Details for: ci

Gene ID: 43767

Symbol: ci

Ensembl ID: FBgn0004859

Description: cubitus interruptus

Associated with

  • Camp response element binding protein binding
    (GO:0008140)
  • Compound eye morphogenesis
    (GO:0001745)
  • Cuticle pattern formation
    (GO:0035017)
  • Cytosol
    (GO:0005829)
  • Dendrite morphogenesis
    (GO:0048813)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Genital disc anterior/posterior pattern formation
    (GO:0035224)
  • Heart formation
    (GO:0060914)
  • Hedgehog signaling complex
    (GO:0035301)
  • Labial disc development
    (GO:0035217)
  • Mucosal immune response
    (GO:0002385)
  • Negative regulation of hippo signaling
    (GO:0035331)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleus
    (GO:0005634)
  • Positive regulation of epithelial cell differentiation
    (GO:0030858)
  • Positive regulation of g1/s transition of mitotic cell cycle
    (GO:1900087)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein-containing complex
    (GO:0032991)
  • Protein binding
    (GO:0005515)
  • Protein homodimerization activity
    (GO:0042803)
  • Protein kinase binding
    (GO:0019901)
  • Regulation of cell proliferation involved in compound eye morphogenesis
    (GO:2000495)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of mitotic cell cycle
    (GO:0007346)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Segment polarity determination
    (GO:0007367)
  • Sequence-specific dna binding
    (GO:0043565)
  • Smoothened signaling pathway
    (GO:0007224)
  • Spiracle morphogenesis, open tracheal system
    (GO:0035277)
  • Transcription cis-regulatory region binding
    (GO:0000976)
  • Wing disc anterior/posterior pattern formation
    (GO:0048100)

Other Information

Genular Protein ID: 860333945

Symbol: CI_DROME

Name: Transcriptional activator cubitus interruptus

UniProtKB Accession Codes:

P19538 O18525 Q8T6T1 Q9V4A8

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CTD 1 ComplexPortal 1 DIP 1 ELM 1 EMBL 5 EnsemblMetazoa 1 EvolutionaryTrace 1 ExpressionAtlas 1 FlyBase 1 GO 37 Gene3D 1 GeneTree 1 GenomeRNAi 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 2 PaxDb 1 Pfam 1 PhylomeDB 1 Proteomes 1 Reactome 13 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 2166702

Title: Cloning and characterization of the segment polarity gene cubitus interruptus Dominant of Drosophila.

PubMed ID: 2166702

DOI: 10.1101/gad.4.6.1053

PubMed ID: 1686006

Title: Lack of polymorphism on the Drosophila fourth chromosome resulting from selection.

PubMed ID: 1686006

DOI: 10.1093/genetics/129.4.1111

PubMed ID: 9332387

Title: Use of ordered deletions in genome sequencing.

PubMed ID: 9332387

DOI: 10.1016/s0378-1119(97)00285-0

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 7600980

Title: Analysis of cubitus interruptus regulation in Drosophila embryos and imaginal disks.

PubMed ID: 7600980

DOI: 10.1242/dev.121.6.1625

PubMed ID: 11778050

Title: Nucleotide variation along the Drosophila melanogaster fourth chromosome.

PubMed ID: 11778050

DOI: 10.1126/science.1064521

PubMed ID: 9244298

Title: Costal2, a novel kinesin-related protein in the Hedgehog signaling pathway.

PubMed ID: 9244298

DOI: 10.1016/s0092-8674(00)80332-3

PubMed ID: 15691767

Title: Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus.

PubMed ID: 15691767

DOI: 10.1016/j.devcel.2005.01.001

PubMed ID: 16326393

Title: Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing.

PubMed ID: 16326393

DOI: 10.1016/j.devcel.2005.10.006

PubMed ID: 16740475

Title: A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor.

