Details for: ASL
Gene ID: 435
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: ASL
Ensembl ID: ENSG00000126522
Description: argininosuccinate lyase
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 22.49rCSI 23.56%PRS 71.95
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CSI 14.1rCSI 10.93%PRS 78.13
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CSI 13.64rCSI 22%PRS 75.08
-
CSI 13.41rCSI 15.75%PRS 76.82
-
CSI 12.94rCSI 16.09%PRS 76.13
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CSI 11.51rCSI 20.6%PRS 74.06
-
CSI 11.16rCSI 29.11%PRS 74.62
-
CSI 10.18rCSI 10.64%PRS 72.55
-
CSI 9.63rCSI 50.59%PRS 81.78
-
CSI 7.69rCSI 9.32%PRS 56.96
-
CSI 7.55rCSI 7.28%PRS 67.18
-
CSI 6.94rCSI 9.09%PRS 86.62
-
CSI 6.48rCSI 15.2%PRS 75.97
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CSI 5.7rCSI 4.73%PRS 75.27
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CSI 5.68rCSI 5.22%PRS 83.34
-
CSI 5.67rCSI 6.03%PRS 81.28
-
CSI 5.51rCSI 8.76%PRS 84.07
-
CSI 5.45rCSI 12.47%PRS 75.54
-
CSI 5.32rCSI 7.63%PRS 76.54
-
CSI 4.78rCSI 7.3%PRS 78.98
-
CSI 4.63rCSI 5.36%PRS 66.41
-
CSI 4.53rCSI 6.83%PRS 80.19
-
CSI 4.12rCSI 3.89%PRS 74
-
CSI 3.85rCSI 3.11%PRS 77.07
-
CSI 3.79rCSI 4.62%PRS 81.77
-
CSI 3.71rCSI 5.93%PRS 78.49
-
CSI 3.69rCSI 3.68%PRS 68.4
-
CSI 3.67rCSI 9.49%PRS 69.84
-
CSI 3.64rCSI 35.74%PRS 86.18
-
CSI 3.62rCSI 12.85%PRS 80.42
-
CSI 3.59rCSI 7.64%PRS 82.34
-
CSI 3.51rCSI 5.37%PRS 83.11
-
CSI 3.51rCSI 8.34%PRS 81.66
-
CSI 3.36rCSI 2.98%PRS 72.69
-
CSI 3.08rCSI 4.71%PRS 84.67
-
CSI 3.07rCSI 6.87%PRS 56.85
-
CSI 3.06rCSI 5.01%PRS 63.91
-
CSI 2.95rCSI 3.75%PRS 80.27
-
CSI 2.95rCSI 7.48%PRS 68.25
-
CSI 2.91rCSI 21.84%PRS 86.47
-
CSI 2.69rCSI 3.59%PRS 82.02
-
CSI 2.53rCSI 3.74%PRS 79.51
-
CSI 2.51rCSI 17.26%PRS 83.45
-
CSI 2.49rCSI 3.32%PRS 80.72
-
CSI 2.46rCSI 9.55%PRS 75.7
-
CSI 2.41rCSI 3%PRS 54.14
-
CSI 2.41rCSI 4.77%PRS 85.72
-
CSI 2.37rCSI 3.36%PRS 71.11
-
CSI 2.35rCSI 5.2%PRS 73.76
-
CSI 2.34rCSI 3.71%PRS 67.34
-
CSI 2.32rCSI 3.17%PRS 79.59
-
CSI 2.31rCSI 5.55%PRS 80.62
-
CSI 2.27rCSI 3.14%PRS 72.96
-
CSI 2.26rCSI 3.66%PRS 70.21
-
CSI 2.17rCSI 2.26%PRS 74.47
-
CSI 2.14rCSI 1.74%PRS 74.59
-
CSI 2.13rCSI 2.4%PRS 89.01
-
CSI 2.1rCSI 2.87%PRS 75.22
-
CSI 2.06rCSI 5.55%PRS 80.55
-
CSI 2.04rCSI 1.54%PRS 80.95
-
CSI 1.98rCSI 4.91%PRS 73.95
-
CSI 1.97rCSI 4.49%PRS 65.88
