold Change: 0.6
Marker Score: 156
Cell Name: renal principal cell (CL0005009)
Fold Change: 0.59
Marker Score: 453
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.56
Marker Score: 339
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 444
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.53
Marker Score: 264
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.5
Marker Score: 262
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 0.49
Marker Score: 10886
Cell Name: goblet cell (CL0000160)
Fold Change: 0.47
Marker Score: 3135.5
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.47
Marker Score: 197
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.47
Marker Score: 492
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.45
Marker Score: 146
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.42
Marker Score: 233
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.42
Marker Score: 132
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.42
Marker Score: 289
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.42
Marker Score: 199
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.41
Marker Score: 150
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.4
Marker Score: 105
Cell Name: reticular cell (CL0000432)
Fold Change: 0.39
Marker Score: 144
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.38
Marker Score: 219
Cell Name: lymphocyte (CL0000542)
Fold Change: 0.35
Marker Score: 175
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.34
Marker Score: 1224.5
Cell Name: ON-bipolar cell (CL0000749)
Fold Change: 0.34
Marker Score: 998
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 0.32
Marker Score: 136
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 0.32
Marker Score: 1146
Cell Name: T cell (CL0000084)
Fold Change: 0.32
Marker Score: 544
Cell Name: lung ciliated cell (CL1000271)
Fold Change: 0.31
Marker Score: 149
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.31
Marker Score: 80
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 0.3
Marker Score: 77
Cell Name: monocyte (CL0000576)
Fold Change: 0.3
Marker Score: 388
Cell Name: fast muscle cell (CL0000190)
Fold Change: 0.3
Marker Score: 89
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 0.29
Marker Score: 193
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 0.29
Marker Score: 79
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.28
Marker Score: 3140
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.28
Marker Score: 88
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 0.28
Marker Score: 2598
Cell Name: mature astrocyte (CL0002627)
Fold Change: 0.27
Marker Score: 179
Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: 0.27
Marker Score: 70
Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: 0.27
Marker Score: 78
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.26
Marker Score: 406
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.26
Marker Score: 138
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.25
Marker Score: 146
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 0.25
Marker Score: 220
Cell Name: hepatocyte (CL0000182)
Fold Change: 0.24
Marker Score: 165
Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 0.24
Marker Score: 76
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.23
Marker Score: 104
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.23
Marker Score: 513
Cell Name: mesangial cell (CL0000650)
Fold Change: 0.23
Marker Score: 279
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.23
Marker Score: 202
Cell Name: lens fiber cell (CL0011004)
Fold Change: 0.22
Marker Score: 71
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 0.22
Marker Score: 273
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.22
Marker Score: 1898
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.22
Marker Score: 131
Cell Name: astrocyte (CL0000127)
Fold Change: 0.22
Marker Score: 190
Cell Name: cardiac neuron (CL0010022)
Fold Change: 0.22
Marker Score: 272
Cell Name: fat cell (CL0000136)
Fold Change: 0.22
Marker Score: 122
Cell Name: club cell (CL0000158)
Fold Change: 0.21
Marker Score: 246
Cell Name: ciliated cell (CL0000064)
Fold Change: 0.21
Marker Score: 723
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 0.21
Marker Score: 319
Cell Name: interneuron (CL0000099)
Fold Change: 0.2
Marker Score: 91
Cell Name: microglial cell (CL0000129)
Fold Change: 0.2
Marker Score: 362
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 0.2
Marker Score: 138
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.2
Marker Score: 80
Cell Name: mature microglial cell (CL0002629)
Fold Change: 0.19
Marker Score: 70
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.19
Marker Score: 219
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.19
Marker Score: 725
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.19
Marker Score: 226
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 0.19
Marker Score: 1763
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 0.19
Marker Score: 158
Cell Name: podocyte (CL0000653)
Fold Change: 0.18
Marker Score: 68
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: 0.18
Marker Score: 75
Cell Name: melanocyte (CL0000148)
Fold Change: 0.18
Marker Score: 73
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.18
Marker Score: 173
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.18
Marker Score: 221
Cell Name: stromal cell (CL0000499)
Fold Change: 0.18
Marker Score: 209
Cell Name: fibroblast (CL0000057)
Fold Change: 0.18
Marker Score: 171

Hover over a box to see details here...