PubMed ID: 16740475

DOI: 10.1016/j.devcel.2006.05.004

PubMed ID: 25639794

Title: Bacterial uracil modulates Drosophila DUOX-dependent gut immunity via Hedgehog-induced signaling endosomes.

PubMed ID: 25639794

DOI: 10.1016/j.chom.2014.12.012

Sequence Information:

  • Length: 1397
  • Mass: 153280
  • Checksum: C3232A71EF9B8004
  • Sequence:
    • MDAYALPTYF PLAYSELQFL ASRRAAAVAA AATVLPGSPC INQHHPTDVS SSVTVPSIIP 
TGGTSDSIKT SIQPQICNEN TLLGNAGHQH NHQPQHVHNI NVTGQPHDFH PAYRIPGYME 
QLYSLQRTNS ASSFHDPYVN CASAFHLAGL GLGSADFLGS RGLSSLGELH NAAVAAAAAG 
SLASTDFHFS VDGNRRLGSP RPPGGSIRAS ISRKRALSSS PYSDSFDINS MIRFSPNSLA 
TIMNGSRGSS AASGSYGHIS ATALNPMSHV HSTRLQQIQA HLLRASAGLL NPMTPQQVAA 
SGFSIGHMPT SASLRVNDVH PNLSDSHIQI TTSPTVTKDV SQVPAAAFSL KNLDDAREKK 
GPFKDVVPEQ PSSTSGGVAQ VEADSASSQL SDRCYNNVVN NITGIPGDVK VNSRLDEYIN 
CGSISIPSNE YDCANADTTD IKDEPGDFIE TNCHWRSCRI EFITQDELVK HINNDHIQTN 
KKAFVCRWED CTRGEKPFKA QYMLVVHMRR HTGEKPHKCT FEGCFKAYSR LENLKTHLRS 
HTGEKPYTCE YPGCSKAFSN ASDRAKHQNR THSNEKPYIC KAPGCTKRYT DPSSLRKHVK 
TVHGAEFYAN KKHKGLPLND ANSRLQQNNS RHNLQEHNID SSPCSEDSHL GKMLGTSSPS 
IKSESDISSS NHHLVNGVRA SDSLLTYSPD DLAENLNLDD GWNCDDDVDV ADLPIVLRAM 
VNIGNGNASA STIGGSVLAR QRFRGRLQTK GINSSTIMLC NIPESNRTFG ISELNQRITE 
LKMEPGTDAE IKIPKLPNTT IGGYTEDPLQ NQTSFRNTVS NKQGTVSGSI QGQFRRDSQN 
STASTYYGSM QSRRSSQSSQ VSSIPTMRPN PSCNSTASFY DPISPGCSRR SSQMSNGANC 
NSFTSTSGLP VLNKESNKSL NACINKPNIG VQGVGIYNSS LPPPPSSHLI ATNLKRLQRK 
DSEYHNFTSG RFSVPSYMHS LHIKNNKPVG ENEFDKAIAS NARRQTDPVP NINLDPLTNI 
SRFSTTPHSF DINVGKTNNI ASSINKDNLR KDLFTVSIKA DMAMTSDQHP NERINLDEVE 
ELILPDEMLQ YLNLVKDDTN HLEKEHQAVP VGSNVSETIA SNHYREQSNI YYTNKQILTP 
PSNVDIQPNT TKFTVQDKFA MTAVGGSFSQ RELSTLAVPN EHGHAKCESF HHQSQKYMNT 
DIGSKQQSAL PSAHQRQTEK SNYNQIIDSS MTSLPELNVD SIYPRNETEN IFKVHGDHDN 
EIQCGIISQS QMSPSTNLNN DGQFSTVNMQ PITTSKLFPP EPQKIVCDTQ ASNTSVMHLD 
TYQRTLEYVQ SCQNWMETNN TSTNQIQSLP GMPVNNTLFP DVSSSTHPYH GTNMVINDMT 
TSLTSLLEEN RYLQMMQ

Genular Protein ID: 2421216017

Symbol: H9XVL6_DROME

Name: N/A

UniProtKB Accession Codes:

H9XVL6

Database IDs:

AGR 1 ARBA 5 AlphaFoldDB 1 Bgee 1 BioGRID-ORCS 1 CTD 1 EMBL 2 EnsemblMetazoa 1 ExpressionAtlas 1 FlyBase 2 GO 4 Gene3D 1 GeneTree 1 HOGENOM 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 Proteomes 2 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537568

Title: Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence.