-
CSI 1.97rCSI 2.53%PRS 57.41
-
CSI 1.92rCSI 2.98%PRS 79.76
-
CSI 1.92rCSI 3.03%PRS 76.54
-
CSI 1.88rCSI 3.52%PRS 84.29
-
CSI 1.87rCSI 4.18%PRS 82.53
-
CSI 1.85rCSI 2.21%PRS 56.11
-
CSI 1.78rCSI 1.57%PRS 63.24
-
CSI 1.73rCSI 2.55%PRS 86.68
-
CSI 1.71rCSI 3.91%PRS 69.27
-
CSI 1.7rCSI 2.91%PRS 82.1
-
CSI 1.69rCSI 1.3%PRS 77.16
-
CSI 1.67rCSI 3.65%PRS 81.02
-
CSI 1.66rCSI 4.21%PRS 64.71
-
CSI 1.63rCSI 3.97%PRS 67.51
-
CSI 1.62rCSI 2.33%PRS 81.86
-
CSI 1.6rCSI 3.05%PRS 89.61
-
CSI 1.57rCSI 1.42%PRS 72.58
-
CSI 1.54rCSI 1.22%PRS 62.49
-
CSI 1.52rCSI 2.07%PRS 66.08
-
CSI 1.48rCSI 2.62%PRS 55.31
-
CSI 1.44rCSI 2.42%PRS 56.14
-
CSI 1.43rCSI 1.47%PRS 84.48
-
CSI 1.43rCSI 3.16%PRS 84.24
-
CSI 1.38rCSI 4.72%PRS 61.55
-
CSI 1.35rCSI 20.95%PRS 85.25
-
CSI 1.25rCSI 4.21%PRS 74.44
-
CSI 1.25rCSI 1.08%PRS 79.31
-
CSI 1.21rCSI 1.86%PRS 83.97
-
CSI 1.18rCSI 1.71%PRS 83
-
CSI 1.16rCSI 5.42%PRS 85.81
-
CSI 1.13rCSI 3.16%PRS 83.17
-
CSI 1.07rCSI 2.85%PRS 65.77
-
CSI 0.98rCSI 1.9%PRS 77.9
-
CSI 0.9rCSI 1.44%PRS 64.32
-
CSI 0.86rCSI 2.48%PRS 63.83
-
CSI 0.83rCSI 3.65%PRS 84.74
-
CSI 0.78rCSI 2.93%PRS 56.56
-
CSI 0.77rCSI 1.7%PRS 60.28
-
CSI 0.6rCSI 2.5%PRS 75.1%
-
CSI 0.6rCSI 2.5%PRS 83.6%
-
CSI 0.7rCSI 3.5%PRS 87.0%
-
CSI 0.8rCSI 1.7%PRS 60.3%
-
CSI 0.8rCSI 2.9%PRS 56.6%
-
CSI 0.8rCSI 3.7%PRS 84.7%
-
CSI 0.9rCSI 2.5%PRS 63.8%
-
CSI 0.9rCSI 1.4%PRS 64.3%
-
CSI 1.0rCSI 1.9%PRS 77.9%
-
CSI 1.1rCSI 2.9%PRS 65.8%
-
CSI 1.1rCSI 3.2%PRS 83.2%
-
CSI 1.2rCSI 5.4%PRS 85.8%
-
CSI 1.2rCSI 1.7%PRS 83.0%
-
CSI 1.2rCSI 1.9%PRS 84.0%
-
CSI 1.3rCSI 1.1%PRS 79.3%
-
CSI 1.3rCSI 4.2%PRS 74.4%
-
CSI 1.4rCSI 21.0%PRS 85.3%
-
CSI 1.4rCSI 4.7%PRS 61.6%
-
CSI 1.4rCSI 3.2%PRS 84.2%
-
CSI 1.4rCSI 1.5%PRS 84.5%
-
CSI 1.4rCSI 2.4%PRS 56.1%
-
CSI 1.5rCSI 2.6%PRS 55.3%
-
CSI 1.5rCSI 2.1%PRS 66.1%
-
CSI 1.5rCSI 1.2%PRS 62.5%
-
CSI 1.6rCSI 1.4%PRS 72.6%
-
CSI 1.6rCSI 3.1%PRS 89.6%
-
CSI 1.6rCSI 2.3%PRS 81.9%
-
CSI 1.6rCSI 4.0%PRS 67.5%
-
CSI 1.7rCSI 4.2%PRS 64.7%
-
CSI 1.7rCSI 3.7%PRS 81.0%
-
CSI 1.7rCSI 1.3%PRS 77.2%
-
CSI 1.7rCSI 2.9%PRS 82.1%
-
CSI 1.7rCSI 3.9%PRS 69.3%
-
CSI 1.7rCSI 2.6%PRS 86.7%
-
CSI 1.8rCSI 1.6%PRS 63.2%
-
CSI 1.9rCSI 2.2%PRS 56.1%
-
CSI 1.9rCSI 4.2%PRS 82.5%
-
CSI 1.9rCSI 3.5%PRS 84.3%
-
CSI 1.9rCSI 3.0%PRS 76.5%
-
CSI 1.9rCSI 3.0%PRS 79.8%
-
CSI 2.0rCSI 2.5%PRS 57.4%
-
CSI 2.0rCSI 4.5%PRS 65.9%
-