**Key characteristics:** * ASIP is a transmembrane protein that is expressed in high levels in the skin and eyes. * It is a key regulator of the production and distribution of melanin, the pigment that gives skin its color. * ASIP is involved in the regulation of cell growth, differentiation, and survival. * It also plays a role in the regulation of inflammation and pain. **Pathways and functions:** * ASIP is involved in the regulation of the cell cycle. It is expressed in cells that are dividing or differentiating. When ASIP is deleted, cells lose the ability to divide and differentiate. * ASIP is also involved in the regulation of apoptosis, the process by which cells die. * It is involved in the regulation of inflammation and pain. * ASIP also plays a role in the development of the eye. It is expressed in retinal cells, which are responsible for producing the pigment that gives the eye its color. **Clinical significance:** * Mutations in the ASIP gene have been linked to a number of skin diseases, including albinism, which is a condition in which the skin loses its color. * ASIP is also a potential therapeutic target for cancer. Studies have shown that ASIP inhibitors can inhibit the growth of cancer cells. **Conclusion:** The agouti signaling protein is a key regulator of melanin production and distribution in the skin and eyes. Its mutations have been linked to a number of skin diseases, including albinism. ASIP is also a potential therapeutic target for cancer.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Agouti-signaling protein

Genular Protein ID: 2857362054

Symbol: ASIP_HUMAN

Name: Agouti-signaling protein

UniProtKB Accession Codes:

P42127 Q3SXL2

Database IDs:

Citations:

PubMed ID: 7937887

Title: Molecular structure and chromosomal mapping of the human homolog of the agouti gene.

PubMed ID: 7937887

DOI: 10.1073/pnas.91.21.9760

PubMed ID: 7757071

Title: Structure and function of ASP, the human homolog of the mouse agouti gene.

PubMed ID: 7757071

DOI: 10.1093/hmg/4.2.223

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15701517

Title: Structures of the agouti signaling protein.

PubMed ID: 15701517

DOI: 10.1016/j.jmb.2004.12.030

PubMed ID: 11833005

Title: A polymorphism in the agouti signaling protein gene is associated with human pigmentation.

PubMed ID: 11833005

DOI: 10.1086/339076

PubMed ID: 36536132

Title: Aberrant expression of agouti signaling protein (ASIP) as a cause of monogenic severe childhood obesity.

PubMed ID: 36536132

DOI: 10.1038/s42255-022-00703-9

Sequence Information:

Length: 132
Mass: 14515
Checksum: AF82CC3C747F2BE6
Sequence:

MDVTRLLLAT LLVFLCFFTA NSHLPPEEKL RDDRSLRSNS SVNLLDVPSV SIVALNKKSK 
QIGRKAAEKK RSSKKEASMK KVVRPRTPLS APCVATRNSC KPPAPACCDP CASCQCRFFR 
SACSCRVLSL NC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: ASIP

Associated with

Cells (max top 100)

Other Information

Molecular structure and chromosomal mapping of the human homolog of the agouti gene. PubMed ID: 7937887

Structure and function of ASP, the human homolog of the mouse agouti gene. PubMed ID: 7757071

The DNA sequence and comparative analysis of human chromosome 20. PubMed ID: 11780052

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Structures of the agouti signaling protein. PubMed ID: 15701517

A polymorphism in the agouti signaling protein gene is associated with human pigmentation. PubMed ID: 11833005

Aberrant expression of agouti signaling protein (ASIP) as a cause of monogenic severe childhood obesity. PubMed ID: 36536132