PubMed ID: 12537568

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537573

Title: The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective.

PubMed ID: 12537573

PubMed ID: 12537574

Title: Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.

PubMed ID: 12537574

PubMed ID: 16110336

Title: Combined evidence annotation of transposable elements in genome sequences.

PubMed ID: 16110336

DOI: 10.1371/journal.pcbi.0010022

PubMed ID: 17569856

Title: The Release 5.1 annotation of Drosophila melanogaster heterochromatin.

PubMed ID: 17569856

DOI: 10.1126/science.1139815

PubMed ID: 17569867

Title: Sequence finishing and mapping of Drosophila melanogaster heterochromatin.

PubMed ID: 17569867

DOI: 10.1126/science.1139816

Sequence Information:

  • Length: 572
  • Mass: 61819
  • Checksum: 472BC8AD4516A84F
  • Sequence:
    • MDAYALPTYF PLAYSELQFL ASRRAAAVAA AATVLPGSPC INQHHPTDVS SSVTVPSIIP 
TGGTSDSIKT SIQPQICNEN TLLGNAGHQH NHQPQHVHNI NVTGQPHDFH PAYRIPGYME 
QLYSLQRTNS ASSFHDPYVN CASAFHLAGL GLGSADFLGS RGLSSLGELH NAAVAAAAAG 
SLASTDFHFS VDGNRRLGSP RPPGGSIRAS ISRKRALSSS PYSDSFDINS MIRFSPNSLA 
TIMNGSRGSS AASGSYGHIS ATALNPMSHV HSTRLQQIQA HLLRASAGLL NPMTPQQVAA 
SGFSIGHMPT SASLRVNDVH PNLSDSHIQI TTSPTVTKDV SQVPAAAFSL KNLDDAREKK 
GPFKDVVPEQ PSSTSGGVAQ VEADSASSQL SDRCYNNVVN NITGIPGDVK VNSRLDEYIN 
CGSISIPSNE YDCANADTTD IKDEPGDFIE TNCHWRSCRI EFITQDELVK HINNDHIQTN 
KKAFVCRWED CTRGEKPFKA QYMLVVHMRR HTGEKPHKCT EKNHTLASIR DVAKPLVMLV 
IAQSIKIEHT VMRNRTFVKH LDAQNVTPTR AL

Genular Protein ID: 3246422284

Symbol: H9XVL7_DROME

Name: N/A

UniProtKB Accession Codes:

H9XVL7

Database IDs:

AGR 1 ARBA 5 AlphaFoldDB 1 Bgee 1 BioGRID-ORCS 1 CTD 1 EMBL 2 EnsemblMetazoa 1 ExpressionAtlas 1 FlyBase 2 GO 4 Gene3D 1 HOGENOM 1 InterPro 3 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 Pfam 1 Proteomes 2 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 10731132

Title: The genome sequence of Drosophila melanogaster.

PubMed ID: 10731132

DOI: 10.1126/science.287.5461.2185

PubMed ID: 12537568

Title: Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence.

PubMed ID: 12537568

PubMed ID: 12537572

Title: Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

PubMed ID: 12537572

DOI: 10.1186/gb-2002-3-12-research0083

PubMed ID: 12537573

Title: The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective.

PubMed ID: 12537573

PubMed ID: 12537574

Title: Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.

