ASL | ENSG00000126522 | NCBI 435

Details for: ASL

Gene ID: 435

Symbol: ASL

Ensembl ID: ENSG00000126522

Description: argininosuccinate lyase

Associated with

Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Ammonia assimilation cycle
(GO:0019676)
Arginine biosynthetic process
(GO:0006526)
Arginine biosynthetic process via ornithine
(GO:0042450)
Arginine metabolic process
(GO:0006525)
Argininosuccinate lyase activity
(GO:0004056)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Extracellular exosome
(GO:0070062)
Identical protein binding
(GO:0042802)
Locomotory behavior
(GO:0007626)
Positive regulation of nitric oxide biosynthetic process
(GO:0045429)
Post-embryonic development
(GO:0009791)
Protein binding
(GO:0005515)
Urea cycle
(GO:0000050)

Other Information

Proteins

Arginosuccinase
A0A0S2Z316_HUMAN

Genular Protein ID: 2650132183

Symbol: ARLY_HUMAN

Name: Arginosuccinase

UniProtKB Accession Codes:

P04424 E7EMI0 E9PE48 Q6LDS5 Q96HS2

Database IDs:

Citations:

PubMed ID: 3391281

Title: Isolation of cDNA clones of human argininosuccinate lyase and corrected amino acid sequence.

PubMed ID: 3391281

DOI: 10.1016/0014-5793(88)80124-8

PubMed ID: 3463959

Title: Cloning and sequence analysis of cDNA for human argininosuccinate lyase.

PubMed ID: 3463959

DOI: 10.1073/pnas.83.19.7211

PubMed ID: 2644168

Title: cDNA sequence, interspecies comparison, and gene mapping analysis of argininosuccinate lyase.

PubMed ID: 2644168

DOI: 10.1016/0888-7543(89)90314-5

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3368457

Title: Gene sharing by delta-crystallin and argininosuccinate lyase.

PubMed ID: 3368457

DOI: 10.1073/pnas.85.10.3479

PubMed ID: 11747433

Title: Mechanisms for intragenic complementation at the human argininosuccinate lyase locus.

PubMed ID: 11747433

DOI: 10.1021/bi011526e

PubMed ID: 20167786

Title: Regulation of cellular metabolism by protein lysine acetylation.

PubMed ID: 20167786

DOI: 10.1126/science.1179689

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22081021

Title: Requirement of argininosuccinate lyase for systemic nitric oxide production.

PubMed ID: 22081021

DOI: 10.1038/nm.2544

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 9256435

Title: Human argininosuccinate lyase: a structural basis for intragenic complementation.

PubMed ID: 9256435

DOI: 10.1073/pnas.94.17.9063

PubMed ID: 11747432

Title: Three-dimensional structure of the argininosuccinate lyase frequently complementing allele Q286R.

PubMed ID: 11747432

DOI: 10.1021/bi011525m

PubMed ID: 2263616

Title: Molecular analysis of human argininosuccinate lyase: mutant characterization and alternative splicing of the coding region.

PubMed ID: 2263616

DOI: 10.1073/pnas.87.24.9625

PubMed ID: 1705937

Title: Analysis of naturally occurring and site-directed mutations in the argininosuccinate lyase gene.

PubMed ID: 1705937

DOI: 10.1016/s0021-9258(19)67785-9

PubMed ID: 9045711

Title: Intragenic complementation at the human argininosuccinate lyase locus. Identification of the major complementing alleles.

PubMed ID: 9045711

DOI: 10.1074/jbc.272.10.6777

PubMed ID: 12408190

Title: Clinical, enzymatic, and molecular genetic characterization of a biochemical variant type of argininosuccinic aciduria: prenatal and postnatal diagnosis in five unrelated families.

PubMed ID: 12408190

DOI: 10.1023/a:1020108002877

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 17326097

Title: Argininosuccinate lyase deficiency: mutational spectrum in Italian patients and identification of a novel ASL pseudogene.

PubMed ID: 17326097

DOI: 10.1002/humu.20498

PubMed ID: 19703900

Title: Functional complementation in yeast allows molecular characterization of missense argininosuccinate lyase mutations.

PubMed ID: 19703900

DOI: 10.1074/jbc.m109.050195

PubMed ID: 24166829

Title: Mutations and polymorphisms in the human argininosuccinate lyase (ASL) gene.