CSI 2.0rCSI 4.9%PRS 74.0%
-
CSI 2.0rCSI 1.5%PRS 81.0%
-
CSI 2.1rCSI 5.6%PRS 80.6%
-
CSI 2.1rCSI 2.9%PRS 75.2%
-
CSI 2.1rCSI 2.4%PRS 89.0%
-
CSI 2.1rCSI 1.7%PRS 74.6%
-
CSI 2.2rCSI 2.3%PRS 74.5%
-
CSI 2.3rCSI 3.7%PRS 70.2%
-
CSI 2.3rCSI 3.1%PRS 73.0%
-
CSI 2.3rCSI 5.6%PRS 80.6%
-
CSI 2.3rCSI 3.2%PRS 79.6%
-
CSI 2.3rCSI 3.7%PRS 67.3%
-
CSI 2.4rCSI 5.2%PRS 73.8%
-
CSI 2.4rCSI 3.4%PRS 71.1%
-
CSI 2.4rCSI 4.8%PRS 85.7%
-
CSI 2.4rCSI 3.0%PRS 54.1%
-
CSI 2.5rCSI 9.6%PRS 75.7%
-
CSI 2.5rCSI 3.3%PRS 80.7%
-
CSI 2.5rCSI 17.3%PRS 83.5%
-
CSI 2.5rCSI 3.7%PRS 79.5%
-
CSI 2.7rCSI 3.6%PRS 82.0%
-
CSI 2.9rCSI 21.8%PRS 86.5%
-
CSI 3.0rCSI 7.5%PRS 68.3%
-
CSI 3.0rCSI 3.8%PRS 80.3%
-
CSI 3.1rCSI 5.0%PRS 63.9%
-
CSI 3.1rCSI 6.9%PRS 56.9%
-
CSI 3.1rCSI 4.7%PRS 84.7%
-
CSI 3.4rCSI 3.0%PRS 72.7%
-
CSI 3.5rCSI 8.3%PRS 81.7%
-
CSI 3.5rCSI 5.4%PRS 83.1%
-
CSI 3.6rCSI 7.6%PRS 82.3%
-
CSI 3.6rCSI 12.9%PRS 80.4%
-
CSI 3.6rCSI 35.7%PRS 86.2%
-
CSI 3.7rCSI 9.5%PRS 69.8%
-
CSI 3.7rCSI 3.7%PRS 68.4%
-
CSI 3.7rCSI 5.9%PRS 78.5%
-
CSI 3.8rCSI 4.6%PRS 81.8%
-
CSI 3.9rCSI 3.1%PRS 77.1%
-
CSI 4.1rCSI 3.9%PRS 74.0%
-
CSI 4.5rCSI 6.8%PRS 80.2%
-
CSI 4.6rCSI 5.4%PRS 66.4%
-
CSI 4.8rCSI 7.3%PRS 79.0%
-
CSI 5.3rCSI 7.6%PRS 76.5%
-
CSI 5.5rCSI 12.5%PRS 75.5%
-
CSI 5.5rCSI 8.8%PRS 84.1%
-
CSI 5.7rCSI 6.0%PRS 81.3%
-
CSI 5.7rCSI 5.2%PRS 83.3%
-
CSI 5.7rCSI 4.7%PRS 75.3%
-
CSI 6.5rCSI 15.2%PRS 76.0%
-
CSI 6.9rCSI 9.1%PRS 86.6%
-
CSI 7.6rCSI 7.3%PRS 67.2%
-
CSI 7.7rCSI 9.3%PRS 57.0%
-
CSI 9.6rCSI 50.6%PRS 81.8%
-
CSI 10.2rCSI 10.6%PRS 72.6%
-
CSI 11.2rCSI 29.1%PRS 74.6%
-
CSI 11.5rCSI 20.6%PRS 74.1%
-
CSI 12.9rCSI 16.1%PRS 76.1%
-
CSI 13.4rCSI 15.8%PRS 76.8%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2650132183
Symbol: ARLY_HUMAN
Name: Arginosuccinase
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3391281
Title: Isolation of cDNA clones of human argininosuccinate lyase and corrected amino acid sequence.
PubMed ID: 3391281
PubMed ID: 3463959
Title: Cloning and sequence analysis of cDNA for human argininosuccinate lyase.
PubMed ID: 3463959
PubMed ID: 2644168
Title: cDNA sequence, interspecies comparison, and gene mapping analysis of argininosuccinate lyase.
PubMed ID: 2644168
PubMed ID: 12853948
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 3368457
Title: Gene sharing by delta-crystallin and argininosuccinate lyase.