PubMed ID: 12537574

PubMed ID: 16110336

Title: Combined evidence annotation of transposable elements in genome sequences.

PubMed ID: 16110336

DOI: 10.1371/journal.pcbi.0010022

PubMed ID: 17569856

Title: The Release 5.1 annotation of Drosophila melanogaster heterochromatin.

PubMed ID: 17569856

DOI: 10.1126/science.1139815

PubMed ID: 17569867

Title: Sequence finishing and mapping of Drosophila melanogaster heterochromatin.

PubMed ID: 17569867

DOI: 10.1126/science.1139816

Sequence Information:

  • Length: 1279
  • Mass: 140651
  • Checksum: 42FFDCE36E7277C9
  • Sequence:
    • MEQLYSLQRT NSASSFHDPY VNCASAFHLA GLGLGSADFL GSRGLSSLGE LHNAAVAAAA 
AGSLASTDFH FSVDGNRRLG SPRPPGGSIR ASISRKRALS SSPYSDSFDI NSMIRFSPNS 
LATIMNGSRG SSAASGSYGH ISATALNPMS HVHSTRLQQI QAHLLRASAG LLNPMTPQQV 
AASGFSIGHM PTSASLRVND VHPNLSDSHI QITTSPTVTK DVSQVPAAAF SLKNLDDARE 
KKGPFKDVVP EQPSSTSGGV AQVEADSASS QLSDRCYNNV VNNITGIPGD VKVNSRLDEY 
INCGSISIPS NEYDCANADT TDIKDEPGDF IETNCHWRSC RIEFITQDEL VKHINNDHIQ 
TNKKAFVCRW EDCTRGEKPF KAQYMLVVHM RRHTGEKPHK CTFEGCFKAY SRLENLKTHL 
RSHTGEKPYT CEYPGCSKAF SNASDRAKHQ NRTHSNEKPY ICKAPGCTKR YTDPSSLRKH 
VKTVHGAEFY ANKKHKGLPL NDANSRLQQN NSRHNLQEHN IDSSPCSEDS HLGKMLGTSS 
PSIKSESDIS SSNHHLVNGV RASDSLLTYS PDDLAENLNL DDGWNCDDDV DVADLPIVLR 
AMVNIGNGNA SASTIGGSVL ARQRFRGRLQ TKGINSSTIM LCNIPESNRT FGISELNQRI 
TELKMEPGTD AEIKIPKLPN TTIGGYTEDP LQNQTSFRNT VSNKQGTVSG SIQGQFRRDS 
QNSTASTYYG SMQSRRSSQS SQVSSIPTMR PNPSCNSTAS FYDPISPGCS RRSSQMSNGA 
NCNSFTSTSG LPVLNKESNK SLNACINKPN IGVQGVGIYN SSLPPPPSSH LIATNLKRLQ 
RKDSEYHNFT SGRFSVPSYM HSLHIKNNKP VGENEFDKAI ASNARRQTDP VPNINLDPLT 
NISRFSTTPH SFDINVGKTN NIASSINKDN LRKDLFTVSI KADMAMTSDQ HPNERINLDE 
VEELILPDEM LQYLNLVKDD TNHLEKEHQA VPVGSNVSET IASNHYREQS NIYYTNKQIL 
TPPSNVDIQP NTTKFTVQDK FAMTAVGGSF SQRELSTLAV PNEHGHAKCE SFHHQSQKYM 
NTDIGSKQQS ALPSAHQRQT EKSNYNQIID SSMTSLPELN VDSIYPRNET ENIFKVHGDH 
DNEIQCGIIS QSQMSPSTNL NNDGQFSTVN MQPITTSKLF PPEPQKIVCD TQASNTSVMH 
LDTYQRTLEY VQSCQNWMET NNTSTNQIQS LPGMPVNNTL FPDVSSSTHP YHGTNMVIND 
MTTSLTSLLE ENRYLQMMQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.