PubMed ID: 24166829

DOI: 10.1002/humu.22469

Sequence Information:

Length: 464
Mass: 51658
Checksum: F751625C1A581883
Sequence:

MASESGKLWG GRFVGAVDPI MEKFNASIAY DRHLWEVDVQ GSKAYSRGLE KAGLLTKAEM 
DQILHGLDKV AEEWAQGTFK LNSNDEDIHT ANERRLKELI GATAGKLHTG RSRNDQVVTD 
LRLWMRQTCS TLSGLLWELI RTMVDRAEAE RDVLFPGYTH LQRAQPIRWS HWILSHAVAL 
TRDSERLLEV RKRINVLPLG SGAIAGNPLG VDRELLRAEL NFGAITLNSM DATSERDFVA 
EFLFWASLCM THLSRMAEDL ILYCTKEFSF VQLSDAYSTG SSLMPQKKNP DSLELIRSKA 
GRVFGRCAGL LMTLKGLPST YNKDLQEDKE AVFEVSDTMS AVLQVATGVI STLQIHQENM 
GQALSPDMLA TDLAYYLVRK GMPFRQAHEA SGKAVFMAET KGVALNQLSL QELQTISPLF 
SGDVICVWDY GHSVEQYGAL GGTARSSVDW QIRQVRALLQ AQQA

Genular Protein ID: 2102925363

Symbol: A0A0S2Z316_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0S2Z316

Database IDs:

Citations:

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

Length: 438
Mass: 48733
Checksum: C05AA06470444AA4
Sequence:

MASESGKLWG GRFVGAVDPI MEKFNASIAY DRHLWEVDVQ GSKAYSRGLE KAGLLTKAEM 
DQILHGLDKV AEEWAQGTFK LNSNDEDIHT ANERRLKELI GATAGKLHTG RSRNDQVVTD 
LRLWMRQTCS TLSGLLWELI RTMVDRAEAE RDVLFPGYTH LQRAQPIRWS HWILSGAIAG 
NPLGVDRELL RAELNFGAIT LNSMDATSER DFVAEFLFWA SLCMTHLSRM AEDLILYCTK 
EFSFVQLSDA YSTGSSLMPQ KKNPDSLELI RSKAGRVFGR CAGLLMTLKG LPSTYNKDLQ 
EDKEAVFEVS DTMSAVLQVA TGVISTLQIH QENMGQALSP DMLATDLAYY LVRKGMPFRQ 
AHEASGKAVF MAETKGVALN QLSLQELQTI SPLFSGDVIC VWDYGHSVEQ YGALGGTARS 
SVDWQIRQVR ALLQAQQA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ASL

Associated with

Other Information

Isolation of cDNA clones of human argininosuccinate lyase and corrected amino acid sequence. PubMed ID: 3391281

Cloning and sequence analysis of cDNA for human argininosuccinate lyase. PubMed ID: 3463959

cDNA sequence, interspecies comparison, and gene mapping analysis of argininosuccinate lyase. PubMed ID: 2644168

The DNA sequence of human chromosome 7. PubMed ID: 12853948

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Gene sharing by delta-crystallin and argininosuccinate lyase. PubMed ID: 3368457

Mechanisms for intragenic complementation at the human argininosuccinate lyase locus. PubMed ID: 11747433

Regulation of cellular metabolism by protein lysine acetylation. PubMed ID: 20167786

Initial characterization of the human central proteome. PubMed ID: 21269460

Requirement of argininosuccinate lyase for systemic nitric oxide production. PubMed ID: 22081021

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Human argininosuccinate lyase: a structural basis for intragenic complementation. PubMed ID: 9256435

Three-dimensional structure of the argininosuccinate lyase frequently complementing allele Q286R. PubMed ID: 11747432

Molecular analysis of human argininosuccinate lyase: mutant characterization and alternative splicing of the coding region. PubMed ID: 2263616

Analysis of naturally occurring and site-directed mutations in the argininosuccinate lyase gene. PubMed ID: 1705937

Intragenic complementation at the human argininosuccinate lyase locus. Identification of the major complementing alleles. PubMed ID: 9045711

Clinical, enzymatic, and molecular genetic characterization of a biochemical variant type of argininosuccinic aciduria: prenatal and postnatal diagnosis in five unrelated families. PubMed ID: 12408190

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974

Argininosuccinate lyase deficiency: mutational spectrum in Italian patients and identification of a novel ASL pseudogene. PubMed ID: 17326097

Functional complementation in yeast allows molecular characterization of missense argininosuccinate lyase mutations. PubMed ID: 19703900

Mutations and polymorphisms in the human argininosuccinate lyase (ASL) gene. PubMed ID: 24166829

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. PubMed ID: 26871637