dco | FBgn0002413 | NCBI 43673

Details for: dco

Gene ID: 43673

Symbol: dco

Ensembl ID: FBgn0002413

Description: discs overgrown

Associated with

Atp binding
(GO:0005524)
Behavioral response to cocaine
(GO:0048148)
Cell body
(GO:0044297)
Cell communication
(GO:0007154)
Cellular response to light stimulus
(GO:0071482)
Circadian rhythm
(GO:0007623)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Endocytosis
(GO:0006897)
Imaginal disc growth
(GO:0007446)
Locomotor rhythm
(GO:0045475)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of canonical wnt signaling pathway
(GO:0090090)
Negative regulation of protein phosphorylation
(GO:0001933)
Negative regulation of smoothened signaling pathway
(GO:0045879)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Positive regulation of actin filament polymerization
(GO:0030838)
Positive regulation of canonical wnt signaling pathway
(GO:0090263)
Positive regulation of cell division
(GO:0051781)
Positive regulation of cell growth
(GO:0030307)
Positive regulation of hippo signaling
(GO:0035332)
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process
(GO:0032436)
Positive regulation of protein catabolic process
(GO:0045732)
Positive regulation of smoothened signaling pathway
(GO:0045880)
Positive regulation of wnt signaling pathway
(GO:0030177)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein serine/threonine kinase activity
(GO:0004674)
Regulation of circadian rhythm
(GO:0042752)
Regulation of ecdysteroid secretion
(GO:0007555)
Regulation of establishment of planar polarity
(GO:0090175)
Signal transduction
(GO:0007165)

Other Information

Proteins

Discs overgrown protein kinase

Genular Protein ID: 1510002501

Symbol: DCO_DROME

Name: Discs overgrown protein kinase

UniProtKB Accession Codes:

O76324 A4V3P5 Q0KHY4 Q9V462

Database IDs:

Citations:

PubMed ID: 9674431

Title: The Drosophila clock gene double-time encodes a protein closely related to human casein kinase I epsilon.

PubMed ID: 9674431

DOI: 10.1016/s0092-8674(00)81225-8

PubMed ID: 10556065

Title: Double-time is identical to discs overgrown, which is required for cell survival, proliferation and growth arrest in Drosophila imaginal discs.

PubMed ID: 10556065

DOI: 10.1242/dev.126.23.5409

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 10731138

Title: A Drosophila complementary DNA resource.

PubMed ID: 10731138

DOI: 10.1126/science.287.5461.2222

PubMed ID: 9674430

Title: Double-time is a novel Drosophila clock gene that regulates PERIOD protein accumulation.

PubMed ID: 9674430

DOI: 10.1016/s0092-8674(00)81224-6

PubMed ID: 16326393

Title: Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing.

PubMed ID: 16326393

DOI: 10.1016/j.devcel.2005.10.006

PubMed ID: 18327897

Title: Phosphoproteome analysis of Drosophila melanogaster embryos.

PubMed ID: 18327897

DOI: 10.1021/pr700696a

PubMed ID: 26082158

Title: A Doubletime Nuclear Localization Signal Mediates an Interaction with Bride of Doubletime to Promote Circadian Function.

PubMed ID: 26082158

DOI: 10.1177/0748730415588189

PubMed ID: 27692068

Title: The novel SH3 domain protein Dlish/CG10933 mediates fat signaling in Drosophila by binding and regulating Dachs.

PubMed ID: 27692068

DOI: 10.7554/elife.16624

PubMed ID: 27824307

Title:

PubMed ID: 27824307

DOI: 10.7554/elife.22672

PubMed ID: 32750048

Title: DAnkrd49 and Bdbt act via Casein kinase Iepsilon to regulate planar polarity in Drosophila.

PubMed ID: 32750048

DOI: 10.1371/journal.pgen.1008820

Sequence Information:

Length: 440
Mass: 47958
Checksum: 0B67B83E44213902
Sequence:

MELRVGNKYR LGRKIGSGSF GDIYLGTTIN TGEEVAIKLE CIRTKHPQLH IESKFYKTMQ 
GGIGIPRIIW CGSEGDYNVM VMELLGPSLE DLFNFCSRRF SLKTVLLLAD QMISRIDYIH 
SRDFIHRDIK PDNFLMGLGK KGNLVYIIDF GLAKKFRDAR SLKHIPYREN KNLTGTARYA 
SINTHLGIEQ SRRDDLESLG YVLMYFNLGA LPWQGLKAAN KRQKYERISE KKLSTSIVVL 
CKGFPSEFVN YLNFCRQMHF DQRPDYCHLR KLFRNLFHRL GFTYDYVFDW NLLKFGGPRN 
PQAIQQAQDG ADGQAGHDAV AAAAAVAAAA AASSHQQQQH KVNAALGGGG GSAAQQQLQG 
GQTLAMLGGN GGGNGSQLIG GNGLNMDDSM AATNSSRPPY DTPERRPSIR MRQGGGGGGG 
GVGVGGMPSG GGGGGVGNAK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: dco

Associated with

Other Information

The Drosophila clock gene double-time encodes a protein closely related to human casein kinase I epsilon. PubMed ID: 9674431

Double-time is identical to discs overgrown, which is required for cell survival, proliferation and growth arrest in Drosophila imaginal discs. PubMed ID: 10556065

The genome sequence of Drosophila melanogaster. PubMed ID: 10731132

Annotation of the Drosophila melanogaster euchromatic genome: a systematic review. PubMed ID: 12537572

A Drosophila complementary DNA resource. PubMed ID: 10731138

Double-time is a novel Drosophila clock gene that regulates PERIOD protein accumulation. PubMed ID: 9674430

Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing. PubMed ID: 16326393

Phosphoproteome analysis of Drosophila melanogaster embryos. PubMed ID: 18327897

A Doubletime Nuclear Localization Signal Mediates an Interaction with Bride of Doubletime to Promote Circadian Function. PubMed ID: 26082158

The novel SH3 domain protein Dlish/CG10933 mediates fat signaling in Drosophila by binding and regulating Dachs. PubMed ID: 27692068