PubMed ID: 3368457
PubMed ID: 11747433
Title: Mechanisms for intragenic complementation at the human argininosuccinate lyase locus.
PubMed ID: 11747433
DOI: 10.1021/bi011526e
PubMed ID: 20167786
Title: Regulation of cellular metabolism by protein lysine acetylation.
PubMed ID: 20167786
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22081021
Title: Requirement of argininosuccinate lyase for systemic nitric oxide production.
PubMed ID: 22081021
DOI: 10.1038/nm.2544
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 9256435
Title: Human argininosuccinate lyase: a structural basis for intragenic complementation.
PubMed ID: 9256435
PubMed ID: 11747432
Title: Three-dimensional structure of the argininosuccinate lyase frequently complementing allele Q286R.
PubMed ID: 11747432
DOI: 10.1021/bi011525m
PubMed ID: 2263616
Title: Molecular analysis of human argininosuccinate lyase: mutant characterization and alternative splicing of the coding region.
PubMed ID: 2263616
PubMed ID: 1705937
Title: Analysis of naturally occurring and site-directed mutations in the argininosuccinate lyase gene.
PubMed ID: 1705937
PubMed ID: 9045711
Title: Intragenic complementation at the human argininosuccinate lyase locus. Identification of the major complementing alleles.
PubMed ID: 9045711
PubMed ID: 12408190
Title: Clinical, enzymatic, and molecular genetic characterization of a biochemical variant type of argininosuccinic aciduria: prenatal and postnatal diagnosis in five unrelated families.
PubMed ID: 12408190
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
PubMed ID: 17326097
Title: Argininosuccinate lyase deficiency: mutational spectrum in Italian patients and identification of a novel ASL pseudogene.
PubMed ID: 17326097
DOI: 10.1002/humu.20498
PubMed ID: 19703900
Title: Functional complementation in yeast allows molecular characterization of missense argininosuccinate lyase mutations.
PubMed ID: 19703900
PubMed ID: 24166829
Title: Mutations and polymorphisms in the human argininosuccinate lyase (ASL) gene.
PubMed ID: 24166829
DOI: 10.1002/humu.22469
Sequence Information:
- Length: 464
- Mass: 51658
- Checksum: F751625C1A581883
- Sequence:
MASESGKLWG GRFVGAVDPI MEKFNASIAY DRHLWEVDVQ GSKAYSRGLE KAGLLTKAEM DQILHGLDKV AEEWAQGTFK LNSNDEDIHT ANERRLKELI GATAGKLHTG RSRNDQVVTD LRLWMRQTCS TLSGLLWELI RTMVDRAEAE RDVLFPGYTH LQRAQPIRWS HWILSHAVAL TRDSERLLEV RKRINVLPLG SGAIAGNPLG VDRELLRAEL NFGAITLNSM DATSERDFVA EFLFWASLCM THLSRMAEDL ILYCTKEFSF VQLSDAYSTG SSLMPQKKNP DSLELIRSKA GRVFGRCAGL LMTLKGLPST YNKDLQEDKE AVFEVSDTMS AVLQVATGVI STLQIHQENM GQALSPDMLA TDLAYYLVRK GMPFRQAHEA SGKAVFMAET KGVALNQLSL QELQTISPLF SGDVICVWDY GHSVEQYGAL GGTARSSVDW QIRQVRALLQ AQQA
Genular Protein ID: 2102925363
Symbol: A0A0S2Z316_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 26871637
Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
PubMed ID: 26871637
Sequence Information:
- Length: 438
- Mass: 48733
- Checksum: C05AA06470444AA4
- Sequence:
MASESGKLWG GRFVGAVDPI MEKFNASIAY DRHLWEVDVQ GSKAYSRGLE KAGLLTKAEM DQILHGLDKV AEEWAQGTFK LNSNDEDIHT ANERRLKELI GATAGKLHTG RSRNDQVVTD LRLWMRQTCS TLSGLLWELI RTMVDRAEAE RDVLFPGYTH LQRAQPIRWS HWILSGAIAG NPLGVDRELL RAELNFGAIT LNSMDATSER DFVAEFLFWA SLCMTHLSRM AEDLILYCTK EFSFVQLSDA YSTGSSLMPQ KKNPDSLELI RSKAGRVFGR CAGLLMTLKG LPSTYNKDLQ EDKEAVFEVS DTMSAVLQVA TGVISTLQIH QENMGQALSP DMLATDLAYY LVRKGMPFRQ AHEASGKAVF MAETKGVALN QLSLQELQTI SPLFSGDVIC VWDYGHSVEQ YGALGGTARS SVDWQIRQVR ALLQAQQA